SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1w2w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_E_CCSE47_0
(GLUTATHIONE
S-TRANSFERASE)		 1w2w 5-METHYLTHIORIBOSE-1
-PHOSPHATE ISOMERASE
5-METHYLTHIORIBOSE-1
-PHOSPHATE ISOMERASE
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 7 THR A 183
LEU B 241
GLY B 238
LEU B 246
 None
 0.96A 1gtiE-1w2wA:
undetectable		 1gtiE-1w2wA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_1
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 1w2w 5-METHYLTHIORIBOSE-1
-PHOSPHATE ISOMERASE
5-METHYLTHIORIBOSE-1
-PHOSPHATE ISOMERASE
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 7 LEU A 143
ILE B 282
THR B 316
MET A 154
 None
 1.29A 1kglA-1w2wA:
undetectable		 1kglA-1w2wA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1w2w 5-METHYLTHIORIBOSE-1
-PHOSPHATE ISOMERASE
(Saccharomyces
cerevisiae) 		3 / 3 THR A  91
LEU A  95
LEU A 102
 None
 0.39A 1mz9C-1w2wA:
undetectable		 1mz9C-1w2wA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_0
(HEMK PROTEIN)		 1w2w 5-METHYLTHIORIBOSE-1
-PHOSPHATE ISOMERASE
(Saccharomyces
cerevisiae) 		5 / 12 THR A 179
GLY A 192
ILE A 198
SER A 189
ALA A 187
 None
 0.89A 1sg9B-1w2wA:
undetectable		 1sg9B-1w2wA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z95_A_198A501_2
(ANDROGEN RECEPTOR)		 1w2w 5-METHYLTHIORIBOSE-1
-PHOSPHATE ISOMERASE
(Saccharomyces
cerevisiae) 		4 / 6 ASN A  96
LEU A 136
LEU A 129
ILE A 122
 None
 0.99A 1z95A-1w2wA:
undetectable		 1z95A-1w2wA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_2
(ESTROGEN RECEPTOR)		 1w2w 5-METHYLTHIORIBOSE-1
-PHOSPHATE ISOMERASE
(Saccharomyces
cerevisiae) 		4 / 4 LEU A 178
THR A 179
ILE B 270
HIS B 226
 None
 0.76A 2jfaB-1w2wA:
undetectable		 2jfaB-1w2wA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 1w2w 5-METHYLTHIORIBOSE-1
-PHOSPHATE ISOMERASE
(Saccharomyces
cerevisiae) 		4 / 6 LEU B 410
ASN A 151
ILE B 390
PHE B 397
 None
 1.24A 2jn3A-1w2wB:
undetectable		 2jn3A-1w2wB:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_1
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 1w2w 5-METHYLTHIORIBOSE-1
-PHOSPHATE ISOMERASE
5-METHYLTHIORIBOSE-1
-PHOSPHATE ISOMERASE
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 5 PRO A  54
ALA A  55
ASP B 280
ASP B 380
 None
None
SO4  A1212 (-3.8A)
None
 1.20A 2nyuB-1w2wA:
undetectable		 2nyuB-1w2wA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		 1w2w 5-METHYLTHIORIBOSE-1
-PHOSPHATE ISOMERASE
(Saccharomyces
cerevisiae) 		4 / 5 VAL A 140
TYR A 137
VAL A  16
ASP A   9
 None
 1.17A 2x45C-1w2wA:
undetectable		 2x45C-1w2wA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1w2w 5-METHYLTHIORIBOSE-1
-PHOSPHATE ISOMERASE
(Saccharomyces
cerevisiae) 		3 / 3 GLY A 184
GLY A 196
GLY A 192
 None
 0.40A 3bogC-1w2wA:
undetectable		 3bogC-1w2wA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_B_TRPB1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1w2w 5-METHYLTHIORIBOSE-1
-PHOSPHATE ISOMERASE
5-METHYLTHIORIBOSE-1
-PHOSPHATE ISOMERASE
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 8 GLY B 225
ILE B 251
VAL B 227
VAL A 177
 None
 0.80A 3fi0B-1w2wB:
undetectable		 3fi0B-1w2wB:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_2
(GLUCOCORTICOID
RECEPTOR)		 1w2w 5-METHYLTHIORIBOSE-1
-PHOSPHATE ISOMERASE
(Saccharomyces
cerevisiae) 		3 / 3 MET A  48
CYH A 181
PRO B 234
 SO4  A1212 (-4.7A)
SO4  A1212 ( 4.0A)
None
 1.14A 3h52C-1w2wA:
undetectable		 3h52C-1w2wA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RFM_A_CFFA330_1
(ADENOSINE RECEPTOR
A2A)		 1w2w 5-METHYLTHIORIBOSE-1
-PHOSPHATE ISOMERASE
(Saccharomyces
cerevisiae) 		4 / 7 VAL A  68
LEU A  99
ASN A  96
ILE A 119
 None
 0.90A 3rfmA-1w2wA:
0.5		 3rfmA-1w2wA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ4_X_DXCX75_0
(CYTOCHROME C7)		 1w2w 5-METHYLTHIORIBOSE-1
-PHOSPHATE ISOMERASE
5-METHYLTHIORIBOSE-1
-PHOSPHATE ISOMERASE
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 9 ILE B 282
LEU B 407
LYS A 153
ILE B 391
PHE B 397
 None
 1.20A 3sj4X-1w2wB:
undetectable		 3sj4X-1w2wB:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SO9_A_017A100_1
(HIV-1 PROTEASE)		 1w2w 5-METHYLTHIORIBOSE-1
-PHOSPHATE ISOMERASE
(Saccharomyces
cerevisiae) 		5 / 8 ASN B 290
GLY B 278
ALA B 279
GLY A  52
THR A 108
 None
None
None
SO4  A1212 (-3.6A)
None
 1.36A 3so9A-1w2wB:
undetectable		 3so9A-1w2wB:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 1w2w 5-METHYLTHIORIBOSE-1
-PHOSPHATE ISOMERASE
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 102
GLY A  41
ILE A   6
VAL A  20
 None
 0.88A 3wrkA-1w2wA:
0.0		 3wrkA-1w2wA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_C_ACTC1113_0
(BLR5658 PROTEIN)		 1w2w 5-METHYLTHIORIBOSE-1
-PHOSPHATE ISOMERASE
(Saccharomyces
cerevisiae) 		4 / 4 ASN A 182
ALA A 187
GLY A 184
THR A 193
 None
 1.11A 4bboC-1w2wA:
undetectable		 4bboC-1w2wA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 1w2w 5-METHYLTHIORIBOSE-1
-PHOSPHATE ISOMERASE
5-METHYLTHIORIBOSE-1
-PHOSPHATE ISOMERASE
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 6 ASP A 147
ALA A  57
THR B 315
THR B 316
 None
 1.42A 4w5qA-1w2wA:
0.0		 4w5qA-1w2wA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5R_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 1w2w 5-METHYLTHIORIBOSE-1
-PHOSPHATE ISOMERASE
5-METHYLTHIORIBOSE-1
-PHOSPHATE ISOMERASE
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 6 ASP A 147
ALA A  57
THR B 315
THR B 316
 None
 1.43A 4w5rA-1w2wA:
undetectable		 4w5rA-1w2wA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 1w2w 5-METHYLTHIORIBOSE-1
-PHOSPHATE ISOMERASE
5-METHYLTHIORIBOSE-1
-PHOSPHATE ISOMERASE
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 6 ASP A 147
ALA A  57
THR B 315
THR B 316
 None
 1.38A 4w5tA-1w2wA:
2.4		 4w5tA-1w2wA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 1w2w 5-METHYLTHIORIBOSE-1
-PHOSPHATE ISOMERASE
5-METHYLTHIORIBOSE-1
-PHOSPHATE ISOMERASE
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 6 ASP A 147
ALA A  57
THR B 315
THR B 316
 None
 1.39A 4z4cA-1w2wA:
undetectable		 4z4cA-1w2wA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 1w2w 5-METHYLTHIORIBOSE-1
-PHOSPHATE ISOMERASE
5-METHYLTHIORIBOSE-1
-PHOSPHATE ISOMERASE
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 6 ASP A 147
