SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1w5e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC2_0
(ACTINOMYCIN D)		 1w5e FTSZ
(Methanocaldococc
us
jannaschii) 		3 / 3 THR A 135
PRO A 101
THR A 137
 GTP  A 500 (-3.6A)
None
None
 0.96A 1dscC-1w5eA:
undetectable		 1dscC-1w5eA:
3.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_G_SAMG199_0
(METHIONINE REPRESSOR)		 1w5e FTSZ
(Methanocaldococc
us
jannaschii) 		5 / 10 GLU A 299
ALA A 300
LEU A 295
ALA A 321
GLY A 230
 None
 1.32A 1mjqG-1w5eA:
undetectable
1mjqH-1w5eA:
undetectable		 1mjqG-1w5eA:
14.25
1mjqH-1w5eA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1w5e FTSZ
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A 221
GLY A 230
ALA A 321
ALA A 300
ASP A 324
 None
 1.07A 2bm9F-1w5eA:
undetectable		 2bm9F-1w5eA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_2
(PROTEASE)		 1w5e FTSZ
(Methanocaldococc
us
jannaschii) 		4 / 8 ILE A  69
GLY A 104
ILE A 103
LEU A  86
 None
 0.74A 2o4nB-1w5eA:
undetectable		 2o4nB-1w5eA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O5Y_H_STRH249_1
(CHIMERIC ANTIBODY
FAB 1E9-DB3)		 1w5e FTSZ
(Methanocaldococc
us
jannaschii) 		4 / 7 ASN A  50
GLY A  49
THR A 128
SER A 139
 None
 1.20A 2o5yH-1w5eA:
undetectable
2o5yL-1w5eA:
undetectable		 2o5yH-1w5eA:
21.37
2o5yL-1w5eA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKM_A_ADNA501_1
(ADENOSINE KINASE)		 1w5e FTSZ
(Methanocaldococc
us
jannaschii) 		5 / 12 ALA A 140
GLY A 138
GLY A 136
ALA A  48
GLY A  99
 None
None
GTP  A 500 (-3.9A)
GTP  A 500 (-3.4A)
GTP  A 500 (-3.3A)
 0.82A 2pkmA-1w5eA:
6.3		 2pkmA-1w5eA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA607_1
(CHITINASE A)		 1w5e FTSZ
(Methanocaldococc
us
jannaschii) 		4 / 8 GLY A 339
THR A 338
GLY A 281
ALA A 282
 None
 0.75A 3aruA-1w5eA:
3.2		 3aruA-1w5eA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC59_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1w5e FTSZ
(Methanocaldococc
us
jannaschii) 		3 / 3 GLY A  99
GLY A 136
GLY A 133
 GTP  A 500 (-3.3A)
GTP  A 500 (-3.9A)
GTP  A 500 (-2.9A)
 0.40A 3bogC-1w5eA:
undetectable		 3bogC-1w5eA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		 1w5e FTSZ
(Methanocaldococc
us
jannaschii) 		5 / 12 THR A 135
VAL A  67
VAL A 125
ILE A 127
THR A  41
 GTP  A 500 (-3.6A)
None
None
None
None
 1.14A 3czhA-1w5eA:
undetectable		 3czhA-1w5eA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL5_B_1UNB201_2
(PROTEASE)		 1w5e FTSZ
(Methanocaldococc
us
jannaschii) 		6 / 12 GLY A 221
VAL A 188
GLY A 252
ILE A 253
THR A 159
VAL A 157
 None
 1.27A 3el5B-1w5eA:
undetectable		 3el5B-1w5eA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_A_ERYA195_0
(REPRESSOR PROTEIN
MPHR(A))		 1w5e FTSZ
(Methanocaldococc
us
jannaschii) 		5 / 12 VAL A 223
LEU A  56
SER A 147
VAL A 219
ILE A  53
 None
 1.32A 3frqA-1w5eA:
undetectable		 3frqA-1w5eA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 1w5e FTSZ
(Methanocaldococc
us
jannaschii) 		4 / 7 TYR A 319
VAL A 188
VAL A 242
ILE A 337
 None
 1.01A 3ms9B-1w5eA:
undetectable		 3ms9B-1w5eA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 1w5e FTSZ
(Methanocaldococc
us
jannaschii) 		4 / 7 TYR A 319
VAL A 188
VAL A 242
ILE A 337
 None
 0.98A 3mssB-1w5eA:
undetectable		 3mssB-1w5eA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA271_0
(PROTEIN SSM1)		 1w5e FTSZ
