SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1wa4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 1wa4 PCZA361.16
(Amycolatopsis
orientalis) 		4 / 7 TYR A 113
VAL A 118
GLY A 117
THR A  65
 None
GOL  A1208 (-4.6A)
GOL  A1208 (-3.3A)
GOL  A1208 (-3.8A)
 0.94A 2a1mA-1wa4A:
undetectable		 2a1mA-1wa4A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITZ_A_IREA2021_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 1wa4 PCZA361.16
(Amycolatopsis
orientalis) 		3 / 3 LEU A 156
LEU A 103
MET A 104
 None
 0.70A 2itzA-1wa4A:
undetectable		 2itzA-1wa4A:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1wa4 PCZA361.16
(Amycolatopsis
orientalis) 		5 / 11 ALA A 153
TYR A  64
ILE A  89
ASP A 151
ALA A 177
 None
 1.20A 3rukD-1wa4A:
undetectable		 3rukD-1wa4A:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFG_B_LEUB289_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 1wa4 PCZA361.16
(Amycolatopsis
orientalis) 		3 / 3 PHE A 122
SER A  52
SER A  54
 None
 1.02A 3ufgB-1wa4A:
undetectable		 3ufgB-1wa4A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_A_AERA601_1
(CYP17A1 PROTEIN)		 1wa4 PCZA361.16
(Amycolatopsis
orientalis) 		5 / 9 ALA A 153
TYR A  64
ILE A  89
ASP A 151
ALA A 177
 None
 1.24A 4r1zA-1wa4A:
undetectable		 4r1zA-1wa4A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NU7_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 4)		 1wa4 PCZA361.16
(Amycolatopsis
orientalis) 		4 / 8 ALA A  72
VAL A 102
TYR A  74
HIS A  39
 None
 0.98A 5nu7A-1wa4A:
undetectable		 5nu7A-1wa4A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_A_SAMA501_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 1wa4 PCZA361.16
(Amycolatopsis
orientalis) 		6 / 12 ILE A  87
GLY A 119
ILE A 158
VAL A 123
ASP A  84
ILE A  85
 None
GOL  A1208 ( 4.4A)
None
None
None
None
 1.50A 6emuA-1wa4A:
undetectable		 6emuA-1wa4A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MXT_A_K5YA1401_1
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		 1wa4 PCZA361.16
(Amycolatopsis
orientalis) 		3 / 3 ASP A  84
SER A  54
SER A  52
 None
 0.83A 6mxtA-1wa4A:
undetectable		 6mxtA-1wa4A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 1wa4 PCZA361.16
(Amycolatopsis
orientalis) 		3 / 3 ASP A 105
LEU A 103
ARG A   4
 None
 0.85A 7dfrA-1wa4A:
undetectable		 7dfrA-1wa4A:
27.27