SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1w8g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_B_TESB904_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 1w8g HYPOTHETICAL UPF0001
PROTEIN YGGS
(Escherichia
coli) 		4 / 7 VAL A  63
ILE A  66
HIS A 101
LEU A  32
 None
 1.00A 1j96B-1w8gA:
5.6		 1j96B-1w8gA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OM5_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1w8g HYPOTHETICAL UPF0001
PROTEIN YGGS
(Escherichia
coli) 		4 / 8 TRP A  99
TRP A  79
PHE A  97
GLU A  78
 None
 1.15A 1om5A-1w8gA:
undetectable
1om5B-1w8gA:
undetectable		 1om5A-1w8gA:
20.28
1om5B-1w8gA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1w8g HYPOTHETICAL UPF0001
PROTEIN YGGS
(Escherichia
coli) 		4 / 8 TRP A  99
TRP A  79
PHE A  97
GLU A  78
 None
 1.14A 1rs6A-1w8gA:
undetectable
1rs6B-1w8gA:
undetectable		 1rs6A-1w8gA:
20.28
1rs6B-1w8gA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G6H_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1w8g HYPOTHETICAL UPF0001
PROTEIN YGGS
(Escherichia
coli) 		4 / 8 TRP A  99
TRP A  79
PHE A  97
GLU A  78
 None
 1.17A 2g6hA-1w8gA:
undetectable
2g6hB-1w8gA:
undetectable		 2g6hA-1w8gA:
19.24
2g6hB-1w8gA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1w8g HYPOTHETICAL UPF0001
PROTEIN YGGS
(Escherichia
coli) 		4 / 6 GLY A  76
GLY A  50
GLN A  51
PHE A  54
 None
 0.92A 2qx6A-1w8gA:
undetectable
2qx6B-1w8gA:
undetectable		 2qx6A-1w8gA:
20.63
2qx6B-1w8gA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B3P_B_H4BB760_1
(NITRIC-OXIDE
SYNTHASE)		 1w8g HYPOTHETICAL UPF0001
PROTEIN YGGS
(Escherichia
coli) 		4 / 8 TRP A  99
TRP A  79
PHE A  97
GLU A  78
 None
 1.09A 3b3pA-1w8gA:
undetectable
3b3pB-1w8gA:
undetectable		 3b3pA-1w8gA:
20.23
3b3pB-1w8gA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_D_H4BD3902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1w8g HYPOTHETICAL UPF0001
PROTEIN YGGS
(Escherichia
coli) 		4 / 8 TRP A  99
TRP A  79
PHE A  97
GLU A  78
 None
 1.16A 3e7gC-1w8gA:
undetectable
3e7gD-1w8gA:
undetectable		 3e7gC-1w8gA:
21.21
3e7gD-1w8gA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLQ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1w8g HYPOTHETICAL UPF0001
PROTEIN YGGS
(Escherichia
coli) 		4 / 8 TRP A  99
TRP A  79
PHE A  97
GLU A  78
 None
 1.14A 3nlqA-1w8gA:
undetectable
3nlqB-1w8gA:
undetectable		 3nlqA-1w8gA:
20.23
3nlqB-1w8gA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROX_A_TEPA266_1
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 1w8g HYPOTHETICAL UPF0001
PROTEIN YGGS
(Escherichia
coli) 		4 / 8 ALA A 149
VAL A 152
LEU A 158
LEU A 126
 None
 0.84A 3roxA-1w8gA:
undetectable		 3roxA-1w8gA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_B_TYLB1187_1
(BROMODOMAIN
CONTAINING 2)		 1w8g HYPOTHETICAL UPF0001
PROTEIN YGGS
(Escherichia
coli) 		4 / 5 VAL A 152
LEU A 155
LEU A 158
ILE A 108
 None
None
None
ICT  A1230 ( 4.2A)
 0.89A 4a9jB-1w8gA:
undetectable		 4a9jB-1w8gA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_C_TYLC1184_1
(BROMODOMAIN
CONTAINING 2)		 1w8g HYPOTHETICAL UPF0001
PROTEIN YGGS
(Escherichia
coli) 		4 / 5 VAL A 152
LEU A 155
LEU A 158
ILE A 108
 None
None
None
ICT  A1230 ( 4.2A)
 0.79A 4a9jC-1w8gA:
undetectable		 4a9jC-1w8gA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWX_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1w8g HYPOTHETICAL UPF0001
PROTEIN YGGS
(Escherichia
coli) 		4 / 7 TRP A  99
TRP A  79
PHE A  97
GLU A  78
