SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1w52'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R9O_A_FLPA501_1
(CYTOCHROME P450 2C9)		 1w52 PANCREATIC LIPASE
RELATED PROTEIN 2
(Equus
caballus) 		5 / 12 VAL X 174
ILE X 123
VAL X 106
GLY X 156
ALA X 157
 None
 0.93A 1r9oA-1w52X:
undetectable		 1r9oA-1w52X:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG7_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 1w52 PANCREATIC LIPASE
RELATED PROTEIN 2
(Equus
caballus) 		3 / 3 ILE X 150
ILE X  76
THR X  72
 None
 0.62A 1rg7A-1w52X:
undetectable		 1rg7A-1w52X:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_1
(VP39)		 1w52 PANCREATIC LIPASE
RELATED PROTEIN 2
(Equus
caballus) 		3 / 3 ASP X 107
ARG X  38
ASP X  85
 None
 0.92A 1vptA-1w52X:
undetectable		 1vptA-1w52X:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_B_GNTB1538_1
(ACETYLCHOLINESTERASE)		 1w52 PANCREATIC LIPASE
RELATED PROTEIN 2
(Equus
caballus) 		5 / 10 TRP X  87
GLY X 156
GLY X  78
SER X 154
HIS X 265
 None
None
None
DDQ  X 502 ( 3.7A)
DDQ  X 502 (-4.2A)
 1.21A 1w76B-1w52X:
9.6		 1w76B-1w52X:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_B_GBNB914_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 1w52 PANCREATIC LIPASE
RELATED PROTEIN 2
(Equus
caballus) 		5 / 10 GLU X 162
GLY X 127
THR X 130
ALA X 131
ALA X 128
 None
 1.14A 2ej3B-1w52X:
undetectable		 2ej3B-1w52X:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_C_GBNC1414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 1w52 PANCREATIC LIPASE
RELATED PROTEIN 2
(Equus
caballus) 		5 / 8 GLU X 162
GLY X 127
THR X 130
ALA X 131
ALA X 128
 None
 1.17A 2ej3C-1w52X:
undetectable		 2ej3C-1w52X:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8L_A_SAMA400_1
(HYPOTHETICAL PROTEIN
LMO1582)		 1w52 PANCREATIC LIPASE
RELATED PROTEIN 2
(Equus
caballus) 		4 / 4 THR X 130
THR X  37
ASP X 107
ASP X  85
 None
 1.43A 2f8lA-1w52X:
undetectable		 2f8lA-1w52X:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB502_1
(CYTOCHROME P450 2C8)		 1w52 PANCREATIC LIPASE
RELATED PROTEIN 2
(Equus
caballus) 		5 / 10 SER X  64
ILE X  53
ILE X 104
LEU X 133
VAL X 148
 None
 1.19A 2nnhB-1w52X:
0.0		 2nnhB-1w52X:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEO_B_LNRB200_1
(D7R4 PROTEIN)		 1w52 PANCREATIC LIPASE
RELATED PROTEIN 2
(Equus
caballus) 		5 / 10 GLU X  99
ILE X  95
HIS X  73
ILE X 151
TYR X 272
 CA  X 601 ( 4.4A)
None
None
None
None
 1.43A 2qeoB-1w52X:
undetectable		 2qeoB-1w52X:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1w52 PANCREATIC LIPASE
RELATED PROTEIN 2
(Equus
caballus) 		5 / 9 GLN X 425
PHE X 299
LEU X 362
VAL X 360
ILE X 398
 None
 1.42A 3claA-1w52X:
undetectable		 3claA-1w52X:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS4_A_AZMA702_1
(CARBONIC ANHYDRASE 2)		 1w52 PANCREATIC LIPASE
RELATED PROTEIN 2
(Equus
caballus) 		4 / 7 VAL X 120
TYR X 116
GLU X 181
PRO X 182
 None
DDQ  X 502 (-4.5A)
None
None
 1.27A 3hs4A-1w52X:
undetectable		 3hs4A-1w52X:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_1
(O-METHYLTRANSFERASE)		 1w52 PANCREATIC LIPASE
RELATED PROTEIN 2
(Equus
caballus) 		3 / 3 ASP X  81
PHE X 269
SER X  89
 DDQ  X 502 (-2.9A)
None
None
 0.86A 3i5uB-1w52X:
undetectable		 3i5uB-1w52X:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZ0_B_CLYB900_1
(LINCOSAMIDE
NUCLEOTIDYLTRANSFERA
SE)		 1w52 PANCREATIC LIPASE
RELATED PROTEIN 2
(Equus
caballus) 		4 / 8 GLU X 140
PHE X  66
SER X  64
ILE X  53
 None
 0.85A 3jz0B-1w52X:
0.4		 3jz0B-1w52X:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_G_SAMG226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1w52 PANCREATIC LIPASE
RELATED PROTEIN 2
(Equus
caballus) 		5 / 12 GLY X 127
ALA X 160
GLY X 161
LEU X 167
ILE X 134
 None
 1.01A 3ku1G-1w52X:
undetectable		 3ku1G-1w52X:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_C_CGEC501_1
