SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1w6j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_B_SAMB105_0
(MET REPRESSOR)		 1w6j LANOSTEROL SYNTHASE
(Homo
sapiens) 		5 / 10 GLU A 578
ARG A 639
GLU A 532
PHE A 585
GLY A 575
 None
 1.27A 1cmcA-1w6jA:
undetectable
1cmcB-1w6jA:
undetectable		 1cmcA-1w6jA:
11.57
1cmcB-1w6jA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_R_TRPR81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 1w6j LANOSTEROL SYNTHASE
(Homo
sapiens) 		5 / 9 HIS A  93
THR A 389
ILE A 393
GLY A  32
SER A 421
 None
 1.20A 1gtfR-1w6jA:
undetectable
1gtfS-1w6jA:
undetectable		 1gtfR-1w6jA:
7.10
1gtfS-1w6jA:
7.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2200_0
(PROTEIN (METHIONINE
REPRESSOR))		 1w6j LANOSTEROL SYNTHASE
(Homo
sapiens) 		5 / 12 PHE A 585
GLY A 575
GLU A 578
ARG A 639
GLU A 532
 None
 1.17A 1mj2A-1w6jA:
undetectable
1mj2B-1w6jA:
undetectable		 1mj2A-1w6jA:
11.39
1mj2B-1w6jA:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC2199_0
(PROTEIN (METHIONINE
REPRESSOR))		 1w6j LANOSTEROL SYNTHASE
(Homo
sapiens) 		5 / 12 PHE A 585
GLY A 575
GLU A 578
ARG A 639
GLU A 532
 None
 1.17A 1mj2C-1w6jA:
undetectable
1mj2D-1w6jA:
undetectable		 1mj2C-1w6jA:
11.39
1mj2D-1w6jA:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_C_SAMC200_0
(METHIONINE REPRESSOR)		 1w6j LANOSTEROL SYNTHASE
(Homo
sapiens) 		5 / 12 PHE A 585
GLY A 575
GLU A 578
ARG A 639
GLU A 532
 None
 1.20A 1mjoC-1w6jA:
undetectable
1mjoD-1w6jA:
undetectable		 1mjoC-1w6jA:
11.39
1mjoD-1w6jA:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1w6j LANOSTEROL SYNTHASE
(Homo
sapiens) 		3 / 3 THR A 457
LEU A 461
VAL A 464
 None
 0.30A 1mz9E-1w6jA:
undetectable		 1mz9E-1w6jA:
5.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_1
(HEMK PROTEIN)		 1w6j LANOSTEROL SYNTHASE
(Homo
sapiens) 		3 / 3 ASP A  66
PHE A  83
ASN A  62
 None
 0.51A 1sg9B-1w6jA:
undetectable		 1sg9B-1w6jA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_A_NCTA1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 1w6j LANOSTEROL SYNTHASE
(Homo
sapiens) 		4 / 8 THR A 602
CYH A 616
TYR A 603
LEU A 593
 None
 1.28A 1uw6A-1w6jA:
undetectable
1uw6B-1w6jA:
undetectable		 1uw6A-1w6jA:
15.56
1uw6B-1w6jA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_D_NCTD1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 1w6j LANOSTEROL SYNTHASE
(Homo
sapiens) 		4 / 8 THR A 602
CYH A 616
TYR A 603
LEU A 593
 None
 1.33A 1uw6D-1w6jA:
undetectable
1uw6E-1w6jA:
undetectable		 1uw6D-1w6jA:
15.56
1uw6E-1w6jA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_G_NCTG1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 1w6j LANOSTEROL SYNTHASE
(Homo
sapiens) 		4 / 8 THR A 602
CYH A 616
TYR A 603
LEU A 593
 None
 1.30A 1uw6G-1w6jA:
undetectable
1uw6H-1w6jA:
undetectable		 1uw6G-1w6jA:
15.56
1uw6H-1w6jA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_P_NCTP1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 1w6j LANOSTEROL SYNTHASE
(Homo
sapiens) 		4 / 8 THR A 602
CYH A 616
