SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1vzo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4008_1
(SERUM ALBUMIN)		 1vzo RIBOSOMAL PROTEIN S6
KINASE ALPHA 5
(Homo
sapiens) 		5 / 8 ALA A 120
LEU A  83
LEU A 127
LEU A  32
ALA A  86
 None
 1.05A 1e7cA-1vzoA:
undetectable		 1e7cA-1vzoA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_2
(LIVER
CARBOXYLESTERASE I)		 1vzo RIBOSOMAL PROTEIN S6
KINASE ALPHA 5
(Homo
sapiens) 		3 / 3 PHE A 318
LEU A 289
LEU A 302
 None
 0.67A 1mx1E-1vzoA:
undetectable		 1mx1E-1vzoA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OHR_A_1UNA201_2
(ASPARTYLPROTEASE)		 1vzo RIBOSOMAL PROTEIN S6
KINASE ALPHA 5
(Homo
sapiens) 		5 / 9 VAL A 331
ILE A 321
GLY A 159
ILE A 161
PRO A 334
 None
 1.00A 1ohrB-1vzoA:
undetectable		 1ohrB-1vzoA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_2
(ESTROGEN RECEPTOR
BETA)		 1vzo RIBOSOMAL PROTEIN S6
KINASE ALPHA 5
(Homo
sapiens) 		3 / 3 ASP A 132
LEU A 131
HIS A 107
 None
 0.77A 1qknA-1vzoA:
undetectable		 1qknA-1vzoA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_0
(VP39)		 1vzo RIBOSOMAL PROTEIN S6
KINASE ALPHA 5
(Homo
sapiens) 		5 / 12 ILE A 312
GLY A 303
VAL A 162
ALA A 235
LEU A 241
 None
None
None
BME  A1304 (-3.3A)
None
 0.90A 1vptA-1vzoA:
undetectable		 1vptA-1vzoA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1vzo RIBOSOMAL PROTEIN S6
KINASE ALPHA 5
(Homo
sapiens) 		5 / 11 ALA A 286
ILE A 290
VAL A 154
LEU A 139
ILE A 161
 None
 1.18A 2h42A-1vzoA:
undetectable		 2h42A-1vzoA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_B_VIAB902_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1vzo RIBOSOMAL PROTEIN S6
KINASE ALPHA 5
(Homo
sapiens) 		5 / 12 ALA A 286
ILE A 290
VAL A 154
LEU A 139
ILE A 161
 None
 1.08A 2h42B-1vzoA:
undetectable		 2h42B-1vzoA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_D_SC2D1290_1
(FICOLIN-2)		 1vzo RIBOSOMAL PROTEIN S6
KINASE ALPHA 5
(Homo
sapiens) 		4 / 5 TRP A 238
TRP A 239
ARG A 301
LEU A 293
 None
 1.47A 2j2pD-1vzoA:
undetectable
2j2pF-1vzoA:
undetectable		 2j2pD-1vzoA:
19.22
2j2pF-1vzoA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKQ_A_ROCA100_2
(PROTEASE)		 1vzo RIBOSOMAL PROTEIN S6
KINASE ALPHA 5
(Homo
sapiens) 		5 / 9 VAL A 331
ILE A 321
GLY A 159
ILE A 161
PRO A 334
 None
 1.12A 3ekqB-1vzoA:
undetectable		 3ekqB-1vzoA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HZN_D_ACTD229_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1vzo RIBOSOMAL PROTEIN S6
KINASE ALPHA 5
(Homo
sapiens) 		4 / 4 ASP A  73
GLY A  75
LYS A  68
GLU A  50
 None
 0.91A 3hznD-1vzoA:
undetectable		 3hznD-1vzoA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU6_B_478B401_1
(PROTEASE)		 1vzo RIBOSOMAL PROTEIN S6
KINASE ALPHA 5
(Homo
sapiens) 		6 / 10 ASP A 325
VAL A 331
ILE A 321
GLY A 159
ILE A 161
PRO A 334
 None
 1.31A 3nu6A-1vzoA:
undetectable		 3nu6A-1vzoA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLS_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 1vzo RIBOSOMAL PROTEIN S6
KINASE ALPHA 5
(Homo
sapiens) 		5 / 12 LEU A 105
ALA A  35
LEU A 129
ILE A  88
HIS A  30
 None
 1.30A 3olsB-1vzoA:
undetectable		 3olsB-1vzoA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3C_A_017A201_2
(HIV-1 PROTEASE)		 1vzo RIBOSOMAL PROTEIN S6
KINASE ALPHA 5
(Homo
sapiens) 		6 / 10 ASP A 325
VAL A 331
ILE A 321
GLY A 159
PRO A 334
ALA A 333
 None
 1.37A 3t3cB-1vzoA:
undetectable		 3t3cB-1vzoA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACHG301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 1vzo RIBOSOMAL PROTEIN S6