(Methanocaldococc
us
jannaschii) 		4 / 5 GLY A 132
GLU A 165
GLY A 130
PRO A 161
 GTP  A 500 ( 4.0A)
GTP  A 500 (-3.1A)
GTP  A 500 (-3.5A)
GTP  A 500 ( 4.5A)
 1.03A 3onnA-1w5eA:
6.0		 3onnA-1w5eA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SO9_A_017A100_2
(HIV-1 PROTEASE)		 1w5e FTSZ
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A 286
ALA A 218
ILE A 190
THR A 338
VAL A 336
 None
 0.80A 3so9B-1w5eA:
undetectable		 3so9B-1w5eA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_1
(METHYLTRANSFERASE
WBDD)		 1w5e FTSZ
(Methanocaldococc
us
jannaschii) 		3 / 3 ARG A 169
ASP A  72
GLN A  74
 GTP  A 500 (-3.5A)
None
None
 0.85A 4azsA-1w5eA:
2.9		 4azsA-1w5eA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_A_IMNA701_1
(CYCLOOXYGENASE-2)		 1w5e FTSZ
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A 225
VAL A 289
GLY A 320
ALA A 321
LEU A 231
 None
 1.06A 4coxA-1w5eA:
undetectable		 4coxA-1w5eA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_B_IMNB701_1
(CYCLOOXYGENASE-2)		 1w5e FTSZ
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A 225
VAL A 289
GLY A 320
ALA A 321
LEU A 231
 None
 1.06A 4coxB-1w5eA:
undetectable		 4coxB-1w5eA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_D_IMND701_1
(CYCLOOXYGENASE-2)		 1w5e FTSZ
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A 225
VAL A 289
GLY A 320
ALA A 321
LEU A 231
 None
 1.07A 4coxD-1w5eA:
undetectable		 4coxD-1w5eA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLG_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 1w5e FTSZ
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A 251
ALA A 218
GLU A 213
GLY A  49
ASN A  51
 None
None
None
None
GTP  A 500 ( 4.2A)
 1.18A 4jlgA-1w5eA:
undetectable		 4jlgA-1w5eA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1w5e FTSZ
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A 270
ILE A 287
ARG A 310
VAL A 333
VAL A 289
 None
 1.04A 4nkvC-1w5eA:
undetectable		 4nkvC-1w5eA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1w5e FTSZ
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A 270
ILE A 287
ARG A 310
VAL A 333
VAL A 289
 None
 1.01A 4nkvD-1w5eA:
undetectable		 4nkvD-1w5eA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OK1_A_198A1001_1
(ANDROGEN RECEPTOR)		 1w5e FTSZ
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A 131
GLY A 130
LEU A 215
VAL A 188
ILE A  53
 None
GTP  A 500 (-3.5A)
None
None
None
 1.15A 4ok1A-1w5eA:
0.0		 4ok1A-1w5eA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKB_A_198A1002_1
(ANDROGEN RECEPTOR)		 1w5e FTSZ
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A 131
GLY A 130
LEU A 215
VAL A 188
ILE A  53
 None
GTP  A 500 (-3.5A)
None
None
None
 1.19A 4okbA-1w5eA:
undetectable		 4okbA-1w5eA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_A_AERA602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 1w5e FTSZ
(Methanocaldococc
us
jannaschii) 		4 / 8 ALA A  64
ASN A 217
GLY A 221
VAL A 155
 None
 0.85A 4r20A-1w5eA:
undetectable		 4r20A-1w5eA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_B_URFB302_1
(URIDINE
PHOSPHORYLASE)		 1w5e FTSZ
(Methanocaldococc
us
jannaschii) 		4 / 7 THR A 184
MET A 243
ALA A 144
ILE A 127
 None
 0.96A 4txnB-1w5eA:
4.5		 4txnB-1w5eA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_C_URFC302_1
(URIDINE
PHOSPHORYLASE)		 1w5e FTSZ
