SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1vtk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KI2_A_GA2A1_1
(THYMIDINE KINASE)		 1vtk THYMIDINE KINASE
(Human
alphaherpesvirus
1) 		10 / 11 HIS A  58
GLU A  83
ILE A 100
TYR A 101
GLN A 125
MET A 128
ARG A 163
TYR A 172
ARG A 176
GLU A 225
 TMP  A 500 (-3.8A)
TMP  A 500 (-2.7A)
TMP  A 500 ( 4.1A)
TMP  A 500 (-4.5A)
TMP  A 500 (-3.0A)
TMP  A 500 ( 4.6A)
TMP  A 500 (-3.3A)
TMP  A 500 (-3.7A)
None
TMP  A 500 (-3.5A)
 0.68A 1ki2A-1vtkA:
47.4		 1ki2A-1vtkA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KI2_A_GA2A1_1
(THYMIDINE KINASE)		 1vtk THYMIDINE KINASE
(Human
alphaherpesvirus
1) 		5 / 11 HIS A  58
ILE A  97
TYR A 101
MET A  85
ARG A 163
 TMP  A 500 (-3.8A)
TMP  A 500 ( 4.5A)
TMP  A 500 (-4.5A)
None
TMP  A 500 (-3.3A)
 1.45A 1ki2A-1vtkA:
47.4		 1ki2A-1vtkA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KI2_A_GA2A1_1
(THYMIDINE KINASE)		 1vtk THYMIDINE KINASE
(Human
alphaherpesvirus
1) 		10 / 11 HIS A  58
ILE A 100
TYR A 101
GLN A 125
MET A 128
ARG A 163
TYR A 172
ARG A 176
ARG A 222
GLU A 225
 TMP  A 500 (-3.8A)
TMP  A 500 ( 4.1A)
TMP  A 500 (-4.5A)
TMP  A 500 (-3.0A)
TMP  A 500 ( 4.6A)
TMP  A 500 (-3.3A)
TMP  A 500 (-3.7A)
None
TMP  A 500 (-3.2A)
TMP  A 500 (-3.5A)
 0.60A 1ki2A-1vtkA:
47.4		 1ki2A-1vtkA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KI2_B_GA2B2_1
(THYMIDINE KINASE)		 1vtk THYMIDINE KINASE
(Human
alphaherpesvirus
1) 		12 / 12 HIS A  58
GLU A  83
TRP A  88
ILE A 100
TYR A 101
GLN A 125
MET A 128
ARG A 163
TYR A 172
ARG A 176
ARG A 222
GLU A 225
 TMP  A 500 (-3.8A)
TMP  A 500 (-2.7A)
None
TMP  A 500 ( 4.1A)
TMP  A 500 (-4.5A)
TMP  A 500 (-3.0A)
TMP  A 500 ( 4.6A)
TMP  A 500 (-3.3A)
TMP  A 500 (-3.7A)
None
TMP  A 500 (-3.2A)
TMP  A 500 (-3.5A)
 0.69A 1ki2B-1vtkA:
48.2		 1ki2B-1vtkA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KI2_B_GA2B2_1
(THYMIDINE KINASE)		 1vtk THYMIDINE KINASE
(Human
alphaherpesvirus
1) 		5 / 12 HIS A  58
ILE A  97
TYR A 101
MET A  85
ARG A 163
 TMP  A 500 (-3.8A)
TMP  A 500 ( 4.5A)
TMP  A 500 (-4.5A)
None
TMP  A 500 (-3.3A)
 1.41A 1ki2B-1vtkA:
48.2		 1ki2B-1vtkA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KI3_A_PE2A1_1
(THYMIDINE KINASE)		 1vtk THYMIDINE KINASE
(Human
alphaherpesvirus
1) 		10 / 12 GLU A  83
TRP A  88
ILE A  97
ILE A 100
TYR A 101
MET A 128
TYR A 172
ARG A 176
ARG A 222
GLU A 225
 TMP  A 500 (-2.7A)
None
TMP  A 500 ( 4.5A)
TMP  A 500 ( 4.1A)
TMP  A 500 (-4.5A)
TMP  A 500 ( 4.6A)
TMP  A 500 (-3.7A)
None
TMP  A 500 (-3.2A)
TMP  A 500 (-3.5A)
 0.79A 1ki3A-1vtkA:
47.5		 1ki3A-1vtkA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KI3_A_PE2A1_1
(THYMIDINE KINASE)		 1vtk THYMIDINE KINASE
