SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1wdi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_C_ADNC603_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 1wdi HYPOTHETICAL PROTEIN
TT0907
(Thermus
thermophilus) 		4 / 5 THR A 215
GLU A 280
THR A 281
LEU A 209
 None
 1.26A 1d4fC-1wdiA:
undetectable		 1d4fC-1wdiA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1wdi HYPOTHETICAL PROTEIN
TT0907
(Thermus
thermophilus) 		3 / 3 LEU A 309
VAL A 312
LEU A 316
 None
 0.42A 1mz9B-1wdiA:
undetectable		 1mz9B-1wdiA:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_A_ACTA1117_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 1wdi HYPOTHETICAL PROTEIN
TT0907
(Thermus
thermophilus) 		3 / 3 ASP A  25
ARG A  44
ARG A  46
 None
 0.75A 2j9dA-1wdiA:
undetectable
2j9dC-1wdiA:
undetectable		 2j9dA-1wdiA:
17.47
2j9dC-1wdiA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNJ_A_225A501_1
(CYTOCHROME P450 2C8)		 1wdi HYPOTHETICAL PROTEIN
TT0907
(Thermus
thermophilus) 		5 / 10 LEU A 204
VAL A 256
ALA A 255
VAL A 243
VAL A 239
 None
 1.09A 2nnjA-1wdiA:
undetectable		 2nnjA-1wdiA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UZ2_A_ACTA1123_0
(XENAVIDIN)		 1wdi HYPOTHETICAL PROTEIN
TT0907
(Thermus
thermophilus) 		4 / 7 ASN A  61
LEU A 209
SER A  63
VAL A 211
 CIT  A1322 (-4.4A)
None
None
None
 1.14A 2uz2A-1wdiA:
undetectable		 2uz2A-1wdiA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_A_EV1A1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 1wdi HYPOTHETICAL PROTEIN
TT0907
(Thermus
thermophilus) 		5 / 12 LEU A  58
LEU A  48
VAL A  45
GLU A 199
PHE A 189
 None
 1.29A 2weyA-1wdiA:
undetectable		 2weyA-1wdiA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1wdi HYPOTHETICAL PROTEIN
TT0907
(Thermus
thermophilus) 		4 / 5 PRO A 236
VAL A 239
THR A 258
GLY A 257
 None
None
CIT  A1322 (-3.0A)
CIT  A1322 (-3.2A)
 0.90A 3elzB-1wdiA:
undetectable		 3elzB-1wdiA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1wdi HYPOTHETICAL PROTEIN
TT0907
(Thermus
thermophilus) 		5 / 12 LEU A  58
PHE A 189
ARG A  24
PRO A  49
LEU A  29
 None
 1.04A 4m6kA-1wdiA:
undetectable		 4m6kA-1wdiA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2D_F_LFXF102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 1wdi HYPOTHETICAL PROTEIN
TT0907
(Thermus
thermophilus) 		3 / 4 ARG A  24
GLY A  20
GLU A  22
 None
 0.65A 4z2dB-1wdiA:
undetectable
4z2dC-1wdiA:
undetectable		 4z2dB-1wdiA:
22.54
4z2dC-1wdiA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_0
(METHYLTRANSFERASE)		 1wdi HYPOTHETICAL PROTEIN
TT0907
(Thermus
thermophilus) 		5 / 12 VAL A  32
GLY A 317
TYR A  33
ALA A 313
TYR A   7
 None
 1.11A 5n5dA-1wdiA:
2.1		 5n5dA-1wdiA:
22.99