SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1w8o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_A_ZMRA466_1
(NEURAMINIDASE)		 1w8o BACTERIAL SIALIDASE
(Micromonospora
viridifaciens) 		5 / 12 ARG A  68
GLU A 260
ARG A 276
ARG A 342
TYR A 370
 CIT  A1649 ( 2.6A)
GOL  A1651 (-3.6A)
CIT  A1649 ( 2.7A)
CIT  A1649 ( 2.9A)
CIT  A1649 (-4.5A)
 0.32A 1a4gA-1w8oA:
25.8		 1a4gA-1w8oA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_B_ZMRB466_1
(NEURAMINIDASE)		 1w8o BACTERIAL SIALIDASE
(Micromonospora
viridifaciens) 		5 / 12 ARG A  68
GLU A 260
ARG A 276
ARG A 342
TYR A 370
 CIT  A1649 ( 2.6A)
GOL  A1651 (-3.6A)
CIT  A1649 ( 2.7A)
CIT  A1649 ( 2.9A)
CIT  A1649 (-4.5A)
 0.35A 1a4gB-1w8oA:
25.7		 1a4gB-1w8oA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_0
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 1w8o BACTERIAL SIALIDASE
(Micromonospora
viridifaciens) 		6 / 12 VAL A 359
ASN A 492
GLY A 452
THR A 485
ALA A 484
LEU A 442
 None
 1.44A 1jg4A-1w8oA:
undetectable		 1jg4A-1w8oA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHQ_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1w8o BACTERIAL SIALIDASE
(Micromonospora
viridifaciens) 		4 / 8 GLY A 293
GLY A 215
LEU A 212
GLY A 269
 None
 0.76A 1jhqA-1w8oA:
undetectable		 1jhqA-1w8oA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NNC_A_ZMRA479_1
(NEURAMINIDASE N9)		 1w8o BACTERIAL SIALIDASE
(Micromonospora
viridifaciens) 		5 / 12 ARG A  68
GLU A 260
ARG A 276
ARG A 342
TYR A 370
 CIT  A1649 ( 2.6A)
GOL  A1651 (-3.6A)
CIT  A1649 ( 2.7A)
CIT  A1649 ( 2.9A)
CIT  A1649 (-4.5A)
 0.50A 1nncA-1w8oA:
21.7		 1nncA-1w8oA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OT7_B_IU5B1002_1
(BILE ACID RECEPTOR)		 1w8o BACTERIAL SIALIDASE
(Micromonospora
viridifaciens) 		5 / 12 LEU A 212
ARG A 270
SER A 289
ILE A 222
TYR A 296
 None
 1.31A 1ot7B-1w8oA:
undetectable		 1ot7B-1w8oA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PJ7_A_FFOA2887_1
(N,N-DIMETHYLGLYCINE
OXIDASE)		 1w8o BACTERIAL SIALIDASE
(Micromonospora
viridifaciens) 		3 / 3 ASP A 412
THR A 500
GLU A 642
 None
 0.83A 1pj7A-1w8oA:
undetectable		 1pj7A-1w8oA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RD7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1w8o BACTERIAL SIALIDASE
(Micromonospora
viridifaciens) 		5 / 12 ALA A 612
LEU A 641
THR A 587
LEU A 558
ILE A 564
 None
 0.99A 1rd7A-1w8oA:
undetectable		 1rd7A-1w8oA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_4
(POL POLYPROTEIN)		 1w8o BACTERIAL SIALIDASE
(Micromonospora
viridifaciens) 		3 / 3 ARG A 200
VAL A 148
GLY A  95
 None
 0.32A 2avvE-1w8oA:
undetectable		 2avvE-1w8oA:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1477_1
(NEURAMINIDASE)		 1w8o BACTERIAL SIALIDASE
(Micromonospora
viridifaciens) 		5 / 12 ARG A  68
GLU A 260
ARG A 276
ARG A 342
TYR A 370
 CIT  A1649 ( 2.6A)
GOL  A1651 (-3.6A)
CIT  A1649 ( 2.7A)
CIT  A1649 ( 2.9A)
CIT  A1649 (-4.5A)
 0.43A 2cmlA-1w8oA:
21.8		 2cmlA-1w8oA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2477_1
(NEURAMINIDASE)		 1w8o BACTERIAL SIALIDASE
(Micromonospora
viridifaciens) 		5 / 12 ARG A  68
GLU A 260
ARG A 276
ARG A 342
TYR A 370
 CIT  A1649 ( 2.6A)
GOL  A1651 (-3.6A)
CIT  A1649 ( 2.7A)
CIT  A1649 ( 2.9A)
CIT  A1649 (-4.5A)
 0.45A 2cmlB-1w8oA:
22.0		 2cmlB-1w8oA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3477_1
(NEURAMINIDASE)		 1w8o BACTERIAL SIALIDASE
(Micromonospora
viridifaciens) 		5 / 12 ARG A  68
GLU A 260
ARG A 276
ARG A 342
TYR A 370
 CIT  A1649 ( 2.6A)
GOL  A1651 (-3.6A)
CIT  A1649 ( 2.7A)
CIT  A1649 ( 2.9A)
CIT  A1649 (-4.5A)
 0.46A 2cmlC-1w8oA:
21.9		 2cmlC-1w8oA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4477_1
(NEURAMINIDASE)		 1w8o BACTERIAL SIALIDASE
(Micromonospora
viridifaciens) 		5 / 12 ARG A  68
GLU A 260
ARG A 276
ARG A 342
TYR A 370
