SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1w27'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4007_1
(SERUM ALBUMIN)		 1w27 PHENYLALANINE
AMMONIA-LYASE 1
(Petroselinum
crispum) 		4 / 8 LEU A 528
HIS A 527
ASN A 650
LEU A 641
 None
 1.05A 1e7cA-1w27A:
1.9		 1e7cA-1w27A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_B_NIOB702_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1w27 PHENYLALANINE
AMMONIA-LYASE 1
(Petroselinum
crispum) 		4 / 5 PHE A 427
GLY A 518
THR A 513
PHE A 685
 None
 1.15A 1icvA-1w27A:
undetectable
1icvB-1w27A:
undetectable		 1icvA-1w27A:
17.89
1icvB-1w27A:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT6_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 1w27 PHENYLALANINE
AMMONIA-LYASE 1
(Petroselinum
crispum) 		5 / 11 LEU A 519
ALA A 458
VAL A 293
LEU A 439
ARG A 665
 None
 1.47A 1kt6A-1w27A:
undetectable		 1kt6A-1w27A:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA501_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 1w27 PHENYLALANINE
AMMONIA-LYASE 1
(Petroselinum
crispum) 		4 / 7 ARG A 376
ILE A 405
PRO A 404
GLU A 377
 None
 1.12A 1oniA-1w27A:
undetectable
1oniB-1w27A:
undetectable		 1oniA-1w27A:
12.30
1oniB-1w27A:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB503_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 1w27 PHENYLALANINE
AMMONIA-LYASE 1
(Petroselinum
crispum) 		4 / 6 ARG A 376
ILE A 405
PRO A 404
GLU A 377
 None
 1.17A 1oniB-1w27A:
undetectable
1oniC-1w27A:
undetectable		 1oniB-1w27A:
12.30
1oniC-1w27A:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_G_BEZG513_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 1w27 PHENYLALANINE
AMMONIA-LYASE 1
(Petroselinum
crispum) 		4 / 5 ARG A 376
ILE A 405
PRO A 404
GLU A 377
 None
 1.15A 1oniG-1w27A:
0.0
1oniH-1w27A:
0.0		 1oniG-1w27A:
12.30
1oniH-1w27A:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_2
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 1w27 PHENYLALANINE
AMMONIA-LYASE 1
(Petroselinum
crispum) 		3 / 3 LEU A 308
HIS A 303
ILE A 315
 None
 0.55A 1s9pB-1w27A:
0.0		 1s9pB-1w27A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 1w27 PHENYLALANINE
AMMONIA-LYASE 1
(Petroselinum
crispum) 		3 / 3 SER A  78
GLY A  79
ARG A 157
 None
 0.65A 1t9wA-1w27A:
1.5		 1t9wA-1w27A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_C_STRC3001_1
(MINERALOCORTICOID
RECEPTOR)		 1w27 PHENYLALANINE
AMMONIA-LYASE 1
(Petroselinum
crispum) 		5 / 12 LEU A 279
LEU A 282
ALA A 283
LEU A 469
THR A 412
 None
 0.91A 1ya3C-1w27A:
undetectable		 1ya3C-1w27A:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_A_H4BA1290_1
(PTERIDINE REDUCTASE
1)		 1w27 PHENYLALANINE
AMMONIA-LYASE 1
(Petroselinum
crispum) 		4 / 8 ARG A 546
PHE A 622
LEU A 593
LEU A 630
 None
 0.96A 2bfpA-1w27A:
0.0		 2bfpA-1w27A:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_B_H4BB1290_1
(PTERIDINE REDUCTASE
1)		 1w27 PHENYLALANINE
AMMONIA-LYASE 1
(Petroselinum
crispum) 		4 / 8 ARG A 546
PHE A 622
LEU A 593
LEU A 630
 None
 0.96A 2bfpB-1w27A:
undetectable		 2bfpB-1w27A:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_C_H4BC1290_1
(PTERIDINE REDUCTASE
1)		 1w27 PHENYLALANINE
AMMONIA-LYASE 1
(Petroselinum
crispum) 		4 / 8 ARG A 546
PHE A 622
LEU A 593
LEU A 630
 None
 0.95A 2bfpC-1w27A:
undetectable		 2bfpC-1w27A:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_D_H4BD1290_1
(PTERIDINE REDUCTASE
1)		 1w27 PHENYLALANINE
AMMONIA-LYASE 1
(Petroselinum
