SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1w9c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_C_CHDC3271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 1w9c CRM1 PROTEIN
(Homo
sapiens) 		4 / 8 LYS A1012
PHE A 997
LEU A1001
PHE A 950
 None
 0.91A 1v54C-1w9cA:
2.4
1v54J-1w9cA:
undetectable		 1v54C-1w9cA:
22.90
1v54J-1w9cA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_P_CHDP4271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 1w9c CRM1 PROTEIN
(Homo
sapiens) 		4 / 8 LYS A1012
PHE A 997
LEU A1001
PHE A 950
 None
 0.91A 1v54P-1w9cA:
2.4
1v54W-1w9cA:
0.0		 1v54P-1w9cA:
22.90
1v54W-1w9cA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD37_0
(GCN4 LEUCINE ZIPPER)		 1w9c CRM1 PROTEIN
(Homo
sapiens) 		3 / 3 LYS A 810
ARG A 765
VAL A 763
 None
 1.06A 2r2vC-1w9cA:
undetectable
2r2vD-1w9cA:
undetectable		 2r2vC-1w9cA:
9.68
2r2vD-1w9cA:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_B_FUAB2002_1
(SERUM ALBUMIN)		 1w9c CRM1 PROTEIN
(Homo
sapiens) 		4 / 9 ILE A 815
ALA A 805
VAL A 808
CYH A 859
 None
 0.92A 2vufB-1w9cA:
4.0		 2vufB-1w9cA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 1w9c CRM1 PROTEIN
(Homo
sapiens) 		4 / 7 LEU A1001
PHE A1011
LEU A1015
PHE A1018
 None
 0.92A 3ag2C-1w9cA:
2.3		 3ag2C-1w9cA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1w9c CRM1 PROTEIN
(Homo
sapiens) 		4 / 8 LEU A1001
PHE A1011
LEU A1015
PHE A1018
 None
 0.87A 3ag4C-1w9cA:
2.3
3ag4J-1w9cA:
undetectable		 3ag4C-1w9cA:
22.90
3ag4J-1w9cA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_D_BRLD478_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1w9c CRM1 PROTEIN
(Homo
sapiens) 		5 / 12 LEU A 785
VAL A 826
LEU A 851
MET A 804
TYR A 714
 None
 1.47A 3dzyD-1w9cA:
0.3		 3dzyD-1w9cA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1C_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 1w9c CRM1 PROTEIN
(Homo
sapiens) 		5 / 10 ILE A 879
ILE A 878
ILE A 922
LEU A 894
HIS A 942
 None
 1.19A 3o1cA-1w9cA:
undetectable		 3o1cA-1w9cA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1X_A_ADNA1450_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 1w9c CRM1 PROTEIN
(Homo
sapiens) 		6 / 10 ILE A 879
ILE A 878
ILE A 922
LEU A 894
SER A 928
HIS A 942
 None
 1.46A 3o1xA-1w9cA:
undetectable		 3o1xA-1w9cA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A2000_1
(P38A)		 1w9c CRM1 PROTEIN
(Homo
sapiens) 		5 / 12 ILE A 819
VAL A 763
ILE A 759
ILE A 822
ALA A 854
 None
 0.91A 3ohtA-1w9cA:
undetectable
3ohtB-1w9cA:
undetectable		 3ohtA-1w9cA:
22.86
3ohtB-1w9cA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGZ_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 1w9c CRM1 PROTEIN
(Homo
sapiens) 		5 / 10 ILE A 879
ILE A 878
ILE A 922
LEU A 894
HIS A 942
 None
 1.18A 3qgzA-1w9cA:
undetectable		 3qgzA-1w9cA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_0
(PUTATIVE REGULATORY
PROTEIN)		 1w9c CRM1 PROTEIN
(Homo
sapiens) 		5 / 12 THR A 740
ILE A 745
SER A 747
ALA A 783
ASP A 787
 None
 1.13A 3vw1D-1w9cA:
2.5		 3vw1D-1w9cA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1w9c CRM1 PROTEIN
(Homo
sapiens) 		4 / 6 LEU A1015
PHE A 997
LEU A1001
PHE A 950
 None
 1.06A 3wg7C-1w9cA:
2.3
3wg7J-1w9cA:
undetectable		 3wg7C-1w9cA:
22.90
3wg7J-1w9cA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KF9_A_ACTA407_0
(GLUTATHIONE
S-TRANSFERASE
PROTEIN)		 1w9c CRM1 PROTEIN
(Homo
sapiens) 		3 / 3 GLU A 839
ARG A 845
HIS A 884
 None
 0.58A 4kf9A-1w9cA:
2.2		 4kf9A-1w9cA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_A_ASDA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1w9c CRM1 PROTEIN
(Homo
sapiens) 		4 / 7 VAL A 953
ILE A 958
LEU A 897
LEU A 901
 None
 1.00A 4xo7A-1w9cA:
undetectable		 4xo7A-1w9cA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUM_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 1w9c CRM1 PROTEIN
(Homo
sapiens) 		4 / 8 VAL A 777
LEU A 781
ILE A 822
ILE A 819
 None
 0.72A 5numA-1w9cA:
undetectable		 5numA-1w9cA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUN_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 1w9c CRM1 PROTEIN
(Homo
sapiens) 		5 / 9 ALA A 773
VAL A 777
LEU A 781
ILE A 822
ILE A 819
 None
 0.91A 5nunA-1w9cA:
undetectable		 5nunA-1w9cA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 1w9c CRM1 PROTEIN
(Homo
sapiens) 		4 / 6 LEU A 780
VAL A 784
LEU A 785
VAL A 800
 None
 0.96A 5x7zA-1w9cA:
undetectable		 5x7zA-1w9cA:
19.14