SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1w25'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_1
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN))		 1w25 STALKED-CELL
DIFFERENTIATION
CONTROLLING PROTEIN
(Caulobacter
vibrioides) 		4 / 6 HIS A 177
LEU A 152
TYR A 274
VAL A 265
 None
 1.31A 1ibgH-1w25A:
1.6		 1ibgH-1w25A:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_A_STIA201_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 1w25 STALKED-CELL
DIFFERENTIATION
CONTROLLING PROTEIN
(Caulobacter
vibrioides) 		4 / 6 VAL A 449
VAL A 395
ILE A 326
ARG A 386
 None
 0.93A 1iepA-1w25A:
undetectable		 1iepA-1w25A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT4_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 1w25 STALKED-CELL
DIFFERENTIATION
CONTROLLING PROTEIN
(Caulobacter
vibrioides) 		5 / 12 LEU A 119
LEU A  51
ALA A  20
VAL A  80
TYR A  27
 None
 1.29A 1kt4A-1w25A:
undetectable		 1kt4A-1w25A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT6_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 1w25 STALKED-CELL
DIFFERENTIATION
CONTROLLING PROTEIN
(Caulobacter
vibrioides) 		5 / 11 LEU A 119
LEU A  51
ALA A  20
VAL A  80
TYR A  27
 None
 1.35A 1kt6A-1w25A:
undetectable		 1kt6A-1w25A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT7_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 1w25 STALKED-CELL
DIFFERENTIATION
CONTROLLING PROTEIN
(Caulobacter
vibrioides) 		5 / 11 LEU A 119
LEU A  51
ALA A  20
VAL A  80
TYR A  27
 None
 1.30A 1kt7A-1w25A:
undetectable		 1kt7A-1w25A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIK_A_ADNA699_1
(ADENOSINE KINASE)		 1w25 STALKED-CELL
DIFFERENTIATION
CONTROLLING PROTEIN
(Caulobacter
vibrioides) 		5 / 12 ASP A 344
LEU A 297
GLY A 343
ASN A 335
THR A 295
 C2E  A 501 (-3.7A)
None
C2E  A 501 (-3.7A)
C2E  A 501 (-3.1A)
None
 1.08A 1likA-1w25A:
2.0		 1likA-1w25A:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_B_ADNB1502_1
(CLASS B ACID
PHOSPHATASE)		 1w25 STALKED-CELL
DIFFERENTIATION
CONTROLLING PROTEIN
(Caulobacter
vibrioides) 		4 / 7 PHE A  62
LEU A  81
THR A  63
LYS A  67
 None
 1.16A 1rmtB-1w25A:
4.3		 1rmtB-1w25A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)		 1w25 STALKED-CELL
DIFFERENTIATION
CONTROLLING PROTEIN
(Caulobacter
vibrioides) 		4 / 6 ASP A 329
SER A 414
SER A 444
GLY A 445
 None
 1.03A 2j2pA-1w25A:
undetectable
2j2pC-1w25A:
undetectable		 2j2pA-1w25A:
19.77
2j2pC-1w25A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA801_1
(TRANSPORTER)		 1w25 STALKED-CELL
DIFFERENTIATION
CONTROLLING PROTEIN
(Caulobacter
vibrioides) 		5 / 11 ARG A 239
VAL A 232
ILE A 246
ALA A 230
ASP A 209
 None
 1.18A 2q72A-1w25A:
0.0		 2q72A-1w25A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_A_CHDA2_0
(FERROCHELATASE)		 1w25 STALKED-CELL
DIFFERENTIATION
CONTROLLING PROTEIN
(Caulobacter
vibrioides) 		4 / 8 MET A 376
LEU A 324
ARG A 386
PRO A 320
 C2E  A 503 ( 4.8A)
None
None
None
 1.15A 2qd2A-1w25A:
4.2		 2qd2A-1w25A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_B_LOCB700_2
(TUBULIN BETA-2B
CHAIN)		 1w25 STALKED-CELL
DIFFERENTIATION
CONTROLLING PROTEIN
(Caulobacter
vibrioides) 		5 / 11 LEU A 244
ALA A 114
ASN A 249
ALA A 230
VAL A 232
 None
 1.26A 3e22B-1w25A:
4.3		 3e22B-1w25A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_D_LOCD700_2
(TUBULIN BETA-2B
CHAIN)		 1w25 STALKED-CELL
DIFFERENTIATION
CONTROLLING PROTEIN
(Caulobacter
vibrioides) 		5 / 11 LEU A 244
ALA A 114
ASN A 249
ALA A 230
VAL A 232
 None
