SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1w66'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_A_KANA558_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 1w66 LIPOYLTRANSFERASE
(Mycobacterium
tuberculosis) 		4 / 7 SER A 179
ASP A 180
GLU A  63
GLU A  60
 None
 1.07A 1knyA-1w66A:
undetectable
1knyB-1w66A:
undetectable		 1knyA-1w66A:
19.24
1knyB-1w66A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_B_KANB559_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 1w66 LIPOYLTRANSFERASE
(Mycobacterium
tuberculosis) 		4 / 8 GLU A  60
SER A 179
ASP A 180
GLU A  63
 None
 1.05A 1knyA-1w66A:
undetectable
1knyB-1w66A:
undetectable		 1knyA-1w66A:
19.24
1knyB-1w66A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_D_AG2D7015_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 1w66 LIPOYLTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 7 LEU A  88
ARG A 200
LEU A  44
LEU A  17
GLY A  18
 None
 1.38A 1n13D-1w66A:
undetectable
1n13E-1w66A:
undetectable		 1n13D-1w66A:
18.45
1n13E-1w66A:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OQ5_A_CELA701_2
(CARBONIC ANHYDRASE
II)		 1w66 LIPOYLTRANSFERASE
(Mycobacterium
tuberculosis) 		4 / 4 HIS A  83
VAL A  89
THR A  74
LEU A 156
 DKA  A 301 ( 4.9A)
None
None
None
 1.13A 1oq5A-1w66A:
undetectable		 1oq5A-1w66A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T87_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 1w66 LIPOYLTRANSFERASE
(Mycobacterium
tuberculosis) 		4 / 7 THR A 155
LEU A  96
VAL A 207
ILE A  12
 None
 0.95A 1t87B-1w66A:
undetectable		 1t87B-1w66A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_A_IMNA379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 1w66 LIPOYLTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 THR A 155
VAL A 207
TYR A 105
ILE A  94
LEU A 109
 None
 1.37A 1z9hA-1w66A:
undetectable		 1z9hA-1w66A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_B_IMNB381_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 1w66 LIPOYLTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 THR A 155
VAL A 207
TYR A 105
ILE A  94
LEU A 109
 None
 1.38A 1z9hB-1w66A:
undetectable		 1z9hB-1w66A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_C_IMNC379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 1w66 LIPOYLTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 THR A 155
VAL A 207
TYR A 105
ILE A  94
LEU A 109
 None
 1.37A 1z9hC-1w66A:
undetectable		 1z9hC-1w66A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_A_ROCA201_2
(PROTEASE)		 1w66 LIPOYLTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 9 LEU A  96
GLY A 147
ILE A 146
PRO A  92
ILE A  94
 None
DKA  A 301 (-4.0A)
None
None
None
 1.04A 3s56B-1w66A:
undetectable		 3s56B-1w66A:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWX_A_ZMRA513_2
(NEURAMINIDASE)		 1w66 LIPOYLTRANSFERASE
(Mycobacterium
tuberculosis) 		3 / 3 ARG A 130
TRP A 134
ILE A 178
 None
 1.10A 4mwxA-1w66A:
undetectable		 4mwxA-1w66A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECO_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 1w66 LIPOYLTRANSFERASE
(Mycobacterium
tuberculosis) 		4 / 6 THR A  74
ALA A  55
THR A  54
VAL A  71
 None
 0.85A 5ecoA-1w66A:
undetectable		 5ecoA-1w66A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1w66 LIPOYLTRANSFERASE
(Mycobacterium
tuberculosis) 		4 / 6 TYR A  91
HIS A 157
ILE A 146
TYR A 105
 DKA  A 301 (-4.9A)
None
None
None
 1.28A 5ih0A-1w66A:
undetectable		 5ih0A-1w66A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQB_B_IBPB706_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		 1w66 LIPOYLTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 8 ALA A 206
LEU A  88
LEU A 161
LEU A  44
LEU A  46
 None
 1.47A 5jqbA-1w66A:
undetectable
5jqbB-1w66A:
undetectable		 5jqbA-1w66A:
22.85
5jqbB-1w66A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAC_C_RFPC3001_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 1w66 LIPOYLTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 GLN A  87
PHE A 159
HIS A  83
LEU A 167
PRO A 175
 None
None
DKA  A 301 ( 4.9A)
None
None
 1.47A 5uacC-1w66A:
undetectable		 5uacC-1w66A:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WGG_A_SAMA504_0
(RADICAL SAM DOMAIN
PROTEIN)		 1w66 LIPOYLTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 TYR A  22
ARG A  76
THR A  74
VAL A  72
VAL A  71
 None
DKA  A 301 (-3.7A)
None
None
None
 1.47A 5wggA-1w66A:
undetectable		 5wggA-1w66A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WHY_A_SAMA504_0
(RADICAL SAM DOMAIN
PROTEIN)		 1w66 LIPOYLTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 11 TYR A  22
ARG A  76
THR A  74
VAL A  72
VAL A  71
 None
DKA  A 301 (-3.7A)
None
None
None
 1.31A 5whyA-1w66A:
undetectable		 5whyA-1w66A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WHY_B_SAMB504_0
(RADICAL SAM DOMAIN
PROTEIN)		 1w66 LIPOYLTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 10 TYR A  22
ARG A  76
THR A  74
VAL A  72
VAL A  71
 None
DKA  A 301 (-3.7A)
None
None
None
 1.48A 5whyB-1w66A:
0.2		 5whyB-1w66A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FDY_U_DB8U302_1
(-)		 1w66 LIPOYLTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 9 LEU A  46
PRO A  92
VAL A  14
LEU A 211
ILE A  12
 None
 1.25A 6fdyU-1w66A:
0.8		 6fdyU-1w66A:
22.30