SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1wa5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DIT_P_2PPP1_1
(ALPHA-THROMBIN
PEPTIDE INHIBITOR
CVS995)		 1wa5 IMPORTIN ALPHA
SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 6 LEU B 437
ILE B 497
GLU B 446
ASP B 450
 None
 1.22A 1ditH-1wa5B:
undetectable
1ditP-1wa5B:
undetectable		 1ditH-1wa5B:
18.34
1ditP-1wa5B:
2.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYR_A_TOPA407_1
(DIHYDROFOLATE
REDUCTASE)		 1wa5 IMPORTIN ALPHA
SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 11 LEU B 343
ILE B 365
ILE B 385
ILE B 376
THR B 334
 None
 1.07A 1dyrA-1wa5B:
undetectable		 1dyrA-1wa5B:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4007_1
(SERUM ALBUMIN)		 1wa5 IMPORTIN ALPHA
RE-EXPORTER
(Saccharomyces
cerevisiae) 		4 / 8 LEU C 432
ASN C 435
LEU C 449
LEU C 450
 None
 1.02A 1e7cA-1wa5C:
2.5		 1e7cA-1wa5C:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_RALA600_2
(ESTROGEN RECEPTOR)		 1wa5 IMPORTIN ALPHA
RE-EXPORTER
(Saccharomyces
cerevisiae) 		4 / 6 LEU C 788
LEU C 798
LEU C 767
LEU C 770
 None
 0.83A 1errA-1wa5C:
undetectable		 1errA-1wa5C:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2501_0
(FERROCHELATASE)		 1wa5 IMPORTIN ALPHA
RE-EXPORTER
(Saccharomyces
cerevisiae) 		5 / 12 LEU C  41
PHE C  61
LEU C  38
ILE C 109
PRO C  79
 None
 1.21A 1hrkB-1wa5C:
undetectable		 1hrkB-1wa5C:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_2
(BETA-LACTAMASE)		 1wa5 IMPORTIN ALPHA
SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 5 TYR B 283
PRO B 250
LEU B 212
THR B 236
 None
 1.33A 1i2wA-1wa5B:
undetectable		 1i2wA-1wa5B:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IWH_A_PEMA501_1
(HEMOGLOBIN ALPHA
CHAIN)		 1wa5 IMPORTIN ALPHA
SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 6 ALA B 164
LYS B 167
ASP B 171
ALA B 172
 None
 0.37A 1iwhA-1wa5B:
undetectable		 1iwhA-1wa5B:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1wa5 IMPORTIN ALPHA
RE-EXPORTER
(Saccharomyces
cerevisiae) 		4 / 7 MET C 860
VAL C 838
TRP C 814
PHE C 848
 None
 1.50A 1p6kA-1wa5C:
undetectable
1p6kB-1wa5C:
undetectable		 1p6kA-1wa5C:
16.67
1p6kB-1wa5C:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1wa5 IMPORTIN ALPHA
RE-EXPORTER
(Saccharomyces
cerevisiae) 		4 / 7 TRP C 814
PHE C 848
MET C 860
VAL C 838
 None
 1.48A 1p6kA-1wa5C:
undetectable
1p6kB-1wa5C:
undetectable		 1p6kA-1wa5C:
16.67
1p6kB-1wa5C:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S3Z_B_RIOB501_0
(AMINOGLYCOSIDE
6'-N-ACETYLTRANSFERA
SE)		 1wa5 IMPORTIN ALPHA
RE-EXPORTER
(Saccharomyces
cerevisiae) 		4 / 8 GLU C 226
VAL C 280
ARG C 159
ASP C 279
 None
 1.21A 1s3zA-1wa5C:
undetectable
1s3zB-1wa5C:
undetectable		 1s3zA-1wa5C:
9.60
1s3zB-1wa5C:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN0_C_T44C601_1
(TRANSTHYRETIN)		 1wa5 IMPORTIN ALPHA
SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 9 LEU B 388
LEU B 384
LYS B 358
GLU B 355
ALA B 361
 None
 1.26A 1sn0A-1wa5B:
undetectable
1sn0C-1wa5B:
undetectable		 1sn0A-1wa5B:
13.51
1sn0C-1wa5B:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_0
(VP39)		 1wa5 IMPORTIN ALPHA
SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 12 LEU B 346
ILE B 326
GLY B 341
VAL B 295
ALA B 319
 None
 1.01A 1vptA-1wa5B:
undetectable		 1vptA-1wa5B:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		 1wa5 IMPORTIN ALPHA
SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 6 SER B 226
ILE B 232
ALA B 235
ALA B 193
 None
 0.98A 1w0gA-1wa5B:
undetectable		 1w0gA-1wa5B:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2887_1
(AMINOMETHYLTRANSFERA
SE)		 1wa5 IMPORTIN ALPHA
SUBUNIT
IMPORTIN ALPHA
RE-EXPORTER
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		3 / 3 ASP B  49
