SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1w2u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_2
(DIPEPTIDYL PEPTIDASE
IV)		 1w2u ENDOGLUCANASE
(Humicola
grisea) 		3 / 3 PHE A 105
TYR A  64
TYR A  66
 None
BGC  A 303 (-4.1A)
None
 0.89A 1x70B-1w2uA:
0.5		 1x70B-1w2uA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TVX_B_PNXB902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		 1w2u ENDOGLUCANASE
(Humicola
grisea) 		4 / 7 ASN A 196
ILE A  77
PHE A 181
GLN A 195
 None
 1.27A 3tvxB-1w2uA:
undetectable		 3tvxB-1w2uA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7N_A_ZMRA601_2
(NEURAMINIDASE)		 1w2u ENDOGLUCANASE
(Humicola
grisea) 		3 / 3 ARG A 171
ARG A 217
TRP A  89
 None
PG4  A 501 (-3.0A)
None
 1.34A 4b7nA-1w2uA:
undetectable		 4b7nA-1w2uA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_C_ZMRC1470_2
(NEURAMINIDASE)		 1w2u ENDOGLUCANASE
(Humicola
grisea) 		3 / 3 ARG A 171
ARG A 217
TRP A  89
 None
PG4  A 501 (-3.0A)
None
 1.41A 4cpzC-1w2uA:
undetectable		 4cpzC-1w2uA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_E_ZMRE1471_2
(NEURAMINIDASE)		 1w2u ENDOGLUCANASE
(Humicola
grisea) 		3 / 3 ARG A 171
ARG A 217
TRP A  89
 None
PG4  A 501 (-3.0A)
None
 1.36A 4cpzE-1w2uA:
undetectable		 4cpzE-1w2uA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_F_ZMRF1470_2
(NEURAMINIDASE)		 1w2u ENDOGLUCANASE
(Humicola
grisea) 		3 / 3 ARG A 171
ARG A 217
TRP A  89
 None
PG4  A 501 (-3.0A)
None
 1.39A 4cpzF-1w2uA:
undetectable		 4cpzF-1w2uA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_H_ZMRH1470_2
(NEURAMINIDASE)		 1w2u ENDOGLUCANASE
(Humicola
grisea) 		3 / 3 ARG A 171
ARG A 217
TRP A  89
 None
PG4  A 501 (-3.0A)
None
 1.36A 4cpzH-1w2uA:
undetectable		 4cpzH-1w2uA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWX_A_ZMRA513_2
(NEURAMINIDASE)		 1w2u ENDOGLUCANASE
(Humicola
grisea) 		3 / 3 ARG A 146
TRP A 148
ILE A 170
 None
 0.93A 4mwxA-1w2uA:
undetectable		 4mwxA-1w2uA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_E_PARE500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 1w2u ENDOGLUCANASE
(Humicola
grisea) 		5 / 12 PHE A 137
TYR A 183
GLU A 120
TYR A 154
GLY A 153
 None
None
BGC  A 303 (-2.9A)
None
None
 1.39A 4qb9E-1w2uA:
undetectable		 4qb9E-1w2uA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		 1w2u ENDOGLUCANASE
(Humicola
grisea) 		4 / 5 LEU A 121
TYR A 190
LEU A 184
THR A 106
 None
 1.05A 4wozF-1w2uA:
undetectable
4wozH-1w2uA:
undetectable		 4wozF-1w2uA:
20.06
4wozH-1w2uA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_H_FK5H201_1
(FK506-BINDING
PROTEIN 1)		 1w2u ENDOGLUCANASE
(Humicola
grisea) 		4 / 8 TYR A 190
ILE A  80
ILE A 198
PHE A 181
 None
 0.98A 5hw8H-1w2uA:
undetectable		 5hw8H-1w2uA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA609_0
(NADH DEHYDROGENASE,
PUTATIVE)		 1w2u ENDOGLUCANASE
(Humicola
grisea) 		3 / 3 VAL A  87
SER A  88
TRP A  89
 None
PG4  A 501 (-3.2A)
None
 1.04A 5jwaA-1w2uA:
undetectable		 5jwaA-1w2uA:
16.54