(Human
alphaherpesvirus
1) 		5 / 12 HIS A  58
GLN A 125
TYR A 172
ARG A 176
ARG A 220
 TMP  A 500 (-3.8A)
TMP  A 500 (-3.0A)
TMP  A 500 (-3.7A)
None
TMP  A 500 (-3.4A)
 1.41A 1ki3A-1vtkA:
47.5		 1ki3A-1vtkA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KI3_A_PE2A1_1
(THYMIDINE KINASE)		 1vtk THYMIDINE KINASE
(Human
alphaherpesvirus
1) 		10 / 12 HIS A  58
GLU A  83
TRP A  88
ILE A  97
ILE A 100
TYR A 101
MET A 128
TYR A 172
ARG A 176
GLU A 225
 TMP  A 500 (-3.8A)
TMP  A 500 (-2.7A)
None
TMP  A 500 ( 4.5A)
TMP  A 500 ( 4.1A)
TMP  A 500 (-4.5A)
TMP  A 500 ( 4.6A)
TMP  A 500 (-3.7A)
None
TMP  A 500 (-3.5A)
 0.67A 1ki3A-1vtkA:
47.5		 1ki3A-1vtkA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KI3_A_PE2A1_1
(THYMIDINE KINASE)		 1vtk THYMIDINE KINASE
(Human
alphaherpesvirus
1) 		10 / 12 HIS A  58
TRP A  88
ILE A  97
ILE A 100
TYR A 101
GLN A 125
MET A 128
TYR A 172
ARG A 176
GLU A 225
 TMP  A 500 (-3.8A)
None
TMP  A 500 ( 4.5A)
TMP  A 500 ( 4.1A)
TMP  A 500 (-4.5A)
TMP  A 500 (-3.0A)
TMP  A 500 ( 4.6A)
TMP  A 500 (-3.7A)
None
TMP  A 500 (-3.5A)
 0.73A 1ki3A-1vtkA:
47.5		 1ki3A-1vtkA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KI3_A_PE2A1_1
(THYMIDINE KINASE)		 1vtk THYMIDINE KINASE
(Human
alphaherpesvirus
1) 		10 / 12 TRP A  88
ILE A  97
ILE A 100
TYR A 101
GLN A 125
MET A 128
TYR A 172
ARG A 176
ARG A 222
GLU A 225
 None
TMP  A 500 ( 4.5A)
TMP  A 500 ( 4.1A)
TMP  A 500 (-4.5A)
TMP  A 500 (-3.0A)
TMP  A 500 ( 4.6A)
TMP  A 500 (-3.7A)
None
TMP  A 500 (-3.2A)
TMP  A 500 (-3.5A)
 0.80A 1ki3A-1vtkA:
47.5		 1ki3A-1vtkA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KI3_B_PE2B2_1
(THYMIDINE KINASE)		 1vtk THYMIDINE KINASE
(Human
alphaherpesvirus
1) 		12 / 12 HIS A  58
GLU A  83
TRP A  88
ILE A  97
ILE A 100
TYR A 101
MET A 121
GLN A 125
MET A 128
TYR A 172
ARG A 176
GLU A 225
 TMP  A 500 (-3.8A)
TMP  A 500 (-2.7A)
None
TMP  A 500 ( 4.5A)
TMP  A 500 ( 4.1A)
TMP  A 500 (-4.5A)
None
TMP  A 500 (-3.0A)
TMP  A 500 ( 4.6A)
TMP  A 500 (-3.7A)
None
TMP  A 500 (-3.5A)
 0.55A 1ki3B-1vtkA:
47.7		 1ki3B-1vtkA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KI7_A_ID2A1_0
(THYMIDINE KINASE)		 1vtk THYMIDINE KINASE
(Human
alphaherpesvirus
1) 		11 / 12 HIS A  58
GLU A  83
TRP A  88
ILE A  97
ILE A 100
TYR A 101
GLN A 125
MET A 128
ALA A 168
TYR A 172
GLU A 225
 TMP  A 500 (-3.8A)
TMP  A 500 (-2.7A)
None
TMP  A 500 ( 4.5A)
TMP  A 500 ( 4.1A)
TMP  A 500 (-4.5A)
TMP  A 500 (-3.0A)
TMP  A 500 ( 4.6A)
TMP  A 500 (-3.5A)
TMP  A 500 (-3.7A)
TMP  A 500 (-3.5A)
 0.38A 1ki7A-1vtkA:
47.4		 1ki7A-1vtkA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KI7_A_ID2A1_0
(THYMIDINE KINASE)		 1vtk THYMIDINE KINASE
(Human
