SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1vyn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_H_ACTH1113_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 1vyn ARGONAUTE2
(Drosophila
melanogaster) 		5 / 9 LYS A  93
ILE A   8
LYS A  19
GLU A  12
ILE A  20
 None
 1.47A 2j9dG-1vynA:
0.0
2j9dH-1vynA:
undetectable
2j9dI-1vynA:
0.0		 2j9dG-1vynA:
17.76
2j9dH-1vynA:
17.76
2j9dI-1vynA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1vyn ARGONAUTE2
(Drosophila
melanogaster) 		5 / 6 ARG A  30
LEU A  11
PHE A  14
LEU A  33
PHE A  32
 None
 1.50A 2zxwP-1vynA:
undetectable
2zxwW-1vynA:
undetectable		 2zxwP-1vynA:
22.73
2zxwW-1vynA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1vyn ARGONAUTE2
(Drosophila
melanogaster) 		4 / 5 ARG A  30
PHE A  14
LEU A  33
PHE A  32
 None
 1.49A 3ablC-1vynA:
undetectable
3ablJ-1vynA:
undetectable		 3ablC-1vynA:
22.73
3ablJ-1vynA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1vyn ARGONAUTE2
(Drosophila
melanogaster) 		4 / 4 ARG A  30
PHE A  14
LEU A  33
PHE A  32
 None
 1.46A 3ag1P-1vynA:
undetectable
3ag1W-1vynA:
0.0		 3ag1P-1vynA:
22.73
3ag1W-1vynA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1vyn ARGONAUTE2
(Drosophila
melanogaster) 		4 / 4 ARG A  30
PHE A  14
LEU A  33
PHE A  32
 None
 1.43A 3ag3P-1vynA:
undetectable
3ag3W-1vynA:
0.0		 3ag3P-1vynA:
22.73
3ag3W-1vynA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K36_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 1vyn ARGONAUTE2
(Drosophila
melanogaster) 		5 / 12 ASN A  21
LEU A  11
ILE A 113
CYH A  99
LEU A 111
 None
 1.47A 4k36A-1vynA:
undetectable		 4k36A-1vynA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K36_B_SAMB504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 1vyn ARGONAUTE2
(Drosophila
melanogaster) 		5 / 12 ASN A  21
LEU A  11
ILE A 113
CYH A  99
LEU A 111
 None
 1.46A 4k36B-1vynA:
undetectable		 4k36B-1vynA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_B_ACTB403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 1vyn ARGONAUTE2
(Drosophila
melanogaster) 		3 / 3 ARG A  30
ASP A  27
ARG A  31
 None
 0.60A 4wq4B-1vynA:
undetectable		 4wq4B-1vynA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUM_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 1vyn ARGONAUTE2
(Drosophila
melanogaster) 		5 / 8 ILE A   8
LEU A  11
ILE A  20
ASN A  22
SER A  68
 None
 1.42A 5numA-1vynA:
undetectable		 5numA-1vynA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_P_CHDP304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1vyn ARGONAUTE2
(Drosophila
melanogaster) 		5 / 7 ARG A  30
LEU A  11
PHE A  14
LEU A  33
PHE A  32
 None
 1.48A 5x1fP-1vynA:
undetectable
5x1fW-1vynA:
undetectable		 5x1fP-1vynA:
22.73
5x1fW-1vynA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1vyn ARGONAUTE2
(Drosophila
melanogaster) 		5 / 7 ARG A  30
LEU A  11
PHE A  14
LEU A  33
PHE A  32
 None
 1.48A 5z85C-1vynA:
undetectable
5z85J-1vynA:
undetectable		 5z85C-1vynA:
22.73
5z85J-1vynA:
16.67