SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1w6s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ6_B_CAMB502_0
(CYTOCHROME P450-CAM)		 1w6s METHANOL
DEHYDROGENASE
SUBUNIT 1
(Methylobacterium
extorquens) 		4 / 5 TYR A 465
VAL A 335
VAL A 355
ASP A 352
 None
 1.38A 1dz6B-1w6sA:
0.0		 1dz6B-1w6sA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G60_B_SAMB501_0
(ADENINE-SPECIFIC
METHYLTRANSFERASE
MBOIIA)		 1w6s METHANOL
DEHYDROGENASE
SUBUNIT 1
(Methylobacterium
extorquens) 		5 / 12 ASN A  52
ILE A  67
GLY A 574
THR A  45
TYR A 534
 None
 1.34A 1g60B-1w6sA:
undetectable		 1g60B-1w6sA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KW0_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1w6s METHANOL
DEHYDROGENASE
SUBUNIT 1
(Methylobacterium
extorquens) 		5 / 12 LEU A 325
LEU A 338
SER A 347
LEU A 363
THR A 341
 None
 1.23A 1kw0A-1w6sA:
undetectable		 1kw0A-1w6sA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA732_1
(ALPHA AMYLASE)		 1w6s METHANOL
DEHYDROGENASE
SUBUNIT 1
(Methylobacterium
extorquens) 		5 / 9 GLY A 573
GLU A  55
GLY A  53
GLY A 518
GLY A  56
 None
PQQ  A1596 (-2.7A)
None
None
None
 1.12A 1mxdA-1w6sA:
undetectable		 1mxdA-1w6sA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA442_1
(ALPHA AMYLASE)		 1w6s METHANOL
DEHYDROGENASE
SUBUNIT 1
(Methylobacterium
extorquens) 		5 / 11 GLY A 573
GLU A  55
GLY A  53
GLY A 518
GLY A  56
 None
PQQ  A1596 (-2.7A)
None
None
None
 1.10A 1mxgA-1w6sA:
undetectable		 1mxgA-1w6sA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 1w6s METHANOL
DEHYDROGENASE
SUBUNIT 1
(Methylobacterium
extorquens) 		3 / 3 LYS A 469
ILE A 411
THR A 491
 None
 0.83A 1rx3A-1w6sA:
undetectable		 1rx3A-1w6sA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 1w6s METHANOL
DEHYDROGENASE
SUBUNIT 1
(Methylobacterium
extorquens) 		4 / 8 VAL A 475
GLY A 410
THR A 479
VAL A 487
 None
 0.81A 2a1mB-1w6sA:
undetectable		 2a1mB-1w6sA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_B_CQAB401_0
(HISTAMINE
N-METHYLTRANSFERASE)		 1w6s METHANOL
DEHYDROGENASE
SUBUNIT 1
METHANOL
DEHYDROGENASE
SUBUNIT 2
(Methylobacterium
extorquens;
Methylobacterium
extorquens) 		4 / 7 GLY B1018
PHE B1019
PRO B1020
THR A 268
 None
 1.05A 2aouB-1w6sB:
undetectable		 2aouB-1w6sB:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 1w6s METHANOL
DEHYDROGENASE
SUBUNIT 1
(Methylobacterium
extorquens) 		5 / 7 TYR A 183
GLY A 172
THR A 185
TYR A 187
ASN A 242
 None
 1.38A 2g70A-1w6sA:
undetectable		 2g70A-1w6sA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 1w6s METHANOL
DEHYDROGENASE
SUBUNIT 1
(Methylobacterium
extorquens) 		4 / 7 TYR A 183
GLY A 172
TYR A 187
ASN A 242
 None
 1.08A 2g70B-1w6sA:
undetectable		 2g70B-1w6sA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 1w6s METHANOL
DEHYDROGENASE
SUBUNIT 1
(Methylobacterium
extorquens) 		4 / 6 TYR A 183
GLY A 172
TYR A 187
ASN A 242
 None
 1.12A 2g72A-1w6sA:
undetectable		 2g72A-1w6sA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 1w6s METHANOL
DEHYDROGENASE
SUBUNIT 1
(Methylobacterium
extorquens) 		4 / 7 TYR A 183
GLY A 172
TYR A 187
ASN A 242
 None
 1.10A 2g72B-1w6sA:
undetectable		 2g72B-1w6sA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1w6s METHANOL
DEHYDROGENASE
SUBUNIT 1
METHANOL
DEHYDROGENASE
SUBUNIT 2
(Methylobacterium
extorquens) 		4 / 6 GLY A 226
GLY B1010
GLN A 295
PHE A 281
 None
 0.96A 2qx6A-1w6sA:
undetectable
2qx6B-1w6sA:
undetectable		 2qx6A-1w6sA:
20.08
2qx6B-1w6sA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1w6s METHANOL
DEHYDROGENASE
SUBUNIT 1
(Methylobacterium
extorquens) 		3 / 3 GLY A 518
GLY A 396
GLY A 477
 None
 0.42A 3bogC-1w6sA:
undetectable		 3bogC-1w6sA:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1w6s METHANOL
DEHYDROGENASE
SUBUNIT 1
(Methylobacterium
extorquens) 		3 / 3 GLY A 518
GLY A 396
GLY A 477
 None
 0.38A 3bogD-1w6sA:
undetectable		 3bogD-1w6sA:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P)		 1w6s METHANOL
DEHYDROGENASE
SUBUNIT 1
(Methylobacterium
extorquens) 		4 / 8 VAL A 144
ILE A 171
VAL A 169
GLY A 192
 None
 0.81A 3hjoB-1w6sA:
undetectable		 3hjoB-1w6sA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LD6_B_KKKB602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1w6s METHANOL
DEHYDROGENASE
SUBUNIT 1
(Methylobacterium
extorquens) 		5 / 12 PHE A 358
TRP A 302
GLY A 555
ALA A 558
ILE A 414
 None
 1.26A 3ld6B-1w6sA:
undetectable		 3ld6B-1w6sA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1w6s METHANOL
DEHYDROGENASE
SUBUNIT 1
(Methylobacterium
extorquens) 		4 / 7 ARG A 404
GLN A 529
LEU A 507
ILE A  32
 None
 1.08A 3ln1C-1w6sA:
undetectable		 3ln1C-1w6sA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 1w6s METHANOL
DEHYDROGENASE
SUBUNIT 1
(Methylobacterium
extorquens) 		3 / 3 GLY A 478
TRP A 245
VAL A 309
 None
 0.59A 3n62B-1w6sA:
undetectable		 3n62B-1w6sA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N65_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 1w6s METHANOL
DEHYDROGENASE
SUBUNIT 1
(Methylobacterium
extorquens) 		3 / 3 GLY A 478
TRP A 245
VAL A 309
 None
 0.57A 3n65B-1w6sA:
undetectable		 3n65B-1w6sA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 1w6s METHANOL
DEHYDROGENASE
SUBUNIT 1
(Methylobacterium
extorquens) 		3 / 3 GLY A 478
TRP A 245
VAL A 309
 None
 0.58A 3n66B-1w6sA:
undetectable		 3n66B-1w6sA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3M_A_DLUA398_1
(PFV INTEGRASE)		 1w6s METHANOL
DEHYDROGENASE
SUBUNIT 1
(Methylobacterium
extorquens) 		4 / 8 ASP A 303
GLY A 306
GLU A 177
ARG A 109
 PQQ  A1596 (-3.9A)
None
CA  A1599 ( 2.3A)
PQQ  A1596 (-3.3A)
 0.98A 3s3mA-1w6sA:
undetectable		 3s3mA-1w6sA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_A_ADNA353_1
(ADENOSINE KINASE)		 1w6s METHANOL
DEHYDROGENASE
SUBUNIT 1
(Methylobacterium
extorquens) 		5 / 12 ILE A 171
GLY A 172
ASN A 242
ARG A 109
THR A 127
 None
None
None
PQQ  A1596 (-3.3A)
None
 0.98A 3uboA-1w6sA:
undetectable		 3uboA-1w6sA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		 1w6s METHANOL
DEHYDROGENASE
SUBUNIT 1
(Methylobacterium
extorquens) 		5 / 12 ASN A 394
HIS A 393
GLY A 410
ALA A  57
GLY A  56
 PQQ  A1596 (-3.6A)
None
None
None
None
 1.16A 3v3oA-1w6sA:
undetectable		 3v3oA-1w6sA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		 1w6s METHANOL