 CIT  A1649 ( 2.6A)
GOL  A1651 (-3.6A)
CIT  A1649 ( 2.7A)
CIT  A1649 ( 2.9A)
CIT  A1649 (-4.5A)
 0.46A 2cmlD-1w8oA:
22.1		 2cmlD-1w8oA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F0Z_A_ZMRA381_1
(SIALIDASE 2)		 1w8o BACTERIAL SIALIDASE
(Micromonospora
viridifaciens) 		5 / 12 ARG A  68
GLU A 260
ARG A 276
ARG A 342
TYR A 370
 CIT  A1649 ( 2.6A)
GOL  A1651 (-3.6A)
CIT  A1649 ( 2.7A)
CIT  A1649 ( 2.9A)
CIT  A1649 (-4.5A)
 0.34A 2f0zA-1w8oA:
43.7		 2f0zA-1w8oA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F10_A_BCZA382_0
(SIALIDASE 2)		 1w8o BACTERIAL SIALIDASE
(Micromonospora
viridifaciens) 		7 / 12 ARG A  68
ILE A  69
ARG A  87
GLU A 260
ARG A 276
ARG A 342
TYR A 370
 CIT  A1649 ( 2.6A)
None
CIT  A1649 (-3.0A)
GOL  A1651 (-3.6A)
CIT  A1649 ( 2.7A)
CIT  A1649 ( 2.9A)
CIT  A1649 (-4.5A)
 0.42A 2f10A-1w8oA:
43.2		 2f10A-1w8oA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HTQ_A_ZMRA472_1
(NEURAMINIDASE)		 1w8o BACTERIAL SIALIDASE
(Micromonospora
viridifaciens) 		5 / 12 ARG A  68
GLU A 260
ARG A 276
ARG A 342
TYR A 370
 CIT  A1649 ( 2.6A)
GOL  A1651 (-3.6A)
CIT  A1649 ( 2.7A)
CIT  A1649 ( 2.9A)
CIT  A1649 (-4.5A)
 0.66A 2htqA-1w8oA:
22.3		 2htqA-1w8oA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_C_TOPC1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 1w8o BACTERIAL SIALIDASE
(Micromonospora
viridifaciens) 		5 / 10 ILE A 222
LEU A 266
ILE A 210
ILE A 314
TYR A 296
 None
 1.13A 2w9sC-1w8oA:
undetectable		 2w9sC-1w8oA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_C_IBPC1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 1w8o BACTERIAL SIALIDASE
(Micromonospora
viridifaciens) 		5 / 10 VAL A 425
GLY A 465
GLY A 452
GLN A 451
THR A 468
 None
 1.29A 2wd9C-1w8oA:
undetectable		 2wd9C-1w8oA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_1
(NEURAMINIDASE A)		 1w8o BACTERIAL SIALIDASE
(Micromonospora
viridifaciens) 		7 / 12 ARG A  68
ILE A  69
ASP A  85
ASP A 131
ARG A 276
ARG A 342
TYR A 370
 CIT  A1649 ( 2.6A)
None
None
GOL  A1650 (-2.7A)
CIT  A1649 ( 2.7A)
CIT  A1649 ( 2.9A)
CIT  A1649 (-4.5A)
 0.37A 2ya7A-1w8oA:
47.5		 2ya7A-1w8oA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_1
(NEURAMINIDASE A)		 1w8o BACTERIAL SIALIDASE
(Micromonospora
viridifaciens) 		7 / 12 ARG A  68
ILE A  69
ASP A  85
ASP A 131
ARG A 276
ARG A 342
TYR A 370
 CIT  A1649 ( 2.6A)
None
None
GOL  A1650 (-2.7A)
CIT  A1649 ( 2.7A)
CIT  A1649 ( 2.9A)
CIT  A1649 (-4.5A)
 0.39A 2ya7B-1w8oA:
47.3		 2ya7B-1w8oA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_1
(NEURAMINIDASE A)		 1w8o BACTERIAL SIALIDASE
(Micromonospora
viridifaciens) 		7 / 12 ARG A  68
ILE A  69
ASP A  85
ASP A 131
ARG A 276
ARG A 342
TYR A 370
 CIT  A1649 ( 2.6A)
None
None
GOL  A1650 (-2.7A)
CIT  A1649 ( 2.7A)
CIT  A1649 ( 2.9A)
CIT  A1649 (-4.5A)
 0.35A 2ya7C-1w8oA:
45.7		 2ya7C-1w8oA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_1
(NEURAMINIDASE A)		 1w8o BACTERIAL SIALIDASE
(Micromonospora
viridifaciens) 		7 / 12 ARG A  68
ILE A  69
ASP A  85
ASP A 131
ARG A 276
ARG A 342
TYR A 370
 CIT  A1649 ( 2.6A)
None
None
GOL  A1650 (-2.7A)
CIT  A1649 ( 2.7A)
CIT  A1649 ( 2.9A)
CIT  A1649 (-4.5A)
 0.38A 2ya7D-1w8oA:
46.9		 2ya7D-1w8oA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_B_CL9B401_2
(DEOXYCYTIDINE KINASE)		 1w8o BACTERIAL SIALIDASE
(Micromonospora
viridifaciens) 		4 / 4 ARG A  68
ASP A  85
LEU A 384
ARG A 276
 CIT  A1649 ( 2.6A)
None
None
CIT  A1649 ( 2.7A)
 1.35A 2ziaB-1w8oA:
undetectable		 2ziaB-1w8oA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZT7_A_GLYA1300_0
(GLYCYL-TRNA
SYNTHETASE)		 1w8o BACTERIAL SIALIDASE
(Micromonospora
viridifaciens) 		4 / 7 ARG A  87
ARG A 276
GLU A 260
SER A 206
 CIT  A1649 (-3.0A)
CIT  A1649 ( 2.7A)
GOL  A1651 (-3.6A)
None
 1.24A 2zt7A-1w8oA:
undetectable		 2zt7A-1w8oA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B7E_A_ZMRA1001_1
