SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1wcg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD6_0
(GRAMICIDIN A)		 1wcg THIOGLUCOSIDASE
(Brevicoryne
brassicae) 		3 / 3 TRP A 135
ALA A 181
VAL A 171
 None
 0.97A 1av2C-1wcgA:
undetectable
1av2D-1wcgA:
undetectable		 1av2C-1wcgA:
3.35
1av2D-1wcgA:
3.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HA2_A_SWFA3001_1
(SERUM ALBUMIN)		 1wcg THIOGLUCOSIDASE
(Brevicoryne
brassicae) 		5 / 11 LEU A 361
ARG A 252
LEU A 370
SER A 224
ILE A 225
 None
 1.05A 1ha2A-1wcgA:
undetectable		 1ha2A-1wcgA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		 1wcg THIOGLUCOSIDASE
(Brevicoryne
brassicae) 		5 / 10 GLY A 227
TRP A 360
LEU A 306
TYR A 304
LEU A 361
 None
 1.41A 1pbcA-1wcgA:
undetectable		 1pbcA-1wcgA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 1wcg THIOGLUCOSIDASE
(Brevicoryne
brassicae) 		4 / 7 GLY A 378
TYR A 309
ASP A 379
ASP A 384
 None
GOL  A1466 ( 3.7A)
None
None
 1.03A 2g72B-1wcgA:
undetectable		 2g72B-1wcgA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_D_DVAD6_0
(GRAMICIDIN D)		 1wcg THIOGLUCOSIDASE
(Brevicoryne
brassicae) 		3 / 3 TRP A 135
ALA A 181
VAL A 171
 None
 0.97A 2izqC-1wcgA:
undetectable
2izqD-1wcgA:
undetectable		 2izqC-1wcgA:
3.35
2izqD-1wcgA:
3.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 1wcg THIOGLUCOSIDASE
(Brevicoryne
brassicae) 		5 / 12 ILE A  45
ALA A  54
GLY A 427
SER A  57
ASN A  50
 None
 1.15A 2okcA-1wcgA:
undetectable		 2okcA-1wcgA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 1wcg THIOGLUCOSIDASE
(Brevicoryne
brassicae) 		5 / 12 ILE A  45
ALA A  54
GLY A 427
SER A  57
ASN A  50
 None
 1.17A 2okcB-1wcgA:
undetectable		 2okcB-1wcgA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO5_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 1wcg THIOGLUCOSIDASE
(Brevicoryne
brassicae) 		5 / 9 TYR A 147
LEU A 151
VAL A 118
LEU A  94
MET A  91
 None
 1.38A 2qo5A-1wcgA:
0.0		 2qo5A-1wcgA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1500_1
(CYTOCHROME P450 3A4)		 1wcg THIOGLUCOSIDASE
(Brevicoryne
brassicae) 		5 / 11 LEU A  73
ILE A  67
ALA A  66
GLU A  21
LEU A 109
 None
 1.24A 2v0mA-1wcgA:
undetectable		 2v0mA-1wcgA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_B_NBVB1504_1
(GLUCOSYLCERAMIDASE)		 1wcg THIOGLUCOSIDASE
(Brevicoryne
brassicae) 		5 / 11 ASN A 166
GLU A 167
TYR A 309
GLU A 374
TRP A 416
 GOL  A1465 (-2.9A)
GOL  A1466 ( 3.1A)
GOL  A1466 ( 3.7A)
GOL  A1465 (-2.6A)
GOL  A1465 (-3.5A)
 0.77A 2v3dB-1wcgA:
15.5		 2v3dB-1wcgA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_B_CE3B304_1
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 1wcg THIOGLUCOSIDASE
(Brevicoryne
brassicae) 		4 / 5 ASN A  32
THR A  15
SER A  79
ARG A  77
 None
 1.48A 3hlwB-1wcgA:
undetectable		 3hlwB-1wcgA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU4_B_478B401_1
(PROTEASE)		 1wcg THIOGLUCOSIDASE
(Brevicoryne
brassicae) 		5 / 9 ILE A 225
GLY A 195
PRO A 258
VAL A 259
ILE A 223
 None
 0.96A 3nu4A-1wcgA:
undetectable		 3nu4A-1wcgA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1wcg THIOGLUCOSIDASE
(Brevicoryne
brassicae) 		3 / 3 TYR A  58
ASP A  56
