SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1wch'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVT_A_FLPA125_1
(TRANSTHYRETIN)		 1wch PROTEIN TYROSINE
PHOSPHATASE,
NON-RECEPTOR TYPE 13
(Homo
sapiens) 		4 / 8 ALA A2473
LEU A2471
LEU A2207
LEU A2204
 None
 0.97A 1dvtA-1wchA:
undetectable
1dvtB-1wchA:
undetectable		 1dvtA-1wchA:
17.98
1dvtB-1wchA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_2
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 1wch PROTEIN TYROSINE
PHOSPHATASE,
NON-RECEPTOR TYPE 13
(Homo
sapiens) 		4 / 4 THR A2193
LEU A2197
VAL A2200
LEU A2204
 None
 0.75A 1fbmD-1wchA:
undetectable		 1fbmD-1wchA:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_3
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 1wch PROTEIN TYROSINE
PHOSPHATASE,
NON-RECEPTOR TYPE 13
(Homo
sapiens) 		4 / 5 THR A2193
LEU A2197
VAL A2200
LEU A2204
 None
 0.76A 1fbmE-1wchA:
undetectable		 1fbmE-1wchA:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HMY_A_SAMA328_0
(HAEIII
METHYLTRANSFERASE)		 1wch PROTEIN TYROSINE
PHOSPHATASE,
NON-RECEPTOR TYPE 13
(Homo
sapiens) 		4 / 8 PHE A2459
ILE A2421
PRO A2382
LEU A2388
 None
 0.94A 1hmyA-1wchA:
undetectable		 1hmyA-1wchA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_B_D16B415_1
(THYMIDYLATE SYNTHASE)		 1wch PROTEIN TYROSINE
PHOSPHATASE,
NON-RECEPTOR TYPE 13
(Homo
sapiens) 		5 / 12 GLU A2236
ASN A2241
LEU A2256
GLY A2261
ALA A2265
 None
 1.31A 1hvyB-1wchA:
undetectable		 1hvyB-1wchA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1wch PROTEIN TYROSINE
PHOSPHATASE,
NON-RECEPTOR TYPE 13
(Homo
sapiens) 		3 / 3 LEU A2197
VAL A2200
LEU A2204
 None
 0.51A 1mz9B-1wchA:
undetectable		 1mz9B-1wchA:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_F_AG2F7016_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 1wch PROTEIN TYROSINE
PHOSPHATASE,
NON-RECEPTOR TYPE 13
(Homo
sapiens) 		4 / 8 ASP A2422
LEU A2425
GLY A2426
MET A2395
 None
 0.88A 1n13A-1wchA:
undetectable
1n13F-1wchA:
undetectable		 1n13A-1wchA:
12.73
1n13F-1wchA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_J_AG2J7013_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 1wch PROTEIN TYROSINE
PHOSPHATASE,
NON-RECEPTOR TYPE 13
(Homo
sapiens) 		4 / 7 ASP A2422
LEU A2425
GLY A2426
MET A2395
 None
 0.89A 1n13G-1wchA:
undetectable
1n13J-1wchA:
undetectable		 1n13G-1wchA:
12.73
1n13J-1wchA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_K_AG2K671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1wch PROTEIN TYROSINE
PHOSPHATASE,
NON-RECEPTOR TYPE 13
(Homo
sapiens) 		4 / 8 MET A2395
ASP A2422
LEU A2425
GLY A2426
 None
 0.89A 2qqcH-1wchA:
undetectable
2qqcK-1wchA:
undetectable		 2qqcH-1wchA:
15.24
2qqcK-1wchA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_B_AG2B671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1wch PROTEIN TYROSINE
PHOSPHATASE,
NON-RECEPTOR TYPE 13
(Homo
sapiens) 		4 / 8 MET A2395
ASP A2422
LEU A2425
GLY A2426
 None
 0.84A 2qqdB-1wchA:
undetectable
2qqdC-1wchA:
undetectable		 2qqdB-1wchA:
15.24
2qqdC-1wchA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		 1wch PROTEIN TYROSINE
PHOSPHATASE,
NON-RECEPTOR TYPE 13
(Homo
sapiens) 		3 / 3 ASN A2241
ASN A2264
ARG A2447
 None
 0.68A 2rlcA-1wchA:
undetectable		 2rlcA-1wchA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_1
