SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1w8j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		 1w8j MYOSIN VA
(Gallus
gallus) 		4 / 5 LEU A  77
SER A  96
LEU A  98
GLY A  70
 None
 0.82A 1a4lB-1w8jA:
undetectable		 1a4lB-1w8jA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_A_DVAA8_0
(GRAMICIDIN A)		 1w8j MYOSIN VA
(Gallus
gallus) 		3 / 3 VAL A  85
TRP A  22
TRP A  14
 None
 1.14A 1c4dA-1w8jA:
undetectable
1c4dB-1w8jA:
undetectable		 1c4dA-1w8jA:
3.07
1c4dB-1w8jA:
3.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMI_A_BHSA1610_1
(NITRIC OXIDE
SYNTHASE)		 1w8j MYOSIN VA
(Gallus
gallus) 		4 / 8 SER A 158
VAL A 435
ALA A 146
PHE A 228
 None
 1.10A 1dmiA-1w8jA:
0.0
1dmiB-1w8jA:
0.0		 1dmiA-1w8jA:
19.79
1dmiB-1w8jA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_2
(TRANSTHYRETIN)		 1w8j MYOSIN VA
(Gallus
gallus) 		4 / 7 LEU A 735
LEU A 732
THR A 727
VAL A 720
 None
 0.79A 1dvxB-1w8jA:
undetectable		 1dvxB-1w8jA:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZM_B_BZMB600_0
(ODORANT-BINDING
PROTEIN)		 1w8j MYOSIN VA
(Gallus
gallus) 		5 / 9 ILE A 226
VAL A 416
ASN A 420
ASN A 238
GLY A 434
 None
 1.38A 1dzmB-1w8jA:
0.0		 1dzmB-1w8jA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K6C_B_MK1B902_2
(POL POLYPROTEIN)		 1w8j MYOSIN VA
(Gallus
gallus) 		5 / 12 GLY A 236
ALA A 237
GLY A 434
ILE A 433
VAL A 196
 None
 0.92A 1k6cB-1w8jA:
undetectable		 1k6cB-1w8jA:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQW_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN)		 1w8j MYOSIN VA
(Gallus
gallus) 		5 / 12 PHE A 340
ILE A 391
VAL A 579
LEU A 357
ILE A 350
 None
 1.12A 1kqwA-1w8jA:
undetectable		 1kqwA-1w8jA:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7J_A_478A200_1
(POL POLYPROTEIN)		 1w8j MYOSIN VA
(Gallus
gallus) 		5 / 11 GLY A 236
ALA A 237
GLY A 434
ILE A 433
VAL A 196
 None
 0.81A 1t7jA-1w8jA:
undetectable		 1t7jA-1w8jA:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_B_SAMB301_0
(HYPOTHETICAL PROTEIN
PH0226)		 1w8j MYOSIN VA
(Gallus
gallus) 		5 / 12 TYR A 658
ILE A 438
SER A 162
ILE A 433
SER A 158
 None
 1.06A 1ve3B-1w8jA:
undetectable		 1ve3B-1w8jA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B60_B_RITB100_1
(GAG-POL POLYPROTEIN)		 1w8j MYOSIN VA
(Gallus
gallus) 		5 / 12 ARG A 178
GLY A 236
ALA A 237
GLY A 434
ILE A 433
 None
 0.76A 2b60A-1w8jA:
undetectable		 2b60A-1w8jA:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2002_1
(SERUM ALBUMIN)		 1w8j MYOSIN VA
(Gallus
gallus) 		5 / 11 ILE A 261
PHE A 412
TYR A 408
ARG A 248
GLY A 207
 None
 1.24A 2bxmA-1w8jA:
1.1		 2bxmA-1w8jA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_IMNA2003_1
(SERUM ALBUMIN)		 1w8j MYOSIN VA
(Gallus
gallus) 		5 / 10 ILE A 261
PHE A 412
TYR A 408
ARG A 248
GLY A 207
 None
 1.30A 2bxqA-1w8jA:
0.0		 2bxqA-1w8jA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FL5_F_RBFF204_1
(IMMUNOGLOBULIN IGG1
LAMBDA LIGHT CHAIN
IMMUNOGLOBULIN IGG1
HEAVY CHAIN)		 1w8j MYOSIN VA
(Gallus
gallus) 		4 / 8 TYR A 439
ASN A 455
GLU A 450
VAL A 557
 None
 1.16A 2fl5E-1w8jA:
undetectable
2fl5F-1w8jA:
0.0		 2fl5E-1w8jA:
14.62
2fl5F-1w8jA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1358_1
(PROSTAGLANDIN
REDUCTASE 2)		 1w8j MYOSIN VA
(Gallus
gallus) 		4 / 6 ASP A 738
PHE A 751
TYR A 742
LEU A 759
 None
 1.21A 2w98A-1w8jA:
undetectable
2w98B-1w8jA:
undetectable		 2w98A-1w8jA:
19.10
2w98B-1w8jA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X0P_A_ADNA1607_1
(ALCALIGIN
BIOSYNTHESIS PROTEIN)		 1w8j MYOSIN VA
(Gallus
gallus) 		5 / 8 GLY A 163
ILE A 454
ASN A 458
ALA A 167
GLU A 164
 None
 1.49A 2x0pA-1w8jA:
undetectable		 2x0pA-1w8jA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1414_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 1w8j MYOSIN VA
(Gallus
gallus) 		4 / 8 LEU A 592
ILE A 407
LEU A 411
LEU A 588
 None
 0.65A 2xfhA-1w8jA:
undetectable		 2xfhA-1w8jA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL4_A_ROCA100_1
(PROTEASE)		 1w8j MYOSIN VA
(Gallus
gallus) 		5 / 12 GLY A 236
ALA A 237
GLY A 434
ILE A 433
VAL A 196
 None
 0.92A 3el4A-1w8jA:
undetectable		 3el4A-1w8jA:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL5_B_1UNB201_2
(PROTEASE)		 1w8j MYOSIN VA
(Gallus
gallus) 		5 / 12 GLY A 236
ALA A 237
GLY A 434
ILE A 433
VAL A 196
 None
 0.89A 3el5B-1w8jA:
undetectable		 3el5B-1w8jA:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1w8j MYOSIN VA
(Gallus
gallus) 		3 / 3 ILE A 332
PHE A 360
HIS A 406
 None
 0.74A 3h0aA-1w8jA:
0.8		 3h0aA-1w8jA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1w8j MYOSIN VA
(Gallus
gallus) 		4 / 8 LEU A 651
LEU A 243
TYR A 242
ILE A 160
 None
 0.87A 3ln1A-1w8jA:
undetectable		 3ln1A-1w8jA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_D_9PLD501_1
(CYTOCHROME P450 2A6)		 1w8j MYOSIN VA
(Gallus
gallus) 		5 / 10 PHE A 228
PHE A 180
ASN A 156
ILE A 433
GLY A 434
 None
 1.34A 3t3rD-1w8jA:
undetectable		 3t3rD-1w8jA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A201_1
(POL POLYPROTEIN)		 1w8j MYOSIN VA
(Gallus
gallus) 		5 / 9 GLY A 236
ALA A 237
GLY A 434
ILE A 433
VAL A 196
 None
 0.94A 3u7sA-1w8jA:
undetectable		 3u7sA-1w8jA:
8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A202_2
(POL POLYPROTEIN)		 1w8j MYOSIN VA
(Gallus
gallus) 		5 / 9 GLY A 236
ALA A 237
GLY A 434
ILE A 433
VAL A 196
 None
 0.99A 3u7sB-1w8jA:
undetectable		 3u7sB-1w8jA:
8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_2
(ADENOSINE KINASE,
PUTATIVE)		 1w8j MYOSIN VA
(Gallus
gallus) 		4 / 5 LEU A 279
GLY A 280
PHE A 262
ASN A 337
 None
 1.17A 3uq6B-1w8jA:
undetectable		 3uq6B-1w8jA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V7P_A_BEZA430_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 1w8j MYOSIN VA
(Gallus
gallus) 		4 / 7 ILE A 332
GLY A 331
PHE A 593
LEU A 580
 None
 0.90A 3v7pA-1w8jA:
undetectable		 3v7pA-1w8jA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF2_A_4CHA506_0
(NADPH DEHYDROGENASE)		 1w8j MYOSIN VA
(Gallus
gallus) 		4 / 6 HIS A 468
HIS A 657
TYR A 658
TYR A 223
 None
 1.46A 4df2A-1w8jA:
undetectable		 4df2A-1w8jA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_B_1LDB501_0
(CYTOSINE DEAMINASE)		 1w8j MYOSIN VA
(Gallus
gallus) 		5 / 12 LEU A 682
PHE A 673
ILE A 110