GLU C 226
ARG C 159
 None
 0.59A 1wopA-1wa5B:
0.0		 1wopA-1wa5B:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_1
(AMINOMETHYLTRANSFERA
SE)		 1wa5 IMPORTIN ALPHA
RE-EXPORTER
(Saccharomyces
cerevisiae) 		3 / 3 ASP C 360
GLU C 571
TYR C 513
 None
 0.68A 1wsvA-1wa5C:
undetectable		 1wsvA-1wa5C:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1wa5 IMPORTIN ALPHA
SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 12 GLY B 329
ARG B  35
ASP B 286
ASN B 330
ALA B 291
 None
 1.24A 2bm9B-1wa5B:
undetectable		 2bm9B-1wa5B:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1wa5 IMPORTIN ALPHA
SUBUNIT
IMPORTIN ALPHA
RE-EXPORTER
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		3 / 3 LYS B 401
ASP C 215
ASP B 441
 None
 0.97A 2br4D-1wa5B:
undetectable		 2br4D-1wa5B:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_B_T44B1395_1
(THYROXINE-BINDING
GLOBULIN)		 1wa5 IMPORTIN ALPHA
RE-EXPORTER
(Saccharomyces
cerevisiae) 		5 / 10 ALA C 867
LEU C 938
SER C 868
LEU C 956
ASN C 954
 None
 1.27A 2ceoB-1wa5C:
0.0		 2ceoB-1wa5C:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 1wa5 IMPORTIN ALPHA
RE-EXPORTER
(Saccharomyces
cerevisiae) 		5 / 12 GLU C 107
ILE C  44
LEU C  41
SER C 110
ARG C 153
 None
 1.17A 2e7fA-1wa5C:
undetectable		 2e7fA-1wa5C:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 1wa5 IMPORTIN ALPHA
RE-EXPORTER
(Saccharomyces
cerevisiae) 		5 / 12 GLU C 107
ILE C  44
LEU C  41
SER C 110
ARG C 153
 None
 1.16A 2e7fB-1wa5C:
undetectable		 2e7fB-1wa5C:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_2
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 1wa5 IMPORTIN ALPHA
SUBUNIT
(Saccharomyces
cerevisiae) 		3 / 3 VAL B 327
VAL B 336
ASP B 381
 None
 0.73A 2fumD-1wa5B:
undetectable		 2fumD-1wa5B:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_B_SCKB951_1
(ACETYLCHOLINESTERASE)		 1wa5 IMPORTIN ALPHA
RE-EXPORTER
(Saccharomyces
cerevisiae) 		4 / 8 TYR C 364
ASP C 368
TYR C 483
TYR C 515
 None
 1.49A 2ha2B-1wa5C:
undetectable		 2ha2B-1wa5C:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_2
(THYMIDYLATE SYNTHASE)		 1wa5 IMPORTIN ALPHA
RE-EXPORTER
(Saccharomyces
cerevisiae) 		3 / 3 HIS C 255
ILE C 260
LEU C 246
 None
 0.74A 2kceA-1wa5C:
undetectable		 2kceA-1wa5C:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LBD_A_REAA500_1
(RETINOIC ACID
RECEPTOR GAMMA)		 1wa5 IMPORTIN ALPHA
RE-EXPORTER
IMPORTIN ALPHA
SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 12 PHE C 174
ILE C 150
ARG B  17
GLY C 142
LEU C 132
 None
 1.31A 2lbdA-1wa5C:
undetectable		 2lbdA-1wa5C:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 1wa5 IMPORTIN ALPHA
RE-EXPORTER
(Saccharomyces
cerevisiae) 		5 / 12 GLU C 107
ILE C  44
LEU C  41
SER C 110
ARG C 153
 None
 1.14A 2ogyA-1wa5C:
undetectable		 2ogyA-1wa5C:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 1wa5 IMPORTIN ALPHA
RE-EXPORTER
(Saccharomyces
cerevisiae) 		5 / 12 GLU C 107
ILE C  44
LEU C  41
SER C 110
ARG C 153
 None
 1.14A 2ogyB-1wa5C:
undetectable		 2ogyB-1wa5C:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1wa5 IMPORTIN ALPHA
RE-EXPORTER
(Saccharomyces
cerevisiae) 		5 / 12 LEU C  41
PHE C  61
LEU C  38
ILE C 109
PRO C  79
 None
 1.19A 2pnjB-1wa5C:
undetectable		 2pnjB-1wa5C:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1wa5 IMPORTIN ALPHA
SUBUNIT
(Saccharomyces
cerevisiae) 		3 / 3 LEU B 388
PRO B 387
LEU B 391
 None
 0.60A 2po5B-1wa5B:
undetectable		 2po5B-1wa5B:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1wa5 IMPORTIN ALPHA
RE-EXPORTER
(Saccharomyces
cerevisiae) 		5 / 12 LEU C  41
PHE C  61
LEU C  38
ILE C 109
PRO C  79
 None
 1.22A 2po7B-1wa5C:
undetectable		 2po7B-1wa5C:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_A_BRLA1_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 1wa5 IMPORTIN ALPHA
