SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1w4t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_E_ESTE600_1
(ESTROGEN RECEPTOR)		 1w4t ARYLAMINE
N-ACETYLTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 8 ALA A  81
LEU A  91
HIS A 113
LEU A 114
 None
 0.70A 1ereE-1w4tA:
undetectable		 1ereE-1w4tA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_E_ESTE600_1
(ESTROGEN RECEPTOR)		 1w4t ARYLAMINE
N-ACETYLTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 8 GLU A  92
LEU A 183
HIS A 113
LEU A 114
 None
 0.70A 1ereE-1w4tA:
undetectable		 1ereE-1w4tA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_F_ESTF600_1
(ESTROGEN RECEPTOR)		 1w4t ARYLAMINE
N-ACETYLTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 8 ALA A  81
LEU A  91
HIS A 113
LEU A 114
 None
 0.70A 1ereF-1w4tA:
undetectable		 1ereF-1w4tA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_F_ESTF600_1
(ESTROGEN RECEPTOR)		 1w4t ARYLAMINE
N-ACETYLTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 8 GLU A  92
LEU A 183
HIS A 113
LEU A 114
 None
 0.70A 1ereF-1w4tA:
undetectable		 1ereF-1w4tA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_B_EAAB224_1
(GLUTATHIONE
TRANSFERASE)		 1w4t ARYLAMINE
N-ACETYLTRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  91
LEU A 116
VAL A 127
LEU A  29
PHE A  80
 None
 1.10A 1gseB-1w4tA:
undetectable		 1gseB-1w4tA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIN_A_KTNA801_1
(CYTOCHROME P450
107A1)		 1w4t ARYLAMINE
N-ACETYLTRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 11 VAL A 266
LEU A 269
ALA A 270
ALA A 274
LEU A 210
 None
 1.06A 1jinA-1w4tA:
undetectable		 1jinA-1w4tA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_B_DIFB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1w4t ARYLAMINE
N-ACETYLTRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 9 VAL A 129
LEU A  76
LEU A   4
TYR A  12
ALA A  81
 None
 1.29A 1pxxB-1w4tA:
undetectable		 1pxxB-1w4tA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1w4t ARYLAMINE
N-ACETYLTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 5 LEU A  29
GLY A 130
ALA A 139
ILE A  33
 None
 0.78A 2aohB-1w4tA:
undetectable		 2aohB-1w4tA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_A_ACTA1467_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 1w4t ARYLAMINE
N-ACETYLTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 5 ARG A  69
ASP A  46
ILE A  53
GLU A  43
 None
 1.19A 2xrzA-1w4tA:
undetectable
2xrzB-1w4tA:
undetectable		 2xrzA-1w4tA:
24.20
2xrzB-1w4tA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F33_A_PFLA2001_1
(FERRITIN LIGHT CHAIN)		 1w4t ARYLAMINE
N-ACETYLTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 6 LEU A  91
TYR A  89
LEU A  87
LEU A 118
 None
 0.86A 3f33A-1w4tA:
undetectable		 3f33A-1w4tA:
20.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LTW_A_HLZA300_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 1w4t ARYLAMINE
N-ACETYLTRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 6 PHE A  42
TYR A  72
CYH A  73
VAL A  98
PHE A 206
 None
 0.36A 3ltwA-1w4tA:
35.5		 3ltwA-1w4tA:
33.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PP1_A_ACTA590_0
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 1w4t ARYLAMINE
N-ACETYLTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 5 GLU A 247
LEU A 248
GLN A 241
GLY A 226
 None
 1.29A 3pp1A-1w4tA:
undetectable		 3pp1A-1w4tA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		 1w4t ARYLAMINE
N-ACETYLTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 6 LEU A  91
TYR A  89
ALA A  86
LEU A 118
 None
 1.09A 3rd0A-1w4tA:
undetectable		 3rd0A-1w4tA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGG_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1w4t ARYLAMINE
N-ACETYLTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 4 VAL A  64
VAL A  65
TYR A  12
GLN A   8
 None
 1.01A 5qggA-1w4tA:
0.0		 5qggA-1w4tA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGO_A_ACTA302_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1w4t ARYLAMINE
N-ACETYLTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 4 VAL A  64
VAL A  65
TYR A  12
GLN A   8
 None
 1.02A 5qgoA-1w4tA:
0.0		 5qgoA-1w4tA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGP_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1w4t ARYLAMINE
N-ACETYLTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 4 VAL A  64
VAL A  65
TYR A  12
GLN A   8
 None
 1.03A 5qgpA-1w4tA:
0.0		 5qgpA-1w4tA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGQ_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1w4t ARYLAMINE
N-ACETYLTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 4 VAL A  64
VAL A  65
TYR A  12
GLN A   8
 None
 1.03A 5qgqA-1w4tA:
0.0		 5qgqA-1w4tA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHB_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1w4t ARYLAMINE
N-ACETYLTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 4 VAL A  64
VAL A  65
TYR A  12
GLN A   8
 None
 0.98A 5qhbA-1w4tA:
0.0		 5qhbA-1w4tA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G1P_B_ACTB403_0
(ADP-RIBOSYLHYDROLASE
LIKE 2)		 1w4t ARYLAMINE
N-ACETYLTRANSFERASE
(Pseudomonas
aeruginosa) 		3 / 3 PHE A 228
ARG A 240
GLN A 230
 None
 1.10A 6g1pB-1w4tA:
0.0		 6g1pB-1w4tA:
22.25