SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1wc8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		 1wc8 TRAFFICKING PROTEIN
PARTICLE COMPLEX
SUBUNIT3
(Mus
musculus) 		4 / 8 LEU A 118
LEU A  44
VAL A  27
VAL A 116
 None
 1.00A 2bdmA-1wc8A:
undetectable		 2bdmA-1wc8A:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1321_0
(CHLOROPEROXIDASE)		 1wc8 TRAFFICKING PROTEIN
PARTICLE COMPLEX
SUBUNIT3
(Mus
musculus) 		4 / 5 LEU A 135
PHE A 103
VAL A 146
ALA A 148
 None
 1.13A 2cizA-1wc8A:
undetectable		 2cizA-1wc8A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 1wc8 TRAFFICKING PROTEIN
PARTICLE COMPLEX
SUBUNIT3
(Mus
musculus) 		5 / 10 LEU A 130
GLY A 133
LEU A 131
LEU A  55
ILE A  51
 None
None
None
MYR  A1168 ( 4.9A)
None
 1.05A 2f8dA-1wc8A:
undetectable		 2f8dA-1wc8A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_B_BEZB1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 1wc8 TRAFFICKING PROTEIN
PARTICLE COMPLEX
SUBUNIT3
(Mus
musculus) 		5 / 10 LEU A 130
GLY A 133
LEU A 131
LEU A  55
ILE A  51
 None
None
None
MYR  A1168 ( 4.9A)
None
 1.04A 2f8dB-1wc8A:
undetectable		 2f8dB-1wc8A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 1wc8 TRAFFICKING PROTEIN
PARTICLE COMPLEX
SUBUNIT3
(Mus
musculus) 		5 / 10 MET A 165
PHE A 103
ALA A  75
ALA A  79
LEU A 107
 None
 1.17A 2wuzA-1wc8A:
undetectable		 2wuzA-1wc8A:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 1wc8 TRAFFICKING PROTEIN
PARTICLE COMPLEX
SUBUNIT3
(Mus
musculus) 		5 / 10 MET A 165
PHE A 103
ALA A  75
ALA A  79
LEU A 107
 None
 1.18A 2wuzB-1wc8A:
undetectable		 2wuzB-1wc8A:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 1wc8 TRAFFICKING PROTEIN
PARTICLE COMPLEX
SUBUNIT3
(Mus
musculus) 		4 / 8 MET A 165
ALA A  75
ALA A  79
LEU A 107
 None
 1.01A 2wx2B-1wc8A:
undetectable		 2wx2B-1wc8A:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YJA_B_ESTB1550_1
(ESTROGEN RECEPTOR)		 1wc8 TRAFFICKING PROTEIN
PARTICLE COMPLEX
SUBUNIT3
(Mus
musculus) 		5 / 12 ALA A  82
LEU A  60
MET A 144
GLY A 137
LEU A 135
 MYR  A1168 (-3.6A)
None
None
None
None
 0.88A 2yjaB-1wc8A:
undetectable		 2yjaB-1wc8A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1R_A_STRA600_1
(CYTOCHROME P450 3A4)		 1wc8 TRAFFICKING PROTEIN
PARTICLE COMPLEX
SUBUNIT3
(Mus
musculus) 		4 / 5 ASP A 101
PHE A 167
PHE A  71
VAL A 146
 None
 1.13A 5a1rA-1wc8A:
undetectable		 5a1rA-1wc8A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_1
(ESTROGEN RECEPTOR)		 1wc8 TRAFFICKING PROTEIN
PARTICLE COMPLEX
SUBUNIT3
(Mus
musculus) 		5 / 12 ALA A  82
LEU A  60
MET A 144
GLY A 137
LEU A 135
 MYR  A1168 (-3.6A)
None
None
None
None
 0.79A 5gs4A-1wc8A:
undetectable		 5gs4A-1wc8A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1wc8 TRAFFICKING PROTEIN
PARTICLE COMPLEX
SUBUNIT3
(Mus
musculus) 		5 / 7 GLY A 133
LEU A 130
ILE A  51
GLY A  52
LEU A  55
 None
None
None
None
MYR  A1168 ( 4.9A)
 1.30A 5vkqA-1wc8A:
undetectable
5vkqB-1wc8A:
undetectable		 5vkqA-1wc8A:
7.74
5vkqB-1wc8A:
7.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AY4_A_TPFA506_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 1wc8 TRAFFICKING PROTEIN
PARTICLE COMPLEX
SUBUNIT3
(Mus
musculus) 		5 / 10 MET A 165
PHE A 103
ALA A  75
ALA A  79
LEU A 107
 None
 1.32A 6ay4A-1wc8A:
undetectable		 6ay4A-1wc8A:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_1
(PROTEIN CYP51)		 1wc8 TRAFFICKING PROTEIN
PARTICLE COMPLEX
SUBUNIT3
(Mus
musculus) 		5 / 12 MET A 165
PHE A 103
ALA A  75
ALA A  79
LEU A 107
 None
 1.13A 6aycA-1wc8A:
undetectable		 6aycA-1wc8A:
20.54