SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1w55'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_1
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 1w55 ISPD/ISPF
BIFUNCTIONAL ENZYME
(Campylobacter
jejuni) 		4 / 4 THR A  38
LEU A  41
VAL A 102
LEU A 106
 None
 0.72A 1fbmB-1w55A:
undetectable		 1fbmB-1w55A:
8.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_2
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 1w55 ISPD/ISPF
BIFUNCTIONAL ENZYME
(Campylobacter
jejuni) 		4 / 4 THR A  38
LEU A  41
VAL A 102
LEU A 106
 None
 0.90A 1fbmD-1w55A:
undetectable		 1fbmD-1w55A:
8.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_3
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 1w55 ISPD/ISPF
BIFUNCTIONAL ENZYME
(Campylobacter
jejuni) 		4 / 5 THR A  38
LEU A  41
VAL A 102
LEU A 106
 None
 0.79A 1fbmE-1w55A:
undetectable		 1fbmE-1w55A:
8.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1w55 ISPD/ISPF
BIFUNCTIONAL ENZYME
(Campylobacter
jejuni) 		4 / 4 THR A  38
LEU A  41
VAL A 102
LEU A 106
 None
 0.82A 1mz9D-1w55A:
undetectable		 1mz9D-1w55A:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN0_B_T44B602_1
(TRANSTHYRETIN)		 1w55 ISPD/ISPF
BIFUNCTIONAL ENZYME
(Campylobacter
jejuni) 		4 / 7 LYS A  82
ALA A  83
LEU A   9
ALA A  11
 None
None
C  A1373 (-3.9A)
C  A1373 (-3.5A)
 1.10A 1sn0B-1w55A:
undetectable
1sn0D-1w55A:
undetectable		 1sn0B-1w55A:
16.53
1sn0D-1w55A:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_4
(POL POLYPROTEIN)		 1w55 ISPD/ISPF
BIFUNCTIONAL ENZYME
(Campylobacter
jejuni) 		3 / 3 ARG A  27
VAL A  97
GLY A  12
 None
C  A1373 (-4.4A)
C  A1373 ( 4.1A)
 0.59A 2avvE-1w55A:
undetectable		 2avvE-1w55A:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_P1ZA2002_1
(SERUM ALBUMIN)		 1w55 ISPD/ISPF
BIFUNCTIONAL ENZYME
(Campylobacter
jejuni) 		5 / 12 LEU A 286
LEU A 300
ILE A 303
ILE A 336
ALA A 326
 None
 0.90A 2bxqA-1w55A:
undetectable		 2bxqA-1w55A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I2Z_A_SALA1100_1
(SERUM ALBUMIN)		 1w55 ISPD/ISPF
BIFUNCTIONAL ENZYME
(Campylobacter
jejuni) 		5 / 5 LEU A 286
LEU A 300
ILE A 303
ILE A 336
ALA A 326
 None
 0.88A 2i2zA-1w55A:
undetectable		 2i2zA-1w55A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKF_A_AB1A501_2
(PROTEASE RETROPEPSIN)		 1w55 ISPD/ISPF
BIFUNCTIONAL ENZYME
(Campylobacter
jejuni) 		6 / 12 LEU A 300
GLY A 213
ALA A 256
ASP A 255
GLY A 262
ILE A 257
 None
 1.41A 2rkfB-1w55A:
undetectable		 2rkfB-1w55A:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1499_1
(CYTOCHROME P450 3A4)		 1w55 ISPD/ISPF
BIFUNCTIONAL ENZYME
(Campylobacter
jejuni) 		4 / 5 PHE A  47
SER A 170
PHE A 107
ILE A 145
 None
 1.16A 2v0mD-1w55A:
undetectable		 2v0mD-1w55A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_1
(PUTATIVE
MODIFICATION
METHYLASE)		 1w55 ISPD/ISPF
BIFUNCTIONAL ENZYME
