SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1w1w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3003_1
(SERUM ALBUMIN)		 1w1w STRUCTURAL
MAINTENANCE OF
CHROMOSOME 1
(Saccharomyces
cerevisiae) 		3 / 4 LYS A1134
ALA A1137
MET A1126
 None
 0.93A 1hk3A-1w1wA:
undetectable		 1hk3A-1w1wA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD507_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 1w1w STRUCTURAL
MAINTENANCE OF
CHROMOSOME 1
(Saccharomyces
cerevisiae) 		4 / 7 ALA A  45
ILE A1215
TYR A  15
ILE A  31
 None
 0.95A 1oniD-1w1wA:
undetectable
1oniF-1w1wA:
undetectable		 1oniD-1w1wA:
17.95
1oniF-1w1wA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBK_A_RAPA225_1
(FKBP25)		 1w1w STRUCTURAL
MAINTENANCE OF
CHROMOSOME 1
(Saccharomyces
cerevisiae) 		5 / 12 GLY A  33
ILE A  31
ALA A  45
ILE A  46
PHE A  23
 None
 0.98A 1pbkA-1w1wA:
undetectable		 1pbkA-1w1wA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1w1w STRUCTURAL
MAINTENANCE OF
CHROMOSOME 1
(Saccharomyces
cerevisiae) 		5 / 11 PHE A  28
SER A  30
PHE A1143
LEU A1139
VAL A1159
 None
 1.36A 1q23L-1w1wA:
undetectable		 1q23L-1w1wA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_B_SAMB301_0
(HYPOTHETICAL PROTEIN
PH0226)		 1w1w STRUCTURAL
MAINTENANCE OF
CHROMOSOME 1
(Saccharomyces
cerevisiae) 		5 / 12 ALA A1172
ARG A1176
ILE A1188
SER A  30
PHE A  28
 None
 1.12A 1ve3B-1w1wA:
undetectable		 1ve3B-1w1wA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_2
(RETINOIC ACID
RECEPTOR, BETA)		 1w1w STRUCTURAL
MAINTENANCE OF
CHROMOSOME 1
(Saccharomyces
cerevisiae) 		3 / 3 LEU A 135
PHE A 134
ARG A   3
 None
 0.86A 1xdkB-1w1wA:
undetectable		 1xdkB-1w1wA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 1w1w SISTER CHROMATID
COHESION PROTEIN 1
STRUCTURAL
MAINTENANCE OF
CHROMOSOME 1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A1175
ALA A1172
MET A1194
ARG E 522
ILE A  32
 None
 1.20A 1y0xX-1w1wA:
undetectable		 1y0xX-1w1wA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A8T_B_ADNB252_1
(U8 SNORNA-BINDING
PROTEIN X29)		 1w1w SISTER CHROMATID
COHESION PROTEIN 1
STRUCTURAL
MAINTENANCE OF
CHROMOSOME 1
(Saccharomyces
cerevisiae) 		4 / 8 GLY A  33
PHE E 504
ILE A  32
ASN A1192
 None
 1.04A 2a8tB-1w1wA:
undetectable		 2a8tB-1w1wA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B9E_A_SAMA1201_0
(NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2)		 1w1w STRUCTURAL
MAINTENANCE OF
CHROMOSOME 1
(Saccharomyces
cerevisiae) 		5 / 12 GLY A  22
LEU A1220
ASP A1199
SER A  30
PHE A1195
 None
 1.45A 2b9eA-1w1wA:
undetectable		 2b9eA-1w1wA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BJF_A_DXCA330_0
(CHOLOYLGLYCINE
HYDROLASE)		 1w1w STRUCTURAL
MAINTENANCE OF
CHROMOSOME 1
(Saccharomyces
cerevisiae) 		5 / 12 TYR A  98
PHE A  23
ASN A 139
ILE A1186
ILE A  46
 None
 1.26A 2bjfA-1w1wA:
undetectable		 2bjfA-1w1wA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_0
(REPRESSOR PROTEIN
MPHR(A))		 1w1w STRUCTURAL
MAINTENANCE OF
CHROMOSOME 1
(Saccharomyces
cerevisiae) 		5 / 12 LEU A   4
VAL A 149
LEU A1139
VAL A1159
ILE A1171
 None
 1.06A 3frqB-1w1wA:
undetectable		 3frqB-1w1wA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J7Z_A_ERYA9000_0
(23S RRNA
50S RIBOSOMAL
PROTEIN L22
ERMCL NASCENT CHAIN)		 1w1w STRUCTURAL
MAINTENANCE OF
CHROMOSOME 1
SISTER CHROMATID
COHESION PROTEIN 1
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		3 / 3 LYS E 521
ILE A1186
PHE A1154
 None
 0.92A 3j7zS-1w1wE:
undetectable
3j7za-1w1wE:
undetectable		 3j7zS-1w1wE:
25.60
3j7za-1w1wE:
10.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA300_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 1w1w STRUCTURAL
MAINTENANCE OF
CHROMOSOME 1
(Saccharomyces
cerevisiae) 		4 / 6 PHE A1185
TYR A1174
VAL A1159
PHE A1143
 None
 1.34A 3ltwA-1w1wA:
undetectable		 3ltwA-1w1wA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_B_BEZB264_0
(ECHA1_1)		 1w1w STRUCTURAL
MAINTENANCE OF
CHROMOSOME 1
(Saccharomyces
cerevisiae) 		4 / 7 LEU A1099
ALA A1116
ALA A1097
MET A1126
 None
 0.86A 3r9tB-1w1wA:
undetectable		 3r9tB-1w1wA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_1
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 1w1w STRUCTURAL
MAINTENANCE OF
CHROMOSOME 1
(Saccharomyces
cerevisiae) 		5 / 11 VAL A  49
LEU A  50
GLU A 106
ALA A  96
VAL A  94
 None
 1.13A 4e0fA-1w1wA:
undetectable		 4e0fA-1w1wA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HDL_A_DXCA75_0
(PPCA)		 1w1w STRUCTURAL
MAINTENANCE OF
CHROMOSOME 1
(Saccharomyces
cerevisiae) 		4 / 8 ILE A1175
LYS A   2
ILE A1186
PHE A1154
 None
 0.94A 4hdlA-1w1wA:
undetectable		 4hdlA-1w1wA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_A_SAMA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 1w1w STRUCTURAL
MAINTENANCE OF
CHROMOSOME 1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A1215
GLY A  33
GLY A1203
ILE A1188
SER A  37
 None
None
None
None
AGS  A2224 (-3.5A)
 0.97A 4iv0A-1w1wA:
undetectable		 4iv0A-1w1wA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 1w1w STRUCTURAL
MAINTENANCE OF
CHROMOSOME 1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A1215
GLY A  33
GLY A1203
ILE A1188
SER A  37
 None
None
None
None
AGS  A2224 (-3.5A)
 0.95A 4iv0B-1w1wA:
undetectable		 4iv0B-1w1wA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 1w1w STRUCTURAL
MAINTENANCE OF
CHROMOSOME 1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A1215
GLY A  33
GLY A1203
ILE A1188
SER A  37
 None
None
None
None
AGS  A2224 (-3.5A)
 0.93A 4mwzA-1w1wA:
undetectable		 4mwzA-1w1wA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 1w1w STRUCTURAL
MAINTENANCE OF
CHROMOSOME 1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A1215
GLY A  33
GLY A1203
ILE A1188
SER A  37
 None
None
None
None
AGS  A2224 (-3.5A)
 0.98A 4mwzB-1w1wA:
undetectable		 4mwzB-1w1wA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA301_1
(CHITOSANASE)		 1w1w STRUCTURAL
MAINTENANCE OF
CHROMOSOME 1
(Saccharomyces
cerevisiae) 		4 / 8 ILE A1188
ASP A1157
GLY A  38
ASN A  35
 None
MG  A2001 ( 4.1A)
AGS  A2224 (-3.0A)
AGS  A2224 (-3.8A)
 0.96A 5hwaA-1w1wA:
undetectable		 5hwaA-1w1wA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IM2_A_BEZA401_0
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL)		 1w1w STRUCTURAL
MAINTENANCE OF
CHROMOSOME 1
(Saccharomyces
cerevisiae) 		5 / 12 PHE A1143
VAL A 149
ILE A1175
LEU A1139
LEU A1163
 None
 1.27A 5im2A-1w1wA:
undetectable		 5im2A-1w1wA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 1w1w STRUCTURAL
MAINTENANCE OF
CHROMOSOME 1
SISTER CHROMATID
COHESION PROTEIN 1
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 8 LEU E 532
LEU A1218
ILE A1186
THR A  29
 None
 1.07A 5ljbA-1w1wE:
undetectable		 5ljbA-1w1wE:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_2
(TUBULIN BETA-2B
CHAIN)		 1w1w STRUCTURAL
MAINTENANCE OF
CHROMOSOME 1
(Saccharomyces
cerevisiae) 		5 / 12 LEU A1075
THR A1135
ILE A1145
ALA A1144
ILE A 157
 None
 1.21A 5nm5B-1w1wA:
undetectable		 5nm5B-1w1wA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1w1w STRUCTURAL
MAINTENANCE OF
CHROMOSOME 1
SISTER CHROMATID
COHESION PROTEIN 1
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 7 GLY E 538
ILE E 540
GLY E 541
LEU E 542
ILE A  32
 None
 1.27A 5vkqA-1w1wE:
undetectable
5vkqB-1w1wE:
undetectable		 5vkqA-1w1wE:
5.57
5vkqB-1w1wE:
5.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1w1w STRUCTURAL
MAINTENANCE OF
CHROMOSOME 1
SISTER CHROMATID
COHESION PROTEIN 1
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 7 LEU E 492
ILE E 553
GLY E 541
LEU E 542
ILE A  32
 None
 1.35A 5vkqA-1w1wE:
undetectable
5vkqB-1w1wE:
undetectable		 5vkqA-1w1wE:
5.57
5vkqB-1w1wE:
5.57