RE-EXPORTER
(Saccharomyces
cerevisiae) 		3 / 3 ILE C 836
ILE C 843
LEU C 748
 None
 0.55A 2prgA-1wa5C:
undetectable		 2prgA-1wa5C:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_CHDA332_0
(CHOLOYLGLYCINE
HYDROLASE)		 1wa5 IMPORTIN ALPHA
SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 12 ILE B 430
ALA B 451
ASN B 473
ILE B 376
ILE B 380
 None
 1.18A 2rlcA-1wa5B:
undetectable		 2rlcA-1wa5B:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_F_ASDF1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1wa5 IMPORTIN ALPHA
RE-EXPORTER
(Saccharomyces
cerevisiae) 		4 / 8 LEU C 719
PRO C 721
LEU C 687
ALA C 683
 None
 0.72A 2vcvF-1wa5C:
3.6		 2vcvF-1wa5C:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_P_ASDP1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1wa5 IMPORTIN ALPHA
RE-EXPORTER
(Saccharomyces
cerevisiae) 		4 / 8 LEU C 719
PRO C 721
LEU C 687
ALA C 683
 None
 0.80A 2vcvP-1wa5C:
3.5		 2vcvP-1wa5C:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 1wa5 IMPORTIN ALPHA
RE-EXPORTER
(Saccharomyces
cerevisiae) 		5 / 10 PHE C 485
TYR C 481
ALA C 433
ALA C 431
THR C 382
 None
 1.36A 2wuzA-1wa5C:
undetectable		 2wuzA-1wa5C:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1wa5 IMPORTIN ALPHA
SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 6 LEU B 350
ILE B 365
ILE B 292
LEU B 304
 None
 0.62A 2xkwB-1wa5B:
undetectable		 2xkwB-1wa5B:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBZ_A_VDXA501_1
(CYTOCHROME P450-SU1)		 1wa5 IMPORTIN ALPHA
RE-EXPORTER
(Saccharomyces
cerevisiae) 		5 / 11 THR C 317
LEU C 308
VAL C 309
SER C 241
ILE C 299
 None
 1.02A 2zbzA-1wa5C:
0.0		 2zbzA-1wa5C:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_B_VD3B2001_1
(VITAMIN D
HYDROXYLASE)		 1wa5 IMPORTIN ALPHA
SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 11 ILE B 365
LEU B 424
ASN B 454
LEU B 388
ILE B 385
 None
 1.13A 3a50B-1wa5B:
3.1		 3a50B-1wa5B:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_C_VD3C2001_1
(VITAMIN D
HYDROXYLASE)		 1wa5 IMPORTIN ALPHA
SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 11 ILE B 365
LEU B 424
ASN B 454
LEU B 388
ILE B 385
 None
 1.10A 3a50C-1wa5B:
3.0		 3a50C-1wa5B:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_E_VD3E2001_1
(VITAMIN D
HYDROXYLASE)		 1wa5 IMPORTIN ALPHA
SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 12 ILE B 365
LEU B 424
ASN B 454
LEU B 388
ILE B 385
 None
 1.11A 3a50E-1wa5B:
3.0		 3a50E-1wa5B:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_A_MIYA2001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 1wa5 IMPORTIN ALPHA
RE-EXPORTER
IMPORTIN ALPHA
SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 8 GLY C 442
GLU B 478
ASN C 437
ILE C 434
 None
 0.92A 3aodA-1wa5C:
undetectable		 3aodA-1wa5C:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB6_0
(FERROCHELATASE)		 1wa5 IMPORTIN ALPHA
RE-EXPORTER
(Saccharomyces
cerevisiae) 		5 / 12 LEU C  41
PHE C  61
LEU C  38
ILE C 109
PRO C  79
 None
 1.21A 3aqiB-1wa5C:
undetectable		 3aqiB-1wa5C:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA607_1
(CHITINASE A)		 1wa5 IMPORTIN ALPHA
RE-EXPORTER
IMPORTIN ALPHA
SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 8 VAL C 914
GLY C 826
ALA C 873
GLU B 464
 None
 0.70A 3aruA-1wa5C:
undetectable		 3aruA-1wa5C:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_2
(PHOSPHOLIPASE A2)		 1wa5 IMPORTIN ALPHA
SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 6 VAL B 168
GLY B 198
ARG B 208
LEU B 242
 None
 1.05A 3bjwE-1wa5B:
undetectable		 3bjwE-1wa5B:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		 1wa5 IMPORTIN ALPHA
RE-EXPORTER
(Saccharomyces
cerevisiae) 		4 / 8 ALA C 555
LEU C 558
GLN C 594
ILE C 626