DEHYDROGENASE
SUBUNIT 1
(Methylobacterium
extorquens) 		5 / 12 ASN A 394
HIS A 393
GLY A 410
ALA A  57
GLY A  56
 PQQ  A1596 (-3.6A)
None
None
None
None
 1.19A 3v3oB-1w6sA:
undetectable		 3v3oB-1w6sA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1w6s METHANOL
DEHYDROGENASE
SUBUNIT 1
(Methylobacterium
extorquens) 		5 / 9 ILE A 171
LEU A 158
SER A  23
GLY A 244
TRP A 245
 None
 1.18A 3w1wB-1w6sA:
0.0		 3w1wB-1w6sA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_B_C2FB302_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 1w6s METHANOL
DEHYDROGENASE
SUBUNIT 1
(Methylobacterium
extorquens) 		5 / 12 ASP A 330
ASN A 308
GLY A 260
ASN A 261
ARG A 270
 None
None
None
CA  A1599 ( 3.5A)
None
 1.30A 4djeB-1w6sA:
undetectable		 4djeB-1w6sA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_2
(DIHYDROFOLATE
REDUCTASE)		 1w6s METHANOL
DEHYDROGENASE
SUBUNIT 1
(Methylobacterium
extorquens) 		3 / 3 LYS A 469
ILE A 411
THR A 491
 None
 0.85A 4gh8A-1w6sA:
undetectable		 4gh8A-1w6sA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H2G_A_ADNA603_1
(5'-NUCLEOTIDASE)		 1w6s METHANOL
DEHYDROGENASE
SUBUNIT 1
(Methylobacterium
extorquens) 		5 / 9 GLY A 538
GLY A 542
GLY A  53
PHE A 547
ASP A 105
 None
 1.36A 4h2gA-1w6sA:
undetectable		 4h2gA-1w6sA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 1w6s METHANOL
DEHYDROGENASE
SUBUNIT 1
(Methylobacterium
extorquens) 		5 / 11 ALA A 176
GLY A 239
GLY A 258
ASN A 261
TRP A 243
 PQQ  A1596 (-3.2A)
None
None
CA  A1599 ( 3.5A)
PQQ  A1596 (-3.6A)
 1.28A 4jdsA-1w6sA:
undetectable		 4jdsA-1w6sA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_B_SAMB401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 1w6s METHANOL
DEHYDROGENASE
SUBUNIT 1
(Methylobacterium
extorquens) 		5 / 11 ALA A 176
GLY A 239
GLY A 258
ASN A 261
TRP A 243
 PQQ  A1596 (-3.2A)
None
None
CA  A1599 ( 3.5A)
PQQ  A1596 (-3.6A)
 1.26A 4jdsB-1w6sA:
undetectable		 4jdsB-1w6sA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_F_CAMF502_0
(CAMPHOR
5-MONOOXYGENASE)		 1w6s METHANOL
DEHYDROGENASE
SUBUNIT 1
(Methylobacterium
extorquens) 		4 / 4 TYR A 246
THR A 185
VAL A 169
ILE A 160
 None
 1.34A 4jx1F-1w6sA:
undetectable		 4jx1F-1w6sA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_A_URFA302_1
(URIDINE
PHOSPHORYLASE)		 1w6s METHANOL
DEHYDROGENASE
SUBUNIT 1
(Methylobacterium
extorquens) 		4 / 7 THR A 491
GLY A 477
ALA A 516
ILE A 533
 None
 0.81A 4txnA-1w6sA:
undetectable		 4txnA-1w6sA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_B_URFB302_1
(URIDINE
PHOSPHORYLASE)		 1w6s METHANOL
DEHYDROGENASE
SUBUNIT 1
(Methylobacterium
extorquens) 		4 / 7 THR A 491
GLY A 477
ALA A 516
ILE A 533
 None
 0.82A 4txnB-1w6sA:
undetectable		 4txnB-1w6sA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_C_URFC302_1
(URIDINE
PHOSPHORYLASE)		 1w6s METHANOL
DEHYDROGENASE
SUBUNIT 1
(Methylobacterium
extorquens) 		4 / 7 THR A 491
GLY A 477
ALA A 516
ILE A 533
 None
 0.79A 4txnC-1w6sA:
undetectable		 4txnC-1w6sA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_D_URFD302_1
(URIDINE
PHOSPHORYLASE)		 1w6s METHANOL
DEHYDROGENASE
SUBUNIT 1
(Methylobacterium
extorquens) 		4 / 7 THR A 491