TYR A 603
LEU A 593
 None
 1.31A 1uw6P-1w6jA:
undetectable
1uw6Q-1w6jA:
undetectable		 1uw6P-1w6jA:
15.56
1uw6Q-1w6jA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_T_NCTT1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 1w6j LANOSTEROL SYNTHASE
(Homo
sapiens) 		4 / 8 LEU A 593
THR A 602
CYH A 616
TYR A 603
 None
 1.35A 1uw6P-1w6jA:
undetectable
1uw6T-1w6jA:
undetectable		 1uw6P-1w6jA:
15.56
1uw6T-1w6jA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_A_SAMA301_0
(RRNA
METHYLTRANSFERASE)		 1w6j LANOSTEROL SYNTHASE
(Homo
sapiens) 		5 / 11 GLU A 558
GLY A 499
GLY A 498
ILE A 556
LEU A 491
 None
 1.03A 1x7pA-1w6jA:
undetectable
1x7pB-1w6jA:
undetectable		 1x7pA-1w6jA:
19.02
1x7pB-1w6jA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		 1w6j LANOSTEROL SYNTHASE
(Homo
sapiens) 		4 / 4 LEU A 131
PRO A 168
ILE A 163
LEU A 164
 None
 1.09A 1ya4B-1w6jA:
0.0		 1ya4B-1w6jA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)		 1w6j LANOSTEROL SYNTHASE
(Homo
sapiens) 		4 / 4 LEU A 131
PRO A 168
ILE A 163
LEU A 164
 None
 1.08A 1ya4C-1w6jA:
0.0		 1ya4C-1w6jA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_B_PNXB2434_1
(CHITINASE)		 1w6j LANOSTEROL SYNTHASE
(Homo
sapiens) 		4 / 6 TRP A 230
TYR A 530
PHE A 696
SER A 699
 None
None
R71  A1733 (-3.6A)
None
 1.39A 2a3cB-1w6jA:
undetectable		 2a3cB-1w6jA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1w6j LANOSTEROL SYNTHASE
(Homo
sapiens) 		4 / 5 ASP A 138
GLY A 142
ALA A 176
ILE A 179
 None
 0.92A 2aofA-1w6jA:
undetectable		 2aofA-1w6jA:
7.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H21_C_SAMC803_0
(RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E)		 1w6j LANOSTEROL SYNTHASE
(Homo
sapiens) 		5 / 11 GLU A 594
GLY A 658
LEU A 659
TYR A 587
PHE A 591
 None
 1.50A 2h21C-1w6jA:
undetectable		 2h21C-1w6jA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_B_SNLB2001_1
(MINERALOCORTICOID
RECEPTOR)		 1w6j LANOSTEROL SYNTHASE
(Homo
sapiens) 		5 / 12 LEU A 491
ALA A 458
LEU A 465
THR A 559
PHE A 500
 None
 0.88A 2oaxB-1w6jA:
undetectable		 2oaxB-1w6jA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_C_SNLC3001_1
(MINERALOCORTICOID
RECEPTOR)		 1w6j LANOSTEROL SYNTHASE
(Homo
sapiens) 		5 / 12 LEU A 491
ALA A 458
LEU A 465
THR A 559
PHE A 500
 None
 0.91A 2oaxC-1w6jA:
undetectable		 2oaxC-1w6jA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_B_LDPB502_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 1w6j LANOSTEROL SYNTHASE
(Homo
sapiens) 		4 / 5 PHE A 391
PHE A 711
TRP A 590
GLY A 582
 None
 1.22A 2qmzA-1w6jA:
undetectable
2qmzB-1w6jA:
undetectable		 2qmzA-1w6jA:
17.08
2qmzB-1w6jA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1w6j LANOSTEROL SYNTHASE
(Homo
sapiens) 		4 / 7 GLY A 499
THR A 534
CYH A 567
GLN A 570
 None
 0.97A 2qx4A-1w6jA:
undetectable
2qx4B-1w6jA:
undetectable		 2qx4A-1w6jA:
17.08
2qx4B-1w6jA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_D_2FAD500_2
(ADENOSYLHOMOCYSTEINA
SE)		 1w6j LANOSTEROL SYNTHASE
(Homo
sapiens) 		4 / 4 LEU A  27