(WNT INHIBITORY
FACTOR 1)		 1wch PROTEIN TYROSINE
PHOSPHATASE,
NON-RECEPTOR TYPE 13
(Homo
sapiens) 		4 / 5 ILE A2405
PRO A2403
VAL A2467
PHE A2277
 None
 1.22A 2ygnA-1wchA:
undetectable		 2ygnA-1wchA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN8_B_DEXB247_1
(GLUCOCORTICOID
RECEPTOR 2)		 1wch PROTEIN TYROSINE
PHOSPHATASE,
NON-RECEPTOR TYPE 13
(Homo
sapiens) 		5 / 12 GLY A2416
MET A2308
MET A2395
VAL A2463
PHE A2459
 None
 1.14A 3gn8B-1wchA:
0.0		 3gn8B-1wchA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LK0_D_Z80D92_1
(PROTEIN S100-B)		 1wch PROTEIN TYROSINE
PHOSPHATASE,
NON-RECEPTOR TYPE 13
(Homo
sapiens) 		3 / 3 HIS A2397
PHE A2391
PHE A2350
 None
 0.73A 3lk0D-1wchA:
0.3		 3lk0D-1wchA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_C_ACHC323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 1wch PROTEIN TYROSINE
PHOSPHATASE,
NON-RECEPTOR TYPE 13
(Homo
sapiens) 		4 / 8 PHE A2434
GLU A2216
TYR A2461
LEU A2204
 None
 1.15A 3rqwC-1wchA:
undetectable
3rqwD-1wchA:
undetectable		 3rqwC-1wchA:
21.94
3rqwD-1wchA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		 1wch PROTEIN TYROSINE
PHOSPHATASE,
NON-RECEPTOR TYPE 13
(Homo
sapiens) 		4 / 8 ILE A2421
PHE A2459
SER A2393
VAL A2183
 None
 0.78A 3ua5A-1wchA:
undetectable		 3ua5A-1wchA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT7_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 1wch PROTEIN TYROSINE
PHOSPHATASE,
NON-RECEPTOR TYPE 13
(Homo
sapiens) 		4 / 4 LEU A2208
ILE A2421
TYR A2466
TYR A2457
 None
 1.48A 3vt7A-1wchA:
undetectable		 3vt7A-1wchA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1wch PROTEIN TYROSINE
PHOSPHATASE,
NON-RECEPTOR TYPE 13
(Homo
sapiens) 		5 / 12 VAL A2423
ILE A2436
ILE A2464
VAL A2467
LEU A2468
 None
 1.01A 3w68D-1wchA:
undetectable		 3w68D-1wchA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A81_A_DXCA1161_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 1wch PROTEIN TYROSINE
PHOSPHATASE,
NON-RECEPTOR TYPE 13
(Homo
sapiens) 		5 / 12 GLY A2190
ASP A2431
ILE A2428
VAL A2424
LEU A2197
 None
 1.22A 4a81A-1wchA:
undetectable		 4a81A-1wchA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_B_DIFB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1wch PROTEIN TYROSINE
PHOSPHATASE,
NON-RECEPTOR TYPE 13
(Homo
sapiens) 		4 / 8 ILE A2421
LEU A2204
LEU A2207
ILE A2436
 None
 0.95A 4xtaB-1wchA:
undetectable		 4xtaB-1wchA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_2
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 1wch PROTEIN TYROSINE
PHOSPHATASE,
NON-RECEPTOR TYPE 13
(Homo
sapiens) 		3 / 3 GLU A2313
TRP A2376
ASN A2372
 None
None
PO4  A3480 (-2.8A)
 1.06A 5dv4A-1wchA:
undetectable		 5dv4A-1wchA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_1
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 1wch PROTEIN TYROSINE
PHOSPHATASE,
NON-RECEPTOR TYPE 13
(Homo
sapiens) 		3 / 3 THR A2309
GLU A2313
HIS A2379
 None
None
PO4  A3478 ( 4.7A)
 0.92A 5xioA-1wchA:
undetectable		 5xioA-1wchA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GQI_A_ACTA604_0
(CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE)		 1wch PROTEIN TYROSINE
PHOSPHATASE,
NON-RECEPTOR TYPE 13
(Homo
sapiens) 		4 / 6 PRO A2255
ILE A2231
GLY A2261
TYR A2262
 None
 1.11A 6gqiA-1wchA:
undetectable		 6gqiA-1wchA:
20.95