alphaherpesvirus
1) 		6 / 12 HIS A  58
ILE A  97
TYR A 101
ALA A 167
ARG A 222
GLU A 225
 TMP  A 500 (-3.8A)
TMP  A 500 ( 4.5A)
TMP  A 500 (-4.5A)
TMP  A 500 ( 4.2A)
TMP  A 500 (-3.2A)
TMP  A 500 (-3.5A)
 0.94A 1ki7A-1vtkA:
47.4		 1ki7A-1vtkA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KI7_A_ID2A1_0
(THYMIDINE KINASE)		 1vtk THYMIDINE KINASE
(Human
alphaherpesvirus
1) 		11 / 12 HIS A  58
TRP A  88
ILE A  97
ILE A 100
TYR A 101
GLN A 125
MET A 128
ALA A 168
TYR A 172
ARG A 222
GLU A 225
 TMP  A 500 (-3.8A)
None
TMP  A 500 ( 4.5A)
TMP  A 500 ( 4.1A)
TMP  A 500 (-4.5A)
TMP  A 500 (-3.0A)
TMP  A 500 ( 4.6A)
TMP  A 500 (-3.5A)
TMP  A 500 (-3.7A)
TMP  A 500 (-3.2A)
TMP  A 500 (-3.5A)
 0.37A 1ki7A-1vtkA:
47.4		 1ki7A-1vtkA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KI7_B_ID2B2_0
(THYMIDINE KINASE)		 1vtk THYMIDINE KINASE
(Human
alphaherpesvirus
1) 		12 / 12 HIS A  58
GLU A  83
TRP A  88
ILE A  97
ILE A 100
GLN A 125
MET A 128
ARG A 163
ALA A 168
TYR A 172
ARG A 222
GLU A 225
 TMP  A 500 (-3.8A)
TMP  A 500 (-2.7A)
None
TMP  A 500 ( 4.5A)
TMP  A 500 ( 4.1A)
TMP  A 500 (-3.0A)
TMP  A 500 ( 4.6A)
TMP  A 500 (-3.3A)
TMP  A 500 (-3.5A)
TMP  A 500 (-3.7A)
TMP  A 500 (-3.2A)
TMP  A 500 (-3.5A)
 0.56A 1ki7B-1vtkA:
48.6		 1ki7B-1vtkA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_A_DMEA998_1
(ACETYLCHOLINESTERASE)		 1vtk THYMIDINE KINASE
(Human
alphaherpesvirus
1) 		5 / 12 ASP A  55
GLY A  59
GLU A 225
TYR A 172
TYR A 239
 None
ADP  A 400 (-3.2A)
TMP  A 500 (-3.5A)
TMP  A 500 (-3.7A)
None
 1.24A 1maaA-1vtkA:
undetectable		 1maaA-1vtkA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P5Z_B_AR3B304_1
(DEOXYCYTIDINE KINASE)		 1vtk THYMIDINE KINASE
(Human
alphaherpesvirus
1) 		5 / 12 GLU A  83
TRP A  88
TYR A 101
GLN A 125
GLU A 225
 TMP  A 500 (-2.7A)
None
TMP  A 500 (-4.5A)
TMP  A 500 (-3.0A)
TMP  A 500 (-3.5A)
 1.14A 1p5zB-1vtkA:
16.5		 1p5zB-1vtkA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1vtk THYMIDINE KINASE
(Human
alphaherpesvirus
1) 		4 / 8 HIS A 164
PRO A 165
THR A 350
ASP A 136
 None
 1.07A 1p7lC-1vtkA:
undetectable		 1p7lC-1vtkA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC885_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1vtk THYMIDINE KINASE
(Human
alphaherpesvirus
1) 		4 / 8 HIS A 164
PRO A 165
THR A 350
ASP A 136
 None
 1.05A 1p7lD-1vtkA:
undetectable		 1p7lD-1vtkA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_A_SAMA385_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1vtk THYMIDINE KINASE
(Human
alphaherpesvirus
1) 		4 / 8 HIS A 164
PRO A 165
THR A 350
ASP A 136
 None
 1.06A 1rg9A-1vtkA:
undetectable		 1rg9A-1vtkA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_B_SAMB485_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1vtk THYMIDINE KINASE
(Human
alphaherpesvirus
1) 		4 / 8 HIS A 164
PRO A 165
THR A 350
ASP A 136
 None
 1.05A 1rg9B-1vtkA:
undetectable		 1rg9B-1vtkA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC585_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1vtk THYMIDINE KINASE
(Human
alphaherpesvirus
1) 		4 / 8 HIS A 164
PRO A 165
THR A 350
ASP A 136
 None
 1.06A 1rg9C-1vtkA:
undetectable		 1rg9C-1vtkA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1vtk THYMIDINE KINASE
(Human
alphaherpesvirus
1) 		4 / 8 HIS A 164
PRO A 165
THR A 350
ASP A 136
 None
 1.05A 1rg9D-1vtkA:
undetectable		 1rg9D-1vtkA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUV_A_VK3A4558_1
(PROTEIN YGIN)		 1vtk THYMIDINE KINASE
(Human
alphaherpesvirus
1) 		4 / 7 TYR A 101
GLU A 225
LEU A 232
TYR A 172
 TMP  A 500 (-4.5A)
TMP  A 500 (-3.5A)
None
TMP  A 500 (-3.7A)
 1.10A 1tuvA-1vtkA:
undetectable		 1tuvA-1vtkA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A7Q_A_CFBA328_1
(DEOXYCYTIDINE KINASE)		 1vtk THYMIDINE KINASE
(Human
alphaherpesvirus
1) 		5 / 12 GLU A  83
TRP A  88
TYR A 101
GLN A 125
GLU A 225
 TMP  A 500 (-2.7A)
None
TMP  A 500 (-4.5A)
TMP  A 500 (-3.0A)
TMP  A 500 (-3.5A)
 1.13A 2a7qA-1vtkA:
16.6		 2a7qA-1vtkA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A7Q_A_CFBA328_1
(DEOXYCYTIDINE KINASE)		 1vtk THYMIDINE KINASE
(Human
alphaherpesvirus
1) 		5 / 12 GLU A  83
TYR A 101
GLN A 125
ARG A 163
GLU A 225
 TMP  A 500 (-2.7A)
TMP  A 500 (-4.5A)
TMP  A 500 (-3.0A)
TMP  A 500 (-3.3A)
TMP  A 500 (-3.5A)
 1.20A 2a7qA-1vtkA:
16.6		 2a7qA-1vtkA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_A_AZZA1211_1
(DEOXYNUCLEOSIDE
KINASE)		 1vtk THYMIDINE KINASE
(Human
alphaherpesvirus
1) 		5 / 10 GLU A  83
TRP A  88
GLN A 125
ARG A 163
ALA A 168
 TMP  A 500 (-2.7A)
None
TMP  A 500 (-3.0A)
TMP  A 500 (-3.3A)
TMP  A 500 (-3.5A)
 1.04A 2jj8A-1vtkA:
13.5		 2jj8A-1vtkA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_B_AZZB1211_1
(DEOXYNUCLEOSIDE
KINASE)		 1vtk THYMIDINE KINASE
(Human
alphaherpesvirus
1) 		6 / 12 GLU A  83
TRP A  88
TYR A 101
GLN A 125
ARG A 163
ALA A 168
 TMP  A 500 (-2.7A)
None
TMP  A 500 (-4.5A)
TMP  A 500 (-3.0A)
TMP  A 500 (-3.3A)
TMP  A 500 (-3.5A)
 1.07A 2jj8B-1vtkA:
13.9		 2jj8B-1vtkA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_C_AZZC1211_1
(DEOXYNUCLEOSIDE
KINASE)		 1vtk THYMIDINE KINASE
(Human
alphaherpesvirus
1) 		5 / 12 GLU A  83
TRP A  88
GLN A 125
ARG A 163
ALA A 168
 TMP  A 500 (-2.7A)
None
TMP  A 500 (-3.0A)
TMP  A 500 (-3.3A)
TMP  A 500 (-3.5A)
 1.03A 2jj8C-1vtkA:
13.3		 2jj8C-1vtkA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_D_AZZD1211_1
