SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1w45'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_2
(BETA-LACTAMASE)		 1w45 ANNEXIN A8
(Homo
sapiens) 		4 / 5 TYR A 257
LEU A 288
THR A 275
ARG A 278
 None
 1.21A 1i2wA-1w45A:
undetectable		 1i2wA-1w45A:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_A_FUAA702_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1w45 ANNEXIN A8
(Homo
sapiens) 		5 / 12 THR A 275
TYR A 257
PHE A 258
LEU A 102
ALA A 121
 None
 1.34A 1q23A-1w45A:
undetectable
1q23B-1w45A:
undetectable		 1q23A-1w45A:
20.48
1q23B-1w45A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2887_1
(AMINOMETHYLTRANSFERA
SE)		 1w45 ANNEXIN A8
(Homo
sapiens) 		3 / 3 ASP A 287
GLU A  98
ARG A  56
 None
 0.85A 1wopA-1w45A:
0.0		 1wopA-1w45A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_B_CFFB2434_1
(CHITINASE)		 1w45 ANNEXIN A8
(Homo
sapiens) 		4 / 6 GLU A  28
ASP A  26
PHE A  21
ARG A  51
 None
 1.19A 2a3bB-1w45A:
undetectable		 2a3bB-1w45A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_A_SALA2006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1w45 ANNEXIN A8
(Homo
sapiens) 		4 / 6 ARG A 167
THR A 251
VAL A 248
ALA A 121
 None
 1.00A 2e1qA-1w45A:
undetectable		 2e1qA-1w45A:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_C_SALC4006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1w45 ANNEXIN A8
(Homo
sapiens) 		4 / 6 ARG A 167
THR A 251
VAL A 248
ALA A 121
 None
 1.04A 2e1qC-1w45A:
undetectable		 2e1qC-1w45A:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1414_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 1w45 ANNEXIN A8
(Homo
sapiens) 		4 / 8 LEU A  30
ILE A  44
LEU A  48
LEU A  71
 None
 0.77A 2xfhA-1w45A:
undetectable		 2xfhA-1w45A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1414_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 1w45 ANNEXIN A8
(Homo
sapiens) 		4 / 8 LEU A 102
ILE A 116
LEU A 120
LEU A 143
 None
 0.78A 2xfhA-1w45A:
undetectable		 2xfhA-1w45A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 1w45 ANNEXIN A8
(Homo
sapiens) 		4 / 6 GLU A 101
GLU A  98
TYR A  95
GLU A  11
 None
 1.47A 4mi4A-1w45A:
undetectable		 4mi4A-1w45A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_A_ACTA701_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 1w45 ANNEXIN A8
(Homo
sapiens) 		3 / 3 LYS A 226
LYS A 233
SER A 234
 None
 1.01A 5odiA-1w45A:
undetectable		 5odiA-1w45A:
19.62