GLN A 385
THR A  95
THR A  37
 None
 1.39A 2zj0D-1w6jA:
undetectable		 2zj0D-1w6jA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA606_1
(CHITINASE A)		 1w6j LANOSTEROL SYNTHASE
(Homo
sapiens) 		4 / 7 TRP A 141
GLY A 167
ASP A 172
ARG A 175
 None
 0.95A 3arrA-1w6jA:
undetectable		 3arrA-1w6jA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGR_A_T27A556_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H
P51 RT)		 1w6j LANOSTEROL SYNTHASE
(Homo
sapiens) 		5 / 11 LEU A 119
VAL A 362
TYR A 368
LEU A 369
TYR A 123
 None
 1.43A 3bgrA-1w6jA:
0.0
3bgrB-1w6jA:
0.0		 3bgrA-1w6jA:
21.18
3bgrB-1w6jA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 1w6j LANOSTEROL SYNTHASE
(Homo
sapiens) 		5 / 12 GLU A 555
GLU A 558
ARG A 552
VAL A 537
ASN A 492
 None
 1.50A 3jb3A-1w6jA:
undetectable		 3jb3A-1w6jA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q87_B_SAMB300_0
(N6 ADENINE SPECIFIC
DNA METHYLASE)		 1w6j LANOSTEROL SYNTHASE
(Homo
sapiens) 		5 / 12 GLY A 375
ILE A 127
ASP A 374
LEU A 373
LEU A  56
 None
 1.07A 3q87B-1w6jA:
undetectable		 3q87B-1w6jA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA214_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		 1w6j LANOSTEROL SYNTHASE
(Homo
sapiens) 		5 / 10 PHE A 391
TYR A 707
PHE A 711
GLY A 582
ASN A 651
 None
 1.20A 3r6wA-1w6jA:
undetectable
3r6wB-1w6jA:
undetectable		 3r6wA-1w6jA:
14.87
3r6wB-1w6jA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_C_ACHC323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 1w6j LANOSTEROL SYNTHASE
(Homo
sapiens) 		4 / 8 PHE A 195
GLU A 519
TYR A 237
LEU A 211
 None
None
C14  A1735 ( 4.4A)
None
 1.15A 3rqwC-1w6jA:
2.2
3rqwD-1w6jA:
2.4		 3rqwC-1w6jA:
16.55
3rqwD-1w6jA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_J_ACHJ323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 1w6j LANOSTEROL SYNTHASE
(Homo
sapiens) 		4 / 8 GLU A 519
TYR A 237
LEU A 211
PHE A 195
 None
C14  A1735 ( 4.4A)
None
None
 1.10A 3rqwF-1w6jA:
1.7
3rqwJ-1w6jA:
undetectable		 3rqwF-1w6jA:
16.55
3rqwJ-1w6jA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		 1w6j LANOSTEROL SYNTHASE
(Homo
sapiens) 		5 / 12 GLN A 135
ARG A 177
ASN A 178
GLY A 140
GLY A 167
 None
 1.18A 3v3oA-1w6jA:
undetectable		 3v3oA-1w6jA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_1
(MINERALOCORTICOID
RECEPTOR)		 1w6j LANOSTEROL SYNTHASE
(Homo
sapiens) 		5 / 12 LEU A 491
ALA A 458
LEU A 465
THR A 559
PHE A 500
 None
 0.88A 3vhuA-1w6jA:
undetectable		 3vhuA-1w6jA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_2
(DIPEPTIDYL PEPTIDASE
4)		 1w6j LANOSTEROL SYNTHASE
(Homo
sapiens) 		3 / 3 ARG A 435
TYR A 528
ASN A 495
 None
 0.88A 4ffwB-1w6jA:
undetectable		 4ffwB-1w6jA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_F_ASWF101_1
(DNA TOPOISOMERASE
2-BETA)		 1w6j LANOSTEROL SYNTHASE
(Homo
sapiens) 		4 / 6 GLY A 372
ALA A  19
GLU A 126
GLN A 689
 None
 1.08A 4g0uA-1w6jA:
undetectable		 4g0uA-1w6jA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_ACTA303_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 1w6j LANOSTEROL SYNTHASE
