SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1w98'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_B_SAMB500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 1w98 G1/S-SPECIFIC CYCLIN
E1
(Homo
sapiens) 		5 / 11 VAL B 140
GLU B 189
ALA B 185
ILE B 183
ALA B 154
 None
 1.27A 2admB-1w98B:
undetectable		 2admB-1w98B:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_A_KKKA413_1
(FLAVOHEMOGLOBIN)		 1w98 G1/S-SPECIFIC CYCLIN
E1
(Homo
sapiens) 		4 / 8 TYR B 281
GLN B 155
ALA B 154
LEU B 153
 None
 0.85A 3ozwA-1w98B:
undetectable		 3ozwA-1w98B:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_A_DVAA6_0
(VAL-GRAMICIDIN A)		 1w98 G1/S-SPECIFIC CYCLIN
E1
(Homo
sapiens) 		4 / 4 ALA B 288
VAL B 313
TRP B 315
TRP B 306
 None
 1.31A 3zq8A-1w98B:
undetectable
3zq8B-1w98B:
undetectable		 3zq8A-1w98B:
4.85
3zq8B-1w98B:
4.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA503_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 1w98 G1/S-SPECIFIC CYCLIN
E1
(Homo
sapiens) 		4 / 6 ARG B  98
VAL B 241
LYS B  88
LEU B 244
 None
 0.96A 4em2A-1w98B:
0.4		 4em2A-1w98B:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 1w98 G1/S-SPECIFIC CYCLIN
E1
(Homo
sapiens) 		4 / 5 LEU B 181
SER B 180
ASP B 159
ASP B 115
 None
 1.20A 4qtuD-1w98B:
undetectable		 4qtuD-1w98B:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_A_STRA601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 1w98 G1/S-SPECIFIC CYCLIN
E1
(Homo
sapiens) 		4 / 6 ALA B 288
GLY B 282
ILE B 263
VAL B 237
 None
 0.76A 4r21A-1w98B:
undetectable		 4r21A-1w98B:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R82_A_ACTA205_0
(OXIDOREDUCTASE)		 1w98 G1/S-SPECIFIC CYCLIN
E1
(Homo
sapiens) 		4 / 5 SER B 328
GLY B 327
ARG B 324
PHE B 292
 None
 1.18A 4r82A-1w98B:
undetectable
4r82B-1w98B:
undetectable		 4r82A-1w98B:
19.79
4r82B-1w98B:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_D_CCSD14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2
PROGRAMMED CELL
DEATH 1 LIGAND 1)		 1w98 G1/S-SPECIFIC CYCLIN
E1
(Homo
sapiens) 		5 / 12 PHE B 151
LEU B 153
ARG B 148
VAL B 232
THR B 230
 None
 1.21A 5o4yD-1w98B:
undetectable
5o4yE-1w98B:
undetectable		 5o4yD-1w98B:
4.43
5o4yE-1w98B:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUP_E_DZPE502_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT BETA-3)		 1w98 G1/S-SPECIFIC CYCLIN
E1
(Homo
sapiens) 		5 / 10 PRO B  89
LEU B  90
MET B 239
LEU B 289
MET B 298
 None
 1.44A 6hupD-1w98B:
undetectable
6hupE-1w98B:
0.8		 6hupD-1w98B:
14.08
6hupE-1w98B:
15.77