GLU A  82
LEU A 688
 None
 1.28A 4r88B-1w8jA:
undetectable		 4r88B-1w8jA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_C_1LDC501_0
(CYTOSINE DEAMINASE)		 1w8j MYOSIN VA
(Gallus
gallus) 		5 / 12 LEU A 682
PHE A 673
ILE A 110
GLU A  82
LEU A 688
 None
 1.29A 4r88C-1w8jA:
undetectable		 4r88C-1w8jA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_D_1LDD501_0
(CYTOSINE DEAMINASE)		 1w8j MYOSIN VA
(Gallus
gallus) 		5 / 12 LEU A 682
PHE A 673
ILE A 110
GLU A  82
LEU A 688
 None
 1.28A 4r88D-1w8jA:
undetectable		 4r88D-1w8jA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_F_1LDF502_0
(CYTOSINE DEAMINASE)		 1w8j MYOSIN VA
(Gallus
gallus) 		5 / 12 LEU A 682
PHE A 673
ILE A 110
GLU A  82
LEU A 688
 None
 1.29A 4r88F-1w8jA:
undetectable		 4r88F-1w8jA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_B_DM2B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1w8j MYOSIN VA
(Gallus
gallus) 		5 / 11 VAL A 572
GLN A 576
PHE A 340
GLY A 336
ILE A 332
 None
 1.35A 4zvmA-1w8jA:
undetectable
4zvmB-1w8jA:
undetectable		 4zvmA-1w8jA:
15.87
4zvmB-1w8jA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_2
(TUBULIN BETA-2B
CHAIN)		 1w8j MYOSIN VA
(Gallus
gallus) 		3 / 3 LEU A 265
LEU A 333
ARG A 219
 None
 0.58A 5hnzB-1w8jA:
undetectable		 5hnzB-1w8jA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_B_ACTB713_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 1w8j MYOSIN VA
(Gallus
gallus) 		3 / 3 GLY A 163
GLN A 681
LYS A 169
 None
 0.96A 5imsB-1w8jA:
undetectable		 5imsB-1w8jA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR1_B_017B101_2
(PROTEASE PR5-DRV)		 1w8j MYOSIN VA
(Gallus
gallus) 		5 / 8 ALA A 173
ASP A 437
VAL A 161
GLY A 434
ILE A 433
 None
 1.50A 5kr1B-1w8jA:
undetectable		 5kr1B-1w8jA:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_2
(CYTOCHROME P450 3A4)		 1w8j MYOSIN VA
(Gallus
gallus) 		4 / 6 PHE A 470
PHE A 465
ILE A 693
THR A 690
 None
 1.14A 5vceA-1w8jA:
undetectable		 5vceA-1w8jA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_1
(CYTOCHROME P450 3A5)		 1w8j MYOSIN VA
(Gallus
gallus) 		5 / 12 PHE A  93
PHE A 673
ILE A 662
ALA A 109
GLY A  70
 None
 1.05A 5veuA-1w8jA:
0.4		 5veuA-1w8jA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_1
(CYTOCHROME P450 3A5)		 1w8j MYOSIN VA
(Gallus
gallus) 		5 / 12 PHE A  93
PHE A 673
ILE A 662
ALA A 109
GLY A  70
 None
 1.06A 5veuH-1w8jA:
0.0		 5veuH-1w8jA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA504_1
(CYTOCHROME P450 2C9)		 1w8j MYOSIN VA
(Gallus
gallus) 		4 / 8 ILE A 105
PHE A 465
ASN A 466
THR A  75
 None
 0.83A 5x23A-1w8jA:
undetectable		 5x23A-1w8jA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEO_A_DHIA4_0
((DPR)PY(DHI)PKDL(DGN
))		 1w8j MYOSIN VA
(Gallus
gallus) 		3 / 3 TYR A  79
PRO A  65
LEU A  68
 None
 0.67A 6beoA-1w8jA:
undetectable		 6beoA-1w8jA:
2.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPL_B_PA1B605_1
(LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA)		 1w8j MYOSIN VA
(Gallus
gallus) 		3 / 3 ARG A 213
ARG A 683
ARG A 677
 None
 1.09A 6bplA-1w8jA:
1.1
6bplB-1w8jA:
undetectable		 6bplA-1w8jA:
6.82
6bplB-1w8jA:
6.82