(NEURAMINIDASE)		 1w8o BACTERIAL SIALIDASE
(Micromonospora
viridifaciens) 		5 / 12 ARG A  68
GLU A 260
ARG A 276
ARG A 342
TYR A 370
 CIT  A1649 ( 2.6A)
GOL  A1651 (-3.6A)
CIT  A1649 ( 2.7A)
CIT  A1649 ( 2.9A)
CIT  A1649 (-4.5A)
 0.42A 3b7eA-1w8oA:
5.5		 3b7eA-1w8oA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B7E_B_ZMRB1002_1
(NEURAMINIDASE)		 1w8o BACTERIAL SIALIDASE
(Micromonospora
viridifaciens) 		5 / 12 ARG A  68
GLU A 260
ARG A 276
ARG A 342
TYR A 370
 CIT  A1649 ( 2.6A)
GOL  A1651 (-3.6A)
CIT  A1649 ( 2.7A)
CIT  A1649 ( 2.9A)
CIT  A1649 (-4.5A)
 0.43A 3b7eB-1w8oA:
22.0		 3b7eB-1w8oA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKZ_A_ZMRA469_1
(NEURAMINIDASE)		 1w8o BACTERIAL SIALIDASE
(Micromonospora
viridifaciens) 		5 / 12 ARG A  68
GLU A 260
ARG A 276
ARG A 342
TYR A 370
 CIT  A1649 ( 2.6A)
GOL  A1651 (-3.6A)
CIT  A1649 ( 2.7A)
CIT  A1649 ( 2.9A)
CIT  A1649 (-4.5A)
 0.41A 3ckzA-1w8oA:
22.1		 3ckzA-1w8oA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_1
(UNCHARACTERIZED
PROTEIN RPA2492)		 1w8o BACTERIAL SIALIDASE
(Micromonospora
viridifaciens) 		3 / 3 TYR A 550
ASP A 515
HIS A 539
 None
None
LBT  A1648 (-3.9A)
 0.87A 3e23A-1w8oA:
undetectable		 3e23A-1w8oA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FW1_A_STIA233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1w8o BACTERIAL SIALIDASE
(Micromonospora
viridifaciens) 		5 / 10 GLY A 382
TYR A 393
ASN A 395
GLU A 208
ILE A 315
 None
 1.32A 3fw1A-1w8oA:
undetectable		 3fw1A-1w8oA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SAN_A_ZMRA901_1
(NEURAMINIDASE)		 1w8o BACTERIAL SIALIDASE
(Micromonospora
viridifaciens) 		5 / 12 ARG A  68
GLU A 260
ARG A 276
ARG A 342
TYR A 370
 CIT  A1649 ( 2.6A)
GOL  A1651 (-3.6A)
CIT  A1649 ( 2.7A)
CIT  A1649 ( 2.9A)
CIT  A1649 (-4.5A)
 0.40A 3sanA-1w8oA:
14.1		 3sanA-1w8oA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SAN_B_ZMRB901_1
(NEURAMINIDASE)		 1w8o BACTERIAL SIALIDASE
(Micromonospora
viridifaciens) 		5 / 12 ARG A  68
GLU A 260
ARG A 276
ARG A 342
TYR A 370
 CIT  A1649 ( 2.6A)
GOL  A1651 (-3.6A)
CIT  A1649 ( 2.7A)
CIT  A1649 ( 2.9A)
CIT  A1649 (-4.5A)
 0.40A 3sanB-1w8oA:
5.6		 3sanB-1w8oA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TI5_A_ZMRA1002_1
(NEURAMINIDASE)		 1w8o BACTERIAL SIALIDASE
(Micromonospora
viridifaciens) 		5 / 12 ARG A  68
GLU A 260
ARG A 276
ARG A 342
TYR A 370
 CIT  A1649 ( 2.6A)
GOL  A1651 (-3.6A)
CIT  A1649 ( 2.7A)
CIT  A1649 ( 2.9A)
CIT  A1649 (-4.5A)
 0.39A 3ti5A-1w8oA:
5.5		 3ti5A-1w8oA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TI5_B_ZMRB1002_1
(NEURAMINIDASE)		 1w8o BACTERIAL SIALIDASE
(Micromonospora
viridifaciens) 		5 / 12 ARG A  68
GLU A 260
ARG A 276
ARG A 342
TYR A 370
 CIT  A1649 ( 2.6A)
GOL  A1651 (-3.6A)
CIT  A1649 ( 2.7A)
CIT  A1649 ( 2.9A)
CIT  A1649 (-4.5A)
 0.40A 3ti5B-1w8oA:
2.7		 3ti5B-1w8oA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_A_ZMRA1002_1
(NEURAMINIDASE)		 1w8o BACTERIAL SIALIDASE
(Micromonospora
viridifaciens) 		5 / 12 ARG A  68
GLU A 260
ARG A 276
ARG A 342
TYR A 370
 CIT  A1649 ( 2.6A)
GOL  A1651 (-3.6A)
CIT  A1649 ( 2.7A)
CIT  A1649 ( 2.9A)
CIT  A1649 (-4.5A)
 0.40A 3ticA-1w8oA:
21.9		 3ticA-1w8oA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_B_ZMRB1002_1
(NEURAMINIDASE)		 1w8o BACTERIAL SIALIDASE
(Micromonospora
viridifaciens) 		5 / 12 ARG A  68
GLU A 260
ARG A 276
ARG A 342
TYR A 370
 CIT  A1649 ( 2.6A)
GOL  A1651 (-3.6A)
CIT  A1649 ( 2.7A)
CIT  A1649 ( 2.9A)
CIT  A1649 (-4.5A)
 0.43A 3ticB-1w8oA:
22.1		 3ticB-1w8oA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_C_ZMRC1002_1
(NEURAMINIDASE)		 1w8o BACTERIAL SIALIDASE
(Micromonospora
viridifaciens) 		5 / 12 ARG A  68
GLU A 260
ARG A 276
ARG A 342
TYR A 370
 CIT  A1649 ( 2.6A)
GOL  A1651 (-3.6A)
CIT  A1649 ( 2.7A)
CIT  A1649 ( 2.9A)