crispum) 		4 / 8 ARG A 546
PHE A 622
LEU A 593
LEU A 630
 None
 0.97A 2bfpD-1w27A:
undetectable		 2bfpD-1w27A:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 1w27 PHENYLALANINE
AMMONIA-LYASE 1
(Petroselinum
crispum) 		4 / 7 VAL A 366
SER A 370
LEU A 414
THR A 501
 None
 1.05A 2f78A-1w27A:
undetectable		 2f78A-1w27A:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_F_SNLF6001_2
(MINERALOCORTICOID
RECEPTOR)		 1w27 PHENYLALANINE
AMMONIA-LYASE 1
(Petroselinum
crispum) 		4 / 5 LEU A 279
LEU A 282
LEU A 519
MET A 692
 None
 1.02A 2oaxF-1w27A:
undetectable		 2oaxF-1w27A:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 1w27 PHENYLALANINE
AMMONIA-LYASE 1
(Petroselinum
crispum) 		5 / 12 ILE A 523
ALA A 522
GLY A 518
ILE A 289
TYR A 661
 None
 0.87A 2qe6A-1w27A:
undetectable		 2qe6A-1w27A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 1w27 PHENYLALANINE
AMMONIA-LYASE 1
(Petroselinum
crispum) 		5 / 12 ILE A 523
ALA A 522
GLY A 518
ILE A 289
TYR A 661
 None
 0.84A 2qe6B-1w27A:
undetectable		 2qe6B-1w27A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQ5_B_LDPB1197_1
(S-NORCOCLAURINE
SYNTHASE)		 1w27 PHENYLALANINE
AMMONIA-LYASE 1
(Petroselinum
crispum) 		4 / 7 LEU A 138
LEU A 134
PHE A 137
GLU A 484
 None
None
DTT  A1717 (-4.9A)
DTT  A1717 ( 3.9A)
 0.66A 2vq5B-1w27A:
undetectable		 2vq5B-1w27A:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKK_E_MFXE1100_1
(TOPOISOMERASE IV
DNA)		 1w27 PHENYLALANINE
AMMONIA-LYASE 1
(Petroselinum
crispum) 		3 / 3 ARG A 656
GLU A 316
SER A 328
 None
 0.88A 2xkkA-1w27A:
undetectable
2xkkC-1w27A:
undetectable		 2xkkA-1w27A:
23.13
2xkkC-1w27A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_A_P1BA1478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1w27 PHENYLALANINE
AMMONIA-LYASE 1
(Petroselinum
crispum) 		4 / 7 GLU A 275
ILE A 698
ALA A 288
ILE A 324
 None
 0.76A 2xkwA-1w27A:
undetectable		 2xkwA-1w27A:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_A_CTCA1385_0
(TETX2 PROTEIN)		 1w27 PHENYLALANINE
AMMONIA-LYASE 1
(Petroselinum
crispum) 		5 / 10 ASP A 205
ASN A 260
GLY A 398
PRO A 404
GLY A 494
 MDO  A 203 ( 4.3A)
DTT  A1717 (-2.8A)
None
None
None
 1.45A 2y6rA-1w27A:
undetectable		 2y6rA-1w27A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 1w27 PHENYLALANINE
AMMONIA-LYASE 1
(Petroselinum
crispum) 		4 / 8 THR A 501
LYS A 509
ASP A 205
GLU A 275
 None
None
MDO  A 203 ( 4.3A)
None
 0.98A 2zw9A-1w27A:
undetectable		 2zw9A-1w27A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI9_X_SAMX501_0
(UPF0217 PROTEIN
MJ1640)		 1w27 PHENYLALANINE
AMMONIA-LYASE 1
(Petroselinum
crispum) 		5 / 9 LEU A 597
ILE A 615
LEU A 566
GLU A 599
CYH A 562
 None
 1.13A 3ai9X-1w27A:
undetectable		 3ai9X-1w27A:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_4
(HIV-1 PROTEASE)		 1w27 PHENYLALANINE
AMMONIA-LYASE 1
(Petroselinum
crispum) 		4 / 4 LEU A 641
ASP A 580
VAL A 634
THR A 535
 None
 1.05A 3cyxB-1w27A:
undetectable		 3cyxB-1w27A:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCM_X_SAMX5452_0
(UNCHARACTERIZED
PROTEIN TM_1570)		 1w27 PHENYLALANINE
AMMONIA-LYASE 1
(Petroselinum
crispum) 		6 / 11 GLY A 218
GLY A 214
ILE A 190
LEU A 232
SER A 233
ALA A 237
 None
 1.17A 3dcmX-1w27A:
undetectable		 3dcmX-1w27A:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQT_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1w27 PHENYLALANINE
AMMONIA-LYASE 1
(Petroselinum
crispum) 		4 / 7 PHE A 515
GLU A 459
