SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1w6v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB8_0
(GRAMICIDIN A)		 1w6v UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15
(Homo
sapiens) 		3 / 3 TRP A  41
VAL A  60
TRP A  37
 None
 1.23A 1c4dA-1w6vA:
undetectable
1c4dB-1w6vA:
undetectable		 1c4dA-1w6vA:
6.31
1c4dB-1w6vA:
6.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_1
(PROTEIN (HIV-1
PROTEASE))		 1w6v UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15
(Homo
sapiens) 		5 / 10 LEU A 100
ASP A  10
ASP A   8
GLY A  46
PRO A  62
 None
 1.13A 1d4sA-1w6vA:
undetectable		 1d4sA-1w6vA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4P_A_TPVA300_1
(PROTEASE)		 1w6v UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15
(Homo
sapiens) 		5 / 11 LEU A 100
ASP A  10
ASP A   8
GLY A  46
PRO A  62
 None
 1.06A 2o4pA-1w6vA:
undetectable		 2o4pA-1w6vA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y5M_F_DVAF8_0
(VAL-GRAMICIDIN A)		 1w6v UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15
(Homo
sapiens) 		3 / 3 TRP A  37
VAL A  60
TRP A  41
 None
 1.03A 2y5mE-1w6vA:
undetectable
2y5mF-1w6vA:
undetectable		 2y5mE-1w6vA:
6.31
2y5mF-1w6vA:
6.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_D_DVAD8_0
(VAL-GRAMICIDIN A)		 1w6v UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15
(Homo
sapiens) 		3 / 3 TRP A  37
VAL A  60
TRP A  41
 None
 1.06A 2y6nC-1w6vA:
undetectable
2y6nD-1w6vA:
undetectable		 2y6nC-1w6vA:
6.31
2y6nD-1w6vA:
6.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_F_DVAF8_0
(VAL-GRAMICIDIN A)		 1w6v UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15
(Homo
sapiens) 		3 / 3 TRP A  37
VAL A  60
TRP A  41
 None
 1.06A 2y6nE-1w6vA:
undetectable
2y6nF-1w6vA:
undetectable		 2y6nE-1w6vA:
6.31
2y6nF-1w6vA:
6.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_2
(NEURAMINIDASE A)		 1w6v UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15
(Homo
sapiens) 		4 / 6 ASP A  15
ILE A  16
LEU A 100
GLU A  95
 None
 1.06A 2ya7B-1w6vA:
undetectable		 2ya7B-1w6vA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_2
(NEURAMINIDASE A)		 1w6v UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15
(Homo
sapiens) 		4 / 6 ASP A  15
ILE A  16
LEU A 100
GLU A  95
 None
 1.07A 2ya7D-1w6vA:
undetectable		 2ya7D-1w6vA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEG_A_BAXA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 1w6v UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15
(Homo
sapiens) 		4 / 6 VAL A  33
ILE A  16
ILE A  90
LEU A  91
 None
 0.79A 3hegA-1w6vA:
undetectable		 3hegA-1w6vA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T8N_D_EDTD135_0
(STEROID
DELTA-ISOMERASE)		 1w6v UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15
(Homo
sapiens) 		5 / 11 THR A  94
GLY A  96
PRO A  93
ARG A  25
ASP A  15
 None
 1.15A 3t8nD-1w6vA:
0.0
3t8nF-1w6vA:
undetectable		 3t8nD-1w6vA:
17.83
3t8nF-1w6vA:
17.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A3P_A_ACTA1223_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 1w6v UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15
(Homo
sapiens) 		4 / 5 ASP A  15
THR A  18
LEU A  19
LYS A  99
 None
 0.71A 4a3pA-1w6vA:
18.6		 4a3pA-1w6vA:
99.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_A_TPVA500_1
(PROTEASE)		 1w6v UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15
(Homo
sapiens) 		5 / 12 LEU A 100
ASP A  10
ASP A   8
GLY A  46
PRO A  62
 None
 1.06A 4njuA-1w6vA:
undetectable		 4njuA-1w6vA:
20.14