SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1w3i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVU_A_PRLA196_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 1w3i 2-KETO-3-DEOXY
GLUCONATE ALDOLASE
(Sulfolobus
solfataricus) 		4 / 6 LEU A  76
THR A 118
TYR A 115
TYR A 104
 None
 1.18A 1qvuA-1w3iA:
undetectable		 1qvuA-1w3iA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 1w3i 2-KETO-3-DEOXY
GLUCONATE ALDOLASE
(Sulfolobus
solfataricus) 		5 / 12 TYR A 246
LEU A  23
TYR A 255
THR A 249
SER A 200
 None
 1.44A 1xoqA-1w3iA:
undetectable		 1xoqA-1w3iA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 1w3i 2-KETO-3-DEOXY
GLUCONATE ALDOLASE
(Sulfolobus
solfataricus) 		5 / 12 TYR A 246
LEU A  23
TYR A 255
THR A 249
SER A 200
 None
 1.42A 1xoqB-1w3iA:
undetectable		 1xoqB-1w3iA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZS9_A_PAUA603_0
(PANTOTHENATE KINASE)		 1w3i 2-KETO-3-DEOXY
GLUCONATE ALDOLASE
(Sulfolobus
solfataricus) 		4 / 6 ASP A 139
LYS A 143
HIS A 163
ASN A 171
 None
 1.21A 2zs9A-1w3iA:
undetectable		 2zs9A-1w3iA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1w3i 2-KETO-3-DEOXY
GLUCONATE ALDOLASE
(Sulfolobus
solfataricus) 		5 / 12 ASN A 245
VAL A 232
LEU A 203
ILE A 233
THR A 207
 None
 1.25A 3em0B-1w3iA:
undetectable		 3em0B-1w3iA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID5_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 1w3i 2-KETO-3-DEOXY
GLUCONATE ALDOLASE
(Sulfolobus
solfataricus) 		5 / 11 TYR A 128
GLY A  95
THR A 152
PHE A  91
ILE A  69
 None
 1.36A 3id5B-1w3iA:
undetectable		 3id5B-1w3iA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID5_F_SAMF301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 1w3i 2-KETO-3-DEOXY
GLUCONATE ALDOLASE
(Sulfolobus
solfataricus) 		5 / 11 TYR A 128
GLY A  95
THR A 152
PHE A  91
ILE A  69
 None
 1.36A 3id5F-1w3iA:
undetectable		 3id5F-1w3iA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PRS_A_RITA1001_1
(ENDOTHIAPEPSIN)		 1w3i 2-KETO-3-DEOXY
GLUCONATE ALDOLASE
(Sulfolobus
solfataricus) 		5 / 10 ALA A 135
ILE A   9
LEU A 242
THR A 249
ILE A  70
 None
None
GOL  A1296 (-3.4A)
None
None
 1.16A 3prsA-1w3iA:
undetectable		 3prsA-1w3iA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5S_A_ACHA1289_0
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 1w3i 2-KETO-3-DEOXY
GLUCONATE ALDOLASE
(Sulfolobus
solfataricus) 		4 / 6 VAL A  94
TYR A 128
GLU A   3
ILE A   5
 None
 1.09A 3q5sA-1w3iA:
undetectable		 3q5sA-1w3iA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_D_QELD2_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 1w3i 2-KETO-3-DEOXY
GLUCONATE ALDOLASE
(Sulfolobus
solfataricus) 		4 / 5 TYR A 259
THR A  13
PHE A  12
LEU A 257
 None
 1.44A 3qelC-1w3iA:
undetectable		 3qelC-1w3iA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1w3i 2-KETO-3-DEOXY
GLUCONATE ALDOLASE
(Sulfolobus
solfataricus) 		5 / 11 THR A 136
ALA A 100
LEU A 112
TYR A 167
ILE A 158
 None
 1.26A 4claA-1w3iA:
undetectable		 4claA-1w3iA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_B_HISB502_0
(HISTIDINE--TRNA
LIGASE)		 1w3i 2-KETO-3-DEOXY
GLUCONATE ALDOLASE
(Sulfolobus
solfataricus) 		5 / 11 THR A  43
TYR A 132
GLY A 179
TYR A 130
ALA A 198
 PYR  A1295 (-4.2A)
None
PYR  A1295 ( 4.6A)
PYR  A1295 (-4.2A)
PYR  A1295 ( 4.8A)
 1.29A 5e3iB-1w3iA:
undetectable		 5e3iB-1w3iA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_1
(METHYLTRANSFERASE)		 1w3i 2-KETO-3-DEOXY
GLUCONATE ALDOLASE
(Sulfolobus
solfataricus) 		4 / 7 GLY A  95
PHE A  71
SER A 123
ASN A  67
 None
None
GOL  A1297 ( 4.8A)
None
 0.98A 5n5dB-1w3iA:
undetectable		 5n5dB-1w3iA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHB_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 1w3i 2-KETO-3-DEOXY
GLUCONATE ALDOLASE
(Sulfolobus
solfataricus) 		3 / 3 PHE A 265
ASP A 268
LEU A 248
 None
 0.80A 5uhbC-1w3iA:
undetectable		 5uhbC-1w3iA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHC_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 1w3i 2-KETO-3-DEOXY
GLUCONATE ALDOLASE
(Sulfolobus
solfataricus) 		3 / 3 PHE A 265
ASP A 268
LEU A 248
 None
 0.79A 5uhcC-1w3iA:
undetectable		 5uhcC-1w3iA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1804_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1w3i 2-KETO-3-DEOXY
GLUCONATE ALDOLASE
(Sulfolobus
solfataricus) 		5 / 8 LEU A  59
VAL A  62
ILE A  93
GLY A  95
ILE A  35
 None
 0.90A 5vkqB-1w3iA:
undetectable
5vkqC-1w3iA:
undetectable		 5vkqB-1w3iA:
11.71
5vkqC-1w3iA:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1w3i 2-KETO-3-DEOXY
GLUCONATE ALDOLASE
(Sulfolobus
solfataricus) 		5 / 9 LEU A  59
VAL A  62
ILE A  93
GLY A  95
ILE A  35
 None
 0.90A 5vkqC-1w3iA:
1.2
5vkqD-1w3iA:
undetectable		 5vkqC-1w3iA:
11.71
5vkqD-1w3iA:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_B_9KLB402_0
(EST-Y29)		 1w3i 2-KETO-3-DEOXY
GLUCONATE ALDOLASE
(Sulfolobus
solfataricus) 		5 / 12 SER A 123
ILE A  93
LEU A  59
HIS A 125
ALA A  85
 GOL  A1297 ( 4.8A)
None
None
None
None
 1.22A 5zwrB-1w3iA:
undetectable		 5zwrB-1w3iA:
20.53