(CYTOCHROME P450 2B4)		 1w52 PANCREATIC LIPASE
RELATED PROTEIN 2
(Equus
caballus) 		5 / 9 VAL X 106
PHE X  39
ILE X  76
ALA X 128
VAL X  35
 None
 1.18A 3me6C-1w52X:
undetectable		 3me6C-1w52X:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_A_FLPA701_1
(CYCLOOXYGENASE-2)		 1w52 PANCREATIC LIPASE
RELATED PROTEIN 2
(Equus
caballus) 		5 / 12 VAL X 223
VAL X 174
GLY X 156
ALA X 157
LEU X 193
 None
 1.21A 3pghA-1w52X:
undetectable		 3pghA-1w52X:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)		 1w52 PANCREATIC LIPASE
RELATED PROTEIN 2
(Equus
caballus) 		5 / 6 SER X 105
VAL X  75
TRP X 108
GLY X  78
GLY X 156
 None
 1.47A 3rxfA-1w52X:
undetectable		 3rxfA-1w52X:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1w52 PANCREATIC LIPASE
RELATED PROTEIN 2
(Equus
caballus) 		5 / 12 ILE X 134
ALA X 163
PHE X  74
ALA X 160
ILE X  61
 None
 1.28A 3uvvB-1w52X:
undetectable		 3uvvB-1w52X:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_B_SHHB700_1
(HISTONE DEACETYLASE
8)		 1w52 PANCREATIC LIPASE
RELATED PROTEIN 2
(Equus
caballus) 		5 / 12 ASP X 227
HIS X 158
ASP X 178
HIS X 205
GLY X 218
 None
 1.44A 4bz6A-1w52X:
undetectable
4bz6B-1w52X:
undetectable		 4bz6A-1w52X:
21.43
4bz6B-1w52X:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 1w52 PANCREATIC LIPASE
RELATED PROTEIN 2
(Equus
caballus) 		5 / 12 GLY X 156
ALA X 160
THR X 130
VAL X 174
ASP X 178
 None
 1.37A 4df3A-1w52X:
undetectable		 4df3A-1w52X:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_1
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 1w52 PANCREATIC LIPASE
RELATED PROTEIN 2
(Equus
caballus) 		3 / 3 ASP X 107
ARG X  38
ASP X  85
 None
 0.86A 4fzvA-1w52X:
undetectable		 4fzvA-1w52X:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GRQ_C_AVLC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 1w52 PANCREATIC LIPASE
RELATED PROTEIN 2
(Equus
caballus) 		4 / 7 PHE X 200
PRO X 307
TYR X 316
PHE X 228
 None
 1.28A 4grqA-1w52X:
0.0
4grqC-1w52X:
0.0		 4grqA-1w52X:
15.25
4grqC-1w52X:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 1w52 PANCREATIC LIPASE
RELATED PROTEIN 2
(Equus
caballus) 		5 / 12 TYR X 116
GLY X  78
ILE X 123
ILE X  76
SER X 154
 DDQ  X 502 (-4.5A)
None
None
None
DDQ  X 502 ( 3.7A)
 1.13A 4iv0B-1w52X:
2.2		 4iv0B-1w52X:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_D_FOLD301_1
(FOLATE RECEPTOR
ALPHA)		 1w52 PANCREATIC LIPASE
RELATED PROTEIN 2
(Equus
caballus) 		3 / 3 HIS X 153
TRP X 108
SER X 268
 None
 1.21A 4lrhD-1w52X:
undetectable		 4lrhD-1w52X:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 1w52 PANCREATIC LIPASE
RELATED PROTEIN 2
(Equus
caballus) 		3 / 3 PRO X 195
VAL X 174
HIS X 149
 None
 0.68A 4pevC-1w52X:
4.3		 4pevC-1w52X:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_A_IBPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1w52 PANCREATIC LIPASE
RELATED PROTEIN 2
(Equus
caballus) 		5 / 10 VAL X 223
VAL X 174
GLY X 156
ALA X 157
LEU X 193
 None
 1.13A 4ph9A-1w52X:
undetectable		 4ph9A-1w52X:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_D_READ602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 1w52 PANCREATIC LIPASE
RELATED PROTEIN 2
(Equus
caballus) 		5 / 12 ILE X 125
GLU X 162
GLY X 127
ARG X 166
ASN X  36
 None
 1.26A 5fhzD-1w52X:
undetectable		 5fhzD-1w52X:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1w52 PANCREATIC LIPASE
RELATED PROTEIN 2
(Equus
caballus) 		3 / 3 VAL X  75
SER X 273
MET X 309
 None
 0.90A 5ikqA-1w52X:
undetectable		 5ikqA-1w52X:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Z_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1w52 PANCREATIC LIPASE
RELATED PROTEIN 2
(Equus
caballus) 		5 / 12 ILE X 134
ALA X 163
ILE X 104
PHE X  74
ALA X 160
 None
 1.16A 6a5zD-1w52X:
undetectable		 6a5zD-1w52X:
13.42