SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1w5f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC2_0
(ACTINOMYCIN D)		 1w5f CELL DIVISION
PROTEIN FTSZ
(Thermotoga
maritima) 		3 / 3 THR A 119
PRO A  85
THR A 121
 G2P  A 500 (-3.6A)
None
None
 0.97A 1dscC-1w5fA:
undetectable		 1dscC-1w5fA:
3.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG7_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 1w5f CELL DIVISION
PROTEIN FTSZ
(Thermotoga
maritima) 		3 / 3 ILE A 141
ILE A 174
THR A 170
 None
 0.60A 1rg7A-1w5fA:
undetectable		 1rg7A-1w5fA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1w5f CELL DIVISION
PROTEIN FTSZ
(Thermotoga
maritima) 		4 / 5 LEU A  93
GLY A 118
PRO A 125
VAL A 126
 None
G2P  A 500 (-3.4A)
None
None
 0.82A 2aojA-1w5fA:
undetectable		 2aojA-1w5fA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1w5f CELL DIVISION
PROTEIN FTSZ
(Thermotoga
maritima) 		4 / 7 LEU A  93
GLY A 118
PRO A 125
VAL A 126
 None
G2P  A 500 (-3.4A)
None
None
 0.78A 2aojB-1w5fA:
undetectable		 2aojB-1w5fA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C49_A_ADNA1301_1
(SUGAR KINASE MJ0406)		 1w5f CELL DIVISION
PROTEIN FTSZ
(Thermotoga
maritima) 		5 / 12 ALA A  32
GLY A  30
GLY A  31
ASN A  54
ASP A  56
 G2P  A 500 (-3.3A)
G2P  A 500 (-3.5A)
G2P  A 500 (-3.1A)
MG  A 501 ( 4.5A)
None
 1.02A 2c49A-1w5fA:
7.9		 2c49A-1w5fA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTH_A_NIMA300_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 1w5f CELL DIVISION
PROTEIN FTSZ
(Thermotoga
maritima) 		4 / 5 LEU A 171
ALA A 128
ILE A 111
SER A 124
 None
 1.10A 2othA-1w5fA:
undetectable		 2othA-1w5fA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q2H_B_ACTB501_0
(SECRETION CHAPERONE,
PHAGE-DISPLAY
DERIVED PEPTIDE)		 1w5f CELL DIVISION
PROTEIN FTSZ
(Thermotoga
maritima) 		3 / 3 ARG A 218
SER A 221
TYR A 216
 None
 1.05A 2q2hA-1w5fA:
undetectable
2q2hB-1w5fA:
undetectable		 2q2hA-1w5fA:
18.47
2q2hB-1w5fA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 1w5f CELL DIVISION
PROTEIN FTSZ
(Thermotoga
maritima) 		5 / 12 PRO A  85
GLY A 118
GLY A 117
LEU A  93
ILE A  99
 None
G2P  A 500 (-3.4A)
G2P  A 500 (-3.6A)
None
None
 0.97A 3douA-1w5fA:
4.8		 3douA-1w5fA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 1w5f CELL DIVISION
PROTEIN FTSZ
(Thermotoga
maritima) 		4 / 5 LEU A 179
GLN A 202
THR A 199
GLU A 182
 None
 1.39A 3n58C-1w5fA:
2.2		 3n58C-1w5fA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA271_0
(PROTEIN SSM1)		 1w5f CELL DIVISION
PROTEIN FTSZ
(Thermotoga
maritima) 		4 / 5 GLY A 116
GLU A 149
GLY A 114
PRO A 145
 G2P  A 500 ( 4.4A)
G2P  A 500 (-2.7A)
G2P  A 500 (-3.5A)
G2P  A 500 (-4.3A)
 1.03A 3onnA-1w5fA:
6.6		 3onnA-1w5fA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_A_ADNA353_1
(ADENOSINE KINASE)		 1w5f CELL DIVISION
PROTEIN FTSZ
(Thermotoga
maritima) 		5 / 12 GLY A  30
GLY A  31
ASN A  54
GLY A  80
ASP A  56
 G2P  A 500 (-3.5A)
G2P  A 500 (-3.1A)
MG  A 501 ( 4.5A)
G2P  A 500 ( 3.7A)
None
 0.98A 3uboA-1w5fA:
8.1		 3uboA-1w5fA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1475_0
(MJ0495-LIKE PROTEIN)		 1w5f CELL DIVISION
PROTEIN FTSZ
(Thermotoga
maritima) 		5 / 8 ILE A  99
ILE A 127
VAL A  51
SER A  63
GLY A  28
 None
 1.49A 4ac9C-1w5fA:
6.6		 4ac9C-1w5fA:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1477_0
(MJ0495-LIKE PROTEIN)		 1w5f CELL DIVISION
PROTEIN FTSZ
(Thermotoga
maritima) 		4 / 6 THR A 119
GLY A  88
ILE A  75
LYS A  98
 G2P  A 500 (-3.6A)
None
None
None
 1.08A 4ac9C-1w5fA:
5.7		 4ac9C-1w5fA:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1w5f CELL DIVISION
PROTEIN FTSZ
(Thermotoga