CIT  A1649 (-4.5A)
 0.41A 3ticC-1w8oA:
21.9		 3ticC-1w8oA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_D_ZMRD1002_1
(NEURAMINIDASE)		 1w8o BACTERIAL SIALIDASE
(Micromonospora
viridifaciens) 		5 / 12 ARG A  68
GLU A 260
ARG A 276
ARG A 342
TYR A 370
 CIT  A1649 ( 2.6A)
GOL  A1651 (-3.6A)
CIT  A1649 ( 2.7A)
CIT  A1649 ( 2.9A)
CIT  A1649 (-4.5A)
 0.40A 3ticD-1w8oA:
22.3		 3ticD-1w8oA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		 1w8o BACTERIAL SIALIDASE
(Micromonospora
viridifaciens) 		5 / 9 LEU A 486
LEU A 457
GLU A 455
PHE A 408
VAL A 425
 None
 1.15A 3tmzA-1w8oA:
0.0		 3tmzA-1w8oA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQB_A_FOLA2001_0
(DIHYDROFOLATE
REDUCTASE)		 1w8o BACTERIAL SIALIDASE
(Micromonospora
viridifaciens) 		5 / 11 ALA A 612
LEU A 641
THR A 587
LEU A 558
ILE A 564
 None
 1.02A 3tqbA-1w8oA:
undetectable		 3tqbA-1w8oA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1w8o BACTERIAL SIALIDASE
(Micromonospora
viridifaciens) 		3 / 3 SER A 343
ASP A 307
ASP A 259
 None
None
GOL  A1651 (-2.8A)
 0.90A 3uj7A-1w8oA:
undetectable		 3uj7A-1w8oA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UWL_B_FOZB316_0
(THYMIDYLATE SYNTHASE)		 1w8o BACTERIAL SIALIDASE
(Micromonospora
viridifaciens) 		5 / 12 LEU A 401
GLY A 382
PHE A 396
ASN A 395
ILE A 315
 None
 1.04A 3uwlB-1w8oA:
undetectable		 3uwlB-1w8oA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UWL_D_FOZD316_0
(THYMIDYLATE SYNTHASE)		 1w8o BACTERIAL SIALIDASE
(Micromonospora
viridifaciens) 		5 / 12 LEU A 401
GLY A 382
PHE A 396
ASN A 395
ILE A 315
 None
 1.05A 3uwlD-1w8oA:
0.0		 3uwlD-1w8oA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7N_A_ZMRA601_1
(NEURAMINIDASE)		 1w8o BACTERIAL SIALIDASE
(Micromonospora
viridifaciens) 		5 / 12 ARG A  68
GLU A 260
ARG A 276
ARG A 342
TYR A 370
 CIT  A1649 ( 2.6A)
GOL  A1651 (-3.6A)
CIT  A1649 ( 2.7A)
CIT  A1649 ( 2.9A)
CIT  A1649 (-4.5A)
 0.44A 4b7nA-1w8oA:
22.0		 4b7nA-1w8oA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_A_ZMRA601_1
(NEURAMINIDASE)		 1w8o BACTERIAL SIALIDASE
(Micromonospora
viridifaciens) 		5 / 12 ARG A  68
GLU A 260
ARG A 276
ARG A 342
TYR A 370
 CIT  A1649 ( 2.6A)
GOL  A1651 (-3.6A)
CIT  A1649 ( 2.7A)
CIT  A1649 ( 2.9A)
CIT  A1649 (-4.5A)
 0.47A 4b7qA-1w8oA:
11.7		 4b7qA-1w8oA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_B_ZMRB601_1
(NEURAMINIDASE)		 1w8o BACTERIAL SIALIDASE
(Micromonospora
viridifaciens) 		5 / 12 ARG A  68
GLU A 260
ARG A 276
ARG A 342
TYR A 370
 CIT  A1649 ( 2.6A)
GOL  A1651 (-3.6A)
CIT  A1649 ( 2.7A)
CIT  A1649 ( 2.9A)
CIT  A1649 (-4.5A)
 0.52A 4b7qB-1w8oA:
22.1		 4b7qB-1w8oA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_C_ZMRC601_1
(NEURAMINIDASE)		 1w8o BACTERIAL SIALIDASE
(Micromonospora
viridifaciens) 		5 / 12 ARG A  68
GLU A 260
ARG A 276
ARG A 342
TYR A 370
 CIT  A1649 ( 2.6A)
GOL  A1651 (-3.6A)
CIT  A1649 ( 2.7A)
CIT  A1649 ( 2.9A)
CIT  A1649 (-4.5A)
 0.37A 4b7qC-1w8oA:
22.0		 4b7qC-1w8oA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_D_ZMRD601_1
(NEURAMINIDASE)		 1w8o BACTERIAL SIALIDASE
(Micromonospora
viridifaciens) 		5 / 12 ARG A  68
GLU A 260
ARG A 276
ARG A 342
TYR A 370
 CIT  A1649 ( 2.6A)
GOL  A1651 (-3.6A)
CIT  A1649 ( 2.7A)
CIT  A1649 ( 2.9A)
CIT  A1649 (-4.5A)
 0.53A 4b7qD-1w8oA:
22.2		 4b7qD-1w8oA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPN_A_ZMRA700_1
(NEURAMINIDASE)		 1w8o BACTERIAL SIALIDASE
(Micromonospora
viridifaciens) 		5 / 12 ARG A  68
GLU A 260
ARG A 276
ARG A 342
TYR A 370
 CIT  A1649 ( 2.6A)
GOL  A1651 (-3.6A)
CIT  A1649 ( 2.7A)
CIT  A1649 ( 2.9A)
CIT  A1649 (-4.5A)
 0.39A 4cpnA-1w8oA:
25.7		 4cpnA-1w8oA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPN_B_ZMRB700_1
(NEURAMINIDASE)		 1w8o BACTERIAL SIALIDASE
(Micromonospora
viridifaciens) 		5 / 12 ARG A  68
GLU A 260
ARG A 276
ARG A 342