GLY A 477
ALA A 516
ILE A 533
 None
 0.82A 4txnD-1w6sA:
undetectable		 4txnD-1w6sA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 1w6s METHANOL
DEHYDROGENASE
SUBUNIT 1
(Methylobacterium
extorquens) 		4 / 4 TYR A 183
THR A 185
GLY A 172
LEU A 158
 None
 1.23A 4w5nA-1w6sA:
0.0		 4w5nA-1w6sA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 1w6s METHANOL
DEHYDROGENASE
SUBUNIT 1
METHANOL
DEHYDROGENASE
SUBUNIT 2
(Methylobacterium
extorquens;
Methylobacterium
extorquens) 		4 / 5 TYR B1001
LYS B1016
PRO B1017
GLU A 267
 None
 1.31A 4w5tA-1w6sB:
undetectable		 4w5tA-1w6sB:
6.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUC_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 1w6s METHANOL
DEHYDROGENASE
SUBUNIT 1
(Methylobacterium
extorquens) 		5 / 12 VAL A  15
TYR A 113
ILE A 170
ILE A 160
TRP A 245
 None
 1.46A 4xucA-1w6sA:
undetectable		 4xucA-1w6sA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 1w6s METHANOL
DEHYDROGENASE
SUBUNIT 1
(Methylobacterium
extorquens) 		5 / 12 VAL A  15
TYR A 113
ILE A 170
ILE A 160
TRP A 245
 None
 1.41A 4xudA-1w6sA:
undetectable		 4xudA-1w6sA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 1w6s METHANOL
DEHYDROGENASE
SUBUNIT 1
METHANOL
DEHYDROGENASE
SUBUNIT 2
(Methylobacterium
extorquens;
Methylobacterium
extorquens) 		4 / 6 TYR B1001
LYS B1016
PRO B1017
GLU A 267
 None
 1.33A 4z4cA-1w6sB:
undetectable		 4z4cA-1w6sB:
6.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 1w6s METHANOL
DEHYDROGENASE
SUBUNIT 1
METHANOL
DEHYDROGENASE
SUBUNIT 2
(Methylobacterium
extorquens;
Methylobacterium
extorquens) 		4 / 6 TYR B1001
LYS B1016
PRO B1017
GLU A 267
 None
 1.28A 4z4gA-1w6sB:
undetectable		 4z4gA-1w6sB:
6.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_1
(CYP51 VARIANT1)		 1w6s METHANOL
DEHYDROGENASE
SUBUNIT 1
(Methylobacterium
extorquens) 		5 / 12 GLY A 428
GLN A 429
LEU A 129
ILE A 517
GLY A 539
 None
None
None
None
PQQ  A1596 (-3.5A)
 1.05A 5fsaB-1w6sA:
undetectable		 5fsaB-1w6sA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_A_ACTA708_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 1w6s METHANOL
DEHYDROGENASE
SUBUNIT 1
METHANOL
DEHYDROGENASE
SUBUNIT 2
(Methylobacterium
extorquens;
Methylobacterium
extorquens) 		3 / 3 GLY A 239
GLY A 238
GLN B1040
 None
 0.39A 5imsA-1w6sA:
undetectable		 5imsA-1w6sA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1w6s METHANOL
DEHYDROGENASE
SUBUNIT 1
METHANOL
DEHYDROGENASE
SUBUNIT 2
(Methylobacterium
extorquens) 		4 / 5 TYR B1001
GLY B1003
THR B1004
GLY A 182
 None
 0.65A 5jlcA-1w6sB:
undetectable		 5jlcA-1w6sB:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGJ_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1w6s METHANOL
DEHYDROGENASE
SUBUNIT 1
(Methylobacterium
extorquens) 		3 / 3 VAL A 133
VAL A 147
GLN A 194
 None
 0.64A 5qgjA-1w6sA:
undetectable		 5qgjA-1w6sA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGL_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1w6s METHANOL
DEHYDROGENASE
SUBUNIT 1
(Methylobacterium
extorquens) 		3 / 3 VAL A 133
VAL A 147
GLN A 194
 None
 0.64A 5qglA-1w6sA:
undetectable		 5qglA-1w6sA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGM_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1w6s METHANOL
DEHYDROGENASE
SUBUNIT 1
(Methylobacterium
extorquens) 		3 / 3 VAL A 133
VAL A 147
GLN A 194
 None
 0.68A 5qgmA-1w6sA:
undetectable		 5qgmA-1w6sA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGU_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1w6s METHANOL
DEHYDROGENASE
SUBUNIT 1
(Methylobacterium
extorquens) 		3 / 3 VAL A 133
VAL A 147
GLN A 194
 None
 0.65A 5qguA-1w6sA:
undetectable		 5qguA-1w6sA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGV_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1w6s METHANOL
DEHYDROGENASE
SUBUNIT 1
(Methylobacterium
extorquens) 		3 / 3 VAL A 133
VAL A 147
GLN A 194
 None
 0.68A 5qgvA-1w6sA:
undetectable		 5qgvA-1w6sA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGW_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1w6s METHANOL
DEHYDROGENASE
SUBUNIT 1
(Methylobacterium
extorquens) 		3 / 3 VAL A 133
VAL A 147
GLN A 194
 None
 0.69A 5qgwA-1w6sA:
undetectable		 5qgwA-1w6sA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGX_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1w6s METHANOL
DEHYDROGENASE
SUBUNIT 1
(Methylobacterium
extorquens) 		3 / 3 VAL A 133
VAL A 147
GLN A 194
 None
 0.69A 5qgxA-1w6sA:
undetectable		 5qgxA-1w6sA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH1_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1w6s METHANOL
DEHYDROGENASE
SUBUNIT 1
(Methylobacterium
extorquens) 		3 / 3 VAL A 133
VAL A 147
GLN A 194
 None
 0.70A 5qh1A-1w6sA:
undetectable		 5qh1A-1w6sA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH4_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1w6s METHANOL
DEHYDROGENASE
SUBUNIT 1
(Methylobacterium
extorquens) 		3 / 3 VAL A 133
VAL A 147
GLN A 194
 None
 0.69A 5qh4A-1w6sA:
undetectable		 5qh4A-1w6sA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH9_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1w6s METHANOL
DEHYDROGENASE
SUBUNIT 1
(Methylobacterium
extorquens) 		3 / 3 VAL A 133
VAL A 147
GLN A 194
 None
 0.68A 5qh9A-1w6sA:
undetectable		 5qh9A-1w6sA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHA_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1w6s METHANOL
DEHYDROGENASE
SUBUNIT 1
(Methylobacterium
extorquens) 		3 / 3 VAL A 133
VAL A 147
GLN A 194
 None
 0.68A 5qhaA-1w6sA:
undetectable		 5qhaA-1w6sA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHC_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1w6s METHANOL
DEHYDROGENASE
SUBUNIT 1
(Methylobacterium
extorquens) 		3 / 3 VAL A 133
VAL A 147
GLN A 194
 None
 0.69A 5qhcA-1w6sA:
undetectable		 5qhcA-1w6sA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHE_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1w6s METHANOL
DEHYDROGENASE
SUBUNIT 1
(Methylobacterium
extorquens) 		3 / 3 VAL A 133
VAL A 147
GLN A 194
 None
 0.66A 5qheA-1w6sA:
undetectable		 5qheA-1w6sA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHF_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1w6s METHANOL
DEHYDROGENASE
SUBUNIT 1
(Methylobacterium
extorquens) 		3 / 3 VAL A 133
VAL A 147
GLN A 194
