SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1w8s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_W_CHDW1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1w8s FRUCTOSE-BISPHOSPHAT
E ALDOLASE CLASS I
(Thermoproteus
tenax) 		4 / 7 LYS A 215
LEU A 214
PHE A 243
LEU A 247
 None
 0.97A 2eimP-1w8sA:
undetectable
2eimW-1w8sA:
undetectable		 2eimP-1w8sA:
22.11
2eimW-1w8sA:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_1
(METHYLTRANSFERASE
MPPJ)		 1w8s FRUCTOSE-BISPHOSPHAT
E ALDOLASE CLASS I
(Thermoproteus
tenax) 		3 / 3 ARG A 237
ASP A  33
ASP A  24
 None
None
FBP  A 270 (-2.8A)
 0.78A 4kicB-1w8sA:
undetectable		 4kicB-1w8sA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_1
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 1w8s FRUCTOSE-BISPHOSPHAT
E ALDOLASE CLASS I
(Thermoproteus
tenax) 		3 / 3 SER A  92
TYR A 114
ASP A  24
 None
None
FBP  A 270 (-2.8A)
 0.85A 4rp8C-1w8sA:
undetectable		 4rp8C-1w8sA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_DIFA601_1
(SERUM ALBUMIN)		 1w8s FRUCTOSE-BISPHOSPHAT
E ALDOLASE CLASS I
(Thermoproteus
tenax) 		5 / 11 LEU A 221
VAL A 220
PHE A 213
LEU A 247
GLY A 203
 None
None
None
None
FBP  A 270 (-3.2A)
 1.33A 4zbqA-1w8sA:
undetectable		 4zbqA-1w8sA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 1w8s FRUCTOSE-BISPHOSPHAT
E ALDOLASE CLASS I
(Thermoproteus
tenax) 		5 / 12 LEU A 104
ILE A  76
GLY A  57
ASP A  56
ALA A  65
 None
 1.04A 5h5fA-1w8sA:
undetectable		 5h5fA-1w8sA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_A_ACTA708_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 1w8s FRUCTOSE-BISPHOSPHAT
E ALDOLASE CLASS I
(Thermoproteus
tenax) 		3 / 3 GLY A 204
GLY A 203
GLN A 216
 FBP  A 270 (-3.2A)
FBP  A 270 (-3.2A)
None
 0.47A 5imsA-1w8sA:
undetectable		 5imsA-1w8sA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_0
(METHYLTRANSFERASE)		 1w8s FRUCTOSE-BISPHOSPHAT
E ALDOLASE CLASS I
(Thermoproteus
tenax) 		5 / 12 VAL A 234
ILE A  76
GLU A  28
PHE A  55
ALA A 229
 None
None
FBP  A 270 (-4.9A)
None
None
 1.03A 5n5dB-1w8sA:
undetectable		 5n5dB-1w8sA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 1w8s FRUCTOSE-BISPHOSPHAT
E ALDOLASE CLASS I
(Thermoproteus
tenax) 		4 / 6 LYS A 215
LEU A 214
PHE A 243
LEU A 247
 None
 1.05A 5x19P-1w8sA:
undetectable		 5x19P-1w8sA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_P_CHDP304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1w8s FRUCTOSE-BISPHOSPHAT
E ALDOLASE CLASS I
(Thermoproteus
tenax) 		4 / 7 LYS A 215
LEU A 214
PHE A 243
LEU A 247
 None
 1.02A 5x1fP-1w8sA:
undetectable
5x1fW-1w8sA:
undetectable		 5x1fP-1w8sA:
22.11
5x1fW-1w8sA:
10.89