SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1w0m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KW0_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1w0m TRIOSEPHOSPHATE
ISOMERASE
(Thermoproteus
tenax) 		5 / 12 VAL A 199
LEU A 201
SER A 203
THR A 178
HIS A  93
 None
PO4  A1226 (-4.6A)
PO4  A1226 (-2.7A)
None
None
 1.23A 1kw0A-1w0mA:
undetectable		 1kw0A-1w0mA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 1w0m TRIOSEPHOSPHATE
ISOMERASE
(Thermoproteus
tenax) 		5 / 12 GLY A 179
ALA A 139
ILE A 177
GLU A 217
ALA A 202
 None
None
None
None
PO4  A1226 (-3.6A)
 0.95A 1vq1A-1w0mA:
undetectable		 1vq1A-1w0mA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_A_PXLA1003_1
(PYRIDOXINE KINASE)		 1w0m TRIOSEPHOSPHATE
ISOMERASE
(Thermoproteus
tenax) 		4 / 8 VAL A 167
VAL A 176
LEU A 166
PRO A 124
 None
 0.89A 2ddwA-1w0mA:
undetectable		 2ddwA-1w0mA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_D_ASDD1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1w0m TRIOSEPHOSPHATE
ISOMERASE
(Thermoproteus
tenax) 		5 / 9 LEU A 218
PRO A 221
LEU A 222
LEU A 192
ALA A 191
 None
 1.18A 2vcvD-1w0mA:
undetectable		 2vcvD-1w0mA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_E_ASDE1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1w0m TRIOSEPHOSPHATE
ISOMERASE
(Thermoproteus
tenax) 		5 / 9 LEU A 218
PRO A 221
LEU A 222
LEU A 192
ALA A 191
 None
 1.26A 2vcvE-1w0mA:
undetectable		 2vcvE-1w0mA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_I_ASDI1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1w0m TRIOSEPHOSPHATE
ISOMERASE
(Thermoproteus
tenax) 		5 / 9 LEU A 218
PRO A 221
LEU A 222
LEU A 192
ALA A 191
 None
 1.17A 2vcvI-1w0mA:
undetectable		 2vcvI-1w0mA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_B_SAMB401_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 1w0m TRIOSEPHOSPHATE
ISOMERASE
(Thermoproteus
tenax) 		5 / 12 GLY A 181
GLY A 147
ALA A 204
LEU A 200
VAL A 199
 PO4  A1226 (-3.6A)
PO4  A1226 (-3.7A)
None
None
None
 0.82A 2yqzB-1w0mA:
undetectable		 2yqzB-1w0mA:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1w0m TRIOSEPHOSPHATE
ISOMERASE
(Thermoproteus
tenax) 		4 / 7 LEU A 194
ARG A 154
PRO A 142
GLY A 181
 None
None
None
PO4  A1226 (-3.6A)
 0.94A 3hcnA-1w0mA:
2.3		 3hcnA-1w0mA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA424_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1w0m TRIOSEPHOSPHATE
ISOMERASE
(Thermoproteus
tenax) 		4 / 8 LEU A 194
ARG A 154
PRO A 142
GLY A 181
 None
None
None
PO4  A1226 (-3.6A)
 0.91A 3hcrA-1w0mA:
2.2		 3hcrA-1w0mA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_B_CHDB924_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1w0m TRIOSEPHOSPHATE
ISOMERASE
(Thermoproteus
tenax) 		4 / 7 LEU A 194
ARG A 154
PRO A 142
GLY A 181
 None
None
None
PO4  A1226 (-3.6A)
 1.04A 3hcrB-1w0mA:
undetectable		 3hcrB-1w0mA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_B_SALB404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 1w0m TRIOSEPHOSPHATE
ISOMERASE
(Thermoproteus
tenax) 		4 / 7 ALA A 204
ARG A 150
ALA A 151
ARG A 154
 None
 1.13A 3twpB-1w0mA:
undetectable		 3twpB-1w0mA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		 1w0m TRIOSEPHOSPHATE
ISOMERASE
(Thermoproteus
tenax) 		5 / 10 ILE A 160
LEU A 194
THR A 178
GLY A 179
GLY A 181
 None
None
None
None
PO4  A1226 (-3.6A)
 0.97A 4bwlC-1w0mA:
13.0		 4bwlC-1w0mA:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1w0m TRIOSEPHOSPHATE
ISOMERASE
(Thermoproteus
tenax) 		4 / 8 SER A  94
GLU A 144
TYR A 155
GLY A 149
 None
 0.95A 4fgzA-1w0mA:
undetectable
4fgzB-1w0mA:
undetectable		 4fgzA-1w0mA:
22.30
4fgzB-1w0mA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1w0m TRIOSEPHOSPHATE
ISOMERASE
(Thermoproteus
tenax) 		4 / 8 SER A  94
TYR A 155
ARG A 154
GLY A 149
 None
 0.91A 4fgzA-1w0mA:
undetectable
4fgzB-1w0mA:
undetectable		 4fgzA-1w0mA:
22.30
4fgzB-1w0mA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLA_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1w0m TRIOSEPHOSPHATE
ISOMERASE
(Thermoproteus
tenax) 		4 / 8 LEU A 103
LEU A 106
LEU A  78
HIS A  45
 None
 0.88A 4klaA-1w0mA:
undetectable		 4klaA-1w0mA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1w0m TRIOSEPHOSPHATE
ISOMERASE
(Thermoproteus
tenax) 		4 / 8 LEU A 194
ARG A 154
PRO A 142
GLY A 181
 None
None
None
PO4  A1226 (-3.6A)
 0.95A 4klrB-1w0mA:
2.3		 4klrB-1w0mA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 1w0m TRIOSEPHOSPHATE
ISOMERASE
(Thermoproteus
tenax) 		3 / 3 ASP A 116
VAL A 138
ASN A  38
 None
 0.58A 4lmnA-1w0mA:
undetectable		 4lmnA-1w0mA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM9_A_FVXA603_1
(TRANSPORTER)		 1w0m TRIOSEPHOSPHATE
ISOMERASE
(Thermoproteus
tenax) 		5 / 11 VAL A  89
ALA A  61
TYR A  60
GLY A 114
GLY A  86
 None
 1.15A 4mm9A-1w0mA:
undetectable		 4mm9A-1w0mA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		 1w0m TRIOSEPHOSPHATE
ISOMERASE
(Thermoproteus
tenax) 		5 / 9 VAL A  89
ALA A  61
TYR A  60
GLY A 114
GLY A  86
 None
 1.19A 4mmbA-1w0mA:
undetectable		 4mmbA-1w0mA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_A_29QA603_1
(TRANSPORTER)		 1w0m TRIOSEPHOSPHATE
ISOMERASE
(Thermoproteus
tenax) 		5 / 9 VAL A  89
ALA A  61
TYR A  60
GLY A 114
GLY A  86
 None
 1.14A 4mmeA-1w0mA:
undetectable		 4mmeA-1w0mA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_B_29QB603_1
(TRANSPORTER)		 1w0m TRIOSEPHOSPHATE
ISOMERASE
(Thermoproteus
tenax) 		5 / 9 VAL A  89
ALA A  61
TYR A  60
GLY A 114
GLY A  86
 None
 1.17A 4mmeB-1w0mA:
undetectable		 4mmeB-1w0mA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_A_29QA603_1
(TRANSPORTER)		 1w0m TRIOSEPHOSPHATE
ISOMERASE
(Thermoproteus
tenax) 		5 / 9 VAL A  89
ALA A  61
TYR A  60
