SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1w5t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_2
(VITAMIN D NUCLEAR
RECEPTOR)		 1w5t ORC2
(Aeropyrum
pernix) 		4 / 6 LEU A 306
ARG A 336
TYR A 345
VAL A 368
 None
 1.05A 1db1A-1w5tA:
undetectable		 1db1A-1w5tA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YI4_A_ADNA306_1
(PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 1w5t ORC2
(Aeropyrum
pernix) 		5 / 10 LEU A  39
ALA A  80
LEU A  85
ASP A  50
LEU A  48
 None
 1.11A 1yi4A-1w5tA:
undetectable		 1yi4A-1w5tA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_2
(PROTEASE)		 1w5t ORC2
(Aeropyrum
pernix) 		5 / 8 LEU A 314
ALA A 387
GLY A  59
ILE A  58
LEU A 303
 None
 1.47A 2o4nB-1w5tA:
undetectable		 2o4nB-1w5tA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_B_SAMB1267_1
(NON-STRUCTURAL
PROTEIN 5)		 1w5t ORC2
(Aeropyrum
pernix) 		3 / 3 SER A 217
HIS A 241
ASP A 284
 None
 0.71A 2wa2B-1w5tA:
undetectable		 2wa2B-1w5tA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC59_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1w5t ORC2
(Aeropyrum
pernix) 		3 / 3 GLY A 257
GLY A 254
GLY A 250
 None
 0.40A 3bogC-1w5tA:
undetectable		 3bogC-1w5tA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1w5t ORC2
(Aeropyrum
pernix) 		5 / 8 LEU A  48
VAL A 167
VAL A 130
ARG A 179
LEU A 133
 None
 1.34A 3kp6A-1w5tA:
4.7
3kp6B-1w5tA:
6.4		 3kp6A-1w5tA:
20.10
3kp6B-1w5tA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB1_0
(INVASIN IPAD)		 1w5t ORC2
(Aeropyrum
pernix) 		4 / 7 LEU A 306
SER A 364
VAL A 189
SER A 193
 None
 1.00A 3r9vA-1w5tA:
undetectable
3r9vB-1w5tA:
undetectable		 3r9vA-1w5tA:
21.60
3r9vB-1w5tA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX5_B_MIYB1103_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 1w5t ORC2
(Aeropyrum
pernix) 		5 / 12 GLN A 110
ASN A  93
ASP A 145
ALA A  90
VAL A 142
 None
None
MG  A 701 ( 4.1A)
None
None
 1.13A 4dx5B-1w5tA:
undetectable		 4dx5B-1w5tA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_A_C2FA302_0
(THYMIDYLATE SYNTHASE)		 1w5t ORC2
(Aeropyrum
pernix) 		5 / 11 HIS A 211
SER A  57
ILE A  63
ASP A 145
TYR A  91
 None
None
ANP  A 700 (-4.5A)
MG  A 701 ( 4.1A)
None
 1.32A 4fogA-1w5tA:
0.3		 4fogA-1w5tA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_E_D16E301_1
(THYMIDYLATE SYNTHASE)		 1w5t ORC2
(Aeropyrum
pernix) 		5 / 12 HIS A 211
SER A  57
ILE A  63
ASP A 145
TYR A  91
 None
None
ANP  A 700 (-4.5A)
MG  A 701 ( 4.1A)
None
 1.36A 4foxE-1w5tA:
0.0		 4foxE-1w5tA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_F_BEZF501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 1w5t ORC2
(Aeropyrum
pernix) 		4 / 8 ALA A 340
SER A 341
ARG A 315
TYR A 345
 None
 1.21A 4ijiF-1w5tA:
0.2		 4ijiF-1w5tA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_H_BEZH501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 1w5t ORC2
(Aeropyrum
pernix) 		4 / 7 ALA A 340
SER A 341
ARG A 315
TYR A 345
 None
 1.16A 4ijiH-1w5tA:
undetectable		 4ijiH-1w5tA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA602_1
(SERUM ALBUMIN)		 1w5t ORC2
(Aeropyrum
pernix) 		5 / 8 ARG A  12
LYS A 267
GLY A 231
LEU A 232
LEU A 281
 None
 1.46A 4po0A-1w5tA:
2.0		 4po0A-1w5tA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_2
(TUBULIN BETA CHAIN)		 1w5t ORC2
(Aeropyrum
pernix) 		5 / 12 LEU A 104
ASN A 132
VAL A 142
ALA A  90
ILE A 180
 None
 1.14A 4x1kD-1w5tA:
undetectable		 4x1kD-1w5tA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_D_LOCD502_2
(TUBULIN BETA CHAIN)		 1w5t ORC2
(Aeropyrum
pernix) 		6 / 12 LEU A 104
LEU A 129
ASN A 132
VAL A 142
ALA A  90
ILE A 180
 None
 1.31A 4x1yD-1w5tA:
undetectable		 4x1yD-1w5tA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_A_ADNA1002_1
(MYOSIN HEAVY CHAIN
KINASE A)		 1w5t ORC2
(Aeropyrum
pernix) 		5 / 11 ALA A 259
GLY A 257
VAL A  26
LEU A  24
LEU A  68
 ANP  A 700 (-3.3A)
None
ANP  A 700 (-4.1A)
ANP  A 700 (-4.5A)
None
 1.13A 4zmeA-1w5tA:
undetectable		 4zmeA-1w5tA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1w5t ORC2
(Aeropyrum
pernix) 		4 / 6 PHE A 182
VAL A 142
MET A 150
ILE A 103
 None
 0.99A 5iwuA-1w5tA:
undetectable		 5iwuA-1w5tA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_1
(CYTOCHROME P450 2C9)		 1w5t ORC2
(Aeropyrum
pernix) 		5 / 12 VAL A 167
LEU A 133
GLY A 181
LEU A 104
LEU A 126
 None
 1.38A 5x23A-1w5tA:
undetectable		 5x23A-1w5tA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_B_BEZB201_0
(NS3 PROTEASE)		 1w5t ORC2
(Aeropyrum
pernix) 		4 / 5 HIS A 211
ALA A 214
SER A  57
GLY A  56
 None
 1.23A 5yodB-1w5tA:
undetectable		 5yodB-1w5tA:
18.09