SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1w99'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_1
(DIHYDROFOLATE
REDUCTASE)		 1w99 PESTICIDIAL CRYSTAL
PROTEIN CRY4BA
(Bacillus
thuringiensis) 		3 / 3 GLU A 629
ILE A 480
ARG A 190
 None
 0.76A 1cd2A-1w99A:
undetectable		 1cd2A-1w99A:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4002_1
(SERUM ALBUMIN)		 1w99 PESTICIDIAL CRYSTAL
PROTEIN CRY4BA
(Bacillus
thuringiensis) 		3 / 3 PHE A 264
LEU A 258
SER A 224
 None
 0.85A 1e7aA-1w99A:
3.3		 1e7aA-1w99A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L2I_A_CCSA417_0
(ESTROGEN RECEPTOR)		 1w99 PESTICIDIAL CRYSTAL
PROTEIN CRY4BA
(Bacillus
thuringiensis) 		3 / 3 GLU A 286
LYS A 467
VAL A 469
 None
P6G  A1667 (-4.1A)
None
 0.95A 1l2iA-1w99A:
undetectable		 1l2iA-1w99A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX8_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO)		 1w99 PESTICIDIAL CRYSTAL
PROTEIN CRY4BA
(Bacillus
thuringiensis) 		5 / 12 PHE A 398
LEU A 374
THR A 450
TYR A 359
ILE A 343
 None
 1.21A 1mx8A-1w99A:
undetectable		 1mx8A-1w99A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG7_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 1w99 PESTICIDIAL CRYSTAL
PROTEIN CRY4BA
(Bacillus
thuringiensis) 		3 / 3 ILE A 523
ILE A 610
THR A 348
 None
 0.63A 1rg7A-1w99A:
undetectable		 1rg7A-1w99A:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RR8_A_TTCA100_1
(DNA TOPOISOMERASE I)		 1w99 PESTICIDIAL CRYSTAL
PROTEIN CRY4BA
(Bacillus
thuringiensis) 		4 / 5 GLU A 569
ARG A 271
ASP A 268
THR A 217
 None
 1.47A 1rr8C-1w99A:
0.0		 1rr8C-1w99A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT6_A_DESA129_1
(TRANSTHYRETIN)		 1w99 PESTICIDIAL CRYSTAL
PROTEIN CRY4BA
(Bacillus
thuringiensis) 		4 / 4 LYS A 400
LEU A 374
LEU A 321
SER A 446
 None
 1.47A 1tt6A-1w99A:
0.0		 1tt6A-1w99A:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 1w99 PESTICIDIAL CRYSTAL
PROTEIN CRY4BA
(Bacillus
thuringiensis) 		5 / 12 ILE A 610
ALA A 611
ARG A 520
LEU A 602
PHE A 594
 None
 1.43A 1y0xX-1w99A:
undetectable		 1y0xX-1w99A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 1w99 PESTICIDIAL CRYSTAL
PROTEIN CRY4BA
(Bacillus
thuringiensis) 		4 / 5 ILE A 100
ARG A  87
LEU A  99
ASN A  98
 None
 1.20A 1y0xX-1w99A:
undetectable		 1y0xX-1w99A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_1
(PROTEASE)		 1w99 PESTICIDIAL CRYSTAL
PROTEIN CRY4BA
(Bacillus
thuringiensis) 		5 / 12 LEU A 491
ALA A 485
ILE A 612
ILE A 541
ILE A 624
 None
 0.98A 2o4nA-1w99A:
undetectable		 2o4nA-1w99A:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQY_A_PARA1201_2
(AAC(6')-IB)		 1w99 PESTICIDIAL CRYSTAL
PROTEIN CRY4BA
(Bacillus
thuringiensis) 		3 / 3 TRP A 243
GLN A 242
TRP A  89
 None
 1.37A 2vqyA-1w99A:
undetectable		 2vqyA-1w99A:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_E_TOPE1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 1w99 PESTICIDIAL CRYSTAL
PROTEIN CRY4BA
(Bacillus
thuringiensis) 		4 / 8 ILE A 624
LEU A 491
ILE A 498
THR A 512
 None
 0.77A 2w9sE-1w99A:
undetectable		 2w9sE-1w99A:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA802_1
(PROSTAGLANDIN
REDUCTASE 1)		 1w99 PESTICIDIAL CRYSTAL
PROTEIN CRY4BA
(Bacillus
thuringiensis) 		4 / 7 VAL A 324
ARG A 323
ASN A 375
VAL A 378
 None
 0.82A 2y05A-1w99A:
undetectable
2y05B-1w99A:
undetectable		 2y05A-1w99A:
18.82
2y05B-1w99A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A65_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 1w99 PESTICIDIAL CRYSTAL
PROTEIN CRY4BA
(Bacillus
thuringiensis) 		5 / 12 TYR A 332
