SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1w6f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQP_A_803A311_1
(ANTIGEN CD11A (P180))		 1w6f ARYLAMINE
N-ACETYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		5 / 10 LEU A 246
VAL A 245
ILE A 249
LEU A  44
VAL A 272
 None
 1.20A 1cqpA-1w6fA:
undetectable
1cqpB-1w6fA:
undetectable		 1cqpA-1w6fA:
20.58
1cqpB-1w6fA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMY_A_AZMA400_1
(MURINE CARBONIC
ANHYDRASE V)		 1w6f ARYLAMINE
N-ACETYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		5 / 11 HIS A 110
VAL A 112
LEU A 125
LEU A 135
THR A 134
 None
 1.25A 1dmyA-1w6fA:
undetectable		 1dmyA-1w6fA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_A_117A2_2
(HMG-COA REDUCTASE)		 1w6f ARYLAMINE
N-ACETYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		5 / 11 ARG A 123
ASN A 111
SER A 114
LEU A 113
LEU A  81
 None
 1.21A 1hwkB-1w6fA:
0.0		 1hwkB-1w6fA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_B_117B1_1
(HMG-COA REDUCTASE)		 1w6f ARYLAMINE
N-ACETYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		5 / 11 ARG A 123
ASN A 111
SER A 114
LEU A 113
LEU A  81
 None
 1.19A 1hwkA-1w6fA:
0.0		 1hwkA-1w6fA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_C_117C4_2
(HMG-COA REDUCTASE)		 1w6f ARYLAMINE
N-ACETYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		5 / 11 ARG A 123
ASN A 111
SER A 114
LEU A 113
LEU A  81
 None
 1.24A 1hwkD-1w6fA:
0.0		 1hwkD-1w6fA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_D_117D3_1
(HMG-COA REDUCTASE)		 1w6f ARYLAMINE
N-ACETYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		5 / 11 ARG A 123
ASN A 111
SER A 114
LEU A 113
LEU A  81
 None
 1.24A 1hwkC-1w6fA:
0.0		 1hwkC-1w6fA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7R_A_NCTA440_1
(CYTOCHROME P450-CAM)		 1w6f ARYLAMINE
N-ACETYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		4 / 7 VAL A 265
VAL A 250
ASP A 256
ILE A 255
 None
 1.00A 1p7rA-1w6fA:
undetectable		 1p7rA-1w6fA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		 1w6f ARYLAMINE
N-ACETYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 PHE A 179
VAL A  29
LEU A  77
LEU A 141
LEU A  25
 None
 1.03A 1ya4C-1w6fA:
undetectable		 1ya4C-1w6fA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHC_B_AB1B9001_1
(PROTEASE RETROPEPSIN)		 1w6f ARYLAMINE
N-ACETYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		5 / 11 ASP A 259
ASP A 256
VAL A 250
VAL A 245
ILE A 249
 None
 0.93A 2qhcA-1w6fA:
undetectable		 2qhcA-1w6fA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		 1w6f ARYLAMINE
N-ACETYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A  14
GLY A  13
LEU A   9
ILE A  28
LEU A  77
 None
 1.04A 3gwvA-1w6fA:
undetectable		 3gwvA-1w6fA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_C_VIBC223_1
(THIAMINE
PYROPHOSPHOKINASE)		 1w6f ARYLAMINE
N-ACETYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 ASP A 127
TYR A 154
LEU A 156
LEU A 125
 None
 1.02A 3lm8A-1w6fA:
undetectable
3lm8C-1w6fA:
undetectable		 3lm8A-1w6fA:
21.43
3lm8C-1w6fA:
21.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LTW_A_HLZA300_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 1w6f ARYLAMINE
N-ACETYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		6 / 6 PHE A  38
TYR A  69
CYH A  70
VAL A  95
THR A 109
PHE A 204
 ISZ  A1276 (-4.4A)
ISZ  A1276 (-3.8A)
ISZ  A1276 (-2.4A)
ISZ  A1276 (-4.5A)
None
ISZ  A1276 (-4.4A)
 0.38A 3ltwA-1w6fA:
43.4		 3ltwA-1w6fA:
61.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LTW_A_HLZA302_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 1w6f ARYLAMINE