GLY A 114
GLY A  86
 None
 1.23A 4mmfA-1w0mA:
undetectable		 4mmfA-1w0mA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_B_29QB603_1
(TRANSPORTER)		 1w0m TRIOSEPHOSPHATE
ISOMERASE
(Thermoproteus
tenax) 		5 / 9 VAL A  89
ALA A  61
TYR A  60
GLY A 114
GLY A  86
 None
 1.21A 4mmfB-1w0mA:
undetectable		 4mmfB-1w0mA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_0
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 1w0m TRIOSEPHOSPHATE
ISOMERASE
(Thermoproteus
tenax) 		5 / 12 ILE A 182
GLY A 198
ILE A   5
ALA A  28
LEU A  24
 None
 1.00A 5e72A-1w0mA:
undetectable		 5e72A-1w0mA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_A_PZAA1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 1w0m TRIOSEPHOSPHATE
ISOMERASE
(Thermoproteus
tenax) 		4 / 7 VAL A  55
SER A  54
GLY A  85
VAL A  59
 None
 0.94A 5fpdA-1w0mA:
undetectable		 5fpdA-1w0mA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6S_A_RAUA400_1
(IMINE REDUCTASE)		 1w0m TRIOSEPHOSPHATE
ISOMERASE
(Thermoproteus
tenax) 		5 / 11 VAL A  22
LEU A  48
SER A  54
GLN A  53
GLY A  85
 None
 1.11A 5g6sA-1w0mA:
1.1
5g6sG-1w0mA:
1.3		 5g6sA-1w0mA:
26.43
5g6sG-1w0mA:
26.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6S_B_RAUB400_1
(IMINE REDUCTASE)		 1w0m TRIOSEPHOSPHATE
ISOMERASE
(Thermoproteus
tenax) 		5 / 11 VAL A  22
LEU A  48
SER A  54
GLN A  53
GLY A  85
 None
 1.10A 5g6sB-1w0mA:
1.2
5g6sC-1w0mA:
1.2		 5g6sB-1w0mA:
26.43
5g6sC-1w0mA:
26.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6S_C_RAUC400_1
(IMINE REDUCTASE)		 1w0m TRIOSEPHOSPHATE
ISOMERASE
(Thermoproteus
tenax) 		5 / 12 SER A  54
GLN A  53
GLY A  85
VAL A  22
LEU A  48
 None
 1.11A 5g6sB-1w0mA:
undetectable
5g6sC-1w0mA:
undetectable		 5g6sB-1w0mA:
26.43
5g6sC-1w0mA:
26.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6S_E_RAUE400_1
(IMINE REDUCTASE)		 1w0m TRIOSEPHOSPHATE
ISOMERASE
(Thermoproteus
tenax) 		5 / 11 VAL A  22
LEU A  48
SER A  54
GLN A  53
GLY A  85
 None
 1.10A 5g6sE-1w0mA:
1.3
5g6sH-1w0mA:
1.3		 5g6sE-1w0mA:
26.43
5g6sH-1w0mA:
26.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6S_F_RAUF400_1
(IMINE REDUCTASE)		 1w0m TRIOSEPHOSPHATE
ISOMERASE
(Thermoproteus
tenax) 		5 / 10 SER A  54
GLN A  53
GLY A  85
VAL A  22
LEU A  48
 None
 1.14A 5g6sD-1w0mA:
1.3
5g6sF-1w0mA:
1.2		 5g6sD-1w0mA:
26.43
5g6sF-1w0mA:
26.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6S_G_RAUG400_1
(IMINE REDUCTASE)		 1w0m TRIOSEPHOSPHATE
ISOMERASE
(Thermoproteus
tenax) 		5 / 10 SER A  54
GLN A  53
GLY A  85
VAL A  22
LEU A  48
 None
 1.10A 5g6sA-1w0mA:
1.0
5g6sG-1w0mA:
1.3		 5g6sA-1w0mA:
26.43
5g6sG-1w0mA:
26.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_A_OAQA302_0
(SULFOTRANSFERASE)		 1w0m TRIOSEPHOSPHATE
ISOMERASE
(Thermoproteus
tenax) 		5 / 12 PRO A  58
ILE A  81
LEU A  78
LEU A  91
LEU A 106
 None
 1.26A 5tiwA-1w0mA:
undetectable		 5tiwA-1w0mA:
21.30