SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1w8a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4Y_A_TPVA501_2
(PROTEIN (HIV-1
PROTEASE))		 1w8a SLIT PROTEIN
(Drosophila
melanogaster) 		4 / 8 GLY A 609
ILE A 610
VAL A 658
ILE A 655
 None
 0.53A 1d4yB-1w8aA:
undetectable		 1d4yB-1w8aA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1w8a SLIT PROTEIN
(Drosophila
melanogaster) 		4 / 7 GLY A 609
ILE A 610
VAL A 658
ILE A 655
 None
 0.74A 2aojB-1w8aA:
undetectable		 2aojB-1w8aA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_C_H4BC1290_1
(PTERIDINE REDUCTASE
1)		 1w8a SLIT PROTEIN
(Drosophila
melanogaster) 		4 / 8 PHE A 688
LEU A 674
LEU A 669
LEU A 666
 None
 0.95A 2bfpC-1w8aA:
undetectable		 2bfpC-1w8aA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 1w8a SLIT PROTEIN
(Drosophila
melanogaster) 		5 / 12 ASN A 677
ILE A 655
ILE A 631
VAL A 658
LEU A 648
 None
 1.20A 2ft9A-1w8aA:
undetectable		 2ft9A-1w8aA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1w8a SLIT PROTEIN
(Drosophila
melanogaster) 		5 / 12 ALA A 618
LEU A 597
LEU A 590
SER A 586
LEU A 582
 None
 1.25A 2oipB-1w8aA:
undetectable		 2oipB-1w8aA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		 1w8a SLIT PROTEIN
(Drosophila
melanogaster) 		4 / 6 LEU A 607
LEU A 582
ILE A 610
ARG A 584
 None
 1.04A 2rlfA-1w8aA:
undetectable
2rlfB-1w8aA:
undetectable		 2rlfA-1w8aA:
15.66
2rlfB-1w8aA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_C_RIMC399_1
(MATRIX PROTEIN 2)		 1w8a SLIT PROTEIN
(Drosophila
melanogaster) 		4 / 6 LEU A 607
LEU A 582
ILE A 610
ARG A 584
 None
 0.95A 2rlfC-1w8aA:
undetectable
2rlfD-1w8aA:
undetectable		 2rlfC-1w8aA:
15.66
2rlfD-1w8aA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_D_NCTD501_1
(CYTOCHROME P450 2A6)		 1w8a SLIT PROTEIN
(Drosophila
melanogaster) 		4 / 7 GLY A 609
ILE A 634
LEU A 650
PHE A 639
 None
 0.89A 4ejjD-1w8aA:
undetectable		 4ejjD-1w8aA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 1w8a SLIT PROTEIN
(Drosophila
melanogaster) 		4 / 4 ASN A 580
GLY A 558
ASP A 542
ASP A 555
 None
 1.28A 4n49A-1w8aA:
undetectable		 4n49A-1w8aA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_C_MTXC604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1w8a SLIT PROTEIN
(Drosophila
melanogaster) 		5 / 12 ALA A 618
LEU A 597
LEU A 590
SER A 586
LEU A 582
 None
 1.28A 4q0dC-1w8aA:
undetectable		 4q0dC-1w8aA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_D_MTXD604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1w8a SLIT PROTEIN
(Drosophila
melanogaster) 		5 / 12 ALA A 618
LEU A 597
LEU A 590
SER A 586
LEU A 582
 None
 1.28A 4q0dD-1w8aA:
undetectable		 4q0dD-1w8aA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_1
(TUBULIN BETA CHAIN)		 1w8a SLIT PROTEIN
(Drosophila
melanogaster) 		5 / 12 GLU A 616
LEU A 602
LEU A 577
ALA A 614
LEU A 642
 None
 1.06A 6ew0B-1w8aA:
undetectable		 6ew0B-1w8aA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_1
(TUBULIN BETA CHAIN)		 1w8a SLIT PROTEIN
(Drosophila
melanogaster) 		5 / 12 GLU A 616
LEU A 602
LEU A 577
ALA A 614
LEU A 642
 None
 1.06A 6ew0D-1w8aA:
undetectable		 6ew0D-1w8aA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_1
(TUBULIN BETA CHAIN)		 1w8a SLIT PROTEIN
(Drosophila
melanogaster) 		5 / 12 GLU A 616
LEU A 602
LEU A 577
ALA A 614
LEU A 642
 None
 1.06A 6ew0H-1w8aA:
undetectable		 6ew0H-1w8aA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_1
(TUBULIN BETA CHAIN)		 1w8a SLIT PROTEIN
(Drosophila
melanogaster) 		5 / 12 GLU A 616
LEU A 602
LEU A 577
ALA A 614
LEU A 642
 None
 1.07A 6ew0I-1w8aA:
undetectable		 6ew0I-1w8aA:
15.79