SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1w0h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GM7_B_PNNB1577_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 1w0h 3'-5' EXONUCLEASE
ERI1
(Homo
sapiens) 		4 / 8 PHE A 147
ALA A 137
PHE A 238
ILE A 152
 None
AMP  A1002 (-3.6A)
AMP  A1002 (-4.5A)
None
 1.03A 1gm7A-1w0hA:
undetectable
1gm7B-1w0hA:
undetectable		 1gm7A-1w0hA:
18.80
1gm7B-1w0hA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SV9_A_DIFA701_1
(PHOSPHOLIPASE A2)		 1w0h 3'-5' EXONUCLEASE
ERI1
(Homo
sapiens) 		4 / 8 ALA A 137
ILE A 151
GLY A 295
HIS A 293
 AMP  A1002 (-3.6A)
None
MG  A1001 ( 4.3A)
AMP  A1002 (-3.9A)
 0.83A 1sv9A-1w0hA:
undetectable		 1sv9A-1w0hA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_A_DR7A100_2
(PROTEASE)		 1w0h 3'-5' EXONUCLEASE
ERI1
(Homo
sapiens) 		5 / 9 ASP A 234
GLY A 295
LEU A 296
VAL A 174
ILE A 151
 MG  A1000 ( 3.1A)
MG  A1001 ( 4.3A)
None
None
None
 1.17A 3em4B-1w0hA:
undetectable		 3em4B-1w0hA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 1w0h 3'-5' EXONUCLEASE
ERI1
(Homo
sapiens) 		5 / 11 ASN A 240
LEU A 239
LEU A 207
VAL A 210
PHE A 253
 None
 1.31A 3jw5A-1w0hA:
undetectable		 3jw5A-1w0hA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_2
(CYCLIN-DEPENDENT
KINASE 8)		 1w0h 3'-5' EXONUCLEASE
ERI1
(Homo
sapiens) 		4 / 7 VAL A 157
LEU A 227
ASP A 134
MET A 235
 None
None
MG  A1000 (-2.0A)
None
 0.96A 3rgfA-1w0hA:
undetectable		 3rgfA-1w0hA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 1w0h 3'-5' EXONUCLEASE
ERI1
(Homo
sapiens) 		4 / 8 VAL A 157
ILE A 132
ASP A 134
PHE A 135
 None
None
MG  A1000 (-2.0A)
None
 0.67A 3wzeA-1w0hA:
undetectable		 3wzeA-1w0hA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 1w0h 3'-5' EXONUCLEASE
ERI1
(Homo
sapiens) 		4 / 6 VAL A 156
LEU A 158
ILE A 132
CYH A 131
 None
 0.89A 4asdA-1w0hA:
undetectable		 4asdA-1w0hA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_B_VORB590_1
(14-ALPHA STEROL
DEMETHYLASE)		 1w0h 3'-5' EXONUCLEASE
ERI1
(Homo
sapiens) 		4 / 7 PHE A 253
TYR A 250
ILE A 151
PHE A 154
 None
 0.97A 4uymB-1w0hA:
undetectable		 4uymB-1w0hA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 1w0h 3'-5' EXONUCLEASE
ERI1
(Homo
sapiens) 		3 / 3 GLU A 136
HIS A 293
ASP A 230
 AMP  A1002 ( 2.6A)
AMP  A1002 (-3.9A)
None
 0.77A 5c0oG-1w0hA:
undetectable		 5c0oG-1w0hA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_1
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 1w0h 3'-5' EXONUCLEASE
ERI1
(Homo
sapiens) 		3 / 3 ARG A 272
ASN A 259
ASP A 134
 None
None
MG  A1000 (-2.0A)
 0.89A 5gwxA-1w0hA:
undetectable		 5gwxA-1w0hA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1w0h 3'-5' EXONUCLEASE
ERI1
(Homo
sapiens) 		5 / 8 ILE A 152
ILE A 132
ILE A 166
ILE A 302
ASP A 297
 None
 1.42A 5hi2A-1w0hA:
undetectable		 5hi2A-1w0hA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_A_PPFA602_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 1w0h 3'-5' EXONUCLEASE
ERI1
(Homo
sapiens) 		4 / 6 ARG A 272
ASP A 234
GLY A 231
ASP A 230
 None
MG  A1000 ( 3.1A)
None
None
 1.12A 5hp1A-1w0hA:
undetectable		 5hp1A-1w0hA:
16.70