ASP A 334
TYR A 455
GLY A 365
ILE A 331
 None
 1.46A 3a65A-1w99A:
0.0		 3a65A-1w99A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_3
(PHOSPHOLIPASE A2)		 1w99 PESTICIDIAL CRYSTAL
PROTEIN CRY4BA
(Bacillus
thuringiensis) 		4 / 7 VAL A 214
LYS A 218
ILE A 221
LEU A 175
 None
 0.68A 3bjwF-1w99A:
undetectable		 3bjwF-1w99A:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_3
(PHOSPHOLIPASE A2)		 1w99 PESTICIDIAL CRYSTAL
PROTEIN CRY4BA
(Bacillus
thuringiensis) 		4 / 7 VAL A 214
LYS A 218
ILE A 221
LEU A 175
 None
 0.57A 3bjwH-1w99A:
undetectable		 3bjwH-1w99A:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U88_A_CHDA611_0
(MENIN)		 1w99 PESTICIDIAL CRYSTAL
PROTEIN CRY4BA
(Bacillus
thuringiensis) 		3 / 3 SER A 446
PHE A 345
LYS A 322
 None
 0.94A 3u88A-1w99A:
2.2		 3u88A-1w99A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ6_A_SAMA300_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1w99 PESTICIDIAL CRYSTAL
PROTEIN CRY4BA
(Bacillus
thuringiensis) 		4 / 4 SER A 266
ASP A 626
ASP A 507
ALA A 262
 None
 1.42A 3uj6A-1w99A:
undetectable		 3uj6A-1w99A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_C_ACTC1113_0
(BLR5658 PROTEIN)		 1w99 PESTICIDIAL CRYSTAL
PROTEIN CRY4BA
(Bacillus
thuringiensis) 		4 / 4 ASN A 492
ALA A 495
GLY A 519
THR A 512
 BR  A1649 (-4.3A)
None
None
None
 1.16A 4bboC-1w99A:
undetectable		 4bboC-1w99A:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1Y_A_RBFA1176_1
(PUTATIVE PROTEASE I)		 1w99 PESTICIDIAL CRYSTAL
PROTEIN CRY4BA
(Bacillus
thuringiensis) 		4 / 8 GLN A 140
ASN A 139
TRP A 133
THR A 148
 None
None
None
BR  A1665 ( 4.0A)
 1.42A 4d1yA-1w99A:
undetectable
4d1yB-1w99A:
undetectable		 4d1yA-1w99A:
16.98
4d1yB-1w99A:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_2
(DIPEPTIDYL PEPTIDASE
4)		 1w99 PESTICIDIAL CRYSTAL
PROTEIN CRY4BA
(Bacillus
thuringiensis) 		3 / 3 ARG A 289
TYR A 347
ASN A 473
 None
 0.65A 4ffwB-1w99A:
undetectable		 4ffwB-1w99A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_1
(METHYLTRANSFERASE
NSUN4)		 1w99 PESTICIDIAL CRYSTAL
PROTEIN CRY4BA
(Bacillus
thuringiensis) 		3 / 3 ASP A 626
ARG A 627
ASP A 507
 None
 0.83A 4fp9A-1w99A:
undetectable		 4fp9A-1w99A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA304_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 1w99 PESTICIDIAL CRYSTAL
PROTEIN CRY4BA
(Bacillus
thuringiensis) 		3 / 3 ARG A 313
HIS A 316
TYR A 447
 None
 1.26A 4fu8A-1w99A:
undetectable		 4fu8A-1w99A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA312_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 1w99 PESTICIDIAL CRYSTAL
PROTEIN CRY4BA
(Bacillus
thuringiensis) 		3 / 3 ARG A 313
HIS A 316
TYR A 447
 None
 1.29A 4fu9A-1w99A:
undetectable		 4fu9A-1w99A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_1
(DIHYDROPTEROATE
SYNTHASE DHPS)		 1w99 PESTICIDIAL CRYSTAL
PROTEIN CRY4BA
(Bacillus
thuringiensis) 		3 / 3 LYS A 395
ASN A 341
ASP A 397
 None
 0.77A 4o1eA-1w99A:
undetectable		 4o1eA-1w99A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_2
(TUBULIN BETA-2B
CHAIN)		 1w99 PESTICIDIAL CRYSTAL
PROTEIN CRY4BA
(Bacillus
thuringiensis) 		5 / 12 LEU A 517
LEU A 511
ALA A 495
THR A 609
ALA A 611
 None
 0.90A 4o2bB-1w99A:
undetectable		 4o2bB-1w99A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_2
(TUBULIN BETA-2B
CHAIN)		 1w99 PESTICIDIAL CRYSTAL
PROTEIN CRY4BA
(Bacillus
thuringiensis) 		5 / 12 LEU A 517
LEU A 511
ALA A 495
THR A 609
ALA A 611
 None
 0.94A 4o2bD-1w99A:
undetectable		 4o2bD-1w99A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA603_1
