SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1vz8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3004_1
(SERUM ALBUMIN)		 1vz8 ORNITHINE
ACETYL-TRANSFERASE
(Streptomyces
clavuligerus) 		4 / 7 GLU A 260
LEU A 175
VAL A 212
LEU A 265
 None
 0.90A 1hk3A-1vz8A:
undetectable		 1hk3A-1vz8A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHV_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1vz8 ORNITHINE
ACETYL-TRANSFERASE
(Streptomyces
clavuligerus) 		4 / 8 GLY A 112
LEU A 183
SER A 219
GLY A 171
 SO4  A1391 (-3.3A)
None
None
SO4  A1391 ( 4.6A)
 0.76A 1jhvA-1vz8A:
undetectable		 1jhvA-1vz8A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_0
(MODIFICATION
METHYLASE RSRI)		 1vz8 ORNITHINE
ACETYL-TRANSFERASE
(Streptomyces
clavuligerus) 		5 / 12 THR A  45
PHE A  49
GLY A  51
VAL A  55
ALA A  76
 None
 1.31A 1nw5A-1vz8A:
undetectable		 1nw5A-1vz8A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_2
(POL POLYPROTEIN)		 1vz8 ORNITHINE
ACETYL-TRANSFERASE
(Streptomyces
clavuligerus) 		5 / 10 ASP A 365
GLY A 272
ILE A 326
ILE A 310
PRO A 335
 None
 1.06A 1sh9B-1vz8A:
undetectable		 1sh9B-1vz8A:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_B_SAMB1267_0
(NON-STRUCTURAL
PROTEIN 5)		 1vz8 ORNITHINE
ACETYL-TRANSFERASE
(Streptomyces
clavuligerus) 		6 / 12 GLY A 261
GLY A 171
GLY A 173
THR A 184
ASP A 258
ILE A 255
 None
SO4  A1391 ( 4.6A)
None
None
None
None
 1.44A 2wa2B-1vz8A:
undetectable		 2wa2B-1vz8A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		 1vz8 ORNITHINE
ACETYL-TRANSFERASE
(Streptomyces
clavuligerus) 		5 / 12 THR A 111
LEU A 182
PHE A 185
VAL A  69
ILE A 255
 SO4  A1391 (-3.4A)
None
None
None
None
 1.10A 3czhB-1vz8A:
undetectable		 3czhB-1vz8A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_B_URFB400_1
(URIDINE
PHOSPHORYLASE 1)		 1vz8 ORNITHINE
ACETYL-TRANSFERASE
(Streptomyces
clavuligerus) 		4 / 8 THR A 184
GLY A 171
LEU A 182
LEU A 175
 None
SO4  A1391 ( 4.6A)
None
None
 0.94A 3nbqB-1vz8A:
undetectable		 3nbqB-1vz8A:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1vz8 ORNITHINE
ACETYL-TRANSFERASE
(Streptomyces
clavuligerus) 		4 / 6 GLU A 155
ARG A 141
ALA A 143
ALA A 142
 None
 1.04A 3ns1C-1vz8A:
3.6		 3ns1C-1vz8A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R75_A_BEZA701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 1vz8 ORNITHINE
ACETYL-TRANSFERASE
(Streptomyces
clavuligerus) 		5 / 12 GLU A 260
GLY A 112
THR A 111
SER A 219
LYS A 181
 None
SO4  A1391 (-3.3A)
SO4  A1391 (-3.4A)
None
SO4  A1391 (-4.4A)
 1.34A 3r75A-1vz8A:
undetectable		 3r75A-1vz8A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R75_B_BEZB701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 1vz8 ORNITHINE
ACETYL-TRANSFERASE
(Streptomyces
clavuligerus) 		5 / 12 GLU A 260
GLY A 112
THR A 111
SER A 219
LYS A 181
 None
SO4  A1391 (-3.3A)
SO4  A1391 (-3.4A)
None
SO4  A1391 (-4.4A)
 1.32A 3r75B-1vz8A:
undetectable		 3r75B-1vz8A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_TESA1000_1
(ANDROGEN RECEPTOR)		 1vz8 ORNITHINE
ACETYL-TRANSFERASE
(Streptomyces
clavuligerus) 		5 / 12 LEU A 175
LEU A 182
LEU A 183
VAL A  43
THR A 218
 None
 1.31A 3zqtA-1vz8A:
undetectable		 3zqtA-1vz8A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1vz8 ORNITHINE
ACETYL-TRANSFERASE
(Streptomyces
clavuligerus) 		4 / 7 ILE A 146
ARG A  26
VAL A 172
MET A 174
 None
None
None
SO4  A1391 ( 4.0A)
 1.29A 4f4dA-1vz8A:
undetectable		 4f4dA-1vz8A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1vz8 ORNITHINE