(Methanocaldococc
us
jannaschii) 		4 / 7 THR A 184
MET A 243
ALA A 144
ILE A 127
 None
 0.96A 4txnC-1w5eA:
4.5		 4txnC-1w5eA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 1w5e FTSZ
(Methanocaldococc
us
jannaschii) 		5 / 11 ILE A 251
ALA A 218
GLU A 213
GLY A  49
ASN A  51
 None
None
None
None
GTP  A 500 ( 4.2A)
 1.12A 5ayfA-1w5eA:
undetectable		 5ayfA-1w5eA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 1w5e FTSZ
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A 104
ILE A  87
THR A 135
GLY A  46
GLY A 176
 None
None
GTP  A 500 (-3.6A)
GTP  A 500 (-2.7A)
None
 1.11A 5d4uA-1w5eA:
5.2		 5d4uA-1w5eA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 1w5e FTSZ
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A 104
ILE A  87
THR A 135
GLY A  46
GLY A 176
 None
None
GTP  A 500 (-3.6A)
GTP  A 500 (-2.7A)
None
 1.11A 5d4uB-1w5eA:
3.8		 5d4uB-1w5eA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 1w5e FTSZ
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A 150
VAL A  67
GLY A  63
THR A 227
PHE A 236
 None
 1.23A 5igiA-1w5eA:
undetectable		 5igiA-1w5eA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_0
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 1w5e FTSZ
(Methanocaldococc
us
jannaschii) 		5 / 12 THR A 316
ALA A 249
GLY A 339
LEU A 187
ALA A 285
 None
 0.71A 5jglB-1w5eA:
4.3		 5jglB-1w5eA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M54_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 1w5e FTSZ
(Methanocaldococc
us
jannaschii) 		5 / 12 VAL A 340
ALA A 282
THR A 306
GLY A 252
LEU A 335
 None
 1.15A 5m54E-1w5eA:
23.9		 5m54E-1w5eA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 1w5e FTSZ
(Methanocaldococc
us
jannaschii) 		5 / 12 VAL A 340
ALA A 282
THR A 306
GLY A 252
LEU A 335
 None
 1.16A 5m5cB-1w5eA:
23.7		 5m5cB-1w5eA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 1w5e FTSZ
(Methanocaldococc
us
jannaschii) 		5 / 10 VAL A 340
ALA A 282
THR A 306
GLY A 252
LEU A 335
 None
 1.16A 5m5cE-1w5eA:
23.6		 5m5cE-1w5eA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUM_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 1w5e FTSZ
(Methanocaldococc
us
jannaschii) 		5 / 8 VAL A 307
ILE A 337
LEU A 311
ILE A 279
ASN A 271
 None
 1.42A 5numA-1w5eA:
undetectable		 5numA-1w5eA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QPA613_1
(SERUM ALBUMIN)		 1w5e FTSZ
(Methanocaldococc
us
jannaschii) 		4 / 8 ARG A 169
ALA A 173
SER A 139
GLY A 130
 GTP  A 500 (-3.5A)
None
None
GTP  A 500 (-3.5A)
 0.98A 5v0vA-1w5eA:
undetectable		 5v0vA-1w5eA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1804_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1w5e FTSZ
(Methanocaldococc
us
jannaschii) 		5 / 8 GLY A 284
LEU A 311
VAL A 307
ILE A 279
ILE A 253
 None
 1.15A 5vkqB-1w5eA:
undetectable
5vkqC-1w5eA:
undetectable		 5vkqB-1w5eA:
13.58
5vkqC-1w5eA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 1w5e FTSZ
(Methanocaldococc
us
jannaschii) 		5 / 10 ARG A 353
ILE A 198
GLY A 252
MET A 268
ALA A 265
 None
 1.42A 5x66D-1w5eA:
undetectable		 5x66D-1w5eA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBF_A_ACTA507_0
(MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1)		 1w5e FTSZ
(Methanocaldococc
us
jannaschii) 		3 / 3 LYS A 263
SER A 256
SER A 258
 None
 1.13A 6gbfA-1w5eA:
2.6		 6gbfA-1w5eA:
24.80