SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1w8d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_0
(FTSJ)		 1w8d 2,4-DIENOYL-COA
REDUCTASE,
MITOCHONDRIAL
PRECURSOR
(Homo
sapiens) 		5 / 12 GLY A  74
GLY A  67
GLY A  66
LEU A  78
LEU A  79
 None
None
NAP  A1330 (-3.5A)
None
None
 1.00A 1eizA-1w8dA:
9.4		 1eizA-1w8dA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_0
(FTSJ)		 1w8d 2,4-DIENOYL-COA
REDUCTASE,
MITOCHONDRIAL
PRECURSOR
(Homo
sapiens) 		5 / 12 GLY A  74
GLY A  67
GLY A  66
LEU A  78
LEU A  79
 None
None
NAP  A1330 (-3.5A)
None
None
 1.00A 1ej0A-1w8dA:
9.3		 1ej0A-1w8dA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 1w8d 2,4-DIENOYL-COA
REDUCTASE,
MITOCHONDRIAL
PRECURSOR
(Homo
sapiens) 		4 / 6 ILE A 114
VAL A 274
ILE A 195
ILE A 243
 None
None
NAP  A1330 (-4.2A)
NAP  A1330 (-4.0A)
 0.85A 1uwhB-1w8dA:
undetectable		 1uwhB-1w8dA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_B_SAMB4001_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 1w8d 2,4-DIENOYL-COA
REDUCTASE,
MITOCHONDRIAL
PRECURSOR
(Homo
sapiens) 		5 / 12 GLY A  66
GLY A  68
ASP A 117
VAL A 118
ILE A 167
 NAP  A1330 (-3.5A)
None
NAP  A1330 (-3.2A)
NAP  A1330 (-3.5A)
NAP  A1330 (-4.1A)
 0.79A 1zq9B-1w8dA:
5.8		 1zq9B-1w8dA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		 1w8d 2,4-DIENOYL-COA
REDUCTASE,
MITOCHONDRIAL
PRECURSOR
(Homo
sapiens) 		4 / 8 LEU A 131
ILE A 179
GLY A 189
LYS A 188
 None
 0.97A 3b9lA-1w8dA:
undetectable		 3b9lA-1w8dA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_B_DXCB92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1w8d 2,4-DIENOYL-COA
REDUCTASE,
MITOCHONDRIAL
PRECURSOR
(Homo
sapiens) 		4 / 5 VAL A 124
VAL A 128
LYS A 185
LYS A 181
 None
 1.25A 3rv5A-1w8dA:
undetectable
3rv5B-1w8dA:
undetectable		 3rv5A-1w8dA:
14.90
3rv5B-1w8dA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_B_RGZB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 1w8d 2,4-DIENOYL-COA
REDUCTASE,
MITOCHONDRIAL
PRECURSOR
(Homo
sapiens) 		5 / 12 PRO A 240
LEU A 277
LEU A 280
LEU A 284
CYH A 285
 NAP  A1330 (-4.5A)
None
None
None
None
 1.08A 4a7aB-1w8dA:
3.4		 4a7aB-1w8dA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1w8d 2,4-DIENOYL-COA
REDUCTASE,
MITOCHONDRIAL
PRECURSOR
(Homo
sapiens) 		4 / 6 GLY A  68
GLY A  67
ASN A 144
ILE A 103
 None
None
NAP  A1330 (-3.2A)
None
 0.74A 4fglD-1w8dA:
7.2		 4fglD-1w8dA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_D_QDND602_1
(CYTOCHROME P450 2D6)		 1w8d 2,4-DIENOYL-COA
REDUCTASE,
MITOCHONDRIAL
PRECURSOR
(Homo
sapiens) 		5 / 10 PHE A  57
LEU A  82
ALA A 282
SER A 286
ALA A 289
 GOL  A1329 ( 4.2A)
None
None
GOL  A1329 (-4.3A)
None
 1.31A 4wnuD-1w8dA:
undetectable		 4wnuD-1w8dA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_A_SAMA304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 1w8d 2,4-DIENOYL-COA
REDUCTASE,
MITOCHONDRIAL
PRECURSOR
(Homo
sapiens) 		5 / 12 THR A  76
GLY A  67
GLN A 102
LEU A  96
ALA A 100
 None
 1.03A 5l0zA-1w8dA:
2.2		 5l0zA-1w8dA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 1w8d 2,4-DIENOYL-COA
REDUCTASE,
MITOCHONDRIAL
PRECURSOR
(Homo
sapiens) 		4 / 7 LEU A 224
ASN A 143
VAL A 141
GLU A 218
 None
 1.10A 5tudA-1w8dA:
0.0		 5tudA-1w8dA:
23.11