SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1w93'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E73_M_ASCM995_0
(MYROSINASE MA1)		 1w93 ACETYL-COENZYME A
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 6 ILE A 418
ARG A 419
TYR A 422
PHE A 436
 None
 1.38A 1e73M-1w93A:
undetectable		 1e73M-1w93A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_B_SAMB293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1w93 ACETYL-COENZYME A
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 12 ASN A 495
HIS A 152
ILE A 110
TYR A 109
TYR A 128
 None
 1.22A 1xvaB-1w93A:
0.8		 1xvaB-1w93A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1w93 ACETYL-COENZYME A
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 11 ALA A 273
ILE A 272
VAL A 265
PHE A 247
ILE A 289
 None
 1.01A 2h42A-1w93A:
undetectable		 2h42A-1w93A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO6_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 1w93 ACETYL-COENZYME A
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 304
ILE A 312
LEU A 314
PHE A 434
HIS A 413
 None
 1.16A 2qo6A-1w93A:
undetectable		 2qo6A-1w93A:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_C_CHDC1265_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1w93 ACETYL-COENZYME A
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 5 ARG A 533
PHE A 490
LEU A 478
PHE A 480
 None
 1.12A 2y69C-1w93A:
0.2
2y69J-1w93A:
undetectable		 2y69C-1w93A:
18.93
2y69J-1w93A:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_P_CHDP1265_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1w93 ACETYL-COENZYME A
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 5 ARG A 533
PHE A 490
LEU A 478
PHE A 480
 None
 1.23A 2y69P-1w93A:
undetectable
2y69W-1w93A:
undetectable		 2y69P-1w93A:
18.93
2y69W-1w93A:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1w93 ACETYL-COENZYME A
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 6 ARG A 533
PHE A 490
LEU A 478
PHE A 480
 None
 1.13A 3ablP-1w93A:
undetectable
3ablW-1w93A:
undetectable		 3ablP-1w93A:
18.93
3ablW-1w93A:
8.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1w93 ACETYL-COENZYME A
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 5 ARG A 533
PHE A 490
LEU A 478
PHE A 480
 None
 1.15A 3abmC-1w93A:
0.0
3abmJ-1w93A:
0.0		 3abmC-1w93A:
18.93
3abmJ-1w93A:
8.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1w93 ACETYL-COENZYME A
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 5 ARG A 533
PHE A 490
LEU A 478
PHE A 480
 None
 1.21A 3abmP-1w93A:
0.1
3abmW-1w93A:
undetectable		 3abmP-1w93A:
18.93
3abmW-1w93A:
8.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1w93 ACETYL-COENZYME A
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 5 ARG A 533
PHE A 490
LEU A 478
PHE A 480
 None
 1.14A 3ag3C-1w93A:
0.0
3ag3J-1w93A:
undetectable		 3ag3C-1w93A:
18.93
3ag3J-1w93A:
8.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA3_0
(FERROCHELATASE)		 1w93 ACETYL-COENZYME A
CARBOXYLASE
(Saccharomyces
cerevisiae) 		3 / 3 PRO A  29
LEU A  28
ARG A  24
 None
 0.85A 3aqiA-1w93A:
3.2		 3aqiA-1w93A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_A_1FLA502_1
(TRANSTHYRETIN)		 1w93 ACETYL-COENZYME A
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 7 LYS A 243
ALA A 242
SER A 204
VAL A 265
 None
 0.97A 3d2tA-1w93A:
undetectable		 3d2tA-1w93A:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_B_1FLB500_1
(TRANSTHYRETIN)		 1w93 ACETYL-COENZYME A
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 6 LYS A 243
ALA A 242
SER A 204
VAL A 265
 None
 1.02A 3d2tB-1w93A:
0.8		 3d2tB-1w93A:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA270_0
(PROTEIN SSM1)		 1w93 ACETYL-COENZYME A
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 384
SER A 360
LEU A 399
PRO A 400
 None
 1.26A 3onnA-1w93A:
3.7		 3onnA-1w93A:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_1
(N-METHYLTRANSFERASE)		 1w93 ACETYL-COENZYME A
CARBOXYLASE
(Saccharomyces
cerevisiae) 		3 / 3 TYR A 128
TYR A 109
GLU A 101
 None
 0.72A 3pfgA-1w93A:
3.4		 3pfgA-1w93A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 1w93 ACETYL-COENZYME A
CARBOXYLASE
(Saccharomyces
cerevisiae) 		3 / 4 SER A 195
GLY A 218
GLU A  27
 None
 0.60A 3raeA-1w93A:
undetectable
3raeC-1w93A:
1.9		 3raeA-1w93A:
22.09
3raeC-1w93A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_A_SALA404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 1w93 ACETYL-COENZYME A
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 7 ALA A 113
TYR A 109
ARG A  76
ALA A  71
 None
 1.04A 3twpA-1w93A:
undetectable		 3twpA-1w93A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_C_T1CC401_1
(TETX2 PROTEIN)		 1w93 ACETYL-COENZYME A
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 11 ASP A 306
