SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1wde'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_A_DVAA6_0
(GRAMICIDIN A)		 1wde PROBABLE DIPHTHINE
SYNTHASE
(Aeropyrum
pernix) 		3 / 3 ALA A  87
VAL A  38
TRP A  15
 None
 0.88A 1grmA-1wdeA:
undetectable		 1grmA-1wdeA:
4.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_B_DVAB6_0
(GRAMICIDIN A)		 1wde PROBABLE DIPHTHINE
SYNTHASE
(Aeropyrum
pernix) 		3 / 3 ALA A  87
VAL A  38
TRP A  15
 None
 0.88A 1grmB-1wdeA:
undetectable		 1grmB-1wdeA:
4.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1wde PROBABLE DIPHTHINE
SYNTHASE
(Aeropyrum
pernix) 		4 / 7 LEU A  10
MET A  95
VAL A  96
MET A  43
 None
 1.09A 1wrlA-1wdeA:
undetectable
1wrlB-1wdeA:
undetectable		 1wrlA-1wdeA:
14.97
1wrlB-1wdeA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_K_BO2K1402_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 1wde PROBABLE DIPHTHINE
SYNTHASE
(Aeropyrum
pernix) 		5 / 10 ALA A 204
ALA A 206
ALA A 199
VAL A 289
LYS A 287
 None
 1.05A 2f16K-1wdeA:
undetectable
2f16L-1wdeA:
undetectable		 2f16K-1wdeA:
22.41
2f16L-1wdeA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_Y_BO2Y1403_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 1wde PROBABLE DIPHTHINE
SYNTHASE
(Aeropyrum
pernix) 		5 / 10 ALA A 204
ALA A 206
ALA A 199
VAL A 289
LYS A 287
 None
 1.06A 2f16Y-1wdeA:
undetectable
2f16Z-1wdeA:
undetectable		 2f16Y-1wdeA:
22.41
2f16Z-1wdeA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_2
(CARBONIC ANHYDRASE 2)		 1wde PROBABLE DIPHTHINE
SYNTHASE
(Aeropyrum
pernix) 		3 / 3 GLU A  39
HIS A 100
THR A  42
 None
 0.78A 3hkuA-1wdeA:
undetectable		 3hkuA-1wdeA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_B_LURB201_1
(TRANSTHYRETIN)		 1wde PROBABLE DIPHTHINE
SYNTHASE
(Aeropyrum
pernix) 		4 / 8 LEU A 143
THR A 169
ALA A 171
LEU A 173
 None
 0.88A 4iizB-1wdeA:
undetectable		 4iizB-1wdeA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 1wde PROBABLE DIPHTHINE
SYNTHASE
(Aeropyrum
pernix) 		4 / 8 PRO A 250
LEU A 132
VAL A 216
TYR A 228
 None
 0.99A 4pwdA-1wdeA:
undetectable		 4pwdA-1wdeA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1wde PROBABLE DIPHTHINE
SYNTHASE
(Aeropyrum
pernix) 		5 / 12 GLY A  92
VAL A  96
SER A 121
ALA A 218
VAL A 244
 None
 1.01A 5n0oA-1wdeA:
6.6		 5n0oA-1wdeA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGJ_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1wde PROBABLE DIPHTHINE
SYNTHASE
(Aeropyrum
pernix) 		3 / 3 VAL A  38
VAL A  89
GLN A  22
 None
 0.63A 5qgjA-1wdeA:
undetectable		 5qgjA-1wdeA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGL_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1wde PROBABLE DIPHTHINE
SYNTHASE
(Aeropyrum
pernix) 		3 / 3 VAL A  38
VAL A  89
GLN A  22
 None
 0.60A 5qglA-1wdeA:
undetectable		 5qglA-1wdeA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGM_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1wde PROBABLE DIPHTHINE
SYNTHASE
(Aeropyrum
pernix) 		3 / 3 VAL A  38
VAL A  89
GLN A  22
 None
 0.65A 5qgmA-1wdeA:
undetectable		 5qgmA-1wdeA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGU_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1wde PROBABLE DIPHTHINE
SYNTHASE
(Aeropyrum
pernix) 		3 / 3 VAL A  38
VAL A  89
GLN A  22
 None
 0.62A 5qguA-1wdeA:
undetectable		 5qguA-1wdeA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGV_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1wde PROBABLE DIPHTHINE
SYNTHASE
(Aeropyrum
pernix) 		3 / 3 VAL A  38
VAL A  89
GLN A  22
 None
 0.68A 5qgvA-1wdeA:
undetectable		 5qgvA-1wdeA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGW_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1wde PROBABLE DIPHTHINE