 1.25A 3e22D-1w25A:
4.3		 3e22D-1w25A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKV_A_478A200_2
(PROTEASE)		 1w25 STALKED-CELL
DIFFERENTIATION
CONTROLLING PROTEIN
(Caulobacter
vibrioides) 		5 / 9 ALA A 114
GLY A 247
ILE A 246
VAL A 232
ILE A 251
 None
 1.12A 3ekvB-1w25A:
undetectable		 3ekvB-1w25A:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1w25 STALKED-CELL
DIFFERENTIATION
CONTROLLING PROTEIN
(Caulobacter
vibrioides) 		4 / 7 MET A 376
LEU A 324
ARG A 386
PRO A 320
 C2E  A 503 ( 4.8A)
None
None
None
 1.11A 3hcnA-1w25A:
3.4		 3hcnA-1w25A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 1w25 STALKED-CELL
DIFFERENTIATION
CONTROLLING PROTEIN
(Caulobacter
vibrioides) 		6 / 12 ASP A 109
LEU A 112
ARG A 115
ILE A   5
LEU A  51
LEU A  18
 None
 1.48A 3k2hA-1w25A:
undetectable		 3k2hA-1w25A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP2_B_PNNB5002_0
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1w25 STALKED-CELL
DIFFERENTIATION
CONTROLLING PROTEIN
(Caulobacter
vibrioides) 		4 / 5 ASN A 202
ALA A 204
ALA A 203
ARG A 239
 None
 1.46A 3kp2B-1w25A:
undetectable		 3kp2B-1w25A:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZV_A_017A200_2
(HIV-1 PROTEASE)		 1w25 STALKED-CELL
DIFFERENTIATION
CONTROLLING PROTEIN
(Caulobacter
vibrioides) 		5 / 11 ALA A 114
GLY A 247
ILE A 246
VAL A 232
ILE A 251
 None
 1.03A 3lzvB-1w25A:
undetectable		 3lzvB-1w25A:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU4_B_478B401_1
(PROTEASE)		 1w25 STALKED-CELL
DIFFERENTIATION
CONTROLLING PROTEIN
(Caulobacter
vibrioides) 		5 / 9 ALA A 114
GLY A 247
ILE A 246
VAL A 232
ILE A 251
 None
 1.05A 3nu4A-1w25A:
undetectable		 3nu4A-1w25A:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUO_B_478B478_1
(PROTEASE)		 1w25 STALKED-CELL
DIFFERENTIATION
CONTROLLING PROTEIN
(Caulobacter
vibrioides) 		5 / 9 ALA A 114
GLY A 247
ILE A 246
VAL A 232
ILE A 251
 None
 1.06A 3nuoA-1w25A:
undetectable		 3nuoA-1w25A:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_B_RBFB190_1
(RIBOFLAVIN UPTAKE
PROTEIN)		 1w25 STALKED-CELL
DIFFERENTIATION
CONTROLLING PROTEIN
(Caulobacter
vibrioides) 		5 / 12 LEU A  52
GLY A  35
ALA A  38
ALA A  42
LEU A   6
 None
 1.13A 3p5nB-1w25A:
undetectable		 3p5nB-1w25A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROX_A_TEPA266_1
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 1w25 STALKED-CELL
DIFFERENTIATION
CONTROLLING PROTEIN
(Caulobacter
vibrioides) 		4 / 8 ALA A 166
VAL A 169
LEU A 173
LEU A 157
 None
 0.70A 3roxA-1w25A:
4.7		 3roxA-1w25A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T8N_D_EDTD135_0
(STEROID
DELTA-ISOMERASE)		 1w25 STALKED-CELL
DIFFERENTIATION
CONTROLLING PROTEIN
(Caulobacter
vibrioides) 		5 / 11 THR A  63
GLY A  61
GLY A  35
PRO A  36
ASP A  53
 None
None
None
None
MG  A 500 (-3.2A)
 1.42A 3t8nD-1w25A:
undetectable
3t8nF-1w25A:
0.0		 3t8nD-1w25A:
14.57
3t8nF-1w25A:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_B_DXCB1473_0
(MJ0495-LIKE PROTEIN)		 1w25 STALKED-CELL
DIFFERENTIATION
CONTROLLING PROTEIN
(Caulobacter
vibrioides) 		5 / 11 ILE A 413
ASP A 327
ILE A 328
PHE A 372
PHE A 400
 None
 1.10A 4ac9B-1w25A:
7.7
4ac9C-1w25A:
7.5		 4ac9B-1w25A:
22.86
4ac9C-1w25A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMM_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1w25 STALKED-CELL
DIFFERENTIATION
CONTROLLING PROTEIN
(Caulobacter
vibrioides) 		4 / 5 MET A 376
LEU A 324
ARG A 386
PRO A 320
 C2E  A 503 ( 4.8A)
None
None
None
 1.09A 4kmmB-1w25A:
3.4		 4kmmB-1w25A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_2
(ANDROGEN RECEPTOR)		 1w25 STALKED-CELL
DIFFERENTIATION
CONTROLLING PROTEIN
(Caulobacter
vibrioides) 		4 / 6 LEU A  39
MET A  56
LEU A  52
ILE A  77
 None
 1.15A 4okxA-1w25A:
undetectable		 4okxA-1w25A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 1w25 STALKED-CELL
DIFFERENTIATION
CONTROLLING PROTEIN
(Caulobacter
vibrioides) 		5 / 12 VAL A 374
ILE A 415
LEU A 324
VAL A 395
PHE A 350
 None
 0.99A 4y0qA-1w25A:
undetectable		 4y0qA-1w25A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJO_D_ERYD1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 1w25 STALKED-CELL
DIFFERENTIATION
CONTROLLING PROTEIN
(Caulobacter
vibrioides) 		5 / 11 SER A 191
SER A 183
ALA A 170
ASP A 319
GLY A 318
 None
 1.33A 4zjoD-1w25A:
4.4		 4zjoD-1w25A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1w25 STALKED-CELL
DIFFERENTIATION
CONTROLLING PROTEIN
(Caulobacter
vibrioides) 		4 / 6 PHE A 350
SER A 356
ALA A 355
LEU A 352
 None
 1.02A 5dzkB-1w25A:
undetectable
5dzkP-1w25A:
undetectable		 5dzkB-1w25A:
18.14
5dzkP-1w25A:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1w25 STALKED-CELL
DIFFERENTIATION
CONTROLLING PROTEIN
(Caulobacter
vibrioides) 		4 / 7 PHE A 350
SER A 356
ALA A 355
LEU A 352
 None
 0.93A 5dzkD-1w25A:
undetectable
5dzkR-1w25A:
undetectable		 5dzkD-1w25A:
18.14
5dzkR-1w25A:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8S_B_SAMB402_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 1w25 STALKED-CELL
DIFFERENTIATION
CONTROLLING PROTEIN
(Caulobacter
vibrioides) 		4 / 8 ALA A 351
ASP A 329
ILE A 328
ILE A 334
 None
 0.96A 5t8sA-1w25A:
undetectable		 5t8sA-1w25A:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_B_REAB503_1
(RETINOIC ACID
RECEPTOR BETA)		 1w25 STALKED-CELL
DIFFERENTIATION
CONTROLLING PROTEIN
(Caulobacter
vibrioides) 		5 / 12 CYH A  65
LEU A  51
ILE A  82
SER A  97
VAL A 116
 None
 1.42A 5uanB-1w25A:
undetectable		 5uanB-1w25A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_E_EY4E500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 1w25 STALKED-CELL
DIFFERENTIATION
CONTROLLING PROTEIN
(Caulobacter
vibrioides) 		4 / 8 ILE A 375
VAL A 321
ALA A 314
THR A 315
 None
 0.79A 6cduD-1w25A:
undetectable
6cduE-1w25A:
undetectable		 6cduD-1w25A:
21.94
6cduE-1w25A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_F_EY4F500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 1w25 STALKED-CELL
DIFFERENTIATION
CONTROLLING PROTEIN
(Caulobacter
vibrioides) 		4 / 7 ALA A 314
THR A 315
ILE A 375
VAL A 321
 None
 0.93A 6cduF-1w25A:
3.2
6cduJ-1w25A:
3.2		 6cduF-1w25A:
21.94
6cduJ-1w25A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBN_B_SAMB401_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1w25 STALKED-CELL
DIFFERENTIATION
CONTROLLING PROTEIN
(Caulobacter
vibrioides) 		4 / 7 ALA A 351
ASP A 329
ILE A 328
ILE A 334
 None
 0.96A 6fbnA-1w25A:
undetectable		 6fbnA-1w25A:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA819_0
(GEPHYRIN)		 1w25 STALKED-CELL
DIFFERENTIATION
CONTROLLING PROTEIN
(Caulobacter
vibrioides) 		3 / 3 ARG A 366
GLY A 369
GLU A 370
 C2E  A 501 ( 4.1A)
C2E  A 501 (-3.3A)
C2E  A 501 (-4.7A)
 0.38A 6fgdA-1w25A:
4.1		 6fgdA-1w25A:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 1w25 STALKED-CELL
DIFFERENTIATION
CONTROLLING PROTEIN
(Caulobacter
vibrioides) 		4 / 6 MET A 376
ALA A 382
LEU A 381
ALA A 419
 C2E  A 503 ( 4.8A)
None
None
None
 1.06A 6fosB-1w25A:
undetectable		 6fosB-1w25A:
10.15