(Campylobacter
jejuni) 		3 / 3 ASP A  31
THR A 212
GLU A 209
 None
 0.72A 2zifB-1w55A:
undetectable		 2zifB-1w55A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BSZ_E_RTLE177_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 1w55 ISPD/ISPF
BIFUNCTIONAL ENZYME
(Campylobacter
jejuni) 		5 / 11 LEU A 314
ALA A 309
VAL A 338
MET A 238
LEU A 249
 None
 1.28A 3bszE-1w55A:
undetectable		 3bszE-1w55A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_1
(16S RRNA METHYLASE)		 1w55 ISPD/ISPF
BIFUNCTIONAL ENZYME
(Campylobacter
jejuni) 		4 / 5 ASN A  40
ASP A  31
GLU A 209
SER A  43
 None
 1.49A 3p2kC-1w55A:
2.1		 3p2kC-1w55A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K7G_B_ACTB902_0
(3-HYDROXYPROLINE
DEHYDRATSE)		 1w55 ISPD/ISPF
BIFUNCTIONAL ENZYME
(Campylobacter
jejuni) 		4 / 7 ASP A 245
SER A 244
HIS A 251
SER A 282
 None
 1.25A 4k7gB-1w55A:
undetectable		 4k7gB-1w55A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M48_A_21BA704_1
(TRANSPORTER)		 1w55 ISPD/ISPF
BIFUNCTIONAL ENZYME
(Campylobacter
jejuni) 		4 / 8 PHE A  69
VAL A  97
SER A  54
ALA A  37
 None
C  A1373 (-4.4A)
None
None
 0.89A 4m48A-1w55A:
undetectable		 4m48A-1w55A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_A_ROCA101_2
(PROTEASE PR5-SQV)		 1w55 ISPD/ISPF
BIFUNCTIONAL ENZYME
(Campylobacter
jejuni) 		5 / 11 ARG A 109
ALA A 117
ASP A 118
ILE A 173
ILE A 120
 None
 1.22A 5kr2B-1w55A:
undetectable		 5kr2B-1w55A:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PBE_A_TYLA2001_1
(BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2B)		 1w55 ISPD/ISPF
BIFUNCTIONAL ENZYME
(Campylobacter
jejuni) 		4 / 6 PRO A 312
VAL A 307
VAL A 338
ILE A 234
 None
 0.73A 5pbeA-1w55A:
undetectable		 5pbeA-1w55A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1w55 ISPD/ISPF
BIFUNCTIONAL ENZYME
(Campylobacter
jejuni) 		5 / 7 GLY A 264
LEU A 258
LEU A 358
ILE A 266
GLY A 267
 None
None
None
None
C  A1372 (-3.1A)
 1.26A 5vkqA-1w55A:
undetectable
5vkqB-1w55A:
undetectable		 5vkqA-1w55A:
12.69
5vkqB-1w55A:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1804_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1w55 ISPD/ISPF
BIFUNCTIONAL ENZYME
(Campylobacter
jejuni) 		5 / 8 GLY A 264
LEU A 258
LEU A 358
ILE A 266
GLY A 267
 None
None
None
None
C  A1372 (-3.1A)
 1.24A 5vkqB-1w55A:
undetectable
5vkqC-1w55A:
undetectable		 5vkqB-1w55A:
12.69
5vkqC-1w55A:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1w55 ISPD/ISPF
BIFUNCTIONAL ENZYME
(Campylobacter
jejuni) 		3 / 3 LEU A 249
ASN A 302
LEU A 329
 None
 0.59A 6exiA-1w55A:
undetectable		 6exiA-1w55A:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_D8ZA831_0
(GEPHYRIN)		 1w55 ISPD/ISPF
BIFUNCTIONAL ENZYME
(Campylobacter
jejuni) 		5 / 11 PRO A 148
ILE A 150
TYR A  45
MET A   4
MET A  93
 None
 1.43A 6fgdA-1w55A:
1.7		 6fgdA-1w55A:
12.96