TYR A 370
 CIT  A1649 ( 2.6A)
GOL  A1651 (-3.6A)
CIT  A1649 ( 2.7A)
CIT  A1649 ( 2.9A)
CIT  A1649 (-4.5A)
 0.38A 4cpnB-1w8oA:
25.9		 4cpnB-1w8oA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_A_ZMRA1471_1
(NEURAMINIDASE)		 1w8o BACTERIAL SIALIDASE
(Micromonospora
viridifaciens) 		5 / 12 ARG A  68
GLU A 260
ARG A 276
ARG A 342
TYR A 370
 CIT  A1649 ( 2.6A)
GOL  A1651 (-3.6A)
CIT  A1649 ( 2.7A)
CIT  A1649 ( 2.9A)
CIT  A1649 (-4.5A)
 0.39A 4cpzA-1w8oA:
25.7		 4cpzA-1w8oA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_B_ZMRB1471_1
(NEURAMINIDASE)		 1w8o BACTERIAL SIALIDASE
(Micromonospora
viridifaciens) 		5 / 12 ARG A  68
GLU A 260
ARG A 276
ARG A 342
TYR A 370
 CIT  A1649 ( 2.6A)
GOL  A1651 (-3.6A)
CIT  A1649 ( 2.7A)
CIT  A1649 ( 2.9A)
CIT  A1649 (-4.5A)
 0.36A 4cpzB-1w8oA:
7.8		 4cpzB-1w8oA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_C_ZMRC1470_1
(NEURAMINIDASE)		 1w8o BACTERIAL SIALIDASE
(Micromonospora
viridifaciens) 		5 / 12 ARG A  68
GLU A 260
ARG A 276
ARG A 342
TYR A 370
 CIT  A1649 ( 2.6A)
GOL  A1651 (-3.6A)
CIT  A1649 ( 2.7A)
CIT  A1649 ( 2.9A)
CIT  A1649 (-4.5A)
 0.39A 4cpzC-1w8oA:
9.1		 4cpzC-1w8oA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_D_ZMRD1471_1
(NEURAMINIDASE)		 1w8o BACTERIAL SIALIDASE
(Micromonospora
viridifaciens) 		5 / 12 ARG A  68
GLU A 260
ARG A 276
ARG A 342
TYR A 370
 CIT  A1649 ( 2.6A)
GOL  A1651 (-3.6A)
CIT  A1649 ( 2.7A)
CIT  A1649 ( 2.9A)
CIT  A1649 (-4.5A)
 0.33A 4cpzD-1w8oA:
25.9		 4cpzD-1w8oA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_E_ZMRE1471_1
(NEURAMINIDASE)		 1w8o BACTERIAL SIALIDASE
(Micromonospora
viridifaciens) 		5 / 12 ARG A  68
GLU A 260
ARG A 276
ARG A 342
TYR A 370
 CIT  A1649 ( 2.6A)
GOL  A1651 (-3.6A)
CIT  A1649 ( 2.7A)
CIT  A1649 ( 2.9A)
CIT  A1649 (-4.5A)
 0.40A 4cpzE-1w8oA:
5.5		 4cpzE-1w8oA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_F_ZMRF1470_1
(NEURAMINIDASE)		 1w8o BACTERIAL SIALIDASE
(Micromonospora
viridifaciens) 		5 / 12 ARG A  68
GLU A 260
ARG A 276
ARG A 342
TYR A 370
 CIT  A1649 ( 2.6A)
GOL  A1651 (-3.6A)
CIT  A1649 ( 2.7A)
CIT  A1649 ( 2.9A)
CIT  A1649 (-4.5A)
 0.41A 4cpzF-1w8oA:
25.8		 4cpzF-1w8oA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_G_ZMRG1471_1
(NEURAMINIDASE)		 1w8o BACTERIAL SIALIDASE
(Micromonospora
viridifaciens) 		5 / 12 ARG A  68
GLU A 260
ARG A 276
ARG A 342
TYR A 370
 CIT  A1649 ( 2.6A)
GOL  A1651 (-3.6A)
CIT  A1649 ( 2.7A)
CIT  A1649 ( 2.9A)
CIT  A1649 (-4.5A)
 0.38A 4cpzG-1w8oA:
25.9		 4cpzG-1w8oA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_H_ZMRH1470_1
(NEURAMINIDASE)		 1w8o BACTERIAL SIALIDASE
(Micromonospora
viridifaciens) 		5 / 12 ARG A  68
GLU A 260
ARG A 276
ARG A 342
TYR A 370
 CIT  A1649 ( 2.6A)
GOL  A1651 (-3.6A)
CIT  A1649 ( 2.7A)
CIT  A1649 ( 2.9A)
CIT  A1649 (-4.5A)
 0.47A 4cpzH-1w8oA:
25.6		 4cpzH-1w8oA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3A_B_ADNB500_1
(SUGAR KINASE PROTEIN)		 1w8o BACTERIAL SIALIDASE
(Micromonospora
viridifaciens) 		6 / 12 ILE A  91
GLY A  95
GLY A  92
ASN A  97
GLY A  86
ASP A  85
 None
None
GOL  A1650 (-3.6A)
None
None
None
 1.42A 4e3aB-1w8oA:
undetectable		 4e3aB-1w8oA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJ1_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1w8o BACTERIAL SIALIDASE
(Micromonospora
viridifaciens) 		5 / 12 ALA A 612
LEU A 641
THR A 587
LEU A 558
ILE A 564
 None
 0.81A 4ej1A-1w8oA:
undetectable		 4ej1A-1w8oA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA503_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 1w8o BACTERIAL SIALIDASE
(Micromonospora
viridifaciens) 		4 / 6 ARG A 620
ILE A 564
VAL A 643
LEU A 504
 None
 1.09A 4em2A-1w8oA:
undetectable		 4em2A-1w8oA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EMA_A_BRLA601_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1w8o BACTERIAL SIALIDASE