ASP A  52
 None
 0.93A 3ou7B-1wcgA:
undetectable		 3ou7B-1wcgA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_A_SAMA6734_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 1wcg THIOGLUCOSIDASE
(Brevicoryne
brassicae) 		5 / 12 VAL A 136
ALA A 194
GLY A 195
LEU A 184
TYR A 180
 None
 1.20A 3qxyA-1wcgA:
undetectable		 3qxyA-1wcgA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_A_SAMA484_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 1wcg THIOGLUCOSIDASE
(Brevicoryne
brassicae) 		5 / 11 VAL A 136
ALA A 194
GLY A 195
LEU A 184
TYR A 180
 None
 1.22A 3rc0A-1wcgA:
undetectable		 3rc0A-1wcgA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_L_CLML221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1wcg THIOGLUCOSIDASE
(Brevicoryne
brassicae) 		5 / 12 CYH A 172
TYR A 264
PHE A 289
VAL A 171
PHE A 165
 None
 1.30A 3u9fJ-1wcgA:
0.0
3u9fL-1wcgA:
0.0		 3u9fJ-1wcgA:
17.74
3u9fL-1wcgA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UZZ_B_ASDB501_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 1wcg THIOGLUCOSIDASE
(Brevicoryne
brassicae) 		4 / 8 TYR A 175
TYR A 121
LEU A 129
TRP A  82
 None
 1.43A 3uzzB-1wcgA:
8.0		 3uzzB-1wcgA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_B_ACTB1358_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 1wcg THIOGLUCOSIDASE
(Brevicoryne
brassicae) 		4 / 7 PRO A 182
ILE A  33
GLN A 130
GLY A 134
 None
 1.00A 4a3uB-1wcgA:
14.0		 4a3uB-1wcgA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_A_P1BA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 1wcg THIOGLUCOSIDASE
(Brevicoryne
brassicae) 		5 / 12 LEU A 358
LEU A 396
ILE A 372
TYR A 413
TYR A 454
 None
 1.41A 4a79A-1wcgA:
undetectable		 4a79A-1wcgA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_B_P1BB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 1wcg THIOGLUCOSIDASE
(Brevicoryne
brassicae) 		5 / 12 LEU A 358
LEU A 396
ILE A 372
TYR A 413
TYR A 454
 None
 1.38A 4a79B-1wcgA:
undetectable		 4a79B-1wcgA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_A_RGZA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 1wcg THIOGLUCOSIDASE
(Brevicoryne
brassicae) 		5 / 11 LEU A 358
LEU A 396
ILE A 372
TYR A 413
TYR A 454
 None
 1.40A 4a7aA-1wcgA:
undetectable		 4a7aA-1wcgA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_A_PXLA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1wcg THIOGLUCOSIDASE
(Brevicoryne
brassicae) 		4 / 7 GLY A  22
ASP A  52
GLY A  51
HIS A  39
 None
 0.93A 4c5nA-1wcgA:
2.0		 4c5nA-1wcgA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_C_PXLC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1wcg THIOGLUCOSIDASE
(Brevicoryne
brassicae) 		4 / 8 GLY A  22
ASP A  52
GLY A  51
HIS A  39
 None
 0.86A 4c5nC-1wcgA:
undetectable		 4c5nC-1wcgA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 1wcg THIOGLUCOSIDASE
(Brevicoryne
brassicae) 		5 / 12 LEU A 371
VAL A 410
ALA A 402
PHE A   5
LEU A 392
 None
 1.19A 4ib4A-1wcgA:
undetectable		 4ib4A-1wcgA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_B_FOLB301_1
(FOLATE RECEPTOR
ALPHA)		 1wcg THIOGLUCOSIDASE
(Brevicoryne
brassicae) 		3 / 3 ASP A 124
TRP A 416
SER A  79
 None