 None
 0.56A 3cldB-1wa5C:
undetectable		 3cldB-1wa5C:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_1
(CYTOCHROME P450 2R1)		 1wa5 IMPORTIN ALPHA
RE-EXPORTER
(Saccharomyces
cerevisiae) 		4 / 5 ASN C 100
ALA C 108
LEU C  40
GLY C  57
 None
 0.89A 3dl9A-1wa5C:
undetectable		 3dl9A-1wa5C:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL1_A_DR7A100_2
(PROTEASE)		 1wa5 IMPORTIN ALPHA
SUBUNIT
(Saccharomyces
cerevisiae) 		6 / 12 ALA B 451
ASP B 450
GLY B 413
ILE B 376
VAL B 425
ILE B 455
 None
 1.50A 3el1B-1wa5B:
undetectable		 3el1B-1wa5B:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1wa5 IMPORTIN ALPHA
RE-EXPORTER
(Saccharomyces
cerevisiae) 		5 / 10 ILE C 813
ILE C 818
VAL C 838
GLY C 787
LEU C 766
 None
 1.21A 3em0A-1wa5C:
undetectable		 3em0A-1wa5C:
9.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_F_TOPF200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 1wa5 IMPORTIN ALPHA
SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 10 LEU B 437
ALA B 501
ILE B 504
LEU B 456
PHE B 509
 None
 1.23A 3fl9F-1wa5B:
undetectable		 3fl9F-1wa5B:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		 1wa5 IMPORTIN ALPHA
SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 12 LEU B 242
LEU B 239
ALA B 235
LEU B 182
THR B 156
 None
 1.19A 3gwuA-1wa5B:
undetectable		 3gwuA-1wa5B:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_A_LEIA16_0
(COIL SER L16D-PEN)		 1wa5 IMPORTIN ALPHA
SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 6 GLN B  91
LEU B  89
GLU B  88
LYS B 110
 None
 0.92A 3h5gA-1wa5B:
undetectable
3h5gC-1wa5B:
undetectable		 3h5gA-1wa5B:
5.43
3h5gC-1wa5B:
5.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 1wa5 IMPORTIN ALPHA
SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 12 GLY B 324
THR B 364
SER B 282
ILE B 292
ARG B  34
 None
 1.31A 3iv6C-1wa5B:
undetectable		 3iv6C-1wa5B:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_A_BCZA1001_0
(NEURAMINIDASE)		 1wa5 IMPORTIN ALPHA
RE-EXPORTER
(Saccharomyces
cerevisiae) 		5 / 12 GLU C 621
LEU C 898
ARG C 575
GLU C 521
ARG C 579
 None
 1.50A 3k39A-1wa5C:
undetectable		 3k39A-1wa5C:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_G_BCZG1001_0
(NEURAMINIDASE)		 1wa5 IMPORTIN ALPHA
RE-EXPORTER
(Saccharomyces
cerevisiae) 		5 / 12 GLU C 621
LEU C 898
ARG C 575
GLU C 521
ARG C 579
 None
 1.49A 3k39G-1wa5C:
undetectable		 3k39G-1wa5C:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_A_CL6A506_1
(CHOLESTEROL
24-HYDROXYLASE)		 1wa5 IMPORTIN ALPHA
RE-EXPORTER
(Saccharomyces
cerevisiae) 		5 / 9 LEU C 926
VAL C 842
ILE C 836
ALA C 867
THR C 866
 None
 1.09A 3mdvA-1wa5C:
undetectable		 3mdvA-1wa5C:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_B_CGEB501_1
(CYTOCHROME P450 2B4)		 1wa5 IMPORTIN ALPHA
SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 8 ILE B 368
ALA B 340
VAL B 323
VAL B 327
 None
 0.91A 3me6B-1wa5B:
undetectable		 3me6B-1wa5B:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1wa5 IMPORTIN ALPHA
SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 12 LEU B 456
PHE B 509
ILE B 486
GLY B 482
LEU B 433
 None
 0.99A 3n8xB-1wa5B:
undetectable		 3n8xB-1wa5B:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA270_0
(PROTEIN SSM1)		 1wa5 IMPORTIN ALPHA
RE-EXPORTER
(Saccharomyces
cerevisiae) 		4 / 5 LEU C 638
SER C 641
LEU C 596
PRO C 593
 None
 1.18A 3onnA-1wa5C:
undetectable		 3onnA-1wa5C:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZV_B_ECNB411_1
(FLAVOHEMOGLOBIN)		 1wa5 IMPORTIN ALPHA
SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 9 ILE B 357
GLN B 316
ALA B 319
LEU B 320
LEU B 350
 None
 0.92A 3ozvB-1wa5B:
undetectable		 3ozvB-1wa5B:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_A_KKKA413_1
(FLAVOHEMOGLOBIN)		 1wa5 IMPORTIN ALPHA
SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 8 ILE B 357
GLN B 316
ALA B 319
LEU B 320
 None
 0.55A 3ozwA-1wa5B:
undetectable		 3ozwA-1wa5B:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_B_KKKB413_1
(FLAVOHEMOGLOBIN)		 1wa5 IMPORTIN ALPHA
SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 12 ILE B 357
HIS B 310
GLN B 316
ALA B 319
LEU B 320
 None
 1.05A 3ozwB-1wa5B:
undetectable		 3ozwB-1wa5B:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1wa5 IMPORTIN ALPHA
RE-EXPORTER
(Saccharomyces
cerevisiae) 		5 / 12 LEU C  41
PHE C  61
LEU C  38
ILE C 109
PRO C  79
 None
 1.12A 3w1wA-1wa5C:
undetectable		 3w1wA-1wa5C:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1wa5 IMPORTIN ALPHA
RE-EXPORTER
(Saccharomyces
cerevisiae) 		5 / 12 LEU C  41
PHE C  61
LEU C  38
ILE C 109
PRO C  79
 None
 1.13A 3w1wB-1wa5C:
undetectable		 3w1wB-1wa5C:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_0
(WBDD)		 1wa5 IMPORTIN ALPHA
SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 12 ILE B 477
ILE B 455
SER B 426
VAL B 425
ILE B 421
 None
 1.00A 4ax8A-1wa5B:
undetectable		 4ax8A-1wa5B:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZV_A_SAMA1474_0
(WBDD)		 1wa5 IMPORTIN ALPHA
SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 12 ILE B 477
ILE B 455
SER B 426
VAL B 425
ILE B 421
 None
 0.95A 4azvA-1wa5B:
undetectable		 4azvA-1wa5B:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_B_ACTB1114_0
(BLR5658 PROTEIN)		 1wa5 IMPORTIN ALPHA
SUBUNIT
(Saccharomyces
cerevisiae) 		3 / 3 TRP B 195
TRP B 237
THR B 238
 None
 1.40A 4bboB-1wa5B:
undetectable		 4bboB-1wa5B:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_B_C2FB300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 1wa5 IMPORTIN ALPHA
RE-EXPORTER
(Saccharomyces
cerevisiae) 		5 / 12 GLU C 107
ILE C  44
LEU C  41
SER C 110
ARG C 153
 None
 1.30A 4djfB-1wa5C:
undetectable		 4djfB-1wa5C:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_C_SAMC800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 1wa5 IMPORTIN ALPHA
RE-EXPORTER
(Saccharomyces
cerevisiae) 		5 / 11 ILE C  90
GLY C 106
GLU C 107
GLY C  57
LYS C  62
 None
 1.23A 4e47C-1wa5C:
undetectable		 4e47C-1wa5C:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1wa5 IMPORTIN ALPHA
RE-EXPORTER
IMPORTIN ALPHA
SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 7 ASP C 279
ASP B  49
GLU C 226
GLU B 396
 None
 1.14A 4feuB-1wa5C:
0.7		 4feuB-1wa5C:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1wa5 IMPORTIN ALPHA
RE-EXPORTER
IMPORTIN ALPHA
SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 8 ASP C 279
ASP B  49
GLU C 226
GLU B 396
 None
 1.15A 4feuF-1wa5C:
0.1		 4feuF-1wa5C:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1wa5 IMPORTIN ALPHA
RE-EXPORTER
IMPORTIN ALPHA
SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 7 ASP C 279
ASP B  49
GLU C 226
GLU B 396
 None
 1.16A 4fevF-1wa5C:
undetectable		 4fevF-1wa5C:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1wa5 IMPORTIN ALPHA
RE-EXPORTER
IMPORTIN ALPHA
SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 8 ASP C 279
ASP B  49
GLU C 226
GLU B 396
 None
 1.14A 4fewD-1wa5C:
undetectable		 4fewD-1wa5C:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1wa5 IMPORTIN ALPHA
RE-EXPORTER
IMPORTIN ALPHA
SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 8 ASP C 279
ASP B  49
GLU C 226
GLU B 396
 None
 1.16A 4fewF-1wa5C:
0.7		 4fewF-1wa5C:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEX_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1wa5 IMPORTIN ALPHA
RE-EXPORTER
IMPORTIN ALPHA
SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 7 ASP C 279
ASP B  49
GLU C 226
GLU B 396
 None
 1.14A 4fexB-1wa5C:
undetectable		 4fexB-1wa5C:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1wa5 IMPORTIN ALPHA
RE-EXPORTER
IMPORTIN ALPHA
SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 8 ASP C 279
ASP B  49
GLU C 226
GLU B 396
 None
 1.21A 4gkhB-1wa5C:
undetectable		 4gkhB-1wa5C:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_A_KANA301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1wa5 IMPORTIN ALPHA
RE-EXPORTER
IMPORTIN ALPHA
SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 8 ASP C 279
ASP B  49
GLU C 226
GLU B 396
 None
 1.15A 4gkiA-1wa5C:
undetectable		 4gkiA-1wa5C:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1wa5 IMPORTIN ALPHA
RE-EXPORTER
IMPORTIN ALPHA
SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 8 ASP C 279
ASP B  49
GLU C 226
GLU B 396
 None
 1.14A 4gkiE-1wa5C:
undetectable
4gkiG-1wa5C:
undetectable		 4gkiE-1wa5C:
14.23
4gkiG-1wa5C:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_B_LURB201_1
(TRANSTHYRETIN)		 1wa5 IMPORTIN ALPHA
RE-EXPORTER
(Saccharomyces
cerevisiae) 		4 / 8 MET C 284
LEU C 269
LEU C 272
VAL C 280
 None
 0.91A 4iizB-1wa5C:
undetectable		 4iizB-1wa5C:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK6_B_LURB201_1
(TRANSTHYRETIN)		 1wa5 IMPORTIN ALPHA
RE-EXPORTER
(Saccharomyces
cerevisiae) 		4 / 8 MET C 284
LEU C 269
LEU C 272
VAL C 280
 None
 0.87A 4ik6B-1wa5C:
undetectable		 4ik6B-1wa5C:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_A_SAMA900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 1wa5 IMPORTIN ALPHA
RE-EXPORTER
(Saccharomyces
cerevisiae) 		5 / 12 PHE C 810
GLY C 837
LEU C 798
SER C 795
ILE C 818
 None
 1.05A 4krhA-1wa5C:
undetectable		 4krhA-1wa5C:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 1wa5 IMPORTIN ALPHA
RE-EXPORTER
(Saccharomyces
cerevisiae) 		5 / 12 PHE C 810
GLY C 837
LEU C 798
SER C 795
ILE C 818
 None
 1.15A 4krhB-1wa5C:
undetectable		 4krhB-1wa5C:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_1
(DIHYDROFOLATE
REDUCTASE)		 1wa5 IMPORTIN ALPHA
RE-EXPORTER
(Saccharomyces
cerevisiae) 		5 / 12 ILE C 818
ILE C 799
PHE C 786
LEU C 767
ILE C 813
 None
 0.98A 4m2xA-1wa5C:
undetectable		 4m2xA-1wa5C:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NNR_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP2)		 1wa5 IMPORTIN ALPHA
RE-EXPORTER
(Saccharomyces
cerevisiae) 		5 / 12 ASP C 741
VAL C 722
ILE C 725
ILE C 698
PRO C 685
 None
 1.08A 4nnrA-1wa5C:
undetectable
4nnrB-1wa5C:
undetectable		 4nnrA-1wa5C:
9.23
4nnrB-1wa5C:
9.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_2
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 1wa5 IMPORTIN ALPHA
SUBUNIT
(Saccharomyces
cerevisiae) 		3 / 3 LEU B 391
LEU B 424
ASN B 383
 None
 0.58A 4otwA-1wa5B:
undetectable		 4otwA-1wa5B:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_B_BQ1B1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 1wa5 IMPORTIN ALPHA
RE-EXPORTER
(Saccharomyces
cerevisiae) 		5 / 8 ALA C 516
ALA C 517
ILE C 520
ALA C 555
LEU C 549
 None
 1.15A 4v1fA-1wa5C:
2.7
4v1fB-1wa5C:
undetectable		 4v1fA-1wa5C:
7.41
4v1fB-1wa5C:
7.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_A_ASDA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1wa5 IMPORTIN ALPHA
SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 7 VAL B 337
ILE B 338
LEU B 388
LEU B 384
 None
 0.96A 4xo7A-1wa5B:
undetectable		 4xo7A-1wa5B:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_B_DIFB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1wa5 IMPORTIN ALPHA
RE-EXPORTER
(Saccharomyces
cerevisiae) 		4 / 8 LEU C 269
LEU C 272
ILE C 221
MET C 233
 None
 0.98A 4xtaB-1wa5C:
undetectable		 4xtaB-1wa5C:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1wa5 IMPORTIN ALPHA
RE-EXPORTER
(Saccharomyces
cerevisiae) 		4 / 7 PHE C 572
ARG C 366
ILE C 365