(Micromonospora
viridifaciens) 		3 / 3 PHE A 537
VAL A 514
ILE A 511
 None
 0.61A 4emaA-1w8oA:
undetectable		 4emaA-1w8oA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1w8o BACTERIAL SIALIDASE
(Micromonospora
viridifaciens) 		4 / 6 GLY A 382
ASN A 395
GLU A 208
ILE A 315
 None
 0.83A 4fglD-1w8oA:
undetectable		 4fglD-1w8oA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA304_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 1w8o BACTERIAL SIALIDASE
(Micromonospora
viridifaciens) 		3 / 3 ARG A 220
HIS A 217
TYR A 240
 GOL  A1652 (-3.1A)
GOL  A1652 (-3.9A)
GOL  A1652 (-4.7A)
 0.99A 4fu8A-1w8oA:
undetectable		 4fu8A-1w8oA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA312_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 1w8o BACTERIAL SIALIDASE
(Micromonospora
viridifaciens) 		3 / 3 ARG A 220
HIS A 217
TYR A 240
 GOL  A1652 (-3.1A)
GOL  A1652 (-3.9A)
GOL  A1652 (-4.7A)
 1.00A 4fu9A-1w8oA:
undetectable		 4fu9A-1w8oA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		 1w8o BACTERIAL SIALIDASE
(Micromonospora
viridifaciens) 		5 / 12 TRP A 357
LEU A 401
ALA A 375
ALA A 317
GLY A 382
 None
 1.08A 4hfpD-1w8oA:
undetectable		 4hfpD-1w8oA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I00_A_ZMRA509_1
(NEURAMINIDASE)		 1w8o BACTERIAL SIALIDASE
(Micromonospora
viridifaciens) 		5 / 12 ARG A  68
GLU A 260
ARG A 276
ARG A 342
TYR A 370
 CIT  A1649 ( 2.6A)
GOL  A1651 (-3.6A)
CIT  A1649 ( 2.7A)
CIT  A1649 ( 2.9A)
CIT  A1649 (-4.5A)
 0.41A 4i00A-1w8oA:
4.2		 4i00A-1w8oA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I13_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1w8o BACTERIAL SIALIDASE
(Micromonospora
viridifaciens) 		5 / 12 ALA A 612
LEU A 641
THR A 587
LEU A 558
ILE A 564
 None
 0.75A 4i13A-1w8oA:
undetectable		 4i13A-1w8oA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I13_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1w8o BACTERIAL SIALIDASE
(Micromonospora
viridifaciens) 		3 / 3 ASP A 259
ARG A  68
THR A 226
 GOL  A1651 (-2.8A)
CIT  A1649 ( 2.6A)
None
 0.87A 4i13A-1w8oA:
undetectable		 4i13A-1w8oA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR3_A_GLYA701_0
(GLYCINE--TRNA LIGASE)		 1w8o BACTERIAL SIALIDASE
(Micromonospora
viridifaciens) 		4 / 6 ARG A  87
ARG A 276
GLU A 260
SER A 206
 CIT  A1649 (-3.0A)
CIT  A1649 ( 2.7A)
GOL  A1651 (-3.6A)
None
 1.25A 4kr3A-1w8oA:
undetectable		 4kr3A-1w8oA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF7_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		 1w8o BACTERIAL SIALIDASE
(Micromonospora
viridifaciens) 		3 / 3 TYR A 370
ARG A 342
SER A 369
 CIT  A1649 (-4.5A)
CIT  A1649 ( 2.9A)
GOL  A1653 (-2.7A)
 1.11A 4lf7I-1w8oA:
undetectable
4lf7J-1w8oA:
undetectable		 4lf7I-1w8oA:
11.15
4lf7J-1w8oA:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF8_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		 1w8o BACTERIAL SIALIDASE
(Micromonospora
viridifaciens) 		3 / 3 TYR A 370
ARG A 342
SER A 369
 CIT  A1649 (-4.5A)
CIT  A1649 ( 2.9A)
GOL  A1653 (-2.7A)
 1.11A 4lf8I-1w8oA:
undetectable
4lf8J-1w8oA:
undetectable		 4lf8I-1w8oA:
11.15
4lf8J-1w8oA:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_A_8PRA603_1
(TRANSPORTER)		 1w8o BACTERIAL SIALIDASE
(Micromonospora
viridifaciens) 		5 / 12 TYR A 296
ASP A 291
ALA A 250
SER A 295
ASP A 242
 None
GOL  A1652 (-4.9A)
None
None
None
 1.29A 4mm4A-1w8oA:
undetectable		 4mm4A-1w8oA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM9_A_FVXA603_1
(TRANSPORTER)		 1w8o BACTERIAL SIALIDASE
(Micromonospora
viridifaciens) 		5 / 11 TYR A 296
ASP A 291
ALA A 250
SER A 295
ASP A 242
 None
GOL  A1652 (-4.9A)
None
None
None
 1.28A 4mm9A-1w8oA:
undetectable		 4mm9A-1w8oA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWR_A_ZMRA513_1
(NEURAMINIDASE)		 1w8o BACTERIAL SIALIDASE
(Micromonospora
