SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1w8i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1w8i PUTATIVE VAPC
RIBONUCLEASE AF_1683
(Archaeoglobus
fulgidus) 		4 / 7 ILE A 154
PHE A  10
PHE A  63
LYS A  62
 None
 0.81A 3em0B-1w8iA:
undetectable		 3em0B-1w8iA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA4_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1w8i PUTATIVE VAPC
RIBONUCLEASE AF_1683
(Archaeoglobus
fulgidus) 		3 / 3 LEU A  58
PRO A  59
LEU A  53
 None
 0.53A 3hcrA-1w8iA:
undetectable		 3hcrA-1w8iA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 1w8i PUTATIVE VAPC
RIBONUCLEASE AF_1683
(Archaeoglobus
fulgidus) 		5 / 12 SER A 106
GLU A  48
VAL A  68
ILE A  75
ASN A  43
 None
 1.37A 3jayA-1w8iA:
undetectable		 3jayA-1w8iA:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1w8i PUTATIVE VAPC
RIBONUCLEASE AF_1683
(Archaeoglobus
fulgidus) 		4 / 8 ILE A 129
GLY A 130
PHE A  99
ASP A   6
 None
 0.89A 5hieD-1w8iA:
undetectable		 5hieD-1w8iA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NN4_A_SC2A1016_1
(LYSOSOMAL
ALPHA-GLUCOSIDASE)		 1w8i PUTATIVE VAPC
RIBONUCLEASE AF_1683
(Archaeoglobus
fulgidus) 		4 / 4 HIS A  20
GLY A 130
ARG A 131
THR A 128
 None
 1.37A 5nn4A-1w8iA:
undetectable		 5nn4A-1w8iA:
10.04