SYNTHASE
(Aeropyrum
pernix) 		3 / 3 VAL A  38
VAL A  89
GLN A  22
 None
 0.70A 5qgwA-1wdeA:
undetectable		 5qgwA-1wdeA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGX_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1wde PROBABLE DIPHTHINE
SYNTHASE
(Aeropyrum
pernix) 		3 / 3 VAL A  38
VAL A  89
GLN A  22
 None
 0.69A 5qgxA-1wdeA:
undetectable		 5qgxA-1wdeA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH0_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1wde PROBABLE DIPHTHINE
SYNTHASE
(Aeropyrum
pernix) 		3 / 3 VAL A  38
VAL A  89
GLN A  22
 None
 0.66A 5qh0A-1wdeA:
undetectable		 5qh0A-1wdeA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH1_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1wde PROBABLE DIPHTHINE
SYNTHASE
(Aeropyrum
pernix) 		3 / 3 VAL A  38
VAL A  89
GLN A  22
 None
 0.71A 5qh1A-1wdeA:
undetectable		 5qh1A-1wdeA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH4_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1wde PROBABLE DIPHTHINE
SYNTHASE
(Aeropyrum
pernix) 		3 / 3 VAL A  38
VAL A  89
GLN A  22
 None
 0.66A 5qh4A-1wdeA:
undetectable		 5qh4A-1wdeA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH7_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1wde PROBABLE DIPHTHINE
SYNTHASE
(Aeropyrum
pernix) 		3 / 3 VAL A  38
VAL A  89
GLN A  22
 None
 0.68A 5qh7A-1wdeA:
undetectable		 5qh7A-1wdeA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH9_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1wde PROBABLE DIPHTHINE
SYNTHASE
(Aeropyrum
pernix) 		3 / 3 VAL A  38
VAL A  89
GLN A  22
 None
 0.66A 5qh9A-1wdeA:
undetectable		 5qh9A-1wdeA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHA_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1wde PROBABLE DIPHTHINE
SYNTHASE
(Aeropyrum
pernix) 		3 / 3 VAL A  38
VAL A  89
GLN A  22
 None
 0.66A 5qhaA-1wdeA:
undetectable		 5qhaA-1wdeA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHC_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1wde PROBABLE DIPHTHINE
SYNTHASE
(Aeropyrum
pernix) 		3 / 3 VAL A  38
VAL A  89
GLN A  22
 None
 0.63A 5qhcA-1wdeA:
undetectable		 5qhcA-1wdeA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHE_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1wde PROBABLE DIPHTHINE
SYNTHASE
(Aeropyrum
pernix) 		3 / 3 VAL A  38
VAL A  89
GLN A  22
 None
 0.65A 5qheA-1wdeA:
undetectable		 5qheA-1wdeA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHF_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1wde PROBABLE DIPHTHINE
SYNTHASE
(Aeropyrum
pernix) 		3 / 3 VAL A  38
VAL A  89
GLN A  22
 None
 0.68A 5qhfA-1wdeA:
undetectable		 5qhfA-1wdeA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHG_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1wde PROBABLE DIPHTHINE
SYNTHASE
(Aeropyrum
pernix) 		3 / 3 VAL A  38
VAL A  89
GLN A  22
 None
 0.67A 5qhgA-1wdeA:
undetectable		 5qhgA-1wdeA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHH_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1wde PROBABLE DIPHTHINE
SYNTHASE
(Aeropyrum
pernix) 		3 / 3 VAL A  38
VAL A  89
GLN A  22
 None
 0.66A 5qhhA-1wdeA:
undetectable		 5qhhA-1wdeA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_A_GLYA717_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 1wde PROBABLE DIPHTHINE
SYNTHASE
(Aeropyrum
pernix) 		4 / 5 SER A  66
ARG A  68
ASP A  69
ARG A  73
 None
 0.99A 6dwdA-1wdeA:
undetectable		 6dwdA-1wdeA:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_D_READ601_1
(RETINOIC ACID
RECEPTOR)		 1wde PROBABLE DIPHTHINE
SYNTHASE
(Aeropyrum
pernix) 		4 / 7 VAL A 240
GLY A 243
LEU A 182
GLY A 187
 None
 0.62A 6eu9D-1wdeA:
undetectable		 6eu9D-1wdeA:
16.50