TYR C 510
 None
 1.08A 5a06B-1wa5C:
undetectable		 5a06B-1wa5C:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AIN_D_QMRD1207_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1wa5 IMPORTIN ALPHA
SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 10 TYR B 267
VAL B 305
CYH B 278
VAL B 323
ILE B 300
 None
 1.50A 5ainD-1wa5B:
undetectable
5ainE-1wa5B:
undetectable		 5ainD-1wa5B:
16.51
5ainE-1wa5B:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 1wa5 IMPORTIN ALPHA
RE-EXPORTER
(Saccharomyces
cerevisiae) 		5 / 11 ILE C  90
GLY C 106
GLU C 107
GLY C  57
LYS C  62
 None
 1.23A 5ayfA-1wa5C:
undetectable		 5ayfA-1wa5C:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESE_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1wa5 IMPORTIN ALPHA
RE-EXPORTER
(Saccharomyces
cerevisiae) 		4 / 8 LEU C 269
PHE C 288
GLY C 234
LEU C 182
 None
 0.79A 5eseA-1wa5C:
undetectable		 5eseA-1wa5C:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQB_B_IBPB706_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		 1wa5 IMPORTIN ALPHA
RE-EXPORTER
(Saccharomyces
cerevisiae) 		4 / 8 LEU C 839
LEU C 835
LEU C 953
LEU C 926
 None
 0.70A 5jqbA-1wa5C:
undetectable
5jqbB-1wa5C:
1.2		 5jqbA-1wa5C:
14.81
5jqbB-1wa5C:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH614_0
(NADH DEHYDROGENASE,
PUTATIVE)		 1wa5 IMPORTIN ALPHA
RE-EXPORTER
(Saccharomyces
cerevisiae) 		4 / 6 ILE C 365
VAL C 476
TYR C 513
VAL C 511
 None
 0.75A 5jwaH-1wa5C:
undetectable		 5jwaH-1wa5C:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 1wa5 IMPORTIN ALPHA
RE-EXPORTER
(Saccharomyces
cerevisiae) 		4 / 8 LEU C 240
LEU C 269
ILE C 322
THR C 274
 None
 0.96A 5ljbA-1wa5C:
undetectable		 5ljbA-1wa5C:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA510_1
(PROTON-GATED ION
CHANNEL)		 1wa5 IMPORTIN ALPHA
RE-EXPORTER
(Saccharomyces
cerevisiae) 		5 / 9 ILE C 623
ALA C 625
ILE C 626
ILE C 577
LEU C 595
 None
 1.11A 5mvmA-1wa5C:
4.1
5mvmE-1wa5C:
3.7		 5mvmA-1wa5C:
6.25
5mvmE-1wa5C:
6.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1wa5 IMPORTIN ALPHA
RE-EXPORTER
(Saccharomyces
cerevisiae) 		3 / 3 LEU C 766
ALA C 763
LEU C 782
 None
 0.50A 5uunB-1wa5C:
1.6		 5uunB-1wa5C:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_1
(CYTOCHROME P450 3A4)		 1wa5 IMPORTIN ALPHA
RE-EXPORTER
(Saccharomyces
cerevisiae) 		5 / 12 ILE C 472
PHE C 357
ALA C 516
THR C 519
ILE C 482
 None
 1.04A 5vceA-1wa5C:
0.0		 5vceA-1wa5C:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1802_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1wa5 IMPORTIN ALPHA
RE-EXPORTER
(Saccharomyces
cerevisiae) 		4 / 7 THR C 645
PHE C 646
VAL C 649
ILE C 602
 None
 1.25A 5vkqA-1wa5C:
2.1
5vkqB-1wa5C:
0.6		 5vkqA-1wa5C:
20.89
5vkqB-1wa5C:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_C_HFGC1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 1wa5 IMPORTIN ALPHA
RE-EXPORTER
(Saccharomyces
cerevisiae) 		5 / 12 GLU C 670
VAL C 668
GLU C 621
HIS C 617
PHE C 895
 None
 1.26A 5xipC-1wa5C:
undetectable		 5xipC-1wa5C:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 1wa5 IMPORTIN ALPHA
RE-EXPORTER
(Saccharomyces
cerevisiae) 		5 / 12 GLU C 670
VAL C 668
GLU C 621
HIS C 617
PHE C 895
 None
 1.33A 5xiqD-1wa5C:
undetectable		 5xiqD-1wa5C:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AJI_A_AY6A1001_0
(DRUG EXPORTERS OF
THE RND
SUPERFAMILY-LIKE
PROTEIN,ENDOLYSIN)		 1wa5 IMPORTIN ALPHA
SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 12 ILE B 179
LEU B 197
VAL B 200
ALA B 201
LEU B 242
 None
 0.93A 6ajiA-1wa5B:
1.1		 6ajiA-1wa5B:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_A_ECLA1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 1wa5 IMPORTIN ALPHA
RE-EXPORTER
(Saccharomyces
cerevisiae) 		4 / 7 ILE C 520
