SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1wcm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4R87_I_SPMI202_1 (SPERMIDINE N1-ACETYLTRANSFERASE)	1wcm	DNA-DIRECTED RNA POLYMERASE II 32 KDA POLYPEPTIDE (Saccharomyces cerevisiae)	4 / 7	ASN D 39 GLU D 43 GLU D 44 GLU D 45	None	0.94A	4r87I-1wcmD: undetectable	4r87I-1wcmD: 23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5AXA_A_ADNA502_2 (ADENOSYLHOMOCYSTEINA SE)	1wcm	DNA-DIRECTED RNA POLYMERASE II 32 KDA POLYPEPTIDE (Saccharomyces cerevisiae)	4 / 5	GLU D 208 THR D 170 HIS D 173 LEU D 198	None	1.29A	5axaA-1wcmD: undetectable	5axaA-1wcmD: 15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5AXA_C_ADNC502_2 (ADENOSYLHOMOCYSTEINA SE)	1wcm	DNA-DIRECTED RNA POLYMERASE II 32 KDA POLYPEPTIDE (Saccharomyces cerevisiae)	4 / 5	GLU D 208 THR D 170 HIS D 173 LEU D 198	None	1.29A	5axaC-1wcmD: undetectable	5axaC-1wcmD: 15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5V1S_A_SAMA604_0 (RADICAL SAM)	1wcm	DNA-DIRECTED RNA POLYMERASE II 32 KDA POLYPEPTIDE (Saccharomyces cerevisiae)	5 / 9	LEU D 172 GLU D 206 THR D 170 VAL D 163 SER D 182	None	1.48A	5v1sA-1wcmD: undetectable	5v1sA-1wcmD: 20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5YSI_A_NCAA1001_0 (UBIQUITINATING/DEUBI QUITINATING ENZYME SDEA)	1wcm	DNA-DIRECTED RNA POLYMERASE II 32 KDA POLYPEPTIDE (Saccharomyces cerevisiae)	4 / 6	ARG D 153 GLY D 181 SER D 215 VAL D 163	None	1.13A	5ysiA-1wcmD: 0.0	5ysiA-1wcmD: 24.60

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["4R87_I_SPMI202_1","SPERMIDINE N1-ACETYLTRANSFERASE","1wcm","DNA-DIRECTED RNA POLYMERASE II 32 KDA POLYPEPTIDE","Saccharomyces cerevisiae",4,"ASN D  39;GLU D  43;GLU D  44;GLU D  45","None","0.94A","4r87I-1wcmD:undetectable","4r87I-1wcmD:23.32"],["5AXA_A_ADNA502_2","ADENOSYLHOMOCYSTEINASE","1wcm","DNA-DIRECTED RNA POLYMERASE II 32 KDA POLYPEPTIDE","Saccharomyces cerevisiae",4,"GLU D 208;THR D 170;HIS D 173;LEU D 198","None","1.29A","5axaA-1wcmD:undetectable","5axaA-1wcmD:15.55"],["5AXA_C_ADNC502_2","ADENOSYLHOMOCYSTEINASE","1wcm","DNA-DIRECTED RNA POLYMERASE II 32 KDA POLYPEPTIDE","Saccharomyces cerevisiae",4,"GLU D 208;THR D 170;HIS D 173;LEU D 198","None","1.29A","5axaC-1wcmD:undetectable","5axaC-1wcmD:15.55"],["5V1S_A_SAMA604_0","RADICAL SAM","1wcm","DNA-DIRECTED RNA POLYMERASE II 32 KDA POLYPEPTIDE","Saccharomyces cerevisiae",5,"LEU D 172;GLU D 206;THR D 170;VAL D 163;SER D 182","None","1.48A","5v1sA-1wcmD:undetectable","5v1sA-1wcmD:20.49"],["5YSI_A_NCAA1001_0","UBIQUITINATING\/DEUBIQUITINATING ENZYME SDEA","1wcm","DNA-DIRECTED RNA POLYMERASE II 32 KDA POLYPEPTIDE","Saccharomyces cerevisiae",4,"ARG D 153;GLY D 181;SER D 215;VAL D 163","None","1.13A","5ysiA-1wcmD:0.0","5ysiA-1wcmD:24.60"]]