SER A 428
VAL A 431
 None
 1.22A 3dqtA-1w27A:
0.3
3dqtB-1w27A:
undetectable		 3dqtA-1w27A:
20.84
3dqtB-1w27A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9X_A_NIMA1_1
(LACTOTRANSFERRIN')		 1w27 PHENYLALANINE
AMMONIA-LYASE 1
(Petroselinum
crispum) 		4 / 4 GLU A 667
GLY A 669
THR A 670
GLU A 671
 None
 1.12A 3e9xA-1w27A:
undetectable		 3e9xA-1w27A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		 1w27 PHENYLALANINE
AMMONIA-LYASE 1
(Petroselinum
crispum) 		4 / 7 LEU A 167
VAL A 259
LEU A 250
LEU A 186
 None
 0.75A 3g8iA-1w27A:
undetectable		 3g8iA-1w27A:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I9J_B_NCAB302_0
(ADP-RIBOSYL CYCLASE)		 1w27 PHENYLALANINE
AMMONIA-LYASE 1
(Petroselinum
crispum) 		4 / 6 LEU A 360
GLU A 284
SER A 356
PHE A 300
 None
 1.35A 3i9jB-1w27A:
2.3		 3i9jB-1w27A:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_A_C2FA314_0
(UNCHARACTERIZED
PROTEIN)		 1w27 PHENYLALANINE
AMMONIA-LYASE 1
(Petroselinum
crispum) 		5 / 12 VAL A 243
GLY A 245
ILE A 178
LEU A 215
ILE A 212
 None
 1.02A 3ijdA-1w27A:
undetectable		 3ijdA-1w27A:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_0
(UNCHARACTERIZED
PROTEIN)		 1w27 PHENYLALANINE
AMMONIA-LYASE 1
(Petroselinum
crispum) 		5 / 12 VAL A 243
GLY A 245
ILE A 178
LEU A 215
ILE A 212
 None
 1.00A 3ijdB-1w27A:
undetectable		 3ijdB-1w27A:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_C_VIAC901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 1w27 PHENYLALANINE
AMMONIA-LYASE 1
(Petroselinum
crispum) 		4 / 7 LEU A 611
GLN A 617
PHE A 616
VAL A 598
 None
 0.96A 3jwqC-1w27A:
undetectable		 3jwqC-1w27A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_A_ADNA300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 1w27 PHENYLALANINE
AMMONIA-LYASE 1
(Petroselinum
crispum) 		5 / 11 ILE A 416
LEU A 469
LEU A 472
THR A 501
ALA A 504
 None
 0.83A 3kw2A-1w27A:
0.0		 3kw2A-1w27A:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_A_ADNA300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 1w27 PHENYLALANINE
AMMONIA-LYASE 1
(Petroselinum
crispum) 		5 / 11 ILE A 419
GLY A 420
SER A 356
LEU A 360
ALA A 283
 None
 1.23A 3kw2A-1w27A:
0.0		 3kw2A-1w27A:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_B_ADNB300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 1w27 PHENYLALANINE
AMMONIA-LYASE 1
(Petroselinum
crispum) 		5 / 11 ILE A 416
LEU A 469
LEU A 472
THR A 501
ALA A 504
 None
 0.88A 3kw2B-1w27A:
undetectable		 3kw2B-1w27A:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA801_0
(GLUTAMATE RECEPTOR 2)		 1w27 PHENYLALANINE
AMMONIA-LYASE 1
(Petroselinum
crispum) 		4 / 8 PRO A 195
GLY A 141
SER A 210
ASN A 221
 None
 0.91A 3lslA-1w27A:
undetectable
3lslD-1w27A:
undetectable		 3lslA-1w27A:
17.39
3lslD-1w27A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID801_0
(GLUTAMATE RECEPTOR 2)		 1w27 PHENYLALANINE
AMMONIA-LYASE 1
(Petroselinum
crispum) 		4 / 8 SER A 210
ASN A 221
PRO A 195
GLY A 141
 None
 0.94A 3lslA-1w27A:
undetectable
3lslD-1w27A:
undetectable		 3lslA-1w27A:
17.39
3lslD-1w27A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLR_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1w27 PHENYLALANINE
AMMONIA-LYASE 1
(Petroselinum
crispum) 		4 / 8 SER A  95
VAL A  99
VAL A 389
TRP A  98
 None
 1.06A 3nlrA-1w27A:
undetectable
3nlrB-1w27A:
undetectable		 3nlrA-1w27A:
20.92
3nlrB-1w27A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEO_B_LLTB261_1
