SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1w2d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 1w2d INOSITOL-TRISPHOSPHA
TE 3-KINASE A
(Homo
sapiens) 		5 / 11 LEU A 455
LEU A 377
SER A 399
LEU A 400
LEU A 451
 None
 1.04A 2ceoA-1w2dA:
undetectable		 2ceoA-1w2dA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_D_ASDD1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 1w2d INOSITOL-TRISPHOSPHA
TE 3-KINASE A
(Homo
sapiens) 		4 / 7 TYR A 373
GLY A 411
LEU A 252
PHE A 255
 None
None
ADP  A1462 ( 4.5A)
None
 1.01A 2vctD-1w2dA:
0.0		 2vctD-1w2dA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN7_A_T44A1355_1
(THYROXINE-BINDING
GLOBULIN)		 1w2d INOSITOL-TRISPHOSPHA
TE 3-KINASE A
(Homo
sapiens) 		5 / 10 LEU A 455
LEU A 377
SER A 399
LEU A 400
LEU A 451
 None
 1.12A 2xn7A-1w2dA:
undetectable
2xn7B-1w2dA:
undetectable		 2xn7A-1w2dA:
20.34
2xn7B-1w2dA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX94_0
(PROTEIN S100-B)		 1w2d INOSITOL-TRISPHOSPHA
TE 3-KINASE A
(Homo
sapiens) 		3 / 3 PHE A 330
CYH A 263
PHE A 402
 None
 0.91A 3cr5X-1w2dA:
undetectable		 3cr5X-1w2dA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MJR_A_AC2A301_1
(DEOXYCYTIDINE KINASE)		 1w2d INOSITOL-TRISPHOSPHA
TE 3-KINASE A
(Homo
sapiens) 		5 / 9 ILE A 380
GLU A 385
ARG A 432
ASP A 449
LEU A 400
 None
 1.31A 3mjrA-1w2dA:
undetectable		 3mjrA-1w2dA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB1_0
(INVASIN IPAD)		 1w2d INOSITOL-TRISPHOSPHA
TE 3-KINASE A
(Homo
sapiens) 		4 / 7 ILE A 415
LEU A 401
LEU A 261
SER A 324
 ADP  A1462 ( 4.2A)
ADP  A1462 ( 4.6A)
None
None
 0.93A 3r9vA-1w2dA:
undetectable
3r9vB-1w2dA:
undetectable		 3r9vA-1w2dA:
18.49
3r9vB-1w2dA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V7P_A_BEZA430_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 1w2d INOSITOL-TRISPHOSPHA
TE 3-KINASE A
(Homo
sapiens) 		4 / 7 ILE A 396
GLY A 397
SER A 398
PHE A 390
 None
 0.81A 3v7pA-1w2dA:
undetectable		 3v7pA-1w2dA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_A_QPSA951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		 1w2d INOSITOL-TRISPHOSPHA
TE 3-KINASE A
(Homo
sapiens) 		4 / 6 GLY A 438
TRP A 435
ARG A 279
ARG A 268
 None
 0.95A 4bqfA-1w2dA:
undetectable		 4bqfA-1w2dA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_B_QPSB951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		 1w2d INOSITOL-TRISPHOSPHA
TE 3-KINASE A
(Homo
sapiens) 		4 / 8 ARG A 440
GLU A 394
GLU A 441
ARG A 433
 None
 1.17A 4bqfB-1w2dA:
undetectable		 4bqfB-1w2dA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAA_A_RTZA401_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 1w2d INOSITOL-TRISPHOSPHA
TE 3-KINASE A
(Homo
sapiens) 		6 / 11 LYS A 209
LEU A 248
VAL A 403
LEU A 401
ILE A 415
ASP A 416
 ADP  A1462 (-2.6A)
ADP  A1462 ( 4.3A)
None
ADP  A1462 ( 4.6A)
ADP  A1462 ( 4.2A)
ADP  A1462 ( 3.4A)
 1.15A 4iaaA-1w2dA:
6.1		 4iaaA-1w2dA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_A_RTZA602_1
(CYTOCHROME P450 2D6)		 1w2d INOSITOL-TRISPHOSPHA
TE 3-KINASE A
(Homo
sapiens) 		5 / 12 PHE A 330
GLY A 334
LEU A 261
VAL A 358
PHE A 402
 None
 1.20A 4wnwA-1w2dA:
undetectable		 4wnwA-1w2dA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1F_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 1w2d INOSITOL-TRISPHOSPHA
TE 3-KINASE A
(Homo
sapiens) 		5 / 12 LEU A 377
LEU A 400
ARG A 381
LEU A 384
ILE A 380
 None
 0.95A 4x1fA-1w2dA:
undetectable		 4x1fA-1w2dA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1G_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 1w2d INOSITOL-TRISPHOSPHA
TE 3-KINASE A
(Homo
sapiens) 		6 / 12 LEU A 377
LEU A 400
MET A 265
ARG A 381
LEU A 384
ILE A 380
 None
 1.05A 4x1gA-1w2dA:
undetectable		 4x1gA-1w2dA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UL4_A_SAMA803_0
(OXSB PROTEIN)		 1w2d INOSITOL-TRISPHOSPHA
TE 3-KINASE A
(Homo
sapiens) 		5 / 12 ARG A 433
GLY A 443
GLY A 266
ILE A 396
LEU A 275
 None
 0.89A 5ul4A-1w2dA:
undetectable		 5ul4A-1w2dA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA310_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1w2d INOSITOL-TRISPHOSPHA
TE 3-KINASE A
(Homo
sapiens) 		3 / 3 GLU A 304
HIS A 305
ARG A 308
 None
 0.80A 5uunA-1w2dA:
undetectable		 5uunA-1w2dA:
20.52