SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1w74'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_A_ACHA546_0
(ACETYLCHOLINESTERASE)		 1w74 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
A
(Mycobacterium
tuberculosis) 		4 / 8 TYR A  95
TYR A  66
PHE A  65
GLY A  82
 None
 1.10A 2ha4A-1w74A:
undetectable		 2ha4A-1w74A:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_1
(CYTOCHROME P450 3A4)		 1w74 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
A
(Mycobacterium
tuberculosis) 		5 / 12 PHE A 127
PHE A 107
PHE A  71
ILE A 148
ALA A  29
 None
 1.20A 3nxuB-1w74A:
undetectable		 3nxuB-1w74A:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA1001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 1w74 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
A
(Mycobacterium
tuberculosis) 		4 / 5 LEU A  30
GLY A 145
PHE A 144
PHE A  42
 None
 1.16A 3smtA-1w74A:
undetectable		 3smtA-1w74A:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZW_A_SAMA1451_0
(WBDD)		 1w74 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
A
(Mycobacterium
tuberculosis) 		5 / 12 TYR A  52
GLY A  44
PHE A  42
ASN A  41
ILE A 181
 None
 1.22A 4azwA-1w74A:
undetectable		 4azwA-1w74A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WRY_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 1w74 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
A
(Mycobacterium
tuberculosis) 		4 / 8 GLY A  91
TYR A  95
SER A 125
SER A  53
 None
 1.03A 4wryA-1w74A:
undetectable		 4wryA-1w74A:
28.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WRZ_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 1w74 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
A
(Mycobacterium
tuberculosis) 		4 / 8 GLY A  91
TYR A  95
SER A 125
SER A  53
 None
 0.97A 4wrzA-1w74A:
undetectable		 4wrzA-1w74A:
28.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WS1_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 1w74 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
A
(Mycobacterium
tuberculosis) 		4 / 8 GLY A  91
TYR A  95
SER A 125
SER A  53
 None
 1.03A 4ws1A-1w74A:
undetectable		 4ws1A-1w74A:
28.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_C_ACTC401_0
(PROTON-GATED ION
CHANNEL)		 1w74 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
A
(Mycobacterium
tuberculosis) 		4 / 7 ILE A  80
PHE A  71
VAL A 156
ILE A  26
 None
 0.97A 4zzbC-1w74A:
undetectable
4zzbD-1w74A:
undetectable		 4zzbC-1w74A:
20.51
4zzbD-1w74A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_A_BEZA301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 1w74 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
A
(Mycobacterium
tuberculosis) 		5 / 10 GLY A  94
TYR A  95
GLY A 124
SER A 125
TYR A  52
 None
 1.29A 5hwkA-1w74A:
undetectable		 5hwkA-1w74A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_B_BEZB301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 1w74 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
A
(Mycobacterium
tuberculosis) 		5 / 10 GLY A  94
TYR A  95
GLY A 124
SER A 125
TYR A  52
 None
 1.29A 5hwkB-1w74A:
undetectable		 5hwkB-1w74A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWY_A_YNUA1101_1
(MINERALOCORTICOID
RECEPTOR)		 1w74 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
A
(Mycobacterium
tuberculosis) 		4 / 6 GLN A  81
ARG A  73
THR A  54
PHE A  65
 None
 1.38A 5mwyA-1w74A:
undetectable		 5mwyA-1w74A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 1w74 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
A
(Mycobacterium
tuberculosis) 		3 / 3 THR A  14
GLU A 104
ASN A  33
 None
 0.78A 6nj9K-1w74A:
undetectable		 6nj9K-1w74A:
18.37