SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1wcz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 1wcz GLUTAMYL
ENDOPEPTIDASE
(Staphylococcus
aureus) 		4 / 8 VAL A  52
VAL A   1
SER A 171
ILE A 183
 None
 0.89A 1igxA-1wczA:
undetectable		 1igxA-1wczA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 1wcz GLUTAMYL
ENDOPEPTIDASE
(Staphylococcus
aureus) 		3 / 3 ILE A  96
ASP A  44
PHE A  99
 None
 0.63A 1uwjB-1wczA:
undetectable		 1uwjB-1wczA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_A_GNTA1538_1
(ACETYLCHOLINESTERASE)		 1wcz GLUTAMYL
ENDOPEPTIDASE
(Staphylococcus
aureus) 		5 / 11 GLY A 166
GLY A 167
SER A 169
PHE A  34
HIS A  51
 None
 1.08A 1w76A-1wczA:
undetectable		 1w76A-1wczA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_C_8MOC501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 1wcz GLUTAMYL
ENDOPEPTIDASE
(Staphylococcus
aureus) 		5 / 10 VAL A  52
GLY A  38
THR A  23
LEU A  63
PHE A  99
 None
 1.07A 1z11C-1wczA:
undetectable		 1z11C-1wczA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_D_8MOD501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 1wcz GLUTAMYL
ENDOPEPTIDASE
(Staphylococcus
aureus) 		5 / 10 VAL A  52
GLY A  38
THR A  23
LEU A  63
PHE A  99
 None
 1.07A 1z11D-1wczA:
0.0		 1z11D-1wczA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M9Q_B_BEZB251_0
(SERINE PROTEASE
INHIBITOR
SERINE PROTEASE
SUBUNIT NS2B, SERINE
PROTEASE NS3)		 1wcz GLUTAMYL
ENDOPEPTIDASE
(Staphylococcus
aureus) 		5 / 9 ILE A  25
PHE A  99
VAL A  53
THR A  56
ALA A  62
 None
 1.13A 2m9qA-1wczA:
6.4		 2m9qA-1wczA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 1wcz GLUTAMYL
ENDOPEPTIDASE
(Staphylococcus
aureus) 		4 / 7 TYR A  88
VAL A 196
GLY A 182
LEU A  47
 None
 0.86A 2wekB-1wczA:
undetectable		 2wekB-1wczA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_B_SAMB300_0
(PUTATIVE RRNA
METHYLASE)		 1wcz GLUTAMYL
ENDOPEPTIDASE
(Staphylococcus
aureus) 		5 / 12 THR A 142
ILE A  35
GLN A  26
GLY A 136
ASN A  71
 None
 1.15A 3eeyB-1wczA:
undetectable		 3eeyB-1wczA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_B_SAMB300_0
(PUTATIVE RRNA
METHYLASE)		 1wcz GLUTAMYL
ENDOPEPTIDASE
(Staphylococcus
aureus) 		5 / 12 THR A 142
ILE A  35
GLN A  26
GLY A 167
ASN A  71
 None
 1.13A 3eeyB-1wczA:
undetectable		 3eeyB-1wczA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 1wcz GLUTAMYL
ENDOPEPTIDASE
(Staphylococcus
aureus) 		4 / 7 TYR A 152
VAL A 180
ILE A 129
ARG A 203
 None
 1.22A 3ms9B-1wczA:
undetectable		 3ms9B-1wczA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 1wcz GLUTAMYL
ENDOPEPTIDASE
(Staphylococcus
aureus) 		4 / 6 ASP A  59
ALA A  82
LYS A  64
THR A  56
 None
 1.28A 4w5qA-1wczA:
undetectable		 4w5qA-1wczA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_B_HFGB802_0
(PROLINE--TRNA LIGASE)		 1wcz GLUTAMYL
ENDOPEPTIDASE
(Staphylococcus
aureus) 		5 / 12 PHE A  99
VAL A  41
THR A  48
HIS A  51
GLY A 167
 None
 1.32A 4ydqB-1wczA:
undetectable		 4ydqB-1wczA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 1wcz GLUTAMYL
ENDOPEPTIDASE
(Staphylococcus
aureus) 		4 / 6 ASP A  59
ALA A  82
LYS A  64
THR A  56
 None
 1.29A 4z4fA-1wczA:
undetectable		 4z4fA-1wczA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 1wcz GLUTAMYL
ENDOPEPTIDASE
(Staphylococcus
aureus) 		4 / 6 ASP A  59
ALA A  82
LYS A  64
THR A  56
 None
 1.31A 4z4iA-1wczA:
undetectable		 4z4iA-1wczA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_A_RBFA201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 1wcz GLUTAMYL
ENDOPEPTIDASE
(Staphylococcus
aureus) 		3 / 3 LYS A  87
LEU A  46
ILE A 183
 None
 0.79A 5kc4A-1wczA:
undetectable		 5kc4A-1wczA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_A_SAMA501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 1wcz GLUTAMYL
ENDOPEPTIDASE
(Staphylococcus
aureus) 		5 / 12 THR A 151
ILE A 129
GLY A 148
LEU A 153
ASN A 126
 None
 0.95A 5nfjA-1wczA:
undetectable		 5nfjA-1wczA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 1wcz GLUTAMYL
ENDOPEPTIDASE
(Staphylococcus
aureus) 		4 / 5 HIS A 184
ASP A 137
GLY A 136
ASN A 168
 None
 1.24A 5x7pB-1wczA:
0.0		 5x7pB-1wczA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_0
(NS3 PROTEASE)		 1wcz GLUTAMYL
ENDOPEPTIDASE
(Staphylococcus
aureus) 		5 / 12 HIS A  51
ASP A  93
GLY A 167
SER A 169
VAL A 188
 None
 0.87A 6c2mC-1wczA:
11.8		 6c2mC-1wczA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_D_ADND502_2
(-)		 1wcz GLUTAMYL
ENDOPEPTIDASE
(Staphylococcus
aureus) 		4 / 5 ILE A 181
GLN A 124
THR A 123
THR A 130
 None
 0.99A 6f3mD-1wczA:
undetectable		 6f3mD-1wczA:
20.13