SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1w7p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOM_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 1w7p VPS36P, YLR417W
(Saccharomyces
cerevisiae) 		5 / 11 ALA D 412
GLU D 410
LEU D 406
PHE D 407
TYR D 444
 None
 1.04A 1jomA-1w7pD:
undetectable		 1jomA-1w7pD:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_A_FOLA605_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1w7p VPS36P, YLR417W
(Saccharomyces
cerevisiae) 		5 / 12 VAL D 495
LEU D 518
LEU D 532
ILE D 503
LEU D 545
 None
 0.98A 1qzfA-1w7pD:
undetectable		 1qzfA-1w7pD:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_B_FOLB609_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1w7p VPS36P, YLR417W
(Saccharomyces
cerevisiae) 		5 / 12 VAL D 495
LEU D 518
LEU D 532
ILE D 503
LEU D 545
 None
 0.98A 1qzfB-1w7pD:
undetectable		 1qzfB-1w7pD:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_C_FOLC613_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1w7p VPS36P, YLR417W
(Saccharomyces
cerevisiae) 		5 / 12 VAL D 495
LEU D 518
LEU D 532
ILE D 503
LEU D 545
 None
 0.98A 1qzfC-1w7pD:
undetectable		 1qzfC-1w7pD:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_D_FOLD617_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1w7p VPS36P, YLR417W
(Saccharomyces
cerevisiae) 		5 / 12 VAL D 495
LEU D 518
LEU D 532
ILE D 503
LEU D 545
 None
 0.98A 1qzfD-1w7pD:
undetectable		 1qzfD-1w7pD:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_E_FOLE621_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1w7p VPS36P, YLR417W
(Saccharomyces
cerevisiae) 		5 / 12 VAL D 495
LEU D 518
LEU D 532
ILE D 503
LEU D 545
 None
 0.99A 1qzfE-1w7pD:
undetectable		 1qzfE-1w7pD:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_C_TFPC208_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1w7p VPS22, YPL002C
(Saccharomyces
cerevisiae) 		4 / 5 PHE A  46
LEU A  54
MET A  67
SER A  69
 None
 1.20A 1wrlC-1w7pA:
undetectable		 1wrlC-1w7pA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_B_CFFB2434_1
(CHITINASE)		 1w7p VPS22, YPL002C
(Saccharomyces
cerevisiae) 		4 / 6 GLU A 120
ASP A 133
PHE A  91
ARG A  61
 None
 1.29A 2a3bB-1w7pA:
undetectable		 2a3bB-1w7pA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 1w7p VPS22, YPL002C
(Saccharomyces
cerevisiae) 		5 / 9 LEU A 119
LEU A 134
ILE A 138
PHE A 116
ILE A 114
 None
 1.23A 2f7aB-1w7pA:
undetectable		 2f7aB-1w7pA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJM_B_BJMB2_1
(DIPEPTIDYL PEPTIDASE
4)		 1w7p VPS22, YPL002C
(Saccharomyces
cerevisiae) 		5 / 12 GLU A 118
PHE A 124
SER A 160
ASN A 110
VAL A 113
 None
 1.46A 3bjmB-1w7pA:
undetectable		 3bjmB-1w7pA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		 1w7p VPS36P, YLR417W
(Saccharomyces
cerevisiae) 		4 / 8 ILE D 455
GLU D 465
LEU D 437
VAL D 487
 None
 0.85A 3ua5A-1w7pD:
undetectable		 3ua5A-1w7pD:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LA0_A_198A601_1
(SERUM ALBUMIN)		 1w7p VPS22, YPL002C
VPS36P, YLR417W
(Saccharomyces
cerevisiae) 		5 / 10 LEU D 454
PRO D 457
MET A 140
GLU A  94
LEU A  76
 None
 1.12A 4la0A-1w7pD:
undetectable		 4la0A-1w7pD:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LA0_B_198B601_1
(SERUM ALBUMIN)		 1w7p VPS22, YPL002C
VPS36P, YLR417W
(Saccharomyces
cerevisiae) 		5 / 9 LEU D 454
PRO D 457
MET A 140
GLU A  94
LEU A  76
 None
 1.32A 4la0B-1w7pD:
0.2		 4la0B-1w7pD:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_A_SAMA301_0
(PANTOTHENATE
SYNTHETASE)		 1w7p VPS22, YPL002C
VPS36P, YLR417W
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 12 GLY A 209
LEU A 210
TYR D 556
GLY A 112
LYS A 107
 None
 1.14A 5hg0A-1w7pA:
undetectable		 5hg0A-1w7pA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_A_RBFA201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 1w7p VPS36P, YLR417W
(Saccharomyces
cerevisiae) 		3 / 3 LYS D 496
LEU D 532
ILE D 503
 None
 0.78A 5kc4A-1w7pD:
undetectable		 5kc4A-1w7pD:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_0
(REGULATORY PROTEIN
TETR)		 1w7p VPS22, YPL002C
(Saccharomyces
cerevisiae) 		5 / 12 MET A  65
GLU A 120
VAL A  95
CYH A  96
PHE A 124
 None
 1.31A 5vlmB-1w7pA:
undetectable		 5vlmB-1w7pA:
23.64