SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1vyt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		 1vyt CALCIUM CHANNEL
BETA-3 SUBUNIT
VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL ALPHA-1C
SUBUNIT
(Rattus
norvegicus) 		5 / 12 SER A 186
MET A 196
ASP A 202
ALA E 444
ILE E 441
 None
 1.42A 1s14B-1vytA:
undetectable		 1s14B-1vytA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_B_RBFB201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1vyt CALCIUM CHANNEL
BETA-3 SUBUNIT
(Rattus
norvegicus) 		4 / 8 THR A 273
ILE A 289
LEU A 223
LEU A 285
 None
 0.98A 4r38B-1vytA:
undetectable		 4r38B-1vytA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UAC_A_ACRA501_2
(CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT1 FAMILY
(TC 3.A.1.1.-))		 1vyt CALCIUM CHANNEL
BETA-3 SUBUNIT
VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL ALPHA-1C
SUBUNIT
(Rattus
norvegicus) 		4 / 7 GLU A 354
GLU A 347
TRP E 440
ASP E 439
 None
 0.91A 4uacA-1vytA:
undetectable		 4uacA-1vytA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 1vyt CALCIUM CHANNEL
BETA-3 SUBUNIT
(Rattus
norvegicus) 		4 / 5 PHE A  62
PRO A 175
VAL A 173
ALA A  63
 None
 1.27A 4w5oA-1vytA:
4.5		 4w5oA-1vytA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_K_CHDK103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1vyt CALCIUM CHANNEL
BETA-3 SUBUNIT
(Rattus
norvegicus) 		5 / 11 GLU A 347
ALA A 350
LEU A 349
TYR A 352
LEU A 337
 None
 1.19A 4wg0I-1vytA:
undetectable
4wg0J-1vytA:
undetectable
4wg0K-1vytA:
undetectable		 4wg0I-1vytA:
3.49
4wg0J-1vytA:
3.49
4wg0K-1vytA:
3.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 1vyt CALCIUM CHANNEL
BETA-3 SUBUNIT
(Rattus
norvegicus) 		4 / 5 PHE A  62
PRO A 175
VAL A 173
ALA A  63
 None
 1.24A 4z4cA-1vytA:
4.2		 4z4cA-1vytA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 1vyt CALCIUM CHANNEL
BETA-3 SUBUNIT
(Rattus
norvegicus) 		4 / 5 PHE A  62
PRO A 175
VAL A 173
ALA A  63
 None
 1.29A 4z4dA-1vytA:
4.2		 4z4dA-1vytA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 1vyt CALCIUM CHANNEL
BETA-3 SUBUNIT
(Rattus
norvegicus) 		4 / 5 PHE A  62
PRO A 175
VAL A 173
ALA A  63
 None
 1.28A 4z4eA-1vytA:
undetectable		 4z4eA-1vytA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_A_ILEA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 1vyt CALCIUM CHANNEL
BETA-3 SUBUNIT
(Rattus
norvegicus) 		4 / 6 THR A  66
VAL A  64
TYR A 171
VAL A  85
 None
 0.97A 5eclA-1vytA:
undetectable		 5eclA-1vytA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1vyt CALCIUM CHANNEL
BETA-3 SUBUNIT
(Rattus
norvegicus) 		3 / 3 LEU A 353
ALA A 350
LEU A 266
 None
 0.51A 5uunB-1vytA:
undetectable		 5uunB-1vytA:
22.07