(DEOXYCYTIDINE KINASE)		 1w27 PHENYLALANINE
AMMONIA-LYASE 1
(Petroselinum
crispum) 		4 / 7 VAL A 259
LEU A 138
GLN A 131
LEU A 130
 None
 0.93A 3qeoB-1w27A:
undetectable		 3qeoB-1w27A:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ4_X_DXCX75_0
(CYTOCHROME C7)		 1w27 PHENYLALANINE
AMMONIA-LYASE 1
(Petroselinum
crispum) 		5 / 9 ILE A 182
LEU A 216
ILE A 190
PHE A 238
GLY A 245
 None
 1.12A 3sj4X-1w27A:
undetectable		 3sj4X-1w27A:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ4_X_DXCX75_0
(CYTOCHROME C7)		 1w27 PHENYLALANINE
AMMONIA-LYASE 1
(Petroselinum
crispum) 		5 / 9 ILE A 182
LEU A 216
ILE A 190
PHE A 238
GLY A 246
 None
 1.23A 3sj4X-1w27A:
undetectable		 3sj4X-1w27A:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 1w27 PHENYLALANINE
AMMONIA-LYASE 1
(Petroselinum
crispum) 		4 / 5 LEU A 130
LEU A 134
LEU A 250
MET A 100
 None
 0.99A 3vhuA-1w27A:
1.7		 3vhuA-1w27A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1w27 PHENYLALANINE
AMMONIA-LYASE 1
(Petroselinum
crispum) 		4 / 8 GLY A  39
GLU A 316
VAL A  45
GLU A  44
 None
 0.93A 4fgzA-1w27A:
undetectable		 4fgzA-1w27A:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FO4_A_MOAA502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 1w27 PHENYLALANINE
AMMONIA-LYASE 1
(Petroselinum
crispum) 		4 / 8 ASP A 410
SER A 408
ASN A 411
GLY A 402
 None
 0.94A 4fo4A-1w27A:
undetectable		 4fo4A-1w27A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB8_A_DXCA75_0
(PPCA)		 1w27 PHENYLALANINE
AMMONIA-LYASE 1
(Petroselinum
crispum) 		5 / 8 ILE A 182
LEU A 216
ILE A 190
PHE A 238
GLY A 245
 None
 1.19A 4hb8A-1w27A:
undetectable		 4hb8A-1w27A:
7.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB8_A_DXCA75_0
(PPCA)		 1w27 PHENYLALANINE
AMMONIA-LYASE 1
(Petroselinum
crispum) 		5 / 8 ILE A 182
LEU A 216
ILE A 190
PHE A 238
GLY A 246
 None
 1.29A 4hb8A-1w27A:
undetectable		 4hb8A-1w27A:
7.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_E_CAME502_0
(CAMPHOR
5-MONOOXYGENASE)		 1w27 PHENYLALANINE
AMMONIA-LYASE 1
(Petroselinum
crispum) 		4 / 5 PHE A 248
THR A 183
PHE A 185
ILE A 178
 None
 1.22A 4jx1E-1w27A:
undetectable		 4jx1E-1w27A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5J_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1w27 PHENYLALANINE
AMMONIA-LYASE 1
(Petroselinum
crispum) 		4 / 7 PHE A 515
GLU A 459
SER A 428
VAL A 431
 None
 1.22A 4k5jA-1w27A:
undetectable
4k5jB-1w27A:
undetectable		 4k5jA-1w27A:
20.44
4k5jB-1w27A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1w27 PHENYLALANINE
AMMONIA-LYASE 1
(Petroselinum
crispum) 		4 / 6 GLN A 488
THR A 114
HIS A 396
ASN A 260
 MDO  A 203 ( 3.9A)
None
None
DTT  A1717 (-2.8A)
 1.26A 4pfjB-1w27A:
undetectable		 4pfjB-1w27A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		 1w27 PHENYLALANINE
AMMONIA-LYASE 1
(Petroselinum
crispum) 		5 / 12 ASP A 205
ILE A 405
PRO A 404
ILE A 374
SER A 270
 MDO  A 203 ( 4.3A)
None
None
None
None
 1.11A 4uroA-1w27A:
undetectable		 4uroA-1w27A:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		 1w27 PHENYLALANINE
AMMONIA-LYASE 1
(Petroselinum
crispum) 		5 / 12 ASP A 205
ILE A 405
PRO A 404
ILE A 374
SER A 270
 MDO  A 203 ( 4.3A)
None
None
None
None
 1.14A 4uroC-1w27A:
undetectable		 4uroC-1w27A:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_2
(ESTROGEN RECEPTOR)		 1w27 PHENYLALANINE
AMMONIA-LYASE 1
(Petroselinum
crispum) 		3 / 3 LEU A 519
ASP A 524
ILE A 324
 None
 0.66A 4xi3D-1w27A:
undetectable		 4xi3D-1w27A:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_A_0HKA1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 1w27 PHENYLALANINE
AMMONIA-LYASE 1
(Petroselinum
crispum) 		3 / 3 ASN A 437
LEU A 443
PHE A 434
 None
 0.72A 5dsgA-1w27A:
2.7		 5dsgA-1w27A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA609_0
(NADH DEHYDROGENASE,
PUTATIVE)		 1w27 PHENYLALANINE
AMMONIA-LYASE 1
(Petroselinum
crispum) 		3 / 3 VAL A 389
SER A  95
TRP A  98
 None
 0.96A 5jwaA-1w27A:
undetectable		 5jwaA-1w27A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1w27 PHENYLALANINE
AMMONIA-LYASE 1
(Petroselinum
crispum) 		4 / 4 GLN A 521
THR A 674
LEU A 532
LEU A 528
 None
 1.26A 5m5kB-1w27A:
undetectable		 5m5kB-1w27A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA511_1
(PROTON-GATED ION
CHANNEL)		 1w27 PHENYLALANINE
AMMONIA-LYASE 1
(Petroselinum
crispum) 		4 / 8 ALA A 213
ILE A 178
ALA A 181
ILE A 182
 None
 0.72A 5mvmA-1w27A:
1.6
5mvmB-1w27A:
1.5		 5mvmA-1w27A:
8.51
5mvmB-1w27A:
8.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUM_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 1w27 PHENYLALANINE
AMMONIA-LYASE 1
(Petroselinum
crispum) 		5 / 8 ILE A 419
LEU A 508
ILE A 416
ILE A 367
ASN A 277
 None
 1.39A 5numA-1w27A:
undetectable		 5numA-1w27A:
7.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1w27 PHENYLALANINE
AMMONIA-LYASE 1
(Petroselinum
crispum) 		3 / 3 LEU A 161
ALA A 158
LEU A  64
 None
 0.53A 5uunB-1w27A:
2.2		 5uunB-1w27A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV7_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1w27 PHENYLALANINE
AMMONIA-LYASE 1
(Petroselinum
crispum) 		4 / 7 PHE A 515
GLU A 459
SER A 428
VAL A 431
 None
 1.23A 5vv7A-1w27A:
undetectable
5vv7B-1w27A:
undetectable		 5vv7A-1w27A:
20.44
5vv7B-1w27A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 1w27 PHENYLALANINE
AMMONIA-LYASE 1
(Petroselinum
crispum) 		5 / 12 VAL A 517
THR A 513
LEU A 673
GLY A 682
VAL A 431
 None
 1.18A 6a94B-1w27A:
0.0		 6a94B-1w27A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_B_H4BB501_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1w27 PHENYLALANINE
AMMONIA-LYASE 1
(Petroselinum
crispum) 		4 / 7 SER A 428
VAL A 431
PHE A 515
GLU A 459
 None
 1.27A 6av6A-1w27A:
0.0
6av6B-1w27A:
undetectable		 6av6A-1w27A:
8.10
6av6B-1w27A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1w27 PHENYLALANINE
AMMONIA-LYASE 1
(Petroselinum
crispum) 		4 / 7 PHE A 515
GLU A 459
SER A 428
VAL A 431
 None
 1.26A 6av6C-1w27A:
undetectable
6av6D-1w27A:
0.0		 6av6C-1w27A:
8.10
6av6D-1w27A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV7_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1w27 PHENYLALANINE
AMMONIA-LYASE 1
(Petroselinum
crispum) 		4 / 7 SER A 428
VAL A 431
PHE A 515
GLU A 459
 None
 1.24A 6av7A-1w27A:
undetectable
6av7B-1w27A:
undetectable		 6av7A-1w27A:
8.10
6av7B-1w27A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0C_D_TA1D502_1
(TUBULIN BETA CHAIN)		 1w27 PHENYLALANINE
AMMONIA-LYASE 1
(Petroselinum
crispum) 		5 / 12 SER A 270
LEU A 186
THR A 183
GLY A  61
LEU A  59
 None
 0.93A 6b0cD-1w27A:
undetectable		 6b0cD-1w27A:
7.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_W_CHDW102_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1w27 PHENYLALANINE
AMMONIA-LYASE 1
(Petroselinum
crispum) 		4 / 5 ARG A 546
MET A 550
THR A 549
LEU A 556
 None
 1.16A 6nknW-1w27A:
undetectable		 6nknW-1w27A:
6.59