(Homo
sapiens) 		3 / 3 TYR A 244
HIS A 307
ARG A 312
 None
 1.00A 4htfA-1w6jA:
undetectable		 4htfA-1w6jA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2V_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		 1w6j LANOSTEROL SYNTHASE
(Homo
sapiens) 		3 / 3 HIS A 403
VAL A  85
LEU A 396
 None
 0.64A 4m2vA-1w6jA:
undetectable		 4m2vA-1w6jA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MFL_B_GCSB502_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN TCP24
TEICOPLANIN
PSEUDOAGLYCONE)		 1w6j LANOSTEROL SYNTHASE
(Homo
sapiens) 		4 / 6 MET A 657
TRP A 590
TRP A 654
ALA A 693
 None
 1.42A 4mflA-1w6jA:
0.5		 4mflA-1w6jA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1w6j LANOSTEROL SYNTHASE
(Homo
sapiens) 		5 / 12 ALA A  70
ASN A 709
ILE A 713
GLY A 685
THR A  82
 None
 0.95A 4nkxB-1w6jA:
undetectable		 4nkxB-1w6jA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_F_PARF500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 1w6j LANOSTEROL SYNTHASE
(Homo
sapiens) 		5 / 11 PHE A 195
SER A 241
GLU A 504
ASP A 327
ASP A 326
 None
 1.24A 4qb9F-1w6jA:
0.0		 4qb9F-1w6jA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_A_SAMA1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 1w6j LANOSTEROL SYNTHASE
(Homo
sapiens) 		5 / 12 GLY A 441
TYR A 430
SER A 454
ALA A 460
ALA A 486
 None
 1.40A 4ymgA-1w6jA:
0.0		 4ymgA-1w6jA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 1w6j LANOSTEROL SYNTHASE
(Homo
sapiens) 		5 / 12 GLY A 441
TYR A 430
SER A 454
ALA A 460
ALA A 486
 None
 1.36A 4ymgB-1w6jA:
undetectable		 4ymgB-1w6jA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_B_DM2B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1w6j LANOSTEROL SYNTHASE
(Homo
sapiens) 		5 / 11 PHE A 391
PHE A 711
TRP A 590
GLY A 582
ILE A 702
 None
 1.36A 4zvmA-1w6jA:
undetectable
4zvmB-1w6jA:
undetectable		 4zvmA-1w6jA:
17.08
4zvmB-1w6jA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_F_MFXF2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 1w6j LANOSTEROL SYNTHASE
(Homo
sapiens) 		4 / 6 ASP A 367
ARG A  33
GLY A  32
GLU A  30
 None
 1.06A 5cdqA-1w6jA:
undetectable
5cdqC-1w6jA:
3.0
5cdqD-1w6jA:
undetectable		 5cdqA-1w6jA:
20.30
5cdqC-1w6jA:
20.30
5cdqD-1w6jA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_ACTA405_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 1w6j LANOSTEROL SYNTHASE
(Homo
sapiens) 		3 / 3 GLN A 570
THR A 529
ASP A 497
 None
 0.92A 5k9dA-1w6jA:
undetectable		 5k9dA-1w6jA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8R_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 1w6j LANOSTEROL SYNTHASE
(Homo
sapiens) 		5 / 9 PHE A  74
SER A 720
GLY A 717
LEU A  78
GLY A  76
 None
 1.30A 5l8rA-1w6jA:
undetectable		 5l8rA-1w6jA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_A_BZMA301_0
(ISATIN HYDROLASE A)		 1w6j LANOSTEROL SYNTHASE
(Homo
sapiens) 		5 / 12 ILE A 338
TRP A 230
GLY A 336
GLY A 380
HIS A 232
 R71  A1733 (-4.8A)
None
None
R71  A1733 (-4.3A)