ACETYL-TRANSFERASE
(Streptomyces
clavuligerus) 		4 / 8 ILE A 146
ARG A  26
PRO A 177
MET A 174
 None
None
None
SO4  A1391 ( 4.0A)
 1.32A 4f4dB-1vz8A:
undetectable		 4f4dB-1vz8A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1vz8 ORNITHINE
ACETYL-TRANSFERASE
(Streptomyces
clavuligerus) 		4 / 8 ILE A 146
ARG A  26
VAL A 172
MET A 174
 None
None
None
SO4  A1391 ( 4.0A)
 1.28A 4f4dB-1vz8A:
undetectable		 4f4dB-1vz8A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_A_SAMA301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 1vz8 ORNITHINE
ACETYL-TRANSFERASE
(Streptomyces
clavuligerus) 		5 / 12 ALA A 211
GLY A 377
ASN A 288
ALA A 262
ALA A 256
 None
 1.20A 4pclA-1vz8A:
undetectable		 4pclA-1vz8A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_2
(HISTONE DEACETYLASE
8)		 1vz8 ORNITHINE
ACETYL-TRANSFERASE
(Streptomyces
clavuligerus) 		3 / 3 PRO A 119
MET A 120
TYR A 118
 None
 1.02A 4qa0B-1vz8A:
undetectable		 4qa0B-1vz8A:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_B_SHHB404_1
(HISTONE DEACETYLASE
8)		 1vz8 ORNITHINE
ACETYL-TRANSFERASE
(Streptomyces
clavuligerus) 		3 / 3 PRO A 119
MET A 120
TYR A 118
 None
 1.03A 4qa0A-1vz8A:
undetectable		 4qa0A-1vz8A:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_2
(HISTONE DEACETYLASE
8)		 1vz8 ORNITHINE
ACETYL-TRANSFERASE
(Streptomyces
clavuligerus) 		3 / 3 PRO A 119
MET A 120
TYR A 118
 None
 0.99A 4qa2B-1vz8A:
undetectable		 4qa2B-1vz8A:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 1vz8 ORNITHINE
ACETYL-TRANSFERASE
(Streptomyces
clavuligerus) 		5 / 12 MET A 205
THR A 188
VAL A 160
LEU A 192
LEU A 200
 None
 1.18A 4qztA-1vz8A:
0.4		 4qztA-1vz8A:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)		 1vz8 ORNITHINE
ACETYL-TRANSFERASE
(Streptomyces
clavuligerus) 		5 / 12 MET A 205
THR A 188
VAL A 160
LEU A 192
LEU A 200
 None
 1.13A 4qzuC-1vz8A:
undetectable		 4qzuC-1vz8A:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1vz8 ORNITHINE
ACETYL-TRANSFERASE
(Streptomyces
clavuligerus) 		4 / 8 GLY A 138
ALA A 143
THR A  30
HIS A  15
 None
 0.95A 5eevL-1vz8A:
undetectable
5eevV-1vz8A:
undetectable		 5eevL-1vz8A:
11.70
5eevV-1vz8A:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1vz8 ORNITHINE
ACETYL-TRANSFERASE
(Streptomyces
clavuligerus) 		4 / 8 GLY A 138
ALA A 143
THR A  30
HIS A  15
 None
 0.95A 5eewL-1vz8A:
undetectable
5eewV-1vz8A:
undetectable		 5eewL-1vz8A:
11.70
5eewV-1vz8A:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1vz8 ORNITHINE
ACETYL-TRANSFERASE
(Streptomyces
clavuligerus) 		4 / 8 GLY A 138
ALA A 143
THR A  30
HIS A  15
 None
 0.95A 5ef3L-1vz8A:
undetectable
5ef3V-1vz8A:
undetectable		 5ef3L-1vz8A:
11.70
5ef3V-1vz8A:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_A_ADNA602_1
(LYSINE--TRNA LIGASE)		 1vz8 ORNITHINE
ACETYL-TRANSFERASE
(Streptomyces
clavuligerus) 		5 / 10 GLU A  59
ALA A  50
GLU A  85
GLY A  51
ILE A 108
 None
 1.22A 6bniA-1vz8A:
undetectable		 6bniA-1vz8A:
9.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_B_ADNB602_1
(LYSINE--TRNA LIGASE)		 1vz8 ORNITHINE
ACETYL-TRANSFERASE
(Streptomyces
clavuligerus) 		5 / 10 GLU A  59
ALA A  50
GLU A  85
GLY A  51
ILE A 108
 None
 1.24A 6bniB-1vz8A:
undetectable		 6bniB-1vz8A:
9.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_B_ACTB804_0
(UNCHARACTERIZED
PROTEIN)		 1vz8 ORNITHINE
ACETYL-TRANSFERASE
(Streptomyces
clavuligerus) 		4 / 4 HIS A 126
VAL A  31
LEU A 130
ALA A  17
 None
 1.45A 6d8pB-1vz8A:
undetectable		 6d8pB-1vz8A:
20.00