 None
 0.67A 5qhfA-1w6sA:
undetectable		 5qhfA-1w6sA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHG_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1w6s METHANOL
DEHYDROGENASE
SUBUNIT 1
(Methylobacterium
extorquens) 		3 / 3 VAL A 133
VAL A 147
GLN A 194
 None
 0.69A 5qhgA-1w6sA:
undetectable		 5qhgA-1w6sA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1w6s METHANOL
DEHYDROGENASE
SUBUNIT 1
(Methylobacterium
extorquens) 		3 / 3 TYR A 294
ALA A 348
TYR A 336
 None
 0.83A 5uunB-1w6sA:
undetectable		 5uunB-1w6sA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_ACTB804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1w6s METHANOL
DEHYDROGENASE
SUBUNIT 1
(Methylobacterium
extorquens) 		3 / 3 GLY A 478
TRP A 245
VAL A 309
 None
 0.58A 5vuoB-1w6sA:
undetectable		 5vuoB-1w6sA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W8A_A_SAMA300_0
(AUTOINDUCER SYNTHASE)		 1w6s METHANOL
DEHYDROGENASE
SUBUNIT 1
(Methylobacterium
extorquens) 		5 / 12 TYR A 439
SER A 388
ILE A 385
GLU A 419
THR A 376
 None
 1.27A 5w8aA-1w6sA:
undetectable		 5w8aA-1w6sA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_0
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 1w6s METHANOL
DEHYDROGENASE
SUBUNIT 1
(Methylobacterium
extorquens) 		5 / 12 GLY A 226
THR A 227
GLY A 224
THR A 279
PHE A 281
 None
 0.93A 5ybbA-1w6sA:
undetectable		 5ybbA-1w6sA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA411_0
(UNCHARACTERIZED
PROTEIN KDOO)		 1w6s METHANOL
DEHYDROGENASE
SUBUNIT 1
(Methylobacterium
extorquens) 		3 / 3 LYS A 497
LEU A 506
ARG A 499
 None
 0.86A 5yw0A-1w6sA:
undetectable		 5yw0A-1w6sA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_A_Y00A406_0
(BETA-1 ADRENERGIC
RECEPTOR)		 1w6s METHANOL
DEHYDROGENASE
SUBUNIT 1
(Methylobacterium
extorquens) 		5 / 12 VAL A 133
VAL A  15
SER A   8
ASN A   1
VAL A 169
 None
 1.36A 6h7lA-1w6sA:
undetectable		 6h7lA-1w6sA:
9.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_B_Y00B405_0
(BETA-1 ADRENERGIC
RECEPTOR)		 1w6s METHANOL
DEHYDROGENASE
SUBUNIT 1
(Methylobacterium
extorquens) 		5 / 12 VAL A 133
VAL A  15
SER A   8
ASN A   1
VAL A 169
 None
 1.35A 6h7lB-1w6sA:
undetectable		 6h7lB-1w6sA:
9.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_H_PCFH604_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 1w6s METHANOL
DEHYDROGENASE
SUBUNIT 1
(Methylobacterium
extorquens) 		4 / 8 GLY A 258
PHE A 281
GLY A 172
ALA A 198
 None
 0.74A 6hu9H-1w6sA:
undetectable
6hu9e-1w6sA:
undetectable		 6hu9H-1w6sA:
9.48
6hu9e-1w6sA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I5Z_D_SAMD401_0
(O-METHYLTRANSFERASE
1)		 1w6s METHANOL
DEHYDROGENASE
SUBUNIT 1
(Methylobacterium
extorquens) 		5 / 11 GLY A 557
GLY A 555
VAL A 543
MET A 438
ASP A 303
 None
None
None
None
PQQ  A1596 (-3.9A)
 1.09A 6i5zD-1w6sA:
undetectable		 6i5zD-1w6sA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N7F_A_RBFA502_0
(PUTATIVE GLUTATHIONE
REDUCTASE (GR))		 1w6s METHANOL
DEHYDROGENASE
SUBUNIT 1
(Methylobacterium
extorquens) 		4 / 7 GLY A  49
HIS A  68
GLU A  55
GLY A  53
 None
None
PQQ  A1596 (-2.7A)
None
 0.90A 6n7fA-1w6sA:
undetectable		 6n7fA-1w6sA:
9.19