R71  A1733 (-3.5A)
 1.15A 5nnaA-1w6jA:
undetectable		 5nnaA-1w6jA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_B_BZMB301_0
(ISATIN HYDROLASE A)		 1w6j LANOSTEROL SYNTHASE
(Homo
sapiens) 		5 / 12 ILE A 338
TRP A 230
GLY A 336
GLY A 380
HIS A 232
 R71  A1733 (-4.8A)
None
None
R71  A1733 (-4.3A)
R71  A1733 (-3.5A)
 1.14A 5nnaB-1w6jA:
undetectable		 5nnaB-1w6jA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_C_BZMC301_0
(ISATIN HYDROLASE A)		 1w6j LANOSTEROL SYNTHASE
(Homo
sapiens) 		5 / 12 ILE A 338
TRP A 230
GLY A 336
GLY A 380
HIS A 232
 R71  A1733 (-4.8A)
None
None
R71  A1733 (-4.3A)
R71  A1733 (-3.5A)
 1.14A 5nnaC-1w6jA:
undetectable		 5nnaC-1w6jA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_D_BZMD301_0
(ISATIN HYDROLASE A)		 1w6j LANOSTEROL SYNTHASE
(Homo
sapiens) 		5 / 12 ILE A 338
TRP A 230
GLY A 336
GLY A 380
HIS A 232
 R71  A1733 (-4.8A)
None
None
R71  A1733 (-4.3A)
R71  A1733 (-3.5A)
 1.15A 5nnaD-1w6jA:
undetectable		 5nnaD-1w6jA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_C_SAMC501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1w6j LANOSTEROL SYNTHASE
(Homo
sapiens) 		5 / 7 GLY A 673
GLY A 627
SER A 621
THR A 652
ALA A 655
 None
 1.36A 5o96C-1w6jA:
undetectable		 5o96C-1w6jA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_B_RBFB201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 1w6j LANOSTEROL SYNTHASE
(Homo
sapiens) 		4 / 7 ARG A 162
TYR A 158
GLU A 262
LEU A 200
 None
 1.16A 5umwB-1w6jA:
undetectable
5umwE-1w6jA:
undetectable		 5umwB-1w6jA:
8.23
5umwE-1w6jA:
8.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_B_C2FB702_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 1w6j LANOSTEROL SYNTHASE
(Homo
sapiens) 		4 / 5 ASP A 497
ASN A 495
ASP A 527
ARG A 639
 None
 1.43A 5vooB-1w6jA:
undetectable		 5vooB-1w6jA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_D_C2FD3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 1w6j LANOSTEROL SYNTHASE
(Homo
sapiens) 		4 / 5 ASP A 497
ASN A 495
ASP A 527
ARG A 639
 None
 1.44A 5vooD-1w6jA:
undetectable		 5vooD-1w6jA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1w6j LANOSTEROL SYNTHASE
(Homo
sapiens) 		3 / 3 SER A 191
HIS A 289
TYR A 297
 None
 1.02A 5y2tA-1w6jA:
0.1		 5y2tA-1w6jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_D_CHDD401_0
(BILE SALT HYDROLASE)		 1w6j LANOSTEROL SYNTHASE
(Homo
sapiens) 		5 / 10 LEU A 293
TYR A 297
LEU A 208
ASN A 516
PHE A 195
 None
 1.21A 5y7pD-1w6jA:
undetectable		 5y7pD-1w6jA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_H_CHDH401_0
(BILE SALT HYDROLASE)		 1w6j LANOSTEROL SYNTHASE
(Homo
sapiens) 		5 / 10 LEU A 293
TYR A 297
LEU A 208
ASN A 516
PHE A 195
 None
 1.24A 5y7pH-1w6jA:
0.0		 5y7pH-1w6jA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_A_SAMA901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 1w6j LANOSTEROL SYNTHASE
(Homo
sapiens) 		5 / 12 HIS A 232
VAL A 346
ILE A 323
ASP A 326
ASP A 327
 R71  A1733 (-3.5A)
None
None
None
None
 1.45A 6bxnA-1w6jA:
undetectable		 6bxnA-1w6jA:
18.21