SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1w2l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_1
(PROGESTERONE
RECEPTOR)		 1w2l CYTOCHROME OXIDASE
SUBUNIT II
(Rhodothermus
marinus) 		5 / 12 LEU A  29
GLY A  31
MET A  76
PHE A  94
LEU A  91
 None
HEM  A1100 ( 3.7A)
HEM  A1100 (-2.2A)
None
HEM  A1100 ( 4.1A)
 1.28A 2w8yA-1w2lA:
undetectable		 2w8yA-1w2lA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_A_PFNA1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 1w2l CYTOCHROME OXIDASE
SUBUNIT II
(Rhodothermus
marinus) 		4 / 6 PRO A  77
SER A  79
TYR A  80
CYH A  18
 HEM  A1100 (-4.6A)
None
HEM  A1100 (-3.3A)
HEM  A1100 (-1.8A)
 0.94A 2x7hA-1w2lA:
undetectable		 2x7hA-1w2lA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U6T_A_KANA4699_1
(RIBOSOME
INACTIVATING PROTEIN)		 1w2l CYTOCHROME OXIDASE
SUBUNIT II
(Rhodothermus
marinus) 		5 / 10 TYR A  38
ILE A  95
ASN A  55
ILE A  92
GLU A  93
 ACT  A1102 (-4.4A)
None
None
None
None
 1.15A 3u6tA-1w2lA:
undetectable		 3u6tA-1w2lA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_E_CLME221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1w2l CYTOCHROME OXIDASE
SUBUNIT II
(Rhodothermus
marinus) 		3 / 3 PHE A  34
CYH A  18
HIS A  22
 HEM  A1100 ( 4.8A)
HEM  A1100 (-1.8A)
HEM  A1100 (-3.2A)
 1.31A 3u9fF-1w2lA:
undetectable		 3u9fF-1w2lA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2S_A_ACTA107_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 1w2l CYTOCHROME OXIDASE
SUBUNIT II
(Rhodothermus
marinus) 		3 / 3 VAL A  69
THR A  43
ARG A  42
 HEM  A1100 ( 3.9A)
None
TRS  A1101 ( 2.0A)
 0.67A 5b2sB-1w2lA:
undetectable		 5b2sB-1w2lA:
6.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2T_A_ACTA108_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 1w2l CYTOCHROME OXIDASE
SUBUNIT II
(Rhodothermus
marinus) 		3 / 3 VAL A  69
THR A  43
ARG A  42
 HEM  A1100 ( 3.9A)
None
TRS  A1101 ( 2.0A)
 0.67A 5b2tB-1w2lA:
undetectable		 5b2tB-1w2lA:
6.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6S_A_CXQA507_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 1w2l CYTOCHROME OXIDASE
SUBUNIT II
(Rhodothermus
marinus) 		4 / 5 ALA A  10
TYR A  13
GLN A  97
ILE A  95
 None
 1.21A 6f6sA-1w2lA:
0.0
6f6sB-1w2lA:
0.0		 6f6sA-1w2lA:
17.82
6f6sB-1w2lA:
18.10