maritima) 		4 / 6 THR A 119
GLY A  88
ILE A  75
LYS A  98
 G2P  A 500 (-3.6A)
None
None
None
 1.05A 4acaC-1w5fA:
5.8		 4acaC-1w5fA:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_A_UEGA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1w5f CELL DIVISION
PROTEIN FTSZ
(Thermotoga
maritima) 		5 / 11 GLY A 120
ALA A  91
GLY A  88
VAL A  53
VAL A 126
 G2P  A 500 (-3.4A)
None
None
None
None
 1.32A 4c5lA-1w5fA:
2.9		 4c5lA-1w5fA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1w5f CELL DIVISION
PROTEIN FTSZ
(Thermotoga
maritima) 		5 / 9 GLY A 120
ALA A  91
GLY A  88
VAL A  53
VAL A 126
 G2P  A 500 (-3.4A)
None
None
None
None
 1.27A 4c5lB-1w5fA:
3.0		 4c5lB-1w5fA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_C_UEGC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1w5f CELL DIVISION
PROTEIN FTSZ
(Thermotoga
maritima) 		5 / 10 GLY A 120
ALA A  91
GLY A  88
VAL A  53
VAL A 126
 G2P  A 500 (-3.4A)
None
None
None
None
 1.30A 4c5lC-1w5fA:
3.1		 4c5lC-1w5fA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1w5f CELL DIVISION
PROTEIN FTSZ
(Thermotoga
maritima) 		5 / 10 GLY A 120
ALA A  91
GLY A  88
VAL A  53
VAL A 126
 G2P  A 500 (-3.4A)
None
None
None
None
 1.30A 4c5lD-1w5fA:
3.0		 4c5lD-1w5fA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1w5f CELL DIVISION
PROTEIN FTSZ
(Thermotoga
maritima) 		5 / 10 GLY A 120
ALA A  91
GLY A  88
VAL A  53
VAL A 126
 G2P  A 500 (-3.4A)
None
None
None
None
 1.28A 4c5nB-1w5fA:
3.2		 4c5nB-1w5fA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 1w5f CELL DIVISION
PROTEIN FTSZ
(Thermotoga
maritima) 		4 / 7 GLU A 285
GLU A 289
GLU A 246
ARG A 250
 None
 1.18A 4mi4B-1w5fA:
undetectable
4mi4C-1w5fA:
undetectable		 4mi4B-1w5fA:
20.67
4mi4C-1w5fA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 1w5f CELL DIVISION
PROTEIN FTSZ
(Thermotoga
maritima) 		5 / 12 GLY A  33
ALA A  32
GLY A  30
GLY A  31
GLY A 120
 None
G2P  A 500 (-3.3A)
G2P  A 500 (-3.5A)
G2P  A 500 (-3.1A)
G2P  A 500 (-3.4A)
 0.86A 4o3fA-1w5fA:
5.0		 4o3fA-1w5fA:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_A_SALA801_1
(PROTEIN POLYBROMO-1)		 1w5f CELL DIVISION
PROTEIN FTSZ
(Thermotoga
maritima) 		4 / 7 ILE A  99
LEU A  93
ALA A 123
ILE A 127
 None
 0.76A 4y03A-1w5fA:
undetectable		 4y03A-1w5fA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1w5f CELL DIVISION
PROTEIN FTSZ
(Thermotoga
maritima) 		5 / 9 SER A 124
GLY A  30
GLY A  31
ALA A  32
ASP A 197
 None
G2P  A 500 (-3.5A)
G2P  A 500 (-3.1A)
G2P  A 500 (-3.3A)
G2P  A 500 (-3.2A)
 1.03A 5d0xK-1w5fA:
undetectable
5d0xL-1w5fA:
undetectable		 5d0xK-1w5fA:
19.49
5d0xL-1w5fA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIY_A_OAQA302_0
(SULFOTRANSFERASE)		 1w5f CELL DIVISION
PROTEIN FTSZ
(Thermotoga
maritima) 		5 / 11 ILE A 207
VAL A  26
MET A 108
LEU A 137
THR A 138
 None
 1.14A 5tiyA-1w5fA:
1.2		 5tiyA-1w5fA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B52_A_OAQA302_0
(SULFOTRANSFERASE)		 1w5f CELL DIVISION
PROTEIN FTSZ
(Thermotoga
maritima) 		5 / 12 ILE A 207
VAL A  26
MET A 108
LEU A 137
THR A 138
 None
 1.13A 6b52A-1w5fA:
1.9		 6b52A-1w5fA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_A_BEZA701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 1w5f CELL DIVISION
PROTEIN FTSZ
(Thermotoga
maritima) 		5 / 11 GLY A 160
LEU A 171
ALA A 140
PHE A 115
ALA A 128
 None
 1.23A 6qgbA-1w5fA:
0.3		 6qgbA-1w5fA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_E_BEZE701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 1w5f CELL DIVISION
PROTEIN FTSZ
(Thermotoga
maritima) 		5 / 11 GLY A 160
LEU A 171
ALA A 140
PHE A 115
ALA A 128
 None
 1.23A 6qgbE-1w5fA:
1.9		 6qgbE-1w5fA:
20.33