LEU C 501
ILE C 365
ALA C 478
 None
 0.88A 6b5vA-1wa5C:
undetectable
6b5vC-1wa5C:
undetectable		 6b5vA-1wa5C:
6.35
6b5vC-1wa5C:
6.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_B_ECLB1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 1wa5 IMPORTIN ALPHA
RE-EXPORTER
(Saccharomyces
cerevisiae) 		4 / 7 ALA C 478
ILE C 520
LEU C 501
ILE C 365
 None
 0.88A 6b5vA-1wa5C:
undetectable
6b5vB-1wa5C:
1.9		 6b5vA-1wa5C:
6.35
6b5vB-1wa5C:
6.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_D_ECLD1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 1wa5 IMPORTIN ALPHA
RE-EXPORTER
(Saccharomyces
cerevisiae) 		4 / 7 ALA C 478
ILE C 520
LEU C 501
ILE C 365
 None
 0.87A 6b5vB-1wa5C:
1.7
6b5vD-1wa5C:
0.7		 6b5vB-1wa5C:
6.35
6b5vD-1wa5C:
6.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 1wa5 IMPORTIN ALPHA
RE-EXPORTER
(Saccharomyces
cerevisiae) 		5 / 10 LEU C 128
LEU C 212
ASP C 215
LYS C 211
ILE C 109
 None
 1.29A 6dlzB-1wa5C:
3.4
6dlzC-1wa5C:
2.8		 6dlzB-1wa5C:
6.01
6dlzC-1wa5C:
6.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 1wa5 IMPORTIN ALPHA
RE-EXPORTER
(Saccharomyces
cerevisiae) 		5 / 11 ILE C 109
LEU C 128
LEU C 212
ASP C 215
LYS C 211
 None
 1.29A 6dlzA-1wa5C:
2.9
6dlzD-1wa5C:
3.3		 6dlzA-1wa5C:
6.01
6dlzD-1wa5C:
6.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 1wa5 IMPORTIN ALPHA
RE-EXPORTER
(Saccharomyces
cerevisiae) 		5 / 9 GLY C 106
LEU C 128
LEU C 212
ASP C 215
LYS C 211
 None
 1.48A 6dm0A-1wa5C:
2.4
6dm0D-1wa5C:
3.4		 6dm0A-1wa5C:
6.01
6dm0D-1wa5C:
6.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 1wa5 IMPORTIN ALPHA
RE-EXPORTER
(Saccharomyces
cerevisiae) 		5 / 10 LEU C 128
LEU C 212
ASP C 215
LYS C 211
ILE C 109
 None
 1.29A 6dm1B-1wa5C:
3.3
6dm1C-1wa5C:
2.9		 6dm1B-1wa5C:
6.01
6dm1C-1wa5C:
6.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 1wa5 IMPORTIN ALPHA
RE-EXPORTER
(Saccharomyces
cerevisiae) 		5 / 11 ILE C 109
LEU C 128
LEU C 212
ASP C 215
LYS C 211
 None
 1.28A 6dm1A-1wa5C:
2.9
6dm1D-1wa5C:
3.4		 6dm1A-1wa5C:
6.01
6dm1D-1wa5C:
6.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 1wa5 IMPORTIN ALPHA
RE-EXPORTER
(Saccharomyces
cerevisiae) 		5 / 9 PRO C  92
SER C  96
LEU C 128
ASP C 136
ILE C 109
 None
 1.50A 6dm2A-1wa5C:
2.6
6dm2D-1wa5C:
3.5		 6dm2A-1wa5C:
6.01
6dm2D-1wa5C:
6.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 1wa5 IMPORTIN ALPHA
RE-EXPORTER
(Saccharomyces
cerevisiae) 		5 / 10 LEU C 128
LEU C 212
ASP C 215
LYS C 211
ILE C 109
 None
 1.30A 6dm2B-1wa5C:
3.3
6dm2C-1wa5C:
2.7		 6dm2B-1wa5C:
6.01
6dm2C-1wa5C:
6.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 1wa5 IMPORTIN ALPHA
RE-EXPORTER
(Saccharomyces
cerevisiae) 		5 / 9 ILE C 109
PRO C  92
SER C  96
LEU C 128
ASP C 136
 None
 1.49A 6dm2B-1wa5C:
3.3
6dm2C-1wa5C:
2.7		 6dm2B-1wa5C:
6.01
6dm2C-1wa5C:
6.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 1wa5 IMPORTIN ALPHA
RE-EXPORTER
(Saccharomyces
cerevisiae) 		5 / 10 ILE C 109
LEU C 128
LEU C 212
ASP C 215
LYS C 211
 None
 1.30A 6dm2A-1wa5C:
undetectable
6dm2D-1wa5C:
3.4		 6dm2A-1wa5C:
6.01
6dm2D-1wa5C:
6.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		 1wa5 IMPORTIN ALPHA
SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 6 SER B 226
ALA B 235
THR B 238
ALA B 193
 None
 1.09A 6ma6A-1wa5B:
undetectable		 6ma6A-1wa5B:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1wa5 IMPORTIN ALPHA
RE-EXPORTER
(Saccharomyces
cerevisiae) 		4 / 6 LYS C  62
GLN C 104
LEU C  40
PHE C  36
 None
 1.22A 6nmpC-1wa5C:
3.5
6nmpJ-1wa5C:
undetectable		 6nmpC-1wa5C:
12.06
6nmpJ-1wa5C:
5.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 1wa5 IMPORTIN ALPHA
RE-EXPORTER
(Saccharomyces
cerevisiae) 		3 / 3 ASP C 368
LEU C 369
ARG C 486
 None
 0.73A 7dfrA-1wa5C:
undetectable		 7dfrA-1wa5C:
10.73