HIS A  31
GLY A 177
SER A 182
GLY A 309
 None
 1.39A 3v3oC-1w93A:
0.6		 3v3oC-1w93A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_A_ACTA1002_0
(PUTATIVE
OXIDOREDUCTASE)		 1w93 ACETYL-COENZYME A
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 6 GLY A 396
VAL A 397
ASP A 417
THR A 420
 None
 1.07A 3vqrA-1w93A:
undetectable		 3vqrA-1w93A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_B_ACTB1002_0
(PUTATIVE
OXIDOREDUCTASE)		 1w93 ACETYL-COENZYME A
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 5 GLY A 396
VAL A 397
ASP A 417
THR A 420
 None
 1.08A 3vqrB-1w93A:
undetectable		 3vqrB-1w93A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_B_SAMB401_1
(MNMC2)		 1w93 ACETYL-COENZYME A
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 4 GLU A 431
ASP A 433
ASP A 306
GLU A 435
 None
 1.47A 3vywB-1w93A:
1.6		 3vywB-1w93A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB8_A_DXCA75_0
(PPCA)		 1w93 ACETYL-COENZYME A
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 110
LEU A 103
ILE A 117
GLY A 121
 None
 0.84A 4hb8A-1w93A:
undetectable		 4hb8A-1w93A:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JUO_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA)		 1w93 ACETYL-COENZYME A
CARBOXYLASE
(Saccharomyces
cerevisiae) 		3 / 4 SER A 195
GLY A 218
GLU A  27
 None
 0.57A 4juoA-1w93A:
2.3
4juoC-1w93A:
2.0		 4juoA-1w93A:
22.09
4juoC-1w93A:
21.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MV7_A_PPFA501_1
(BIOTIN CARBOXYLASE)		 1w93 ACETYL-COENZYME A
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 7 LYS A 327
ASN A 381
ARG A 383
GLN A 385
 None
 1.10A 4mv7A-1w93A:
36.6		 4mv7A-1w93A:
34.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1w93 ACETYL-COENZYME A
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 6 ARG A 533
PHE A 490
LEU A 478
PHE A 480
 None
 1.15A 5b1bC-1w93A:
undetectable
5b1bJ-1w93A:
undetectable		 5b1bC-1w93A:
18.93
5b1bJ-1w93A:
8.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA301_1
(CHITOSANASE)		 1w93 ACETYL-COENZYME A
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 110
GLY A  68
THR A 474
ASN A 495
 None
 0.88A 5hwaA-1w93A:
undetectable		 5hwaA-1w93A:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM2_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 1w93 ACETYL-COENZYME A
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 9 VAL A  92
LEU A 404
ALA A 401
HIS A  53
ILE A  59
 None
 1.21A 5om2A-1w93A:
undetectable
5om2B-1w93A:
undetectable		 5om2A-1w93A:
8.64
5om2B-1w93A:
5.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHA_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1w93 ACETYL-COENZYME A
CARBOXYLASE
(Saccharomyces
cerevisiae) 		3 / 3 VAL A 222
VAL A 211
GLN A 194
 None
 0.65A 5qhaA-1w93A:
undetectable		 5qhaA-1w93A:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1w93 ACETYL-COENZYME A
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 5 ARG A 533
PHE A 490
LEU A 478
PHE A 480
 None
 1.13A 5wauC-1w93A:
undetectable
5wauJ-1w93A:
undetectable		 5wauC-1w93A:
18.93
5wauJ-1w93A:
8.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1w93 ACETYL-COENZYME A
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 5 ARG A 533
PHE A 490
LEU A 478
PHE A 480
 None
 1.17A 5wauc-1w93A:
undetectable
5wauj-1w93A:
undetectable		 5wauc-1w93A:
18.93
5wauj-1w93A:
8.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1w93 ACETYL-COENZYME A
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 5 ARG A 533
PHE A 490
LEU A 478
PHE A 480
 None
 1.17A 5xdqC-1w93A:
undetectable
5xdqJ-1w93A:
undetectable		 5xdqC-1w93A:
18.93
5xdqJ-1w93A:
8.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1w93 ACETYL-COENZYME A
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 5 ARG A 533
PHE A 490
LEU A 478
PHE A 480
 None
 1.18A 5xdqP-1w93A:
undetectable
5xdqW-1w93A:
undetectable		 5xdqP-1w93A:
18.93
5xdqW-1w93A:
8.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1w93 ACETYL-COENZYME A
CARBOXYLASE
(Saccharomyces
cerevisiae) 		3 / 3 TYR A 308
ARG A  24
THR A  26
 None
 0.97A 5z84J-1w93A:
undetectable		 5z84J-1w93A:
8.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_I_PACI1_0
(SERINE PROTEASE NS3
SERINE PROTEASE
SUBUNIT NS2B
PEPTIDE
PAC-DLY-DLY-DAR)		 1w93 ACETYL-COENZYME A
CARBOXYLASE
(Saccharomyces
cerevisiae) 		3 / 3 VAL A  72
TYR A 109
GLU A 477
 None
 0.62A 5zmqD-1w93A:
undetectable
5zmqE-1w93A:
undetectable		 5zmqD-1w93A:
15.30
5zmqE-1w93A:
7.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLP_A_GAWA1501_1
(SUBSTANCE-P
RECEPTOR,SUBSTANCE-P
RECEPTOR)		 1w93 ACETYL-COENZYME A
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 5 ASN A 381
GLN A 326
HIS A 508
TYR A 489
 None
 1.48A 6hlpA-1w93A:
4.6		 6hlpA-1w93A:
22.45