KINASE ALPHA 5
(Homo
sapiens) 		4 / 8 TYR A  60
THR A 116
ARG A 109
LEU A 105
 None
 1.18A 3wipG-1vzoA:
undetectable
3wipH-1vzoA:
undetectable		 3wipG-1vzoA:
19.56
3wipH-1vzoA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_J_ACHJ301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 1vzo RIBOSOMAL PROTEIN S6
KINASE ALPHA 5
(Homo
sapiens) 		4 / 8 ARG A 109
LEU A 105
TYR A  60
THR A 116
 None
 1.16A 3wipF-1vzoA:
undetectable
3wipJ-1vzoA:
undetectable		 3wipF-1vzoA:
19.56
3wipJ-1vzoA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8Z_A_BBIA402_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 1vzo RIBOSOMAL PROTEIN S6
KINASE ALPHA 5
(Homo
sapiens) 		4 / 5 PHE A 318
PHE A 317
LEU A 294
PRO A 254
 None
 1.35A 4o8zA-1vzoA:
undetectable		 4o8zA-1vzoA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_D_RBFD201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1vzo RIBOSOMAL PROTEIN S6
KINASE ALPHA 5
(Homo
sapiens) 		4 / 8 ILE A 134
LEU A 180
LEU A 193
ILE A 178
 None
 0.85A 4r38D-1vzoA:
undetectable		 4r38D-1vzoA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_A_1N1A601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 1vzo RIBOSOMAL PROTEIN S6
KINASE ALPHA 5
(Homo
sapiens) 		3 / 3 MET A 295
ASP A 288
PHE A 317
 None
 0.96A 4xeyA-1vzoA:
19.8		 4xeyA-1vzoA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_B_1N1B601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 1vzo RIBOSOMAL PROTEIN S6
KINASE ALPHA 5
(Homo
sapiens) 		3 / 3 MET A 295
ASP A 288
PHE A 317
 None
 0.97A 4xeyB-1vzoA:
19.6		 4xeyB-1vzoA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_H_TR6H101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 1vzo RIBOSOMAL PROTEIN S6
KINASE ALPHA 5
(Homo
sapiens) 		3 / 5 GLY A  56
GLY A  58
GLU A 138
 None
 0.29A 4z2eA-1vzoA:
undetectable
4z2eD-1vzoA:
undetectable		 4z2eA-1vzoA:
23.15
4z2eD-1vzoA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB201_0
(HYDROXYNITRILE LYASE)		 1vzo RIBOSOMAL PROTEIN S6
KINASE ALPHA 5
(Homo
sapiens) 		5 / 11 VAL A 154
TYR A 219
ILE A 178
ILE A 161
LEU A 139
 None
 1.00A 5e4dB-1vzoA:
undetectable		 5e4dB-1vzoA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNY_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 1vzo RIBOSOMAL PROTEIN S6
KINASE ALPHA 5
(Homo
sapiens) 		5 / 12 ASP A 186
LEU A 244
LEU A 180
LEU A 248
PRO A 334
 None
 1.22A 5hnyB-1vzoA:
undetectable		 5hnyB-1vzoA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 1vzo RIBOSOMAL PROTEIN S6
KINASE ALPHA 5
(Homo
sapiens) 		5 / 12 LEU A 168
LEU A 165
ALA A 164
LEU A 131
LEU A 117
 None
 1.14A 5ljeA-1vzoA:
undetectable		 5ljeA-1vzoA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_E_PFLE406_1
(PROTON-GATED ION
CHANNEL)		 1vzo RIBOSOMAL PROTEIN S6
KINASE ALPHA 5
(Homo
sapiens) 		5 / 10 PRO A 276
TYR A 246
ILE A 271
ILE A 267
ILE A 217
 None
 1.08A 5murE-1vzoA:
undetectable		 5murE-1vzoA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_BEZA401_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 1vzo RIBOSOMAL PROTEIN S6
KINASE ALPHA 5
(Homo
sapiens) 		5 / 9 LEU A 244
SER A 240
ILE A 183
VAL A 191
ILE A 161
 None
 1.17A 6ef6A-1vzoA:
4.5		 6ef6A-1vzoA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_2
(TUBULIN BETA CHAIN)		 1vzo RIBOSOMAL PROTEIN S6
KINASE ALPHA 5
(Homo
sapiens) 		4 / 6 LEU A 105
LEU A 129
THR A  87
ARG A 209
 None
 1.06A 6ew0G-1vzoA:
undetectable		 6ew0G-1vzoA:
13.74