SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1wd5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM4_A_DXCA1002_0
(MAJOR POLLEN
ALLERGEN BET V 1-L)		 1wd5 HYPOTHETICAL PROTEIN
TT1426
(Thermus
thermophilus) 		5 / 12 VAL A  41
TYR A 188
VAL A 184
SER A 176
LEU A  13
 None
 1.28A 1fm4A-1wd5A:
undetectable		 1fm4A-1wd5A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JST_A_HLTA101_1
(FOUR-ALPHA-HELIX
BUNDLE)		 1wd5 HYPOTHETICAL PROTEIN
TT1426
(Thermus
thermophilus) 		4 / 5 ALA A  42
TRP A 206
LEU A 203
ALA A  38
 None
 1.32A 2jstA-1wd5A:
undetectable
2jstB-1wd5A:
undetectable		 2jstA-1wd5A:
16.26
2jstB-1wd5A:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_B_CHDB1_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1wd5 HYPOTHETICAL PROTEIN
TT1426
(Thermus
thermophilus) 		4 / 4 LEU A 175
PRO A 156
LEU A  13
ARG A  44
 None
None
None
MES  A2955 ( 3.9A)
 1.31A 3hcoB-1wd5A:
undetectable		 3hcoB-1wd5A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_1
(GENOME POLYPROTEIN)		 1wd5 HYPOTHETICAL PROTEIN
TT1426
(Thermus
thermophilus) 		5 / 12 GLY A  68
VAL A 153
SER A 141
PHE A 144
ALA A 170
 None
 1.05A 3keeB-1wd5A:
undetectable		 3keeB-1wd5A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_C_30BC500_1
(GENOME POLYPROTEIN)		 1wd5 HYPOTHETICAL PROTEIN
TT1426
(Thermus
thermophilus) 		5 / 12 GLY A  68
VAL A 153
SER A 141
PHE A 144
ALA A 170
 None
 1.05A 3keeC-1wd5A:
undetectable		 3keeC-1wd5A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X30_A_T44A401_1
(THYROXINE-BINDING
GLOBULIN)		 1wd5 HYPOTHETICAL PROTEIN
TT1426
(Thermus
thermophilus) 		5 / 9 ALA A 170
LEU A  28
LEU A 140
LEU A 125
ARG A 118
 None
 1.42A 4x30A-1wd5A:
0.0		 4x30A-1wd5A:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_3
(PROTEASE)		 1wd5 HYPOTHETICAL PROTEIN
TT1426
(Thermus
thermophilus) 		3 / 3 ASP A 128
VAL A 126
LEU A  13
 None
 0.61A 5e5jB-1wd5A:
undetectable		 5e5jB-1wd5A:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_A_SAMA301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 1wd5 HYPOTHETICAL PROTEIN
TT1426
(Thermus
thermophilus) 		5 / 12 ALA A 131
ASP A 180
PRO A 178
PHE A 181
GLU A 161
 None
 1.24A 5hfjA-1wd5A:
2.0		 5hfjA-1wd5A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V02_R_657R201_0
(CALMODULIN-1
SMALL CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL
PROTEIN 2)		 1wd5 HYPOTHETICAL PROTEIN
TT1426
(Thermus
thermophilus) 		5 / 10 LEU A 125
VAL A 126
LEU A 140
GLU A 171
VAL A 172
 None
 1.06A 5v02B-1wd5A:
undetectable
5v02R-1wd5A:
undetectable		 5v02B-1wd5A:
16.75
5v02R-1wd5A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_1
(NS3 PROTEASE)		 1wd5 HYPOTHETICAL PROTEIN
TT1426
(Thermus
thermophilus) 		5 / 9 VAL A  35
GLY A  29
LEU A 204
ARG A  32
ASP A 196
 None
 1.39A 6c2mC-1wd5A:
undetectable		 6c2mC-1wd5A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB9_C_NMYC302_0
(AAC(3)-IIIB PROTEIN)		 1wd5 HYPOTHETICAL PROTEIN
TT1426
(Thermus
thermophilus) 		5 / 10 TYR A 109
ASP A 196
ASP A  39
GLY A  33
ASP A 128
 None
 1.36A 6mb9C-1wd5A:
1.6		 6mb9C-1wd5A:
20.48