N-ACETYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		4 / 6 GLU A 152
PRO A 153
ARG A 218
HIS A 229
 None
 0.36A 3ltwA-1w6fA:
43.4		 3ltwA-1w6fA:
61.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA309_1
(BETA-LACTAMASE)		 1w6f ARYLAMINE
N-ACETYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		4 / 5 ILE A 139
ARG A 218
THR A 136
GLU A 152
 None
 1.40A 3ny4A-1w6fA:
undetectable		 3ny4A-1w6fA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1w6f ARYLAMINE
N-ACETYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 ILE A 255
ARG A  66
LEU A 257
VAL A 269
 None
 0.64A 3w1wA-1w6fA:
undetectable		 3w1wA-1w6fA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_A_9TPA601_1
(SERUM ALBUMIN)		 1w6f ARYLAMINE
N-ACETYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A 221
ARG A 222
ILE A 255
LEU A  44
GLY A  67
 None
 1.26A 4l9qA-1w6fA:
undetectable		 4l9qA-1w6fA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_A_9TPA601_1
(SERUM ALBUMIN)		 1w6f ARYLAMINE
N-ACETYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A 221
ARG A 222
ILE A 255
LEU A  44
GLY A  68
 None
 1.33A 4l9qA-1w6fA:
undetectable		 4l9qA-1w6fA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 1w6f ARYLAMINE
N-ACETYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		4 / 5 THR A 234
GLY A 232
GLU A 152
HIS A 151
 None
 1.04A 5c0oH-1w6fA:
undetectable		 5c0oH-1w6fA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_C_FK5C201_1
(FK506-BINDING
PROTEIN 1)		 1w6f ARYLAMINE
N-ACETYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		5 / 10 ASP A  21
VAL A  29
ILE A  28
LEU A  84
PHE A  86
 None
 1.11A 5hw8C-1w6fA:
undetectable
5hw8H-1w6fA:
undetectable		 5hw8C-1w6fA:
17.10
5hw8H-1w6fA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_1
(CDL2.3B)		 1w6f ARYLAMINE
N-ACETYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A  61
LEU A 260
LEU A 257
GLU A  72
LEU A 208
 None
 1.02A 5iepA-1w6fA:
0.0		 5iepA-1w6fA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1w6f ARYLAMINE
N-ACETYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		4 / 7 LEU A 135
GLN A 133
PHE A 130
LEU A 125
 None
None
ISZ  A1276 (-4.0A)
None
 0.97A 5iy5C-1w6fA:
undetectable
5iy5J-1w6fA:
undetectable		 5iy5C-1w6fA:
22.30
5iy5J-1w6fA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQB_B_IBPB706_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		 1w6f ARYLAMINE
N-ACETYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		5 / 8 ARG A 268
ALA A 267
LEU A  45
LEU A  44
LEU A 246
 None
 1.19A 5jqbA-1w6fA:
undetectable
5jqbB-1w6fA:
undetectable		 5jqbA-1w6fA:
20.18
5jqbB-1w6fA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_H_EZLH303_1
(ALPHA-CARBONIC
ANHYDRASE)		 1w6f ARYLAMINE
N-ACETYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 HIS A 110
VAL A 112
LEU A 135
THR A 134
 None
 0.94A 5tt3H-1w6fA:
undetectable		 5tt3H-1w6fA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA811_0
(GEPHYRIN)		 1w6f ARYLAMINE
N-ACETYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 LEU A  84
LEU A   5
ARG A  17
 None
 0.64A 6fgcA-1w6fA:
undetectable		 6fgcA-1w6fA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA810_0
(GEPHYRIN)		 1w6f ARYLAMINE
N-ACETYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 LEU A  84
LEU A   5
ARG A  17
 None
 0.58A 6fgdA-1w6fA:
undetectable		 6fgdA-1w6fA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MXT_A_K5YA1401_0
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		 1w6f ARYLAMINE
N-ACETYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 VAL A 269
VAL A 272
ASP A 259
ASN A  40
ILE A  47
 None
 1.40A 6mxtA-1w6fA:
0.0		 6mxtA-1w6fA:
19.24