viridifaciens) 		5 / 12 ARG A  68
GLU A 260
ARG A 276
ARG A 342
TYR A 370
 CIT  A1649 ( 2.6A)
GOL  A1651 (-3.6A)
CIT  A1649 ( 2.7A)
CIT  A1649 ( 2.9A)
CIT  A1649 (-4.5A)
 0.43A 4mwrA-1w8oA:
9.1		 4mwrA-1w8oA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_B_FK5B203_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 1w8o BACTERIAL SIALIDASE
(Micromonospora
viridifaciens) 		3 / 3 ALA A 375
GLN A 211
GLY A 219
 None
 0.31A 4odoC-1w8oA:
0.0		 4odoC-1w8oA:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3R_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1w8o BACTERIAL SIALIDASE
(Micromonospora
viridifaciens) 		3 / 3 ASP A 259
ARG A  68
THR A 226
 GOL  A1651 (-2.8A)
CIT  A1649 ( 2.6A)
None
 0.90A 4p3rA-1w8oA:
undetectable		 4p3rA-1w8oA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		 1w8o BACTERIAL SIALIDASE
(Micromonospora
viridifaciens) 		5 / 12 SER A 133
ASP A 320
ILE A 315
SER A 313
ARG A 138
 None
 1.38A 4uroA-1w8oA:
undetectable		 4uroA-1w8oA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA5_A_ZMRA501_1
(NEURAMINIDASE)		 1w8o BACTERIAL SIALIDASE
(Micromonospora
viridifaciens) 		5 / 12 ARG A  68
GLU A 260
ARG A 276
ARG A 342
TYR A 370
 CIT  A1649 ( 2.6A)
GOL  A1651 (-3.6A)
CIT  A1649 ( 2.7A)
CIT  A1649 ( 2.9A)
CIT  A1649 (-4.5A)
 0.40A 4wa5A-1w8oA:
22.6		 4wa5A-1w8oA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1w8o BACTERIAL SIALIDASE
(Micromonospora
viridifaciens) 		5 / 12 ALA A 612
LEU A 641
THR A 587
LEU A 558
ILE A 564
 None
 0.77A 4x5iA-1w8oA:
undetectable		 4x5iA-1w8oA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YSH_B_GLYB401_0
(GLYCINE OXIDASE)		 1w8o BACTERIAL SIALIDASE
(Micromonospora
viridifaciens) 		4 / 6 PHE A 396
GLY A 382
TYR A 381
ALA A 375
 None
 1.03A 4yshB-1w8oA:
undetectable		 4yshB-1w8oA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1w8o BACTERIAL SIALIDASE
(Micromonospora
viridifaciens) 		5 / 12 ALA A 612
LEU A 641
THR A 587
LEU A 558
ILE A 564
 None
 0.82A 5eajA-1w8oA:
undetectable		 5eajA-1w8oA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1w8o BACTERIAL SIALIDASE
(Micromonospora
viridifaciens) 		3 / 3 LEU A 376
TYR A 393
SER A 104
 None
 0.90A 5iktA-1w8oA:
undetectable		 5iktA-1w8oA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L17_A_ZMRA512_1
(NEURAMINIDASE)		 1w8o BACTERIAL SIALIDASE
(Micromonospora
viridifaciens) 		5 / 12 ARG A  68
GLU A 260
ARG A 276
ARG A 342
TYR A 370
 CIT  A1649 ( 2.6A)
GOL  A1651 (-3.6A)
CIT  A1649 ( 2.7A)
CIT  A1649 ( 2.9A)
CIT  A1649 (-4.5A)
 0.41A 5l17A-1w8oA:
21.9		 5l17A-1w8oA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UJX_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1w8o BACTERIAL SIALIDASE
(Micromonospora
viridifaciens) 		5 / 12 ALA A 612
LEU A 641
THR A 587
LEU A 558
ILE A 564
 None
 0.81A 5ujxA-1w8oA:
undetectable		 5ujxA-1w8oA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 1w8o BACTERIAL SIALIDASE
(Micromonospora
viridifaciens) 		5 / 12 GLU A 208
GLY A 207
VAL A 271
LEU A 272
ILE A 210
 None
 1.17A 5vopB-1w8oA:
undetectable		 5vopB-1w8oA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WM2_A_ACTA605_0
(SALICYLATE-AMP
LIGASE)		 1w8o BACTERIAL SIALIDASE
(Micromonospora
viridifaciens) 		3 / 3 THR A 162
THR A 190
ARG A 202
 None
 0.59A 5wm2A-1w8oA:
undetectable		 5wm2A-1w8oA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WM7_A_ACTA603_0
(SALICYLATE-AMP
LIGASE)		 1w8o BACTERIAL SIALIDASE
(Micromonospora
viridifaciens) 		4 / 4 THR A 162
THR A 190
ALA A 191
ARG A 202
 None
 1.05A 5wm7A-1w8oA:
0.0		 5wm7A-1w8oA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_A_EY4A502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 1w8o BACTERIAL SIALIDASE
(Micromonospora
viridifaciens) 		4 / 7 ALA A 175
THR A 176
GLN A 115
VAL A 117
 None
 0.89A 6cduA-1w8oA:
3.2
6cduE-1w8oA:
undetectable		 6cduA-1w8oA:
21.89
6cduE-1w8oA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_B_EY4B500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 1w8o BACTERIAL SIALIDASE
(Micromonospora
viridifaciens) 		4 / 6 GLN A 115
VAL A 117
ALA A 175
THR A 176
 None
 0.91A 6cduB-1w8oA:
3.1
6cduC-1w8oA:
0.0		 6cduB-1w8oA:
21.89
6cduC-1w8oA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_E_EY4E500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 1w8o BACTERIAL SIALIDASE
(Micromonospora
viridifaciens) 		4 / 8 GLN A 115
VAL A 117
ALA A 175
THR A 176
 None
 0.90A 6cduD-1w8oA:
3.1
6cduE-1w8oA:
undetectable		 6cduD-1w8oA:
21.89
6cduE-1w8oA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_F_EY4F500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 1w8o BACTERIAL SIALIDASE
(Micromonospora
viridifaciens) 		4 / 7 ALA A 175
THR A 176
GLN A 115
VAL A 117
 None
 0.91A 6cduF-1w8oA:
undetectable
6cduJ-1w8oA:
2.6		 6cduF-1w8oA:
21.89
6cduJ-1w8oA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_H_EY4H500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 1w8o BACTERIAL SIALIDASE
(Micromonospora
viridifaciens) 		4 / 7 GLN A 115
VAL A 117
ALA A 175
THR A 176
 None
 0.89A 6cduH-1w8oA:
undetectable
6cduI-1w8oA:
undetectable		 6cduH-1w8oA:
21.89
6cduI-1w8oA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_1
(SIALIDASE)		 1w8o BACTERIAL SIALIDASE
(Micromonospora
viridifaciens) 		7 / 12 ARG A  68
ILE A  69
ARG A  87
ARG A 276
ASP A 259
ARG A 342
TYR A 370
 CIT  A1649 ( 2.6A)
None
CIT  A1649 (-3.0A)
CIT  A1649 ( 2.7A)
GOL  A1651 (-2.8A)
CIT  A1649 ( 2.9A)
CIT  A1649 (-4.5A)
 0.79A 6ekuA-1w8oA:
43.3		 6ekuA-1w8oA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_1
(SIALIDASE)		 1w8o BACTERIAL SIALIDASE
(Micromonospora
viridifaciens) 		7 / 12 ARG A  68
ILE A  69
ARG A  87
GLU A 260
ARG A 276
ARG A 342
TYR A 370
 CIT  A1649 ( 2.6A)
None
CIT  A1649 (-3.0A)
GOL  A1651 (-3.6A)
CIT  A1649 ( 2.7A)
CIT  A1649 ( 2.9A)
CIT  A1649 (-4.5A)
 0.41A 6ekuA-1w8oA:
43.3		 6ekuA-1w8oA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_1
(SIALIDASE)		 1w8o BACTERIAL SIALIDASE
(Micromonospora
viridifaciens) 		7 / 12 ARG A  68
ILE A  69
ASP A 131
ARG A 276
ASP A 259
ARG A 342
TYR A 370
 CIT  A1649 ( 2.6A)
None
GOL  A1650 (-2.7A)
CIT  A1649 ( 2.7A)
GOL  A1651 (-2.8A)
CIT  A1649 ( 2.9A)
CIT  A1649 (-4.5A)
 1.01A 6ekuA-1w8oA:
43.3		 6ekuA-1w8oA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_1
(SIALIDASE)		 1w8o BACTERIAL SIALIDASE
(Micromonospora
viridifaciens) 		7 / 12 ARG A  68
ILE A  69
ASP A 131
GLU A 260
ARG A 276
ARG A 342
TYR A 370
 CIT  A1649 ( 2.6A)
None
GOL  A1650 (-2.7A)
GOL  A1651 (-3.6A)
CIT  A1649 ( 2.7A)
CIT  A1649 ( 2.9A)
CIT  A1649 (-4.5A)
 0.68A 6ekuA-1w8oA:
43.3		 6ekuA-1w8oA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_1
(TUBULIN BETA CHAIN)		 1w8o BACTERIAL SIALIDASE
(Micromonospora
viridifaciens) 		5 / 12 GLU A 644
ALA A 612
PHE A 603
ARG A 623
LEU A 641
 None
 1.18A 6ew0G-1w8oA:
undetectable		 6ew0G-1w8oA:
9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_D_ADND502_2
(-)		 1w8o BACTERIAL SIALIDASE
(Micromonospora
viridifaciens) 		4 / 5 ILE A 143
THR A  73
THR A 140
LEU A 221
 None
 1.12A 6f3mD-1w8oA:
undetectable		 6f3mD-1w8oA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_Q_PCFQ202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1w8o BACTERIAL SIALIDASE
(Micromonospora
viridifaciens) 		4 / 6 TYR A 370
ILE A  69
ALA A 205
ASP A 307
 CIT  A1649 (-4.5A)
None
None
None
 1.14A 6hu9m-1w8oA:
undetectable
6hu9q-1w8oA:
undetectable		 6hu9m-1w8oA:
22.99
6hu9q-1w8oA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_B_FOZB403_0
(THYMIDYLATE SYNTHASE)		 1w8o BACTERIAL SIALIDASE
(Micromonospora
viridifaciens) 		5 / 12 LEU A 401
GLY A 382
PHE A 396
ASN A 395
ILE A 315
 None
 0.98A 6qxsB-1w8oA:
undetectable		 6qxsB-1w8oA:
20.27