GOL  A1465 (-3.5A)
None
 1.01A 4lrhB-1wcgA:
undetectable		 4lrhB-1wcgA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_F_FOLF301_1
(FOLATE RECEPTOR
ALPHA)		 1wcg THIOGLUCOSIDASE
(Brevicoryne
brassicae) 		3 / 3 ASP A 124
TRP A 416
SER A  79
 None
GOL  A1465 (-3.5A)
None
 1.09A 4lrhF-1wcgA:
undetectable		 4lrhF-1wcgA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M51_A_BEZA501_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 1wcg THIOGLUCOSIDASE
(Brevicoryne
brassicae) 		4 / 6 ILE A  68
ILE A  20
SER A  57
LEU A 105
 None
 0.94A 4m51A-1wcgA:
undetectable		 4m51A-1wcgA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 1wcg THIOGLUCOSIDASE
(Brevicoryne
brassicae) 		5 / 12 LEU A 371
VAL A 410
ALA A 402
PHE A   5
LEU A 392
 None
 1.25A 4nc3A-1wcgA:
undetectable		 4nc3A-1wcgA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1wcg THIOGLUCOSIDASE
(Brevicoryne
brassicae) 		4 / 7 GLU A 364
THR A 300
HIS A 202
LEU A 199
 None
 1.09A 4pfjA-1wcgA:
undetectable		 4pfjA-1wcgA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3M_A_ADNA301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)		 1wcg THIOGLUCOSIDASE
(Brevicoryne
brassicae) 		5 / 9 LEU A 434
GLY A 433
ILE A  68
VAL A 415
THR A  13
 None
 1.50A 4x3mA-1wcgA:
2.8		 4x3mA-1wcgA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XZK_A_AG2A700_1
(PUTATIVE
NAD(+)--ARGININE
ADP-RIBOSYLTRANSFERA
SE VIS)		 1wcg THIOGLUCOSIDASE
(Brevicoryne
brassicae) 		4 / 7 ARG A 252
SER A 226
GLU A 374
GLU A 167
 None
None
GOL  A1465 (-2.6A)
GOL  A1466 ( 3.1A)
 1.28A 4xzkA-1wcgA:
undetectable		 4xzkA-1wcgA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA605_1
(CHITINASE)		 1wcg THIOGLUCOSIDASE
(Brevicoryne
brassicae) 		3 / 3 TRP A 123
ILE A 169
SER A 226
 None
 0.87A 5gqbA-1wcgA:
5.7		 5gqbA-1wcgA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 1wcg THIOGLUCOSIDASE
(Brevicoryne
brassicae) 		4 / 8 SER A  14
SER A 417
ASP A  64
SER A  57
 None
 1.13A 5l5fY-1wcgA:
0.0
5l5fZ-1wcgA:
undetectable		 5l5fY-1wcgA:
18.61
5l5fZ-1wcgA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_2
(SCRFP-TAG,GP41)		 1wcg THIOGLUCOSIDASE
(Brevicoryne
brassicae) 		3 / 3 LYS A 285
TRP A 283
SER A 276
 None
 1.09A 5nwwA-1wcgA:
undetectable		 5nwwA-1wcgA:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 1wcg THIOGLUCOSIDASE
(Brevicoryne
brassicae) 		5 / 12 LEU A 371
VAL A 410
ALA A 402
PHE A   5
LEU A 392
 None
 1.13A 5tudA-1wcgA:
undetectable		 5tudA-1wcgA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1wcg THIOGLUCOSIDASE
(Brevicoryne
brassicae) 		5 / 9 GLY A  89
LEU A 208
ILE A  85
LEU A  94
PHE A 213
 None
 0.82A 5vkqC-1wcgA:
undetectable
5vkqD-1wcgA:
undetectable		 5vkqC-1wcgA:
13.31
5vkqD-1wcgA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 1wcg THIOGLUCOSIDASE
(Brevicoryne
brassicae) 		4 / 5 PHE A 455
THR A 453
ASP A 385
ASN A 421
 None
 1.41A 5ybbA-1wcgA:
undetectable		 5ybbA-1wcgA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_A_TRPA403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 1wcg THIOGLUCOSIDASE
(Brevicoryne
brassicae) 		4 / 8 GLU A 387
THR A 344
ILE A 348
PRO A 349
 None
 0.96A 6a4iA-1wcgA:
0.0		 6a4iA-1wcgA:
20.65