(DEOXYNUCLEOSIDE
KINASE)		 1vtk THYMIDINE KINASE
(Human
alphaherpesvirus
1) 		5 / 10 GLU A  83
TRP A  88
GLN A 125
ARG A 163
ALA A 168
 TMP  A 500 (-2.7A)
None
TMP  A 500 (-3.0A)
TMP  A 500 (-3.3A)
TMP  A 500 (-3.5A)
 1.03A 2jj8D-1vtkA:
14.0		 2jj8D-1vtkA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_2
(THYMIDYLATE SYNTHASE)		 1vtk THYMIDINE KINASE
(Human
alphaherpesvirus
1) 		3 / 3 HIS A 142
ILE A 358
LEU A 159
 None
 0.76A 2kceA-1vtkA:
undetectable		 2kceA-1vtkA:
20.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2KI5_A_AC2A1_1
(PROTEIN (THYMIDINE
KINASE))		 1vtk THYMIDINE KINASE
(Human
alphaherpesvirus
1) 		5 / 12 HIS A  58
GLN A 125
TYR A 172
ARG A 176
ARG A 220
 TMP  A 500 (-3.8A)
TMP  A 500 (-3.0A)
TMP  A 500 (-3.7A)
None
TMP  A 500 (-3.4A)
 1.44A 2ki5A-1vtkA:
47.2		 2ki5A-1vtkA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2KI5_A_AC2A1_1
(PROTEIN (THYMIDINE
KINASE))		 1vtk THYMIDINE KINASE
(Human
alphaherpesvirus
1) 		11 / 12 HIS A  58
GLU A  83
TRP A  88
ILE A  97
ILE A 100
TYR A 101
MET A 128
TYR A 172
ARG A 176
ARG A 222
GLU A 225
 TMP  A 500 (-3.8A)
TMP  A 500 (-2.7A)
None
TMP  A 500 ( 4.5A)
TMP  A 500 ( 4.1A)
TMP  A 500 (-4.5A)
TMP  A 500 ( 4.6A)
TMP  A 500 (-3.7A)
None
TMP  A 500 (-3.2A)
TMP  A 500 (-3.5A)
 0.78A 2ki5A-1vtkA:
47.2		 2ki5A-1vtkA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2KI5_A_AC2A1_1
(PROTEIN (THYMIDINE
KINASE))		 1vtk THYMIDINE KINASE
(Human
alphaherpesvirus
1) 		11 / 12 HIS A  58
TRP A  88
ILE A  97
ILE A 100
TYR A 101
GLN A 125
MET A 128
TYR A 172
ARG A 176
ARG A 222
GLU A 225
 TMP  A 500 (-3.8A)
None
TMP  A 500 ( 4.5A)
TMP  A 500 ( 4.1A)
TMP  A 500 (-4.5A)
TMP  A 500 (-3.0A)
TMP  A 500 ( 4.6A)
TMP  A 500 (-3.7A)
None
TMP  A 500 (-3.2A)
TMP  A 500 (-3.5A)
 0.63A 2ki5A-1vtkA:
47.2		 2ki5A-1vtkA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2KI5_B_AC2B2_1
(PROTEIN (THYMIDINE
KINASE))		 1vtk THYMIDINE KINASE
(Human
alphaherpesvirus
1) 		11 / 12 HIS A  58
GLU A  83
TRP A  88
ILE A  97
ILE A 100
TYR A 101
MET A 128
ARG A 163
TYR A 172
ARG A 176
ARG A 222
 TMP  A 500 (-3.8A)
TMP  A 500 (-2.7A)
None
TMP  A 500 ( 4.5A)
TMP  A 500 ( 4.1A)
TMP  A 500 (-4.5A)
TMP  A 500 ( 4.6A)
TMP  A 500 (-3.3A)
TMP  A 500 (-3.7A)
None
TMP  A 500 (-3.2A)
 0.73A 2ki5B-1vtkA:
48.2		 2ki5B-1vtkA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2KI5_B_AC2B2_1
(PROTEIN (THYMIDINE
KINASE))		 1vtk THYMIDINE KINASE
(Human
alphaherpesvirus
1) 		5 / 12 HIS A  58
ILE A  97
TYR A 101
MET A  85
ARG A 163
 TMP  A 500 (-3.8A)
TMP  A 500 ( 4.5A)
TMP  A 500 (-4.5A)
None
TMP  A 500 (-3.3A)
 1.43A 2ki5B-1vtkA:
48.2		 2ki5B-1vtkA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2KI5_B_AC2B2_1