ALA A  57
THR B 315
THR B 316
 None
 1.41A 4z4fA-1w2wA:
2.5		 4z4fA-1w2wA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 1w2w 5-METHYLTHIORIBOSE-1
-PHOSPHATE ISOMERASE
5-METHYLTHIORIBOSE-1
-PHOSPHATE ISOMERASE
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 5 ASP A 147
ALA A  57
THR B 315
THR B 316
 None
 1.41A 4z4gA-1w2wA:
undetectable		 4z4gA-1w2wA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 1w2w 5-METHYLTHIORIBOSE-1
-PHOSPHATE ISOMERASE
5-METHYLTHIORIBOSE-1
-PHOSPHATE ISOMERASE
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 6 ASP A 147
ALA A  57
THR B 315
THR B 316
 None
 1.38A 4z4iA-1w2wA:
undetectable		 4z4iA-1w2wA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_C_ACTC403_0
(D-ALANINE--D-ALANINE
LIGASE)		 1w2w 5-METHYLTHIORIBOSE-1
-PHOSPHATE ISOMERASE
5-METHYLTHIORIBOSE-1
-PHOSPHATE ISOMERASE
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 4 TYR B 244
GLY A 184
SER A 185
LEU A 186
 None
 1.37A 5bphC-1w2wB:
3.1		 5bphC-1w2wB:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1w2w 5-METHYLTHIORIBOSE-1
-PHOSPHATE ISOMERASE
(Saccharomyces
cerevisiae) 		4 / 6 PHE B 228
ARG B 264
PRO B 229
ILE B 256
 None
 1.32A 5ih0A-1w2wB:
undetectable		 5ih0A-1w2wB:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8D_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 1w2w 5-METHYLTHIORIBOSE-1
-PHOSPHATE ISOMERASE
5-METHYLTHIORIBOSE-1
-PHOSPHATE ISOMERASE
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		3 / 3 THR B 316
PRO B 313
ASP A 147
 None
 0.92A 5l8dB-1w2wB:
undetectable		 5l8dB-1w2wB:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWU_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 1w2w 5-METHYLTHIORIBOSE-1
-PHOSPHATE ISOMERASE
5-METHYLTHIORIBOSE-1
-PHOSPHATE ISOMERASE
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		3 / 3 THR B 316
PRO B 313
ASP A 147
 None
 0.92A 5mwuB-1w2wB:
undetectable		 5mwuB-1w2wB:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_A_NCAA402_0
(NADPH DEHYDROGENASE
3)		 1w2w 5-METHYLTHIORIBOSE-1
-PHOSPHATE ISOMERASE
(Saccharomyces
cerevisiae) 		4 / 8 TRP B 375
ASN B 376
PHE B 337
PRO B 234
 None
 1.15A 5v4vA-1w2wB:
undetectable		 5v4vA-1w2wB:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_B_NCAB402_0
(NADPH DEHYDROGENASE
3)		 1w2w 5-METHYLTHIORIBOSE-1
-PHOSPHATE ISOMERASE
(Saccharomyces
cerevisiae) 		4 / 8 TRP B 375
ASN B 376
PHE B 337
PRO B 234
 None
 1.19A 5v4vB-1w2wB:
undetectable		 5v4vB-1w2wB:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_A_9SCA601_0
(SERUM ALBUMIN)		 1w2w 5-METHYLTHIORIBOSE-1
-PHOSPHATE ISOMERASE
5-METHYLTHIORIBOSE-1
-PHOSPHATE ISOMERASE
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 12 LEU A 166
ILE A 163
PHE B 276
LEU B 386
GLY A 158
 None
 1.21A 6a7pA-1w2wA:
2.7		 6a7pA-1w2wA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_C_SAMC301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 1w2w 5-METHYLTHIORIBOSE-1
-PHOSPHATE ISOMERASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A  62
ILE A  58
ILE A  56
VAL A  33
ILE A   6
 None
 0.95A 6emuC-1w2wA:
undetectable		 6emuC-1w2wA:
20.80