 None
 1.16A 4cwxA-1w8gA:
0.0
4cwxB-1w8gA:
0.3		 4cwxA-1w8gA:
21.90
4cwxB-1w8gA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWY_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1w8g HYPOTHETICAL UPF0001
PROTEIN YGGS
(Escherichia
coli) 		4 / 7 TRP A  99
TRP A  79
PHE A  97
GLU A  78
 None
 1.17A 4cwyA-1w8gA:
0.1
4cwyB-1w8gA:
0.3		 4cwyA-1w8gA:
21.90
4cwyB-1w8gA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWY_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1w8g HYPOTHETICAL UPF0001
PROTEIN YGGS
(Escherichia
coli) 		4 / 7 TRP A  99
TRP A  79
PHE A  97
GLU A  78
 None
 1.16A 4cwyA-1w8gA:
0.1
4cwyB-1w8gA:
0.3		 4cwyA-1w8gA:
21.90
4cwyB-1w8gA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LZR_A_LOCA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 1w8g HYPOTHETICAL UPF0001
PROTEIN YGGS
(Escherichia
coli) 		4 / 8 VAL A 152
LEU A 155
LEU A 158
ILE A 108
 None
None
None
ICT  A1230 ( 4.2A)
 0.81A 4lzrA-1w8gA:
undetectable		 4lzrA-1w8gA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCH_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1w8g HYPOTHETICAL UPF0001
PROTEIN YGGS
(Escherichia
coli) 		4 / 8 TRP A  99
TRP A  79
PHE A  97
GLU A  78
 None
 1.17A 4uchA-1w8gA:
undetectable
4uchB-1w8gA:
undetectable		 4uchA-1w8gA:
19.44
4uchB-1w8gA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3W_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1w8g HYPOTHETICAL UPF0001
PROTEIN YGGS
(Escherichia
coli) 		4 / 7 TRP A  99
TRP A  79
PHE A  97
GLU A  78
 None
 1.10A 4v3wA-1w8gA:
undetectable
4v3wB-1w8gA:
undetectable		 4v3wA-1w8gA:
20.23
4v3wB-1w8gA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_A_SALA801_1
(PROTEIN POLYBROMO-1)		 1w8g HYPOTHETICAL UPF0001
PROTEIN YGGS
(Escherichia
coli) 		4 / 7 ILE A  29
LEU A 200
ALA A 211
ILE A 212
 None
 0.82A 4y03A-1w8gA:
undetectable		 4y03A-1w8gA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CPR_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 1w8g HYPOTHETICAL UPF0001
PROTEIN YGGS
(Escherichia
coli) 		3 / 3 HIS A 101
SER A 138
ASN A  57
 None
None
PLP  A1229 (-3.0A)
 0.88A 5cprB-1w8gA:
undetectable		 5cprB-1w8gA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_C_08JC602_1
(CYTOCHROME P450 3A4)		 1w8g HYPOTHETICAL UPF0001
PROTEIN YGGS
(Escherichia
coli) 		4 / 7 LEU A 155
ALA A 151
ILE A 127
LEU A 160
 None
 0.85A 5te8C-1w8gA:
undetectable		 5te8C-1w8gA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVD_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1w8g HYPOTHETICAL UPF0001
PROTEIN YGGS
(Escherichia
coli) 		4 / 7 TRP A  99
TRP A  79
PHE A  97
GLU A  78
 None
 1.12A 5vvdA-1w8gA:
0.0
5vvdB-1w8gA:
0.0		 5vvdA-1w8gA:
20.98
5vvdB-1w8gA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1w8g HYPOTHETICAL UPF0001
PROTEIN YGGS
(Escherichia
coli) 		4 / 7 TRP A  99
TRP A  79
PHE A  97
GLU A  78
 None
 1.15A 6auuA-1w8gA:
undetectable
6auuB-1w8gA:
undetectable		 6auuA-1w8gA:
17.84
6auuB-1w8gA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_B_ACTB804_0
(UNCHARACTERIZED
PROTEIN)		 1w8g HYPOTHETICAL UPF0001
PROTEIN YGGS
(Escherichia
coli) 		4 / 4 HIS A  68
VAL A  74
LEU A  72
ALA A  44
 None
 1.30A 6d8pB-1w8gA:
undetectable		 6d8pB-1w8gA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_D_ZOLD401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 1w8g HYPOTHETICAL UPF0001
PROTEIN YGGS
(Escherichia
coli) 		4 / 7 LEU A 120
ASP A  98
ARG A 116
GLN A  70
 None
 1.20A 6g31D-1w8gA:
undetectable		 6g31D-1w8gA:
16.46