(PROTEIN (THYMIDINE
KINASE))		 1vtk THYMIDINE KINASE
(Human
alphaherpesvirus
1) 		11 / 12 HIS A  58
TRP A  88
ILE A  97
ILE A 100
TYR A 101
GLN A 125
MET A 128
ARG A 163
TYR A 172
ARG A 176
ARG A 222
 TMP  A 500 (-3.8A)
None
TMP  A 500 ( 4.5A)
TMP  A 500 ( 4.1A)
TMP  A 500 (-4.5A)
TMP  A 500 (-3.0A)
TMP  A 500 ( 4.6A)
TMP  A 500 (-3.3A)
TMP  A 500 (-3.7A)
None
TMP  A 500 (-3.2A)
 0.54A 2ki5B-1vtkA:
48.2		 2ki5B-1vtkA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VPP_A_GEOA1210_1
(DEOXYNUCLEOSIDE
KINASE)		 1vtk THYMIDINE KINASE
(Human
alphaherpesvirus
1) 		5 / 12 GLU A  83
TRP A  88
TYR A 101
ARG A 163
ALA A 168
 TMP  A 500 (-2.7A)
None
TMP  A 500 (-4.5A)
TMP  A 500 (-3.3A)
TMP  A 500 (-3.5A)
 1.09A 2vppA-1vtkA:
14.9		 2vppA-1vtkA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VPP_A_GEOA1210_1
(DEOXYNUCLEOSIDE
KINASE)		 1vtk THYMIDINE KINASE
(Human
alphaherpesvirus
1) 		5 / 12 TRP A  88
TYR A 101
GLN A 125
ARG A 163
ALA A 168
 None
TMP  A 500 (-4.5A)
TMP  A 500 (-3.0A)
TMP  A 500 (-3.3A)
TMP  A 500 (-3.5A)
 0.98A 2vppA-1vtkA:
14.9		 2vppA-1vtkA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VPP_B_GEOB1207_1
(DEOXYNUCLEOSIDE
KINASE)		 1vtk THYMIDINE KINASE
(Human
alphaherpesvirus
1) 		5 / 12 GLU A  83
TRP A  88
TYR A 101
GLN A 125
ARG A 163
 TMP  A 500 (-2.7A)
None
TMP  A 500 (-4.5A)
TMP  A 500 (-3.0A)
TMP  A 500 (-3.3A)
 0.98A 2vppB-1vtkA:
14.3		 2vppB-1vtkA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VPP_B_GEOB1207_1
(DEOXYNUCLEOSIDE
KINASE)		 1vtk THYMIDINE KINASE
(Human
alphaherpesvirus
1) 		5 / 12 GLU A  83
TYR A 101
GLN A 125
ARG A 163
ALA A 168
 TMP  A 500 (-2.7A)
TMP  A 500 (-4.5A)
TMP  A 500 (-3.0A)
TMP  A 500 (-3.3A)
TMP  A 500 (-3.5A)
 0.95A 2vppB-1vtkA:
14.3		 2vppB-1vtkA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YCJ_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 1vtk THYMIDINE KINASE
(Human
alphaherpesvirus
1) 		5 / 12 PHE A 292
ILE A 203
LEU A 205
ASP A  55
ILE A 166
 None
 1.19A 2ycjA-1vtkA:
undetectable		 2ycjA-1vtkA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZI9_A_CL9A401_1
(DEOXYCYTIDINE KINASE)		 1vtk THYMIDINE KINASE
(Human
alphaherpesvirus
1) 		5 / 12 GLU A  83
TRP A  88
TYR A 101
GLN A 125
GLU A 225
 TMP  A 500 (-2.7A)
None
TMP  A 500 (-4.5A)
TMP  A 500 (-3.0A)
TMP  A 500 (-3.5A)
 1.11A 2zi9A-1vtkA:
15.3		 2zi9A-1vtkA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZI9_A_CL9A401_1
(DEOXYCYTIDINE KINASE)		 1vtk THYMIDINE KINASE
(Human
alphaherpesvirus
1) 		5 / 12 GLU A  83
TYR A 101
GLN A 125
ARG A 163
GLU A 225
 TMP  A 500 (-2.7A)
TMP  A 500 (-4.5A)
TMP  A 500 (-3.0A)
TMP  A 500 (-3.3A)
TMP  A 500 (-3.5A)
 1.19A 2zi9A-1vtkA:
15.3		 2zi9A-1vtkA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZI9_B_CL9B401_1
(DEOXYCYTIDINE KINASE)		 1vtk THYMIDINE KINASE
(Human
alphaherpesvirus
1) 		5 / 12 GLU A  83
TRP A  88
GLN A 125
ARG A 220
GLU A 225
 TMP  A 500 (-2.7A)
None
TMP  A 500 (-3.0A)
TMP  A 500 (-3.4A)
TMP  A 500 (-3.5A)
 1.27A 2zi9B-1vtkA:
16.5		 2zi9B-1vtkA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZI9_B_CL9B401_1
(DEOXYCYTIDINE KINASE)		 1vtk THYMIDINE KINASE
(Human
alphaherpesvirus
1) 		5 / 12 GLU A  83
TRP A  88
TYR A 101
GLN A 125
GLU A 225
 TMP  A 500 (-2.7A)
None
TMP  A 500 (-4.5A)
TMP  A 500 (-3.0A)
TMP  A 500 (-3.5A)
 1.02A 2zi9B-1vtkA:
16.5		 2zi9B-1vtkA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_A_CL9A401_1
(DEOXYCYTIDINE KINASE)		 1vtk THYMIDINE KINASE
(Human
alphaherpesvirus
1) 		5 / 12 GLU A  83
TRP A  88
TYR A 101
GLN A 125
GLU A 225
 TMP  A 500 (-2.7A)
None
TMP  A 500 (-4.5A)
TMP  A 500 (-3.0A)
TMP  A 500 (-3.5A)
 0.95A 2ziaA-1vtkA:
17.2		 2ziaA-1vtkA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_A_CL9A401_1
(DEOXYCYTIDINE KINASE)		 1vtk THYMIDINE KINASE
(Human
alphaherpesvirus
1) 		5 / 12 GLU A  83
TYR A 101
GLN A 125
ARG A 163
GLU A 225
 TMP  A 500 (-2.7A)
TMP  A 500 (-4.5A)
TMP  A 500 (-3.0A)
TMP  A 500 (-3.3A)
TMP  A 500 (-3.5A)
 1.01A 2ziaA-1vtkA:
17.2		 2ziaA-1vtkA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_B_CL9B401_1
(DEOXYCYTIDINE KINASE)		 1vtk THYMIDINE KINASE
(Human
alphaherpesvirus
1) 		5 / 12 GLU A  83
TRP A  88
TYR A 101
GLN A 125
GLU A 225
 TMP  A 500 (-2.7A)
None
TMP  A 500 (-4.5A)
TMP  A 500 (-3.0A)
TMP  A 500 (-3.5A)
 1.00A 2ziaB-1vtkA:
16.7		 2ziaB-1vtkA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_B_478B200_1
(PROTEASE)		 1vtk THYMIDINE KINASE
(Human
alphaherpesvirus
1) 		5 / 8 ASP A  55
GLY A  56
VAL A 324
GLY A 240
ILE A 203
 None
 1.21A 3ekpA-1vtkA:
undetectable		 3ekpA-1vtkA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HP1_A_LLTA401_1
(DEOXYCYTIDINE KINASE)		 1vtk THYMIDINE KINASE
(Human
alphaherpesvirus
1) 		5 / 12 GLU A  83
TRP A  88
TYR A 101
ALA A 167
GLU A 225
 TMP  A 500 (-2.7A)
None
TMP  A 500 (-4.5A)
TMP  A 500 ( 4.2A)
TMP  A 500 (-3.5A)
 1.05A 3hp1A-1vtkA:
16.7		 3hp1A-1vtkA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HP1_A_LLTA401_1
(DEOXYCYTIDINE KINASE)		 1vtk THYMIDINE KINASE
(Human
alphaherpesvirus
1) 		5 / 12 TRP A  88
TYR A 101
GLN A 125
ALA A 167
GLU A 225
 None
TMP  A 500 (-4.5A)
TMP  A 500 (-3.0A)
TMP  A 500 ( 4.2A)
TMP  A 500 (-3.5A)
 1.22A 3hp1A-1vtkA:
16.7		 3hp1A-1vtkA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_C_478C200_1
(HIV-1 PROTEASE)		 1vtk THYMIDINE KINASE
(Human
alphaherpesvirus
1) 		6 / 9 ASP A  55