(SERUM ALBUMIN)		 1w99 PESTICIDIAL CRYSTAL
PROTEIN CRY4BA
(Bacillus
thuringiensis) 		5 / 10 LEU A 338
VAL A 324
LEU A 374
LEU A 321
VAL A 378
 None
 1.21A 4po0A-1w99A:
3.7		 4po0A-1w99A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_B_LOCB502_1
(TUBULIN BETA CHAIN)		 1w99 PESTICIDIAL CRYSTAL
PROTEIN CRY4BA
(Bacillus
thuringiensis) 		5 / 12 LEU A 517
LEU A 511
ALA A 495
THR A 609
ALA A 611
 None
 1.08A 4x1yB-1w99A:
undetectable		 4x1yB-1w99A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_B_LOCB502_1
(TUBULIN BETA CHAIN)		 1w99 PESTICIDIAL CRYSTAL
PROTEIN CRY4BA
(Bacillus
thuringiensis) 		5 / 12 LEU A 517
LEU A 511
ALA A 495
THR A 609
ALA A 611
 None
 0.96A 4x20B-1w99A:
undetectable		 4x20B-1w99A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_B_SALB801_1
(PROTEIN POLYBROMO-1)		 1w99 PESTICIDIAL CRYSTAL
PROTEIN CRY4BA
(Bacillus
thuringiensis) 		4 / 5 LEU A 167
TYR A 163
ALA A 112
ILE A 177
 None
 0.91A 4y03B-1w99A:
2.2		 4y03B-1w99A:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_1
(BETA-LACTOGLOBULIN)		 1w99 PESTICIDIAL CRYSTAL
PROTEIN CRY4BA
(Bacillus
thuringiensis) 		3 / 3 LYS A 487
ILE A 523
ILE A 610
 None
 0.63A 4y0qA-1w99A:
undetectable		 4y0qA-1w99A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0S_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 1w99 PESTICIDIAL CRYSTAL
PROTEIN CRY4BA
(Bacillus
thuringiensis) 		5 / 12 VAL A 623
LEU A 539
ILE A 541
ILE A 566
VAL A 553
 None
None
None
BR  A1664 ( 4.6A)
None
 0.96A 4y0sA-1w99A:
undetectable		 4y0sA-1w99A:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_B_ACTB404_0
(D-ALANINE--D-ALANINE
LIGASE)		 1w99 PESTICIDIAL CRYSTAL
PROTEIN CRY4BA
(Bacillus
thuringiensis) 		4 / 7 LYS A 380
TYR A 379
GLY A 403
LEU A 405
 None
 1.09A 5bphB-1w99A:
undetectable		 5bphB-1w99A:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ITZ_B_LOCB502_1
(TUBULIN BETA-2B
CHAIN)		 1w99 PESTICIDIAL CRYSTAL
PROTEIN CRY4BA
(Bacillus
thuringiensis) 		5 / 12 LEU A 517
LEU A 511
ALA A 495
THR A 609
ALA A 611
 None
 0.93A 5itzB-1w99A:
undetectable		 5itzB-1w99A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIO_B_LOCB502_1
(TUBULIN BETA CHAIN)		 1w99 PESTICIDIAL CRYSTAL
PROTEIN CRY4BA
(Bacillus
thuringiensis) 		5 / 12 LEU A 517
LEU A 511
ALA A 495
THR A 609
ALA A 611
 None
 0.92A 5mioB-1w99A:
undetectable		 5mioB-1w99A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 1w99 PESTICIDIAL CRYSTAL
PROTEIN CRY4BA
(Bacillus
thuringiensis) 		4 / 5 TYR A 590
SER A 266
ALA A 265
THR A 217
 None
 1.33A 5n0tA-1w99A:
undetectable		 5n0tA-1w99A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_F_CVIF301_1
(REGULATORY PROTEIN
TETR)		 1w99 PESTICIDIAL CRYSTAL
PROTEIN CRY4BA
(Bacillus
thuringiensis) 		4 / 8 ILE A 194
ARG A 190
TRP A 199
ASP A 278
 BR  A1645 ( 4.4A)
None
None
None
 1.14A 5vlmF-1w99A:
1.4		 5vlmF-1w99A:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_B_LOCB504_2
(TUBULIN BETA CHAIN)		 1w99 PESTICIDIAL CRYSTAL
PROTEIN CRY4BA
(Bacillus
thuringiensis) 		5 / 12 LEU A 517
LEU A 511
ALA A 495
THR A 609
ALA A 611
 None
 0.98A 5xiwB-1w99A:
undetectable		 5xiwB-1w99A:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DYO_A_LDPA901_0
(EBONY)		 1w99 PESTICIDIAL CRYSTAL
PROTEIN CRY4BA
(Bacillus
thuringiensis) 		4 / 5 GLU A 286
VAL A 469
HIS A 316
THR A 348
 None
 1.27A 6dyoA-1w99A:
undetectable		 6dyoA-1w99A:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		 1w99 PESTICIDIAL CRYSTAL
PROTEIN CRY4BA
(Bacillus
thuringiensis) 		3 / 3 ASP A 478
ASP A 470
ASN A 377
 None
 0.58A 6gngB-1w99A:
undetectable		 6gngB-1w99A:
19.75