GLY A  56
VAL A 324
GLY A 240
VAL A 238
ILE A 203
 None
 1.23A 3oxvC-1vtkA:
undetectable		 3oxvC-1vtkA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1vtk THYMIDINE KINASE
(Human
alphaherpesvirus
1) 		5 / 12 VAL A 314
ILE A 235
GLY A 240
ALA A 174
ALA A 175
 None
 1.01A 3sufD-1vtkA:
undetectable		 3sufD-1vtkA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB8_A_DXCA75_0
(PPCA)		 1vtk THYMIDINE KINASE
(Human
alphaherpesvirus
1) 		4 / 8 ILE A  54
LEU A 340
ILE A 326
GLY A 346
 None
 0.79A 4hb8A-1vtkA:
undetectable		 4hb8A-1vtkA:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 1vtk THYMIDINE KINASE
(Human
alphaherpesvirus
1) 		4 / 6 ILE A 143
THR A 350
VAL A 138
ASP A 363
 None
 1.13A 4iaqA-1vtkA:
2.6		 4iaqA-1vtkA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_A_STRA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 1vtk THYMIDINE KINASE
(Human
alphaherpesvirus
1) 		5 / 11 ALA A 114
ALA A 117
ALA A 118
THR A 122
VAL A 187
 None
 1.06A 4j6cA-1vtkA:
1.5		 4j6cA-1vtkA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_B_STRB503_1
(CYTOCHROME P450
MONOOXYGENASE)		 1vtk THYMIDINE KINASE
(Human
alphaherpesvirus
1) 		5 / 10 ALA A 114
ALA A 117
ALA A 118
THR A 122
VAL A 187
 None
 1.07A 4j6cB-1vtkA:
undetectable		 4j6cB-1vtkA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_A_TESA503_1
(CYTOCHROME P450
MONOOXYGENASE)		 1vtk THYMIDINE KINASE
(Human
alphaherpesvirus
1) 		5 / 12 ALA A 114
ALA A 117
ALA A 118
THR A 122
VAL A 187
 None
 1.06A 4j6dA-1vtkA:
undetectable		 4j6dA-1vtkA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_A_ASDA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 1vtk THYMIDINE KINASE
(Human
alphaherpesvirus
1) 		5 / 12 ALA A 114
ALA A 117
ALA A 118
THR A 122
VAL A 187
 None
 1.07A 4jbtA-1vtkA:
undetectable		 4jbtA-1vtkA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_B_ASDB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 1vtk THYMIDINE KINASE
(Human
alphaherpesvirus
1) 		5 / 11 ALA A 114
ALA A 117
ALA A 118
THR A 122
VAL A 187
 None
 1.07A 4jbtB-1vtkA:
undetectable		 4jbtB-1vtkA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8S_B_SAMB402_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 1vtk THYMIDINE KINASE
(Human
alphaherpesvirus
1) 		4 / 8 HIS A 164
PRO A 165
THR A 350
ASP A 136
 None
 0.97A 5t8sB-1vtkA:
undetectable		 5t8sB-1vtkA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_0
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 1vtk THYMIDINE KINASE
(Human
alphaherpesvirus
1) 		5 / 12 PRO A 195
GLY A 129
ALA A 133
ALA A 168
ALA A 167
 None
None
None
TMP  A 500 (-3.5A)
TMP  A 500 ( 4.2A)
 0.82A 5zw4A-1vtkA:
undetectable		 5zw4A-1vtkA:
22.09